HIGASHIKUNI Yasutomi 東邦康智

… Alternative Names

東邦康智ヒガシクニヤストミ

Higashikuni Yasutomi 東邦康智

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Researcher Number	10586481
Other IDs
Affiliation (Current)	2023: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2023: 東京大学, 医学部附属病院, 助教 2019 – 2021: 東京大学, 医学部附属病院, 助教 2011 – 2017: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Cardiovascular medicine / Basic Section 53020:Cardiology-related / Circulatory organs internal medicine / 0903:Organ-based internal medicine and related fields Except Principal Investigator Cardiovascular medicine / Pediatrics / Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 心不全 / 炎症 / 心肥大 / 自然炎症 / IL-1β / 心血管病 / 酸化ストレス / 血管新生 / 膜輸送蛋白 / 血管内皮細胞 … More / グルタチオン / 動脈硬化 / 分子心臓病態学 / TLR2 / 熱ショック蛋白質 / NLRP3 / インフラマソーム / 適応応答 / NF-κB / IL-１β / 心リモデリング / NLRP3インフラマソーム / IκBζ / IL-6 / 遺伝子治療 / 合成遺伝子回路 / 表現型スクリーニング / microRNA / 合成生物学 / 心筋細胞保護関連因子 / 病的ストレス感受性遺伝子プロモーター / RNA代謝 / RNAヘリカーゼ / ヘリカーゼ … More Except Principal Investigator 自然免疫 / 動脈硬化 / 慢性炎症 / メタボリックシンドローム / インスリン抵抗性 / 肥満 / 脂肪組織 / マクロファージ / 生活習慣病 / インフラマソーム / カスパーゼ / サイトカイン / 可視化 / 血管周囲脂肪 / 脂肪 / 血管 / コンストラクト / FRET / 川崎病 / 血管炎 / 冠動脈 / TLR / NLRP3 / HMGB1 / ドパミン受容体 / 心不全 / 不整脈 / D1R / 心筋細胞 Less

転写調節因子IκBζを軸としたRNA代謝と蛋白質相互作用による心不全発症機序の解明Principal Investigator
- Principal Investigator
  
  東邦康智
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
Clarification of the mechanism of severe heart failure via cardiac dopamine receptor
- Principal Investigator
  
  山口敏弘
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
Developing novel heart failure therapy targeting DEAD-box RNA helicasePrincipal Investigator
- Principal Investigator
  
  東邦康智
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
Development of Next-Generation Gene Therapy for Heart Failure Through Synthetic Biology ApproachPrincipal Investigator
- Principal Investigator
  
  Higashikuni Yasutomi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0903:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo
Roll of innate immune system in vasculitis of Kawasaki disease
- Principal Investigator
  
  HIRATA Yoichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
心臓における自然炎症制御機構の解明とその心リモデリングにおける役割の検討Principal Investigator
- Principal Investigator
  
  東邦康智
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo
Visualization of chronic inflammation in arterial wall and perivascular adipose tissue
- Principal Investigator
  
  SATA Masataka
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokushima
The Role and the Molecular Mechanisms of Homeostatic Inflammation in the Pathophysiology of Cardiac HypertrophyPrincipal Investigator
- Principal Investigator
  
  HIGASHIKUNI YASUTOMI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo
The Role of ATP-Binding Cassette Transporter ABCG2 in thePathophysiology of Cardiovascular DiseasesPrincipal Investigator
- Principal Investigator
  
  HIGASHIKUNI Yasutomi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo

All 2022 2020 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice.2016
- Author(s)
  Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M.
- Journal Title
  
  Vascular Pharmacology
  
  Volume: 79 Pages: 16-23
- DOI
  10.1016/j.vph.2015.08.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460369, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-16K09517
[Journal Article] Obesity-Induced DNA Released from Adipocytes Stimulates Chronic Adipose Tissue Inflammation and Insulin Resistance.2016
- Author(s)
  Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Murata C, Kim-Kaneyama JR, Sato F, Bando M, Yagi S, Soeki T, Hayashi T, Imoto I, Sakaue H, Shimabukuro M, Sata M.
- Journal Title
  
