Nakamura Toshifumi 中村俊文

Researcher Number	10594583
Other IDs
Affiliation (Current)	2026: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2024: 慶應義塾大学, 医学部(信濃町), 専任講師 2022 – 2023: 慶應義塾大学, 医学部(信濃町), 助教 2018: 慶應義塾大学, 医学部(信濃町), 共同研究員 2017: 慶應義塾大学, 医学部(信濃町), 助教
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / 0903:Organ-based internal medicine and related fields / Kidney internal medicine
Keywords	Principal Investigator MR拮抗薬 / 糖尿病性腎症 / ミネラルコルチコイド受容体 / シングルセル解析 / RNA-seq / 糖尿病腎症 / 食塩感受性 / 高血圧 / ミネラルコルチコイド受容体（MR）

細胞特異的MR機能を観点とした糖尿病性腎症の病態解明と新規治療的アプローチ法の探索Principal Investigator
- Principal Investigator
  
  中村俊文
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Keio University
The analysis of the pathophysiology of MR activation-mediated diabetic nephropathy and the exploration of its novel therapeutic approaches.Principal Investigator
- Principal Investigator
  
  Nakamura Toshifumi
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0903:Organ-based internal medicine and related fields
- Research Institution
  Keio University
Elucidation of novel intestinal MR function in hypertension and metabolism associated disorderPrincipal Investigator
- Principal Investigator
  
  Nakamura Toshifumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University

All 2024 2023 2022 2018 2017

All Journal Article Presentation

[Journal Article] Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway2024
- Author(s)
  Palacios-Ramirez Roberto、Soulie Matthieu、Fernandez-Celis Amaya、Nakamura Toshifumi、Boujardine Nabiha、Bonnard Benjamin、Bamberg Krister、Lopez-Andres Natalia、Jaisser Frederic
- Journal Title
  
  Clinical Science
  
  Volume: 138 Issue: 16 Pages: 1025-1038
- DOI
  10.1042/cs20240302
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K19135
[Journal Article] Prevalence of unilateral hyperaldosteronism in primary aldosteronism: impact of a novel chemiluminescent immunoassay for measuring plasma aldosterone in Japan2024
- Author(s)
  Kobayashi H, Nakamura Y, Abe M, Nakamura T, Nozato Y, Izawa S, Kakutani M, Katabami T, Wada N, Takahashi K, Yoneda T, Okamoto R, Murakami M, Okamura S, Naruse M, Yokota K, Sone M; JPAS II Study Group.
- Journal Title
  
  Hypertension Research
  
  Volume: 47 Issue: 11 Pages: 3035-3044
- DOI
  10.1038/s41440-024-01786-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-22K08646, KAKENHI-PROJECT-24K11397, KAKENHI-PROJECT-24K19135
[Journal Article] Differences in target organ damage between captopril challenge test-defined definitive-positive and borderline-range groups among patients with primary aldosteronism2024
- Author(s)
  Fujiwara N, Haze T, Wakui H, Tamura K, Tsuiki M, Kamemura K, Taura D, Ichijo T, Takahashi Y, Watanabe M, Kobayashi H, Nakamura T, Izawa S, Wada N, Yamada T, Yokota K, Naruse M, Sone M
- Journal Title
  
  Hypertension Research
  
  Volume: 48 Issue: 2 Pages: 540-552
- DOI
  10.1038/s41440-024-01943-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24385, KAKENHI-PROJECT-24K10576, KAKENHI-PROJECT-24K11397, KAKENHI-PROJECT-24K19135
[Journal Article] The Mineralocorticoid Receptor on Smooth Muscle Cells Promotes Tacrolimus-Induced Renal Injury in Mice2023
- Author(s)
  Figueroa Stefanny M.、Bertocchio Jean-Philippe、Nakamura Toshifumi、El-Moghrabi Soumaya、Jaisser Frederic、Amador Cristian A.
- Journal Title
  
  Pharmaceutics
  
  Volume: 15 Issue: 5 Pages: 1373-1373
- DOI
  10.3390/pharmaceutics15051373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K20914
[Journal Article] Association Between Renal Sinus Fat and Cardiometabolic and Renin-Angiotensin System Parameters in Primary Aldosteronism2023
- Author(s)
  Mitsuno Ryunosuke、Kaneko Kenji、Nakamura Toshifumi、Kojima Daiki、Mizutani Yosuke、Azegami Tatsuhiko、Yamaguchi Shintaro、Yamada Yoshitake、Jinzaki Masahiro、Kinouchi Kenichiro、Yoshino Jun、Hayashi Kaori
- Journal Title
  
  Journal of the Endocrine Society
  
  Volume: 8 Issue: 1
- DOI
  10.1210/jendso/bvad154
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-24K19135
[Journal Article] Mechanisms of mineralocorticoid receptor-associated hypertension in diabetes mellitus: the role of O-GlcNAc modification2022
- Author(s)
  Jo Rie、Shibata Hirotaka、Kurihara Isao、Yokota Kenichi、Kobayashi Sakiko、Murai-Takeda Ayano、Mitsuishi Yuko、Hayashi Takeshi、Nakamura Toshifumi、Itoh Hiroshi
- Journal Title
  
