YAMAMOTO KEISUKE 山本恵介

… Alternative Names

Yamamoto Keisuke 山本恵介

YAMAMOTO Keisuke 山本恵介

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Researcher Number	10608532
Other IDs	https://orcid.org/0000-0002-6323-9540
Affiliation (Current)	2026: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 東京大学, 医学部附属病院, 助教 2015 – 2017: 東京大学, 医学部附属病院, 助教 2014 – 2015: 東京大学, 医学部附属病院, 特任臨床医 2012 – 2013: 東京大学, 医学部附属病院, その他
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Gastroenterology / 0901:Oncology and related fields Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 50010:Tumor biology-related / Gastroenterology
Keywords	Principal Investigator 膵癌 / アミノ酸代謝 / セリン生合成経路 / 肝転移 / エピジェネティクス / 代謝クロストーク / 腫瘍微小環境 / 合成致死 / 代謝 / 癌関連線維芽細胞 / 癌微小環境 / ヒストン修飾 … More Except Principal Investigator … More 膵癌 / クロマチン / 液-液相分離 / basal型膵癌 / オルガノイド / 腫瘍免疫 / 腫瘍微小環境 / KRAS / エピジェネテイクス / 膵がん / KDM6B Less

癌－肝細胞間代謝クロストークに着目した膵癌肝転移制御法の開発Principal Investigator
- Principal Investigator
  
  山本恵介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
膵癌の生物学的可塑性における三次元クロマチン構造の重要性と標的化
- Principal Investigator
  
  立石敬介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  St. Marianna University School of Medicine
相分離に基づく転写制御機構を標的とした膵癌分子サブタイプ特異的治療法の開発
- Principal Investigator
  
  中井陽介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Women's Medical University
Identification and validation of novel molecular targets for pancreatic cancer using cell lineage analysis from chromatin 3D structure
- Principal Investigator
  
  Tateishi Keisuke
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  St. Marianna University School of Medicine
変異KRASシグナルに着目した膵癌の腫瘍微小環境・免疫応答制御機構の解明
- Principal Investigator
  
  白田龍之介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
Identification of novel vulnerabilities in serine biosynthesis pathway-deficient pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Yamamoto Keisuke
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
Targeting liver metabolism to control metastatic pancreatic cancer in the liverPrincipal Investigator
- Principal Investigator
  
  Yamamoto Keisuke
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  The University of Tokyo
患者由来膵癌異種移植腫瘍を用いたエピジェネティック因子を標的とした新規治療の開発Principal Investigator
- Principal Investigator
  
  山本恵介
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Identification of a molecular marker relating to the progression of pancreatic cancer cells
- Principal Investigator
  
  Nakai Yousuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
An investigation of histone modifications that modulate malignant properties of pancreatic cancer.Principal Investigator
- Principal Investigator
  
  YAMAMOTO Keisuke
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo

All 2024 2022 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Microsatellite instability: A 2024 update2024
- Author(s)
  Yamamoto Hiroyuki、Watanabe Yoshiyuki、Arai Hiroyuki、Umemoto Kumiko、Tateishi Keisuke、Sunakawa Yu
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 6 Pages: 1738-1748
- DOI
  10.1111/cas.16160
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24236, KAKENHI-PROJECT-23K24314
[Journal Article] HNF1B‐driven three‐dimensional chromatin structure for molecular classification in pancreatic cancers2022
- Author(s)
  Kato Hiroyuki、Tateishi Keisuke、Iwadate Dosuke、Yamamoto Keisuke、Fujiwara Hiroaki、Nakatsuka Takuma、Kudo Yotaro、Hayakawa Yoku、Ijichi Hideaki、Otsuka Motoyuki、Kishikawa Takahiro、Takahashi Ryota、Miyabayashi Koji、Nakai Yousuke、Hirata Yoshihiro、Toyoda Atsushi、Morishita Shinichi、Fujishiro Mitsuhiro
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 4 Pages: 1672-1685
- DOI
  10.1111/cas.15690
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19517, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02893, KAKENHI-PROJECT-21K15966, KAKENHI-PROJECT-23K07350, KAKENHI-PROJECT-21K07886, KAKENHI-PROJECT-21K07907, KAKENHI-PROJECT-23K24314, KAKENHI-PROJECT-23K24159, KAKENHI-PROJECT-21K20828
[Journal Article] Targeting autophagy as a therapeutic strategy against pancreatic cancer2022
- Author(s)
  Yamamoto Keisuke、Iwadate Dosuke、Kato Hiroyuki、Nakai Yousuke、Tateishi Keisuke、Fujishiro Mitsuhiro
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 57 Issue: 9 Pages: 603-618
- DOI
  10.1007/s00535-022-01889-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24159, KAKENHI-PROJECT-21K20828
[Journal Article] Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment2022
- Author(s)
  Yamamoto Keisuke、Iwadate Dosuke、Kato Hiroyuki、Nakai Yousuke、Tateishi Keisuke、Fujishiro Mitsuhiro
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 18 Pages: 4351-4351
- DOI
  10.3390/cancers14184351
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24159, KAKENHI-PROJECT-21K20828
[Journal Article] Thromboembolisms in Advanced Pancreatic Cancer: A Retrospective Analysis of 475 Patients.2017
- Author(s)
  Ishigaki K(1), Nakai Y, Isayama H, Saito K, Hamada T, Takahara N, Mizuno S, Mohri D, Kogure H, Matsubara S, Yamamoto N, Tada M, Koike K.
- Journal Title
  