  Sci Adv
  
  Volume: 2(3)
- DOI
  10.1126/sciadv.1501332
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461149, KAKENHI-PROJECT-25460369, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-16H05299, KAKENHI-PROJECT-16K01823, KAKENHI-PROJECT-16K09517, KAKENHI-PROJECT-16K09753
[Journal Article] Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice2015
- Author(s)
  Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
- Journal Title
  
  Atherosclerosis
  
  Volume: 印刷中 Pages: 639-646
- DOI
  10.1016/j.atherosclerosis.2015.03.023
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461131, KAKENHI-PROJECT-26860565, KAKENHI-PROJECT-25460369, KAKENHI-PROJECT-25293184
[Journal Article] Endothelial PGC-1α mediates vascular dysfunction in diabetes.2014
- Author(s)
  N. Sawada, A. Jiang, F. Takizawa, A. Safdar, A. Manika, Y. Tesmenitsky, K.-T. Kang, J. Bischoff, H. Kalwa, J.L. Sartoretto, Y. Kamei, L.E. Benjamin, H. Watada, Y. Ogawa, Y. Higashikuni, C.W. Kessinger, F.A. Jaffer, T. Michel, M. Sata, K. Croce, R. Tanaka, Z Arany
- Journal Title
  
  Cell Metab.
  
  Volume: 19 Pages: 246-258
- DOI
  10.1016/j.cmet.2013.12.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21117007, KAKENHI-PUBLICLY-25126723, KAKENHI-PROJECT-25292076, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-25670439
[Journal Article] Toll-like receptor-2 mediates adaptive cardiac hypertrophy in response to pressure overload through interleukin-1β upregulation via nuclear factor κB activation2013
- Author(s)
  Higashikuni Y and Komuro I（8人中7番目）
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 2
- DOI
  10.1161/jaha.113.000267
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-21229010, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-25670390, KAKENHI-PROJECT-25860586
[Journal Article] 高血圧性心疾患の病態生理における自然炎症の役割を識る2013
- Author(s)
  東邦康智、小室一成
- Journal Title
  
  Heart View
  
  Volume: 17 Pages: 87-92
- Data Source
  KAKENHI-PROJECT-25860586
[Journal Article] HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9.2013
- Author(s)
  Y. Hirata, H. Kurobe, M. Higashida, D. Fukuda, M. Shimabukuro, Y. Higashikuni, T. Kitagawa, M. Sata
- Journal Title
  
  Atherosclerosis.
  