  Hypertension Research
  
  Volume: 46 Issue: 1 Pages: 19-31
- DOI
  10.1038/s41440-022-01036-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08236, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-23K09671, KAKENHI-PROJECT-22K20914
[Journal Article] Intestinal Mineralocorticoid Receptor Contributes to Epithelial Sodium Channel?Mediated Intestinal Sodium Absorption and Blood Pressure Regulation2018
- Author(s)
  Nakamura Toshifumi、Kurihara Isao、Kobayashi Sakiko、Yokota Kenichi、Murai‐Takeda Ayano、Mitsuishi Yuko、Morisaki Mitsuha、Kohata Nao、Oshima Yosuke、Minami Yukiko、Shibata Hirotaka、Itoh Hiroshi
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 7 Issue: 13
- DOI
  10.1161/jaha.117.008259
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09734, KAKENHI-PROJECT-18K08250, KAKENHI-PROJECT-18K16007, KAKENHI-PROJECT-16K09656, KAKENHI-PROJECT-17K16095
[Presentation] Biglycan, a newly identified mediator of mineralocorticoid receptor activation-induced nephropathy2022
- Author(s)
  Toshifumi Nakamura, Benjamin Bonnard, Roberto Palacios-Ramirez, Amaya Fernandez-Celis, Frederic Jaisser and Natalia Lopez-Andres
- Organizer
  The 29th Scientific Meeting of the International Society of Hypertension
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20914
[Presentation] 腎尿細管特異的OGT欠損マウスの表現型解析を通して見る腎尿細管OGT機能の多面性2018
- Author(s)
  南悠季子, 中村俊文, 三石木綿子, 横田健一, 小林佐紀子, 武田彩乃, 中島秀明, 栗原勲, 伊藤裕
- Organizer
  第36回　内分泌代謝学サマーセミナー
- Data Source
  KAKENHI-PROJECT-17K16095
[Presentation] Analysis of intestinal epithelial MR function in sodium balance and blood pressure regulation2018
- Author(s)
  中村俊文, 栗原勲, 伊藤裕
- Organizer
  Gastrointestinal hormones update research forum 2018
- Data Source
  KAKENHI-PROJECT-17K16095
[Presentation] 血圧調節における腸管上皮MR機能の解析2017
- Author(s)
  中村俊文、栗原勲、伊藤裕
- Organizer
  第40回日本高血圧学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K16095
[Presentation] 遺伝子改変マウスを用いた血圧調節における腸管上皮MR機能の解析2017
- Author(s)
  中村俊文、栗原勲、小林佐紀子、横田健一、盛崎瑞葉、高畑尚、大嶋洋佑、小池悠季子、伊藤裕
- Organizer
  第90回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16095

1. 横田健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 岡本隆二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 吉野純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 山田哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakamura Toshifumi 中村 俊文

Research Projects

Research Products

Co-Researchers

細胞特異的MR機能を観点とした糖尿病性腎症の病態解明と新規治療的アプローチ法の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The analysis of the pathophysiology of MR activation-mediated diabetic nephropathy and the exploration of its novel therapeutic approaches.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of novel intestinal MR function in hypertension and metabolism associated disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prevalence of unilateral hyperaldosteronism in primary aldosteronism: impact of a novel chemiluminescent immunoassay for measuring plasma aldosterone in Japan2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differences in target organ damage between captopril challenge test-defined definitive-positive and borderline-range groups among patients with primary aldosteronism2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Mineralocorticoid Receptor on Smooth Muscle Cells Promotes Tacrolimus-Induced Renal Injury in Mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association Between Renal Sinus Fat and Cardiometabolic and Renin-Angiotensin System Parameters in Primary Aldosteronism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanisms of mineralocorticoid receptor-associated hypertension in diabetes mellitus: the role of O-GlcNAc modification2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intestinal Mineralocorticoid Receptor Contributes to Epithelial Sodium Channel?Mediated Intestinal Sodium Absorption and Blood Pressure Regulation2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Biglycan, a newly identified mediator of mineralocorticoid receptor activation-induced nephropathy2022

Author(s)

Organizer

Data Source

[Presentation] 腎尿細管特異的OGT欠損マウスの表現型解析を通して見る腎尿細管OGT機能の多面性2018

Author(s)

Organizer

Data Source

[Presentation] Analysis of intestinal epithelial MR function in sodium balance and blood pressure regulation2018

Author(s)

Organizer

Data Source

[Presentation] 血圧調節における腸管上皮MR機能の解析2017

Author(s)

Organizer

Data Source

[Presentation] 遺伝子改変マウスを用いた血圧調節における腸管上皮MR機能の解析2017

Author(s)

Organizer

Data Source

Nakamura Toshifumi 中村俊文