KIMURA SANAE 木村佐奈衣

… Alternative Names

Hayashi Sanae 林佐奈衣

HAYASHI Sanae 林佐奈衣

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Researcher Number	10597587
Other IDs	https://orcid.org/0000-0001-9164-9152
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 特任助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 熊本大学, 大学院生命科学研究部(医), 特任助教 2021: 熊本大学, 大学院生命科学研究部(医), 学術研究員 2020: 熊本大学, 大学院生命科学研究部(医), 特定事業研究員 2016 – 2017: 名古屋市立大学, 大学院医学研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 54030:Infectious disease medicine-related
Keywords	Principal Investigator 肝臓学 / 核酸アナログ / B型肝炎ウイルス / genotype / 変異 / HBs抗原 / 新規治療薬 / 多剤耐性 / 薬剤耐性 / 耐性 … More / テノホビル / 炎症 / 免疫 / 肝障害 / NK細胞 … More Except Principal Investigator 新規核酸系抗HBV化合物 / HBV / B型慢性肝炎 / cccDNA / ヒト肝キメラマウス / 抗ウイルス薬開発 / ヒトB型肝炎ウイルス / HBV感染症 Less

Does cccDNA depletion by complete blockage of HBV replication result in a cure for hepatitis B? -Elucidation using PXB mice model-
- Principal Investigator
  
  鍬田伸好 (東伸好)
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Center for Global Health and Medicine
核酸アナログ耐性機序の解明及び多剤耐性HBVに有効な新規治療薬の開発Principal Investigator
- Principal Investigator
  
  林佐奈衣
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kumamoto University
Identification of novel HBV resistant to tenofovir (TDF) and elucidation of the resistance mechanismsPrincipal Investigator
- Principal Investigator
  
  Hayashi Sanae
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kumamoto University
Elucidating the mechanism of ameliorated liver disease and HBs antigen elimination by nucleos(t)ide analogs in chronic hepatitis B patientsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Sanae
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University

All 2024 2023 2022 2021 2020 2017

All Journal Article Presentation

[Journal Article] A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA2024
- Author(s)
  Watanabe Takehisa、Hayashi Sanae、Zhaoyu Yan、Inada Hiroki、Nagaoka Katsuya、Tateyama Masakuni、Tanaka Yasuhito
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 59 Issue: 4 Pages: 315-328
- DOI
  10.1007/s00535-023-02070-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15971, KAKENHI-PROJECT-22K16023, KAKENHI-PROJECT-23K07442, KAKENHI-PROJECT-21K07904
[Journal Article] Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation to analyze extracellular viral markers2024
- Author(s)
  Kitagawa Kosaku、Kim Kwang Su、Iwamoto Masashi、Hayashi Sanae、Park Hyeongki、Nishiyama Takara、Nakamura Naotoshi、Fujita Yasuhisa、Nakaoka Shinji、Aihara Kazuyuki、Perelson Alan S.、Allweiss Lena、Dandri Maura、Watashi Koichi、Tanaka Yasuhito、Iwami Shingo
- Journal Title
  
  PLOS Computational Biology
  
  Volume: 20 Issue: 3 Pages: 1011238-1011238
- DOI
  10.1371/journal.pcbi.1011238
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07442, KAKENHI-PROJECT-21K19813, KAKENHI-PROJECT-23K27415
[Journal Article] Droplet digital PCR assay provides intrahepatic HBV?cccDNA quantification tool for clinical application2022
- Author(s)
  Hayashi Sanae、Isogawa Masanori、Kawashima Keigo、Ito Kyoko、Chuaypen Natthaya、Morine Yuji、Shimada Mitsuo、Higashi-Kuwata Nobuyo、Watanabe Takehisa、Tangkijvanich Pisit、Mitsuya Hiroaki、Tanaka Yasuhito
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41598-022-05882-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-20K16996
[Journal Article] Drug Discovery Study Aimed at a Functional Cure for HBV.2022
- Author(s)
  Takehisa Watanabe, Sanae Hayashi, Yasuhito Tanaka
- Journal Title
  