  Volume: 231 Pages: 227-233
- DOI
  10.1016/j.atherosclerosis.2013.09.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-21117007, KAKENHI-PROJECT-23591314, KAKENHI-PROJECT-24390331, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-25670390, KAKENHI-PROJECT-25860843
[Journal Article] The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response.2012
- Author(s)
  Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Kimie T, Sahara M, Hirata Y, Nagai R, Sata M
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 32 Pages: 654-661
- DOI
  10.1161/atvbaha.111.240341
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117007, KAKENHI-PROJECT-22390159, KAKENHI-PROJECT-22590822, KAKENHI-PROJECT-23659420, KAKENHI-PROJECT-23790836, KAKENHI-PROJECT-24659392
[Journal Article] The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response2012
- Author(s)
  Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Tanaka K, Sahara M, Hirata Y, Nagai R, Sata M
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 32 Pages: 654-61
- Data Source
  KAKENHI-PROJECT-23790836
[Presentation] Homeostatic Inflammation in Heart Disease2022
- Author(s)
  Yasutomi Higashikuni
- Organizer
  The 86th Annual Scientific Meeting of the Japanese Circulation Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08488
[Presentation] 次世代循環器病治療プラットフォーム開発の展望2020
- Author(s)
  東邦　康智
- Organizer
  日本麻酔科学会　第67回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K23988
[Presentation] 次世代循環器病治療プラットフォーム開発の展望2020
- Author(s)
  東邦　康智
- Organizer
  日本麻酔科学会　第67回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08488
[Presentation] Next-Generation Gene Therapy for Heart Failure2020
- Author(s)
  Yasutomi Higashikuni
- Organizer
  84th Annual Scientific Meeting of the Japanese Circulation Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08488
[Presentation] Next-Generation Gene Therapy for Heart Failure2020
- Author(s)
  Yasutomi Higashikuni
- Organizer
  84th Annual Scientific Meeting of the Japanese Circulation Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23988
[Presentation] Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Ameliorates Endothelial Dysfunction and Atherogenesis in Normoglycemic Apolipoprotein-E Deficient Mice through GLP-1 Dependent Manner.2016
- Author(s)
  Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] ω3系不飽和脂肪酸の脂質ラフト構造変化を介した抗動脈硬化作用の解明2016
- Author(s)
  高島啓、福田大受、田中君枝、東邦康智、平田陽一郎、山田博胤、添木武、若槻哲三、島袋充生、佐田政隆
- Organizer
  第45回日本心脈管作動物質学会
- Place of Presentation
  阿波観光ホテル（徳島県徳島市）
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] プロテアーゼ活性化受容体2によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討2016
- Author(s)
  原知也、福田大受、田中君枝、東邦康智、平田陽一郎、八木秀介、添木武、島袋充生、佐田政隆
- Organizer
  第45回日本心脈管作動物質学会
- Place of Presentation
  阿波観光ホテル（徳島県徳島市）
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] 動脈硬化におけるマクロファージTLR9の役割2016
- Author(s)
  西本幸子、福田大受、東邦康智、田中君枝、平田陽一郎、八木秀介、添木武、阪上浩、島袋充生、佐田政隆
- Organizer
  第45回日本心脈管作動物質学会
- Place of Presentation
  阿波観光ホテル（徳島県徳島市）
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Deletion of Toll-Like Receptor 9 Prevented Atherosclerosis Induced by Angiotensin II.2016
- Author(s)
  Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in apolipoprotein-E deficient mice through GLP-1 dependent and independent manners.2016
- Author(s)
  Hotimah Masdan Salim、福田大受、東邦康智、田中君枝、平田陽一郎、八木秀介、添木武、島袋充生、佐田政隆
- Organizer
  第45回日本心脈管作動物質学会
- Place of Presentation
  阿波観光ホテル（徳島県徳島市）
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Cell-Free DNA/Toll-like Receptor 9 Axis Plays a Pivotal Role in Metabolic Disorder-induced Chronic Inflammation, Leading to Atherogenesis and Insulin Resistance.2016
- Author(s)
  Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2016-03-18
- Invited
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] TLR9の活性化は虚血肢における炎症を増強し血流改善を遅延させる2016
- Author(s)
  六車隆太郎、福田大受、西本幸子、東邦康智、田中君枝、平田陽一郎、八木秀介、添木武、島袋充生、佐田政隆
- Organizer
  第45回日本心脈管作動物質学会
- Place of Presentation
  阿波観光ホテル（徳島県徳島市）
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Critical Role in Bone Marrow Protease-Activated Receptor-2 in the Pathogenesis of Vascular Inflammation and Atherosclerosis in ApoE-Deficient Mice.2016
- Author(s)
  Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] 自己遊離核酸断片の認識を介した血管の炎症と動脈硬化発症メカニズム2015
- Author(s)
  福田大受、西本幸子、東邦康智、田中君枝、平田陽一郎、八木秀介、添木武、島袋充生、佐田政隆
- Organizer
  CVMW 2015
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-10
- Invited
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Dipeptidyl Peptidase-4 Inhibitor, Linagliptin, Ameliorates Endothelial Dysfunction and Atherogenesis in Apolipoprotein-e Deficient Mice Through GLP-1 Dependent and Independent Manners.2015
- Author(s)
  Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M.
