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Shindo Keisuke  新堂 啓祐

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SHINDO Keisuke  新堂 啓祐

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Researcher Number 10602344
Other IDs
Affiliation (Current) 2022: 京都大学, 医学研究科, 特定病院助教
Affiliation (based on the past Project Information) *help 2016 – 2019: 京都大学, 医学研究科, 特定病院助教
2016: 京都大学, 医学研究科, 助教
Review Section/Research Field
Principal Investigator
Virology
Except Principal Investigator
Biological Sciences
Keywords
Principal Investigator
HIV-1 / Vif / CBF-beta / PP2A / MDM2 / anti-HIV drug / cell cycle arrest / ubiquitination / ubiquitin / Viral infectivity factor … More / ユビキチン / プロテアソーム / タンパク間相互作用 / ウイルス / 蛋白質 / 発現制御 / 感染症 … More
Except Principal Investigator
自然免疫 / インターフェロン / ウイルス / 感染症 / RIG-I / ストレス顆粒 / イメージング / 複製複合体 / ゲノム / 遺伝子 / 免疫学 / APOBEC Less
  • Research Projects

    (2 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (12 People)
  •  Elcidating the regulatory mechanisms of intracellular level and function of HIV-1 VifPrincipal Investigator

    • Principal Investigator
      Shindo Keisuke
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Kyoto University
  •  Competition between viruses and intracellular antiviral immunity

    • Principal Investigator
      Fujita Takashi
    • Project Period (FY)
      2012 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

All 2021 2018 2017 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest2021

    • Author(s)
      Nagata Kayoko、Shindo Keisuke、Matsui Yusuke、Shirakawa Kotaro、Takaori-Kondo Akifumi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 527 Pages: 257-263

    • DOI

      10.1016/j.bbrc.2020.04.123

    • NAID

      120006865708

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08807, KAKENHI-PROJECT-19K07591
  • [Journal Article] Core binding factor beta protects HIV-1, type 1 accessory protein viral infectivity factor from MDM2-mediated degradation2016

    • Author(s)
      Yusuke Matsui, Keisuke Shindo, Kayoko Nagata, Noriyoshi Yoshinaga, Kotaro Shirakawa, Masayuki Kobayashi and Akifumi Takaori-Kondo
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Pages: 24892-24899

    • DOI

      10.1074/jbc.m116.734673

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16K08807
  • [Journal Article] ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction.2015

    • Author(s)
      Miyakawa K, Matsunaga S, Kanou K, Matsuzawa A, Morishita R, Kudoh A, Shindo K, Yokoyama M, Sato H, Kimura H, Tamura T, Yamamoto N, Ichijo H, Takaori-Kondo A, Ryo A.
    • Journal Title

      Nat Commun

      Volume: 6:6945 Pages: 6945-6945

    • DOI

      10.1038/ncomms7945

    • NAID

      120005745628

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390115, KAKENHI-PROJECT-26860306, KAKENHI-PLANNED-24115004
  • [Journal Article] Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia.2015

    • Author(s)
      Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A.
    • Journal Title

      Sci Adv.

      Volume: 1 Pages: 1-9

    • DOI

      10.1126/sciadv.1400203

    • NAID

      120005601014

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-24115004, KAKENHI-PUBLICLY-26116518, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25281021
  • [Journal Article] Defining HIV-1 Vif residues that interact with CBFβ by site-directed mutagenesis.2014

    • Author(s)
      Matsui Y, Shindo K, Nagata K, Io K, Tada K, Iwai F, Kobayashi M, Kadowaki N, Harris R, Takaori-Kondo A
    • Journal Title

      Virology

      Volume: 449 Pages: 82-87

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Journal Article] CKIP-1 is an intrinsic negative regulator of T-cell activation through an interaction with CARMA12014

    • Author(s)
      Sakamoto T, Kobayashi M, Tada K, Shinohara M, Io K, Nagata K, Iwai F, Takiuchi Y, Arai Y, Yamashita K, Shindo K, Kadowaki N, Koyanagi Y, Takaori-Kondo A
    • Journal Title

      PLOS ONE

      Volume: 9 Pages: 1-11

    • DOI

      10.1371/journal.pone.0085762

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390110, KAKENHI-PROJECT-23591383, KAKENHI-PROJECT-23591474, KAKENHI-PLANNED-24115004, KAKENHI-PLANNED-24115008
  • [Journal Article] Small molecules that inhibit Vif-induced degradation of APOBEC3G.2014

    • Author(s)
      2.Matsui M, Shindo K, Izumi T, Io K, Shinohara M, Komano J, Kobayashi M, Kadowaki N, Harris RS, Takaori-Kondo A
    • Journal Title

      Virology Journal

      Volume: 11 Pages: 122-129

    • DOI

      10.1186/1743-422x-11-122

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Presentation] Examining HIV-1 Vif determinants for inducing the cell cycle arrest2018

    • Author(s)
      Kayoko Nagata, Keisuke Shindo, Akifumi Takaori-Kondo
    • Organizer
      Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-16K08807
  • [Presentation] The roles of PP2A degradation in HIV-1 Vif-mediated cell cycle arrest2017

    • Author(s)
      Kayoko Nagata, Keisuke Shindo, Akifumi Takaori-Kondo
    • Organizer
      Cold Spring Harbor Meeting on Retroviruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08807
  • [Presentation] PP2A-B56delta degradation is crucial for HIV-1 Vif-mediated cell cycle arrest2017

    • Author(s)
      Kayoko Nagata, Keisuke Shindo, Akifumi Takaori-Kondo
    • Organizer
      日本ウイルス学会
    • Data Source
      KAKENHI-PROJECT-16K08807
  • [Presentation] Ezamining three models for Vif-mediated cell cycle arrest2016

    • Author(s)
      Kayoko Nagata, Keisuke Shindo, Yusuke Matsui and Akifumi Takaori-Kondo
    • Organizer
      Cold Spring Harbor Meeting on Retroviruses
    • Place of Presentation
      New York, USA
    • Year and Date
      2016-05-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08807
  • 1.  Fujita Takashi (10156870)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  KATO Hiroki (10597173)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  高折 晃史 (20324626)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 4.  YAMASHITA Kouhei
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  MIYAKAWA Kei
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  白川 康太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  小柳 義夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  小林 正行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  梁 明秀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  廣田 耕志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  笹沼 博之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  武田 俊一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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