Shikama Yosuke 四釜洋介

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SHIKAMA Yosuke 四釜洋介

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Researcher Number	10588908
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立長寿医療研究センター, 研究所口腔疾患研究部, 副部長
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立長寿医療研究センター, 研究所口腔疾患研究部, 副部長 2021 – 2023: 国立研究開発法人国立長寿医療研究センター, 研究所口腔疾患研究部, 副部長 2021: 国立研究開発法人国立長寿医療研究センター, 口腔疾患研究部, 副部長 2016 – 2020: 国立研究開発法人国立長寿医療研究センター, 口腔疾患研究部, 室長 2012 – 2014: 徳島大学, 大学病院, 特任助教 2013: 徳島大学, 病院, 特任助教
Review Section/Research Field	Principal Investigator Pathobiological dentistry/Dental radiology / Basic Section 57020:Oral pathobiological science-related / Basic Section 57080:Social dentistry-related Except Principal Investigator Basic Section 57050:Prosthodontics-related
Keywords	Principal Investigator シェーグレン症候群 / 国際情報交換 / 遊離脂肪酸 / 唾液腺 / 慢性炎症 / 個体老化 / 細胞老化 / 口腔乾燥症 / ウイルス / インターフェロン … More / ウイルス感染 / 自然免疫 / 口腔粘膜 / 脂質代謝異常 / ドライマウス / 糖脂質代謝異常 / 飽和脂肪酸 / 代謝異常 / 国際情報研究 … More Except Principal Investigator 慢性筋痛 / 慢性疼痛 / エラスターゼ / 好中球細胞外トラップ / 筋衛星細胞 / サイトカイン / 好中球 / 顎関節症 / 筋-筋膜性疼痛 Less

選択的オートファジーを基軸とした加齢・糖尿病に起因する口腔乾燥症の新たな病因論Principal Investigator
- Principal Investigator
  
  四釜洋介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  National Center for Geriatrics and Gerontology
Common molecular mechanisms underlying age- and autoimmune-related disturbance of salivary secretionPrincipal Investigator
- Principal Investigator
  
  四釜洋介
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  National Center for Geriatrics and Gerontology
Inflammatory transformation of myofibers via neutrophil fusion - Elucidation of the onset mechanism of chronic myalgia-
- Principal Investigator
  
  TSUCHIYA MASAHIRO
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Tohoku University
  Tohoku Fukushi University
Potential role of interleukin-29 in oral mucosal defense against virusesPrincipal Investigator
- Principal Investigator
  
  Shikama Yosuke
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  National Center for Geriatrics and Gerontology
Possible involvement of palmitate in the pathogenesis of primary Sjogren's SyndromePrincipal Investigator
- Principal Investigator
  
  SHIKAMA Yosuke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  National Center for Geriatrics and Gerontology
飽和脂肪酸がシェーグレン症候群の病態増悪に関与する可能性：モデルマウスによる解析Principal Investigator
- Principal Investigator
  
  四釜洋介
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The University of Tokushima
Crosstalk between salivary gland chronic inflammation and saturated fatty acids in plasmaPrincipal Investigator
- Principal Investigator
  
  SHIKAMA Yosuke
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The University of Tokushima

All 2022 2021 2020 2019 2018 2017 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] 高齢者糖尿病の口腔と健康2022
- Author(s)
  四釜洋介　松下健二
- Journal Title
  
  月刊糖尿病
  
  Volume: 14 Pages: 77-83
- Data Source
  KAKENHI-PROJECT-21H03115
[Journal Article] Analysis of senescence in gingival tissues and gingival fibroblast cultures2022
- Author(s)
  Furukawa, M., Matsuda ,K. et al.
- Journal Title
  
  Clinical and Experimental Dental Research
  
  Volume: 8 Issue: 4 Pages: 1-11
- DOI
  10.1002/cre2.581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-22K10112, KAKENHI-PROJECT-21H03115, KAKENHI-PROJECT-22KJ3207
[Journal Article] Molar loss induces hypothalamic and hippocampal astrogliosis in aged mice2022
- Author(s)
  Furukawa, M., Tada, H., Wang, J. et al.
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 6409-6409
- DOI
  10.1038/s41598-022-10321-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-22KJ3207, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-21H03115, KAKENHI-PROJECT-20K21779, KAKENHI-PROJECT-23K24805
[Journal Article] The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa2022
- Author(s)
  Shikama Yosuke、Kurosawa Mie、Furukawa Masae、Kudo Yasusei、Ishimaru Naozumi、Matsushita Kenji
- Journal Title
  