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orange County Convention Center（Orlando, USA）
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] The Role of the Central Nervous System in Heart Disease.2015
- Author(s)
  Higashikuni Y, Sata M, Komuro I
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Inhibition of Activated Factor X Attenuates Neointima Formation after Wire-Mediated Vascular Injury.2015
- Author(s)
  Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata S.
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] The activation of toll-like receptor 9 deteriorates blood flow recovery after hind-limb ischemia.2015
- Author(s)
  Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Sakaue H, Shimabukuro M, Sata M.
- Organizer
  ESC Congress 2015
- Place of Presentation
  ExCel London（London, UK）
- Year and Date
  2015-08-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] N-3 Polyunsaturated Fatty Acids Inhibit Inflammatory Responses in Macrophages by the Reduction of Toll-like Receptor 4 Expression in Lipid Rafts, Leading to the Suppression of Atherogenesis in Apolipoprotein E Deficient Mice.2015
- Author(s)
  Takashima A, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orange County Convention Center（Orlando, USA）
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Inhibition of Activated Factor X Attenuates Vascular Inflammation and Atherosclerosis in ApoE-deficient Mice.2015
- Author(s)
  Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Toll-like Receptor 9 Plays a Pivotal Role in Angiotensin II-induced Atherosclerosis.2015
- Author(s)
  Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Sakaue H, Shimabukuro M, Sata M.
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orange County Convention Center（Orlando, USA）
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] 活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討2015
- Author(s)
  原知也、福田大受、田中君枝、東邦康智、平田陽一郎、八木秀介、山田博胤、添木武、若槻哲三、島袋充生、佐田政隆
- Organizer
  第2回日本心血管脳卒中学会学術集会
- Place of Presentation
  ホテルクレメント徳島（徳島県徳島市）
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Hematopoietic Protease-activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in ApoE-Deficient Mice.2015
- Author(s)
  Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orange County Convention Center（Orlando, USA）
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] The Inducible Nuclear Protein IκBζ Plays a Pivotal Role in Transition from Adaptive to Maladaptive Cardiac Hypertrophy during Pressure Overload2015
- Author(s)
  Yasutomi Higashikuni, Masataka Sata, Issei Komuro
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪国際会議場　（大阪府大阪市）
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15K09133
[Presentation] Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and the development of atherosclerosis in normoglycemic apolipoprotein-E deficient mice.2015
- Author(s)
  Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M
- Organizer
  CVMW 2015
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] The Role of the Central Nervous System in Heart Disease2015
- Author(s)
  Yasutomi Higashikuni, Masataka Sata, Issei Komuro
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  ABCホール　（大阪府大阪市）
- Year and Date
  2015-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-15K09133
[Presentation] The Role and the Regulatory Mechanisms of Homeostatic Inflammation in Heart Disease2015
- Author(s)
  Yasutomi Higashikuni
- Organizer
  The 3rd Homeostatic Inflammation International Symposium
- Place of Presentation
  東京
- Year and Date
  2015-01-29
- Invited
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] The Inducible Nuclear Protein IκBζ Plays a Pivotal Role in Transition from Adaptive to Maladaptive Cardiac Hypertrophy during Pressure Overload.2015
- Author(s)
  Higashikuni Y, Fukuda D, Sata M, Komuro I.
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Pathogen Recognition Receptors-Mediated Inflammation Induces Adaptive Cardiac Hypertrophy2014
- Author(s)
  Yasutomi Higashikuni, Masataka Sata, Issei Komuro
- Organizer
  Keystone Symposia
- Place of Presentation
  Keystone, USA
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] 心肥大の病態生理におけるNLRP3インフラマソームを介した心脳連関の役割2014
- Author(s)
  東邦康智、小室一成、佐田政隆
- Organizer
  第10回宮崎サイエンスキャンプ
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] NLRP3 inflammasome activation through the heart-brain interaction contributes to adaptive cardiac hypertrophy in response to pressure overload2014
- Author(s)
  Yasutomi Higashikuni, Masataka Sata, Issei Komuro
- Organizer
  第78日本循環器学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] Toll-Like Receptor 2-Mediated Inflammation Induces Adaptive Cardiac Hypertrophy in Response to Pressure Overload2013
- Author(s)