  Viruses
  
  Volume: 14 Pages: 1393-1393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16996
[Journal Article] Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA22022
- Author(s)
  Anna Nakanishi, Hiroki Okumura, Tadahiro Hashita, Aya Yamashita, Yuka Nishimura, Chihiro Watanabe, Sakina Kamimura, Sanae Hayashi, Shuko Murakami, Kyoko Ito, Takahiro Iwao, Akari Ikeda, Tomoyasu Hirose, Toshiaki Sunazuka, Yasuhito Tanaka, Tamihide Matsunaga
- Journal Title
  
  Viruses
  
  Volume: 14 Pages: 2468-2468
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16996
[Journal Article] Blood-Based Biomarkers in Hepatitis B Virus-Related Hepatocellular Carcinoma, Including the Viral Genome and Glycosylated Proteins2021
- Author(s)
  Hayashi Sanae、Nagaoka Katsuya、Tanaka Yasuhito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 20 Pages: 11051-11051
- DOI
  10.3390/ijms222011051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17403, KAKENHI-PROJECT-20K16996
[Journal Article] Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV2020
- Author(s)
  Higashi-Kuwata Nobuyo、Hayashi Sanae、Kumamoto Hiroki、Ogata-Aoki Hiromi、Das Debananda、Venzon David、Hattori Shin-ichiro、Bulut Haydar、Hashimoto Mai、Otagiri Masaki、Takamune Nobutoki、Kishimoto Naoki、Davis David A.、Misumi Shogo、Kakuni Masakazu、Tanaka Yasuhito、Mitsuya Hiroaki
- Journal Title
  
  Journal of Hepatology
  
  Volume: 15 Issue: 5 Pages: 33843-5
- DOI
  10.1016/j.jhep.2020.12.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16996, KAKENHI-PROJECT-18K08460
[Presentation] 新規核酸系抗HBV化合物, E-CFCP,によるcccDNAの減衰/枯渇効果の検討2023
- Author(s)
  鍬田伸好, 林佐奈衣,熊本浩樹,青木宏美, 井本修平,田中靖人,満屋裕明
- Organizer
  第31回日本抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K27645
[Presentation] Discovery of an orally available HBV destabilizer,SAG-524, and its novel therapeutic strategy2023
- Author(s)
  Sanae Hayashi
- Organizer
  The HBV International Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07442
[Presentation] Clinical Utility of Droplet Digital PCR for HBV cccDNA quantification2022
- Author(s)
  Sanae Hayashi, Yuji Morine, Mitsuo Shimada, Takehisa Watanabe, Yasuhito Tanaka
- Organizer
  APASL Oncology 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16996
[Presentation] ddPCR法を用いたcccDNA定量法の開発と臨床応用2022
- Author(s)
  林佐奈衣 ,渡邊丈久 ,田中靖人
- Organizer
  the japan society of hepatology
- Data Source
  KAKENHI-PROJECT-20K16996
[Presentation] 核酸アナログ多剤耐性例のウイルス学的特徴2022
- Author(s)
  林佐奈衣、榎本大、松浦健太郎、井出達也、松居剛志、髭修平、榎本平之、渡邊丈久、長岡克弥、立山雅邦、田中靖人
- Organizer
  JDDW
- Data Source
  KAKENHI-PROJECT-20K16996
[Presentation] In vivoで強力な抗HBV活性を発揮する長時間作用型新規核酸アナログE-CFCPの開発2021
- Author(s)
  林佐奈衣,田中靖人,満屋裕明
- Organizer
  The Japan Society of Hepatology
- Data Source
  KAKENHI-PROJECT-20K16996
[Presentation] A novel droplet digital PCR reveals the stability of intrahepatic hepatitis B virus cccDNA and its clinical application2021
- Author(s)
  Sanae Hayashi, Masanori Isogawa, Keigo Kawashima, Kyoko Ito, Natthaya Chuaypen, Nobuyo Higashi-Kuwata, Pisit Tangkijvanich, Hiroaki Mitsuya, Yasuhito Tanaka
- Organizer
  The Liver Meeting AASLD 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16996
[Presentation] 新規cccDNA絶対定量系の開発とその臨床応用2020
- Author(s)
  Sanae Hayashi,Tangkijvanich Pisit,Yasuhito Tanaka
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K16996
[Presentation] Novel Nucleosides, CMCP and CFCP, Potently Block the Infectivity and Replication of Wild-type and Drug-resistant HBVs in Culture and in Human-liver-chimeric Mice and Show Potential QW or Q2W.2017
- Author(s)
  Higashi-kuwata N, Hayashi S, Kumamoto H, Kohgo S, Das D, Bulut H, Sarafianos S, Tanaka Y, Mitsuya H.
- Organizer
  HEP DART
- Data Source
  KAKENHI-PROJECT-16K19360
[Presentation] 新規4'-置換-7-デアザプリンヌクレオシド類の合成と抗HBV活性評価2017
- Author(s)
  苫谷晃太, 大野裕太郎, 杉原匠, 山田浩平, 鍬田伸好, 林佐奈衣, 村上周子, 前田賢次, 田中靖人, 満屋裕明.
- Organizer
  第27回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-16K19360
[Presentation] 新規抗HBV薬候補化合物CFCPのin vitroウイルス学・細胞生物学的特性2017
- Author(s)
  鍬田伸好, 林佐奈衣, 熊本浩樹, 服部真一朗, 橋本麻衣, 林宏典, 松田幸樹, 青木学, 前田賢次, 小田切優樹, 田中靖人, 満屋裕明.
- Organizer
  第27回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-16K19360
[Presentation] Entecavirよりも持続的かつ強力に抗HBV活性を有する新規核酸アナログCFCPの同定2017
- Author(s)
  林佐奈衣, 鍬田伸好, 熊本浩樹, 村上周子, 尾曲克己, 五十川正記, 前田賢次, 満屋裕明, 田中靖人.
- Organizer
  第27回抗ウイルス療法学会学術集会・総会.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19360