  Pancreas
  
  Volume: 46 Issue: 8 Pages: 1069-1075
- DOI
  10.1097/mpa.0000000000000889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09038, KAKENHI-PROJECT-15K09042
[Journal Article] The Role of Pancreatic Enzyme Replacement Therapy in Unresectable Pancreatic Cancer: A Prospective CohortStudy2017
- Author(s)
  Saito T, Hirano K, Isayama H, Nakai Y, Saito K, Umefune G, Akiyama D, Watanabe T, Takagi K, Hamada T, Takahara N, Uchino R, Mizuno S, Kogure H, Matsubara S, Yamamoto N, Tada M, Koike K.
- Journal Title
  
  Dig Endosc
  
  Volume: 46 Issue: 3 Pages: 341-346
- DOI
  10.1097/mpa.0000000000000767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09042
[Journal Article] Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer2016
- Author(s)
  Yamamoto K, Tateishi K, Kudo Y, Hoshikawa M, Tanaka M, Nakatsuka T, Fujiwara H, Miyabayashi K, Takahashi R, Tanaka Y, Ijichi H, Nakai Y,Isayama H, Morishita Y, Aoki T, Sakamoto Y, Hasegawa K, Kokudo N, Fukayama M, Koike K.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 38 Pages: 61469-61484
- DOI
  10.18632/oncotarget.11129
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09040, KAKENHI-PROJECT-26460985
[Journal Article] The inhibition of renin-angiotensin system in advanced pancreatic cancer: an exploratory analysis in 349 patients2015
- Author(s)
  Nakai Y, Isayama H, Sasaki T, Takahara N, Saito K, Ishigaki K, Hamada T, Mizuno S, Miyabayashi K, Yamamoto K, Mohri D, Kogure H, Yamamoto N, Ijichi H, Tateishi K, Tada M, Koike K.
- Journal Title
  
  J Cancer Res Clin Oncol.
  
  Volume: 144 Issue: 5 Pages: 933-939
- DOI
  10.1007/s00432-014-1873-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09042
[Journal Article] Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPα.2014
- Author(s)
  Yamamoto K, Tateishi K, Kudo Y, Sato T, Yamamoto S, Miyabayashi K, Asaoka Y, Ijichi H, Hirata Y, Otsuka M, Nakai Y, Isayama H, Ikenoue T, Kurokawa M, Fukayama M, Kokudo N, Omata M and Koike K.
- Journal Title
  