  Yasutomi Higashikuni, Ryozo Nagai, Masataka Sata, Issei Komuro
- Organizer
  AHA Scientific Sessions 2013
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] 自然免疫受容体を介した炎症反応が心臓の圧負荷に対する適応応答を誘導する2013
- Author(s)
  東邦康智、佐田政隆、小室一成
- Organizer
  第17回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] Role of pathogen receptor-mediated non-infectious inflammation in cardiac adaptive response to pressure overload2013
- Author(s)
  Yasutomi Higashikuni, Masataka Sata, Issei Komuro
- Organizer
  第21回日本血管生物医学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] 高血圧による炎症誘導メカニズムの解明及びその心肥大における役割の検討2013
- Author(s)
  東邦康智、佐田政隆、小室一成
- Organizer
  第19回TMFC研究発表会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] Pathogen receptor-mediated inflammation contributes to adaptive cardiac hypertrophy in response to pressure overload2013
- Author(s)
  Yasutomi Higashikuni, Ryozo Nagai, Masataka Sata, Issei Komuro
- Organizer
  第20回国際心臓研究学会日本部会総会
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] The ATP-Binding Cassette Transporter ABCG2 Protects against Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure via Regulation of Antioxidant Response2012
- Author(s)
  Yasutomi Higashikuni
- Organizer
  第76回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790836
[Presentation] TheATP-Binding Cassette Transporter ABCG2Protects against Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure via Regulation ofAntioxidant Response2012
- Author(s)
  Higashikuni Y, Ryozo Nagai, Sata M
- Organizer
  第76回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790836
[Presentation] 心臓での酸化ストレス応答における血管内皮細胞の役割2012
- Author(s)
  東邦康智,永井良三,佐田政隆
- Organizer
  第8回宮崎サイエンスキャンプ
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-23790836
[Presentation] 心臓での酸化ストレス応答におけるABCトランスポーターABCG2の役割2011
- Author(s)
  東邦康智,永井良三,佐田政隆
- Organizer
  第15回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23790836
[Presentation] The Roleof the ATP-Binding Cassette TransporterABCG2 in Antioxidant Response in the Heart2011
- Author(s)
  Higashikuni Y, Nagai R, Sata M
- Organizer
  第28回ISHR日本部会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790836
[Presentation] The ATP-Binding Cassette Transporter ABCG2 Protects Against Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure by Promoting Angiogenesis and Antioxidant Response. American Heart Association2011
- Author(s)
  Higashikuni Y, Nagai R, Sata M
- Organizer
  Scientific Sessions
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-23790836
[Presentation] The ATP-Binding Cassette Transporter ABCG2 Protects Against Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure by Promoting Angiogenesis and Antioxidant Response2011
- Author(s)
  Yasutomi Higashikuni
- Organizer
  American Heart Association, Scientific Sessions 2011
- Place of Presentation
  Orlando
- Data Source
  KAKENHI-PROJECT-23790836
[Presentation] The Role of the ATP-Binding Cassette Transporter ABCG2 in Antioxidant Response in the Heart2011
- Author(s)
  Yasutomi Higashikuni
- Organizer
  第28回ISHR日本部会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790836
[Presentation] 心疾患における自然炎症の役割とその制御機構
- Author(s)
  東邦康智、佐田政隆、小室一成
- Organizer
  第18回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-11-21 – 2014-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] NLRP3 inflammasome activation through the heart-brain interaction is important for adaptive cardiac hypertrophy in response to pressure overload.
- Author(s)
  Higashikuni Y, Sata M, Komuro I.
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  みやこめっせ（京都府京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Rivaroxaban, a direct factor Xa inhibitor, attenuates plaque progression and destabilization in ApoE-deficient mice by inhibiting macrophage activation.
- Author(s)
  Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
- Organizer
  ESC 2014
- Place of Presentation
  FIRA de Barcelona(Barcelona, Spain)
- Year and Date
  2014-08-29 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Rivaroxaban, a direct factor Xa inhibitor, attenuates neointima formation following vascular injury in the mouse through the inhibition of proliferative activation of vascular smooth muscle cells.
- Author(s)
  Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
- Organizer
  ESC 2014
- Place of Presentation
  FIRA de Barcelona(Barcelona, Spain)
- Year and Date
  2014-08-29 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Rivaroxaban, a direct factor Xa inhibitor, attenuates neointima formation after mechanical vascular injury.
- Author(s)
  Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
- Organizer
  AHA Scientific Sessions 2014
- Place of Presentation
  McCormick Place(Chicago, America)
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] 圧負荷心肥大における心脳連関を介した炎症制御メカニズムとその役割