  Inflammation
  
  Volume: - Issue: 3 Pages: 1-14
- DOI
  10.1007/s10753-022-01624-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-19H01070, KAKENHI-PROJECT-20H03904, KAKENHI-PROJECT-21K19605, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-22KJ3207, KAKENHI-PROJECT-21H03115
[Journal Article] Chemokines Up-Regulated in Epithelial Cells Control Senescence-Associated T Cell Accumulation in Salivary Glands of Aged and Sj?gren’s Syndrome Model Mice2021
- Author(s)
  Kurosawa Mie、Shikama Yosuke、Furukawa Masae、Arakaki Rieko、Ishimaru Naozumi、Matsushita Kenji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 5 Pages: 2302-2302
- DOI
  10.3390/ijms22052302
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-19H01070, KAKENHI-PROJECT-21K09859, KAKENHI-PROJECT-20H03904
[Journal Article] Effect of green propolis extracts on experimental aged gingival irritation in vivo and in vitro2021
- Author(s)
  Furukawa Masae、Wang Jingshu、Kurosawa Mie、Ogiso Noboru、Shikama Yosuke、Kanekura Takuro、Matsushita Kenji
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 63 Issue: 1 Pages: 58-65
- DOI
  10.1016/j.job.2020.12.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-20H03904
[Journal Article] ヒトとマウスの相違およびアディポネクチンの関連性2021
- Author(s)
  四釜洋介
- Journal Title
  
  Frontiers in Dry Eye
  
  Volume: 16 Pages: 20-21
- Data Source
  KAKENHI-PROJECT-21H03115
[Journal Article] Basic Studies on the Mechanism, Prevention, and Treatment of Osteonecrosis of the Jaw Induced by Bisphosphonates2020
- Author(s)
  Endo Yasuo、Funayama Hiromi、Yamaguchi Kouji、Monma Yuko、Yu Zhiqian、Deng Xue、Oizumi Takefumi、Shikama Yosuke、Tanaka Yukinori、Okada Satoshi、Kim Siyoung、Kiyama Tomomi、Bando Kanan、Shima Kazuhiro、Suzuki Hikari、Takahashi Tetsu
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 140 Issue: 1 Pages: 63-79
- DOI
  10.1248/yakushi.19-00125
- NAID
  130007778763
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2020-01-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11976, KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-18K17240, KAKENHI-PROJECT-16K11672, KAKENHI-PROJECT-18K17111
[Journal Article] Periodontal Disease and Periodontal Disease-Related Bacteria Involved in the Pathogenesis of Alzheimer’s Disease2020
- Author(s)
  Matsushita Kenji、Yamada-Furukawa Masae、Kurosawa Mie、Shikama Yosuke
- Journal Title
  
  Journal of Inflammation Research
  
  Volume: Volume 13 Pages: 275-283
- DOI
  10.2147/jir.s255309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-20K18494
[Journal Article] High concentration of glucose induces filaggrin-1 expression through AP-1 in skin keratinocytes2020
- Author(s)
  Masae Furukawa, Kiyoko Yamada, Mie Kurosawa, Yosuke Shikama, Takuro Kanekura and Kenji Matsushita
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: - Issue: 2 Pages: 137-140
- DOI
  10.1016/j.jdermsci.2020.04.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-20H03904
[Journal Article] Imaging of muscle activity‐induced morphometric changes in fibril network of myofascia by two‐photon microscopy2020
- Author(s)
  Chaweewannakorn Chayanit、Harada Takashi、Nyasha Mazvita R.、Koide Masashi、Shikama Yosuke、Hagiwara Yoshihiro、Sasaki Keiichi、Kanzaki Makoto、Tsuchiya Masahiro
- Journal Title
  