  Carcinogenesis
  
  Volume: 35 Issue: 11 Pages: 2404-14
- DOI
  10.1093/carcin/bgu136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590932, KAKENHI-PROJECT-24591009, KAKENHI-PROJECT-26460985, KAKENHI-PROJECT-26461031, KAKENHI-PROJECT-26860257
[Presentation] Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer2016
- Author(s)
  Keisuke Yamamoto, Keisuke Tateishi, Mayumi Hoshikawa, Mariko Tanaka, Koji Miyabayashi, Ryota Takahashi, Hideaki Ijichi, Yosuke Nakai, Hiroyuki Isayama, Minoru Tada, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Masashi Fukayama, Kazuhiko Koike
- Organizer
  第47回日本膵臓学会大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-08-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09040
[Presentation] Epigenetic remodeling of cancer-associated fibroblasts through BET inhibition suppresses pancreatic cancer progression2016
- Author(s)
  Keisuke Yamamoto, Keisuke Tateishi, Takuma Nakatsuka, Yasuo Tanaka, Hideaki Ijichi, Norihiro Kokudo, Masashi Fukayama, Kazuhiko Koike
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09040
[Presentation] 臨床検体を用いた膵癌xenograft モデルの樹立とその応用2016
- Author(s)
  山本恵介, 立石敬介, 小池和彦
- Organizer
  第１０２回　日本消化器病学会総会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K09040
[Presentation] Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer.2016
- Author(s)
  Keisuke Yamamoto, Keisuke Tateishi, Yotaro Kudo, Mayumi Hoshikawa, Mariko Tanaka, Hideaki Ijichi, Yousuke Nakai, Hiroyuki Isayama, Yasuyuki Morishita, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Masashi Fukayama, and Kazuhiko Koike
- Organizer
  AACR 2016, Special conference on pancreatic cancer
- Place of Presentation
  JW Marriott Orlando Grande Lakes in Orlando, FL.
- Year and Date
  2016-05-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09040
[Presentation] Reduced expression of histone demethylase KDM6B promotes pancreatic cancer progression through downregulation of C/EBPα.2013
- Author(s)
  山本　恵介
- Organizer
  American Association of Cancer Research Annual Meeting 2013
- Place of Presentation
  Washingto, DC
- Data Source
  KAKENHI-PROJECT-24591009
[Presentation] ヒストン脱メチル化酵素KDM6Bの発現低下はCEBPAの発現低下を介し膵癌の進展を促進する
- Author(s)
  山本恵介、立石敬介、工藤洋太郎、佐藤智彦、松坂恵介、山本信三、宮林弘至、浅岡良成、伊地知秀明、中井陽介、伊佐山浩通、池上恒雄、黒川峰夫、深山正久、國土典宏、小俣政男、小池和彦
- Organizer
  第４５回大会　日本膵臓学会大会
- Place of Presentation
  北九州国際会議場
- Year and Date
  2014-07-11 – 2014-07-12
- Data Source
  KAKENHI-PROJECT-24591009

1. TATEISHI Keisuke (20396948)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. IJICHI Hideaki (70463841)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. Nakai Yousuke (80466755)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 工藤洋太郎 (90608358)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 松原三郎 (40750550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 白田龍之介 (10843716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. WATANABE Yoshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 岸川孝弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 山本夏代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 山本博幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAMOTO KEISUKE 山本 恵介

Yamamoto Keisuke 山本 恵介

YAMAMOTO Keisuke 山本 恵介

Research Projects

Research Products

Co-Researchers

癌－肝細胞間代謝クロストークに着目した膵癌肝転移制御法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵癌の生物学的可塑性における三次元クロマチン構造の重要性と標的化

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

相分離に基づく転写制御機構を標的とした膵癌分子サブタイプ特異的治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and validation of novel molecular targets for pancreatic cancer using cell lineage analysis from chromatin 3D structure

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

変異KRASシグナルに着目した膵癌の腫瘍微小環境・免疫応答制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel vulnerabilities in serine biosynthesis pathway-deficient pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting liver metabolism to control metastatic pancreatic cancer in the liverPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

患者由来膵癌異種移植腫瘍を用いたエピジェネティック因子を標的とした新規治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a molecular marker relating to the progression of pancreatic cancer cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An investigation of histone modifications that modulate malignant properties of pancreatic cancer.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Microsatellite instability: A 2024 update2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HNF1B‐driven three‐dimensional chromatin structure for molecular classification in pancreatic cancers2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting autophagy as a therapeutic strategy against pancreatic cancer2022

Author(s)

Journal Title

DOI

YAMAMOTO KEISUKE 山本恵介

Yamamoto Keisuke 山本恵介

YAMAMOTO Keisuke 山本恵介