- Author(s)
  東邦康智、佐田政隆、小室一成
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Invited
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] Genetic deletion of toll-like receptor 9 accelerates blood flow recovery after hindlimb ischemia.
- Author(s)
  Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Sakaue H, Shimabukuro M, Sata M.
- Organizer
  AHA Scientific Sessions 2014
- Place of Presentation
  McCormick Place(Chicago, America)
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] The inducible nuclear protein IκBζ plays a pivotal role in the transition from adaptive to maladaptive cardiac hypertrophy during pressure overload.
- Author(s)
  Higashikuni Y, Fukuda D, Sata M, Komuro I.
- Organizer
  AHA Scientific Sessions 2014
- Place of Presentation
  McCormick Place(Chicago, America)
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] The inducible nuclear protein IκBζ plays a pivotal role in the transition from adaptive to maladaptive cardiac hypertrophy during pressure overload.
- Author(s)
  Higashikuni Y, Fukuda D, Sata M, Komuro I.
- Organizer
  The 31st Annual Meeting of the International Society for Heart Research Japanese Section
- Place of Presentation
  ウインクあいち(愛知県名古屋市)
- Year and Date
  2014-11-28 – 2014-11-29
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] The central nervous system regulates inflammation and cardiac remodeling during pressure overload through NLRP3 inflammasome activation
- Author(s)
  Yasutomi Higashikuni, Masataka Sata, Issei Komuro
- Organizer
  AHA Scientific Sessions 2014
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] 高血圧性心疾患における自然免疫系の役割
- Author(s)
  東邦康智、佐田政隆、小室一成
- Organizer
  第8回高血圧と冠動脈疾患研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] 圧負荷心肥大におけるNLRP3インフラマソームを介した心脳連関の役割
- Author(s)
  東邦康智、佐田政隆、小室一成
- Organizer
  第35回日本炎症・再生医学会
- Place of Presentation
  沖縄
- Year and Date
  2014-07-01 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] NLRP3 inflammasome activation through the heart-brain interaction is important for adaptive cardiac hypertrophy in response to pressure overload
- Author(s)
  Yasutomi Higashikuni, Masataka Sata, Issei Komuro
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  京都
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] 圧負荷心肥大の病態生理におけるNLRP3インフラマソームを介した心脳連関の役割
- Author(s)
  東邦康智、佐田政隆、小室一成
- Organizer
  第35回日本炎症・再生医学会
- Place of Presentation
  万国津梁館（沖縄県名護市）
- Year and Date
  2014-07-01 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] 圧負荷心肥大の病態生理におけるNLRP3インフラマソームを介した心脳連関の役割
- Author(s)
  東邦康智、佐田政隆、小室一成
- Organizer
  第51回日本臨床分子医学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-04-11 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-25860586
[Presentation] Combined administration of eicosapentaenoic acid and docosahexaenoic acid reduces atherosclerotic lesion in apolipoprotein E-deficient mice.
- Author(s)
  Takashima A, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
- Organizer
  ESC 2014
- Place of Presentation
  FIRA de Barcelona(Barcelona, Spain)
- Year and Date
  2014-08-29 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] 心疾患における自然炎症の役割とその制御機構
- Author(s)
  東邦康智、佐田政隆、小室一成
- Organizer
  第18回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  横浜市開港記念会館（神奈川横浜市）
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] 活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討
- Author(s)
  原知也、福田大受、田中君江、東邦康智、平田陽一郎、八木秀介、山田博胤、添木武、若槻哲三、島袋充生、佐田政隆
- Organizer
  第44回日本心脈管作動物質学会
- Place of Presentation
  高松センタービル（香川県高松市）
- Year and Date
  2015-02-06 – 2015-02-07
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] Rivaroxaban, A Novel Oral Anticoagulant, Attenuates Plaque Progression in ApoE-Deficient Mice Through the Inhibition of Pro-Inflammatory Activation of Macrophages.
- Author(s)
  Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
- Organizer
  AHA Scientific Sessions 2013
- Place of Presentation
  ﾀﾞﾗｽｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ（Dallas, America）
- Year and Date
  2013-11-16 – 2013-11-20
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] The central nervous system regulates inflammation and cardiac remodeling during pressure overload through NLRP3 inflammasome activation.
- Author(s)
  Higashikuni Y, Sata M, Komuro I.
- Organizer
  AHA Scientific Sessions 2014
- Place of Presentation
  McCormick Place(Chicago, America)
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25293184
[Presentation] 圧負荷心肥大における心脳連関を介した炎症制御メカニズムとその役割（The Regulatory Mechanism of Inflammation in the Heart through the Heart-Brain　Interaction and Its Role in Pressure Overload-Induced Cardiac Hypertrophy）
- Author(s)
  東邦康智、佐田政隆、小室一成
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25293184