  Journal of Anatomy
  
  Volume: 238 Issue: 3 Pages: 515-526
- DOI
  10.1111/joa.13339
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-19K10229, KAKENHI-PROJECT-20H04118
[Journal Article] Dietary diversity and characteristics of lifestyle and awareness of health in Japanese workers : a cross-sectional study2020
- Author(s)
  Nakamoto Mariko、Yun Yuna、Omine Mariko、Mori Sarasa、Shuto Emi、Nakamoto Akiko、Hata Akiko、Aki Nanako、Shikama Yosuke、Bando Yukiko、Ichihara Takako、Minagawa Takako、Tamura Ayako、Kuwamura Yumi、Funaki Makoto、Sakai Tohru
- Journal Title
  
  J. Med. Invest.
  
  Volume: 67 Issue: 3.4 Pages: 255-264
- DOI
  10.2152/jmi.67.255
- NAID
  130007936871
- ISSN
  1343-1420, 1349-6867
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09548
[Journal Article] Associations of Dietary Diversity With Allergic Diseases in Japanese Workers: A Cross-Sectional Study2019
- Author(s)
  Nakamoto M, Omine M, Yun Y, Shuto E, Nakamoto A, Hata A, Aki N, Shikama Y, Bando Y, Ichihara T, Minamigawa T, Tamura A, Kuwamura Y, Funaki M, Sakai T.
- Journal Title
  
  Asia Pac J Clin Nutr
  
  Volume: 28 Pages: 857-869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09548
[Journal Article] Involvement of adiponectin in age-related increases in tear production in mice2019
- Author(s)
  Shikama Yosuke、Kurosawa Mie、Furukawa Masae、Ishimaru Naozumi、Matsushita Kenji
- Journal Title
  
  Aging
  
  Volume: 11 Issue: 19 Pages: 8329-8346
- DOI
  10.18632/aging.102322
- NAID
  120007146099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-19H01070, KAKENHI-PROJECT-18K19648, KAKENHI-PROJECT-18K17037
[Journal Article] IL-29 は口腔粘膜上皮細胞においてRIG-IおよびIFI-16発現誘導を介し抗ウイルス活性を増強する2019
- Author(s)
  四釜洋介、黒澤実愛、松下健二
- Journal Title
  
  エンドトキシン・自然免疫研究２２エンドトキシン・自然免疫研究の新たな可能性を求めて
  
  Volume: 22 Pages: 40-42
- Data Source
  KAKENHI-PROJECT-18K09548
[Journal Article] Soy product and isoflavone intake associations with allergic diseases in Japanese workers: rhinitis, dermatitis and asthma.2018
- Author(s)
  Nakamoto M, Shuto E, Nakamoto A, Hata A, Aki N, Shikama Y, Bando Y, Ichihara T, Minagawa T, Tamura A, Kuwamura Y, Funaki M, Sakai T.
- Journal Title
  
  Asia Pacific Journal of Clinical Nutrition
  
  Volume: 27 Pages: 1277-1285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09548
[Journal Article] Free fatty acids may be involved in the pathogenesis of oral-related and cardiovascular diseases2018
- Author(s)
  Shikama Y.
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 60 Pages: 65-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09548
[Journal Article] Associations between intake of dietary fermented soy food and concentrations of inflammatory markers: a cross‐sectional study in Japanese workers2018
- Author(s)
  Yang X, Nakamoto M, Shuto E, Hata A, Aki N, Shikama Y, Bando Y, Ichihara T, Minamigawa T, Kuwamura Y, Tamura A, Uemura H, Arisawa K, Funaki M, Sakai T
- Journal Title
  