1. 鍬田伸好 (60361218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 熊本浩樹 (80297019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 青木宏美 (90970351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. ISOGAWA Masanori

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. TANAKA Yasuhito

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. NAGAOKA KATSUYA

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 東伸好

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIMURA SANAE 木村 佐奈衣

Hayashi Sanae 林 佐奈衣

HAYASHI Sanae 林 佐奈衣

Research Projects

Research Products

Co-Researchers

Does cccDNA depletion by complete blockage of HBV replication result in a cure for hepatitis B? -Elucidation using PXB mice model-

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

核酸アナログ耐性機序の解明及び多剤耐性HBVに有効な新規治療薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel HBV resistant to tenofovir (TDF) and elucidation of the resistance mechanismsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the mechanism of ameliorated liver disease and HBs antigen elimination by nucleos(t)ide analogs in chronic hepatitis B patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation to analyze extracellular viral markers2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Droplet digital PCR assay provides intrahepatic HBV?cccDNA quantification tool for clinical application2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drug Discovery Study Aimed at a Functional Cure for HBV.2022

Author(s)

Journal Title

Data Source

[Journal Article] Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA22022

Author(s)

Journal Title

Data Source

[Journal Article] Blood-Based Biomarkers in Hepatitis B Virus-Related Hepatocellular Carcinoma, Including the Viral Genome and Glycosylated Proteins2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 新規核酸系抗HBV化合物, E-CFCP,によるcccDNAの減衰/枯渇効果の検討2023

Author(s)

Organizer

Data Source

[Presentation] Discovery of an orally available HBV destabilizer,SAG-524, and its novel therapeutic strategy2023

Author(s)

Organizer

Data Source

[Presentation] Clinical Utility of Droplet Digital PCR for HBV cccDNA quantification2022

Author(s)

Organizer

Data Source

[Presentation] ddPCR法を用いたcccDNA定量法の開発と臨床応用2022

Author(s)

Organizer

Data Source

[Presentation] 核酸アナログ多剤耐性例のウイルス学的特徴2022

KIMURA SANAE 木村佐奈衣

Hayashi Sanae 林佐奈衣

HAYASHI Sanae 林佐奈衣