1. HIRATA Yoichiro (40447397)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. SATA Masataka (80345214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 42 results
3. HORIKAWA Kazuki (70420247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. FUKUDA Daiju (40637568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 33 results
5. SATOMI Junichi (10304510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAYAMA Taisuke (80582791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 犬塚亮 (00597560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山口敏弘 (50802394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 瀧本英樹 (20709513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAGI Shusuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. KUROBE Hirotsugu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 平田恭信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 金山朱里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 添木武

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 島袋充生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 阪上浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 小川佳宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 亀井康富

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 田中都

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 小室一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 原知也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 北川哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGASHIKUNI Yasutomi 東邦 康智

東邦 康智 ヒガシクニ ヤストミ

Higashikuni Yasutomi 東邦 康智

Research Projects

Research Products

Co-Researchers

転写調節因子IκBζを軸としたRNA代謝と蛋白質相互作用による心不全発症機序の解明Principal Investigator

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Clarification of the mechanism of severe heart failure via cardiac dopamine receptor

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Developing novel heart failure therapy targeting DEAD-box RNA helicasePrincipal Investigator

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Development of Next-Generation Gene Therapy for Heart Failure Through Synthetic Biology ApproachPrincipal Investigator

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Roll of innate immune system in vasculitis of Kawasaki disease

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心臓における自然炎症制御機構の解明とその心リモデリングにおける役割の検討Principal Investigator

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Visualization of chronic inflammation in arterial wall and perivascular adipose tissue

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The Role and the Molecular Mechanisms of Homeostatic Inflammation in the Pathophysiology of Cardiac HypertrophyPrincipal Investigator

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The Role of ATP-Binding Cassette Transporter ABCG2 in thePathophysiology of Cardiovascular DiseasesPrincipal Investigator

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[Journal Article] Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice.2016

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[Journal Article] Obesity-Induced DNA Released from Adipocytes Stimulates Chronic Adipose Tissue Inflammation and Insulin Resistance.2016

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[Journal Article] Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice2015

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[Journal Article] Endothelial PGC-1α mediates vascular dysfunction in diabetes.2014

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HIGASHIKUNI Yasutomi 東邦康智

東邦康智ヒガシクニヤストミ

Higashikuni Yasutomi 東邦康智