  J. Med. Invest.
  
  Volume: 65 Issue: 1.2 Pages: 74-80
- DOI
  10.2152/jmi.65.74
- NAID
  130006575620
- ISSN
  1343-1420, 1349-6867
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00063, KAKENHI-PROJECT-16H07017
[Journal Article] Potential Role of Free Fatty Acids in the Pathogenesis of Periodontitis and Primary Sjogren’s Syndrome2017
- Author(s)
  Shikama Y, Kudo Y, Ishimaru N, Funaki M.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18 Issue: 4 Pages: 1-8
- DOI
  10.3390/ijms18040836
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02690, KAKENHI-PROJECT-16K09785, KAKENHI-PROJECT-16H07017
[Journal Article] Pulmonary platelet accumulation induced by catecholamines: its nvolvement in lipopolysaccharide-induced anaphylaxis-like shock.2017
- Author(s)
  Zhiqian Yu, Hiroko Saito, Hirotada Otsuka, Yosuke Shikama, Hiromi Funayama, Mai Sakai, Shigeo Murai, Masanori Nakamura, Takashi Yokochi, Haruhiko Takada, Shunji Sugawara, Yasuo Endo.
- Journal Title
  
  International Immunopharmacol
  
  Volume: 43 Pages: 40-53
- DOI
  10.1016/j.intimp.2016.11.034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K20367, KAKENHI-PROJECT-16K11672, KAKENHI-PROJECT-15K11022, KAKENHI-PROJECT-17K17089, KAKENHI-PROJECT-16H07017
[Journal Article] Palmitate-stimulated monocytes induce adhesion molecule expression in endothelial cells via IL-1 signaling pathway.2015
- Author(s)
  Shikama Y, Aki N, Hata A, Nishimura M, Oyadomari S, Funaki M.
- Journal Title
  
  J Cell Physiol
  
  Volume: 230 Issue: 3 Pages: 732-742
- DOI
  10.1002/jcp.24797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293080, KAKENHI-PROJECT-26462840, KAKENHI-PROJECT-26670270
[Journal Article] Correlation of fibroblast growth factor 21 serum levels with metabolic parameters in Japanese subjects2014
- Author(s)
  Jin Q, Bando Y, Miyawaki K, Shikama Y, Kosugi C, Aki N, Funaki M, Noji S
- Journal Title
  
  J Med Invest
  
  Volume: 61 Pages: 28-34
- NAID
  130004822713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792001
[Journal Article] Effect of substrate rigidity in tissue culture on the function of insulin-secreting INS-1E cells2014
- Author(s)
  Naujok O, Bandou Y, Shikama Y, Funaki M, Lenzen S
- Journal Title
  
  J Tissue Eng Regen Med
  
  Volume: 11 Issue: 1 Pages: 58-65
- DOI
  10.1002/term.1857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792001
[Journal Article] Effects of free fatty acids on human salivary gland epithelial cells2013
- Author(s)
  Shikama Y, Ishimaru N, Kudo Y, Bando Y, Aki N, Hayashi Y, Funaki M
- Journal Title
  
  J Dent Res
  
  Volume: 92 Pages: 540-546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792001
[Journal Article] Effects of free fatty acids on human salivary gland epithelial cells2013
- Author(s)
  Yosuke Shikama, Naozumi Ishimaru, Yasusei Kudo, Yukiko Bando, Nanako Aki, Yoshio Hayashi, Makoto Funaki
- Journal Title
  
  Journal of Dental Research
  
  Volume: 92 Issue: 6 Pages: 540-546
- DOI
  10.1177/0022034513487378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] 口腔領域における自然免疫系を介した慢性炎症・免疫賦活に関する研究2022
- Author(s)
  四釜洋介
- Organizer
  第 27 回日本エンドトキシン・自然免疫研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03115
[Presentation] 唾液腺および口腔粘膜上皮細胞におけるACE2発現：AMPKの役割2022
- Author(s)
  四釜洋介　古川匡恵　松下健二
- Organizer
  第64回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-21H03115
[Presentation] 老齢マウスにおけるアディポネクチンと涙液分泌の関連性2021
- Author(s)
  四釜洋介、黒澤実愛、古川匡恵、松下健二
- Organizer
  第43回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-18K09548
[Presentation] 老化関連T細胞および唾液腺上皮の細胞老化が口腔乾燥症の病態形成に関与する可能性2021
- Author(s)
  黒澤実愛、古川匡恵、松下健二、四釜洋介
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09548
[Presentation] III型interferon(IFN)であるinterleukin(IL)-29の口腔粘膜における抗ウイルス応答増強作用2021
- Author(s)
  四釜洋介　古川匡恵　松下健二
- Organizer
  第64回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-21H03115
[Presentation] 加齢に伴う涙液分泌の変化：ヒトとマウスの相違およびアディポネクチンの関連性2021
- Author(s)
  四釜洋介
- Organizer
  第74回日本臨床眼科学会
- Data Source
  KAKENHI-PROJECT-18K09548
[Presentation] III型interferon(IFN)であるinterleukin(IL)-29の口腔粘膜における抗ウイルス応答増強作用2021
- Author(s)
  四釜洋介、古川匡恵、松下健二
- Organizer
  第64回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09548
[Presentation] エストロゲンの欠乏は唾液腺上皮細胞にCXCL13産生を誘導し、老化関連T細胞集積を促進する2019
- Author(s)
  四釜洋介、黒澤実愛、古川匡恵、松下健二
- Organizer
  第42回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-18K09548
[Presentation] 免疫老化及び細胞老化による唾液腺へのSA-T細胞集積メカニズムの解析2019
- Author(s)
  黒澤実愛、古川匡恵、松下健二、四釜洋介
- Organizer
  第38回分子病理学研究会
- Data Source
  KAKENHI-PROJECT-18K09548
[Presentation] 唾液腺上皮の細胞老化及び免疫老化が唾液腺機能に与える影響:老齢マウスおよびモデルマウスを用いた解析2019
- Author(s)
  黒澤実愛、古川匡恵、松下健二、四釜洋介
- Organizer
  第28回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-18K09548
[Presentation] Senescence-associated T-lymphocytes accumulate in the submandibular glands of aged mice2019
- Author(s)
  Kurosawa Mie, Furukawa Masae, Matsushita Kenji, Shikama Yosuke
- Organizer
  97th IADR General Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09548
[Presentation] IL-29は口腔粘膜上皮細胞においてRIG-I発現誘導を介し抗ウイルス活性を増強する2018
- Author(s)
  四釜洋介、黒澤実愛、松下健二
- Organizer
  第24回日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-18K09548
[Presentation] 口腔粘膜におけるIL-29の抗真菌および抗ウイルス作用：臨床応用の可能性2018
- Author(s)
  四釜洋介、黒澤実愛、山田（古川）匡恵、松下健二
- Organizer
  第61回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09548
[Presentation] 加齢および脂質代謝異常によるドライマウス発症機序とその病態解明2018
- Author(s)
  四釜洋介
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09548
[Presentation] 糖脂質代謝異常とシェーグレン症候群の病態:Adipokine の関連性2017
- Author(s)
  四釜洋介、新垣理恵子、大塚邦紘、石丸直澄、松下健二
- Organizer
  第26回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-16H07017
[Presentation] 飽和脂肪酸が歯周病の病態形成に関与する可能性2017
- Author(s)
  四釜洋介、工藤保誠、石丸直澄、船木真理
- Organizer
  第59回歯科基礎医学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H07017
[Presentation] Palmitate may exacerbate the pathogenesis of periodontitis2017
- Author(s)
  Shikama Y, Ishimaru N, Kudo Y, Matsushita K, Funaki M
- Organizer
  American Academy of Periodontology 103rd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07017
[Presentation] 口腔粘膜での抗ウイルス自然免疫応答におけるinterleukin (IL)-29の役割2017
- Author(s)
  四釜洋介、松下健二
- Organizer
  日本歯周病学会60周年記念京都大会
- Data Source
  KAKENHI-PROJECT-16H07017
[Presentation] High levels of saturated fatty acids may exacerbate the pathogenesis of primary Sjogren’s syndrome2014
- Author(s)
  Yosuke Shikama, Naozumi Ishimaru,Yasusei Kudo, Rieko Arakaki, Yoshio Hayashi, Makoto Funaki
- Organizer
  The 5th International Symposium for Interface Oral Health Science
- Place of Presentation
  片平さくらホール（宮城県仙台市)
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] High levels of saturated fatty acids may exacerbate the pathogenesis of primary Sjögren's syndrome2014
- Author(s)
  Shikama Y, Ishimaru N, Kudo Y, Arakaki R, Hayashi Y, Funaki
- Organizer
  The 5th International Symposium for Interface Oral Health Science
- Place of Presentation
  片平さくらホール (宮城県, 仙台市)
- Year and Date
  2014-01-21
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] ヒト単球における遊離脂肪酸のIL-1 受容体アンタゴニスト(IL-1Ra)産生に対する効果2013
- Author(s)
  四釜洋介, 安藝菜奈子, 秦明子, 坂東由記子, 西村美穂, 船木真理
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台国際センター (宮城県, 仙台市)
- Year and Date
  2013-04-26
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] High levels of free fatty acids may advance the severity of primary Sjögren's syndrome2013
- Author(s)
  Shikama Y, Ishimaru N, Kudo Y, Bando Y, Aki N, Hayashi Y, Funaki M
- Organizer
  American Diabetes Association 73rd scientific sessions
- Place of Presentation
  McCormick Place (Chicago, USA)
- Year and Date
  2013-06-22
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] Palmitate induces IL-6 production and alpha-fodrin degradation in salivary gland epithelial cells2013
- Author(s)
  Yosuke Shikama, Naozumi Ishimaru, Yukiko Bando, Nanako Aki, Makoto Funaki
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本市現代美術館 (熊本県熊本市)
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] 飽和脂肪酸が唾液腺におけるシェーグレン症候群の病態を増悪する可能性2013
- Author(s)
  四釜洋介, 石丸直澄, 新垣理恵子, 工藤保誠, 林良夫, 船木真理
- Organizer
  第22回日本シェーグレン症候群学会学術集会
- Place of Presentation
  ブリーゼプラザ (大阪府, 大阪市)
- Year and Date
  2013-09-14
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] 飽和脂肪酸が唾液腺におけるシェーグレン症候群の病態を増悪する可能性2013
- Author(s)
  四釜洋介、石丸直澄、新垣理恵子、工藤保誠、林良夫、船木真理
- Organizer
  第22回日本シェーグレン症候群学会学術集会
- Place of Presentation
  ブリーゼプラザ小ホール (大阪府大阪市)
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] High levels of free fatty acids may advance the severity of primary Sjogren’s syndrome2013
- Author(s)
  Yosuke Shikama, Naozumi Ishimaru, Yasusei Kudo, Yukiko Bando, Nanako Aki, Yoshio Hayashi, Makoto Funaki
- Organizer
  American Diabetes Association 73rd scientific sessions
- Place of Presentation
  McCormick Place (Chicago, Illinois)
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] Palmitate induces IL-6 production and alpha-fodrin degradation in salivary gland epithelial cells2013
- Author(s)
  Shikama Y, Ishimaru N, Bando Y, Aki N, Funaki M
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本市現代美術館 (熊本県, 熊本市)
- Year and Date
  2013-05-16
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] 遊離脂肪酸の内因性リガンドとしての唾液腺上皮細胞に対する影響: アディポネクチンの効果2012
- Author(s)
  四釜洋介
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] Crosstalk between Salivary Gland Chronic Inflammation and the Endocrine Function of Adipocytes in Insulin Resistance2012
- Author(s)
  Shikama Y, Li Q, Bando Y, Aki N, Kosugi C, Funaki M
- Organizer
  American Diabetes Association 72nd scientific sessions
- Place of Presentation
  Pennsylvania Convention Center (Philadelphia, USA)
- Year and Date
  2012-06-09
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] 遊離脂肪酸の内因性リガンドとしての唾液腺上皮細胞に対する影響2012
- Author(s)
  四釜洋介, 李勤凱, 坂東由記子, 安藝菜奈子, 小杉知里, 西村美穂, 船木真理
- Organizer
  アディポネクチンの効果第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜(神奈川県, 横浜市)
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] Crosstalk between Salivary Gland Chronic Inflammation and the Endocrine Function of Adipocytes2012
- Author(s)
  Shikama Y
- Organizer
  American Diabetes Association 72nd scientific sessions
- Place of Presentation
  Pennsylvania Convention Center, Philadelphia, PA, USA
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] 遊離脂肪酸の内因性リガンドとしての唾液腺上皮細胞に対する影響:シェーグレン症候群との関連性2012
- Author(s)
  四釜洋介
- Organizer
  第２１回日本シェーグレン症候群学会学術集会
- Place of Presentation
  ウェスティン都ホテル京都（京都府）
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] 遊離脂肪酸の内因性リガンドとしての唾液腺上皮細胞に対する影響 : シェーグレン症候群との関連性2012
- Author(s)
  四釜洋介, 石丸直澄, 李勤凱, 坂東由記子, 安藝菜奈子, 船木真理
- Organizer
  第21回日本シェーグレン症候群学会学術集会
- Place of Presentation
  ウェスティン都ホテル京都 (京都府, 京都市)
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-24792001
[Presentation] 単球における遊離脂肪酸のIL-1beta および IL-1 receptor antagonist(Ra)産生に対する効果:血管内皮細胞の接着因子発現との関連性
- Author(s)
  四釜洋介、安藝菜奈子、秦明子、西村美穂、船木真理
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場 (大阪府・大阪市)
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26462840
[Presentation] 飽和脂肪酸が歯周病の病態形成に関与する可能性
- Author(s)
  四釜洋介、工藤保誠、石丸直澄、船木真理
- Organizer
  第56回歯科基礎医学会学術大会
- Place of Presentation
  福岡国際会議場 (福岡県・福岡市)
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26462840
[Presentation] Palmitate-Stimulated Monocytes Induce ICAM-1 and E-selectin Expression in Vascular Endothelial Cells via an IL-1-Dependent Pathway
- Author(s)
  Shikama Y, Aki N, Hata A, Nishimura M, Funaki M.
- Organizer
  American Diabetes Association (ADA) 74th Scientific Sessions
- Place of Presentation
  Moscone Center (San Francisco, USA)
- Year and Date
  2014-06-13 – 2014-06-17
- Data Source
  KAKENHI-PROJECT-26462840

1. TSUCHIYA MASAHIRO (60372322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 神崎展 (10272262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 萩原嘉廣 (90436139)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 石丸直澄 (60314879)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. OYADOMARI Seiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. OTSUKA Hirotada

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 古川匡恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 松下健二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 親泊美帆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 工藤保誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shikama Yosuke 四釜 洋介

SHIKAMA Yosuke 四釜 洋介

Research Projects

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Co-Researchers

選択的オートファジーを基軸とした加齢・糖尿病に起因する口腔乾燥症の新たな病因論Principal Investigator

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Common molecular mechanisms underlying age- and autoimmune-related disturbance of salivary secretionPrincipal Investigator

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Inflammatory transformation of myofibers via neutrophil fusion - Elucidation of the onset mechanism of chronic myalgia-

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Potential role of interleukin-29 in oral mucosal defense against virusesPrincipal Investigator

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Possible involvement of palmitate in the pathogenesis of primary Sjogren's SyndromePrincipal Investigator

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飽和脂肪酸がシェーグレン症候群の病態増悪に関与する可能性：モデルマウスによる解析Principal Investigator

Principal Investigator

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Crosstalk between salivary gland chronic inflammation and saturated fatty acids in plasmaPrincipal Investigator

Principal Investigator

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[Journal Article] 高齢者糖尿病の口腔と健康2022

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[Journal Article] Analysis of senescence in gingival tissues and gingival fibroblast cultures2022

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[Journal Article] Molar loss induces hypothalamic and hippocampal astrogliosis in aged mice2022

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[Journal Article] The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa2022

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[Journal Article] Chemokines Up-Regulated in Epithelial Cells Control Senescence-Associated T Cell Accumulation in Salivary Glands of Aged and Sj?gren’s Syndrome Model Mice2021

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[Journal Article] Effect of green propolis extracts on experimental aged gingival irritation in vivo and in vitro2021

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[Journal Article] ヒトとマウスの相違およびアディポネクチンの関連性2021

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Shikama Yosuke 四釜洋介

SHIKAMA Yosuke 四釜洋介

[Journal Article] IL-29 は口腔粘膜上皮細胞においてRIG-IおよびIFI-16発現誘導を介し抗ウイルス活性を増強する2019