SAKAI Yusuke 堺裕輔

Researcher Number	10608904
Other IDs
External Links
Affiliation (Current)	2019: 九州大学, 工学研究院, 助教
Affiliation (based on the past Project Information) *help	2019: 九州大学, 工学研究院, 助教 2014 – 2018: 長崎大学, 医歯薬学総合研究科(医学系), 助教 2015: 長崎大学, 医歯薬学総合研究科 (医学系), 助教 2013: 長崎大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 90110:Biomedical engineering-related / Medium-sized Section 90:Biomedical engineering and related fields / Biomedical engineering/Biomaterial science and engineering / General surgery Except Principal Investigator General surgery / Digestive surgery / Biomedical engineering/Biomaterial science and engineering
Keywords	Principal Investigator 肝細胞 / 血管新生 / 内皮細胞 / 細胞シート / 再生医療 / 類洞 / 肝臓 / 肝毛細胆管 / 胆管 / 肝内胆管 / 肝再生医療 / アレイ化 … More Except Principal Investigator … More

Reconstruction of liver from arranged-hepatocytes/liver sinusoidal endothelial cells/cholangiocytes tissuesPrincipal InvestigatorOngoing
- Principal Investigator
  
  堺裕輔
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kyushu University
In vitro reconstruction of functional bile canaliculus-intrahepatic bile duct structurePrincipal InvestigatorOngoing
- Principal Investigator
  
  堺裕輔
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Nagasaki University
Fabrication of human liver with mimicking hepatic lobule structures by alternately-arranged human hepatocyte/endotherial cell tissue transplantationPrincipal InvestigatorOngoing
- Principal Investigator
  
  堺裕輔
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Nagasaki University
ハイブリッド人工胆管構築技術を基盤とした術後胆管狭窄予防Ongoing
- Principal Investigator
  
  曽山明彦
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Nagasaki University
Acute liver failure treatment using rapid fabricated engineered hepatocyte sheets
- Principal Investigator
  
  EGUCHI Susumu
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Nagasaki University
Construction of liver tissue in vivo with preparative partial hepatic irradiation and growth stimulus: investigations of less invasive techniques and progenitor cells.
- Principal Investigator
  
  YAMANOUCHI Kosho
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagasaki University
Construction of vascularized ectopic liver tissue from engineered human hepatocyte sheetPrincipal Investigator
- Principal Investigator
  
  SAKAI Yusuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  Nagasaki University
Reconstruction of human liver sheet for preclinical study of liver regenerative medicine
- Principal Investigator
  
  EGUCHI Susumu
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Nagasaki University

All 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] 再生医療用語ハンドブック：　肝細胞移植2015
- Author(s)
  堺裕輔、江口晋
- Total Pages
  1
- Publisher
  株式会社メディカルトリビューン
- Data Source
  KAKENHI-PROJECT-25861161
[Journal Article] Controlled cell morphology and liver-specific function of engineered primary hepatocytes by fibroblast layer cell densities2018
- Author(s)
  Sakai Yusuke、Koike Makiko、Kawahara Daisuke、Hasegawa Hideko、Murai Tomomi、Yamanouchi Kosho、Soyama Akihiko、Hidaka Masaaki、Takatsuki Mitsuhisa、Fujita Fumihiko、Kuroki Tamotsu、Eguchi Susumu
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 印刷中 Issue: 2 Pages: 249-257
- DOI
  10.1016/j.jbiosc.2018.02.006
- ISSN
  1389-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05908, KAKENHI-PROJECT-26461916
[Journal Article] Tissue Repair Promotion and Functional Tissue Fabrication of Digestive Organ by Cell Sheets2018
- Author(s)
  堺裕輔、江口晋
- Journal Title
  
  膜
  
  Volume: 43 Issue: 2 Pages: 34-39
- DOI
  10.5360/membrane.43.34
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-16H05908, KAKENHI-PROJECT-26461916
[Journal Article] In vivo construction of liver tissue by implantation of a hepatic non-parenchymal/adipose-derived stem cell sheet.2018
- Author(s)
  Fujii Mio、Yamanouchi Kosho、Sakai Yusuke、Baimakhanov Zhassulan、Yamaguchi Izumi、Soyama Akihiko、Hidaka Masaaki、Takatsuki Mitsuhisa、Kuroki Tamotsu、Eguchi Susumu
- Journal Title
  
  J Tissue Eng Regen Med.
  
  Volume: 12
- DOI
  10.1002/term.2424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05908, KAKENHI-PROJECT-26461916, KAKENHI-PROJECT-26861087
[Journal Article] Spontaneous hepatocyte migration towards an endothelial cell tube network2018
- Author(s)
  Baimakhanov Zhassulan、Sakai Yusuke、Yamanouchi Kosho、Hidaka Masaaki、Soyama Akihiko、Takatsuki Mitsuhisa、Eguchi Susumu
- Journal Title
  
  Journal of Tissue Engineering and Regenerative Medicine
  
  Volume: 12
- DOI
  10.1002/term.2577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05908, KAKENHI-PROJECT-26461916
[Journal Article] 細胞を用いた肝再生医療の最前線2017
- Author(s)
  岡田尚子、堺裕輔、江口晋
- Journal Title
  
  PHARMSTAGE
  
  Volume: 17 Pages: 10-16
- Data Source
  KAKENHI-PROJECT-26461916
[Journal Article] 細胞を用いた肝再生医療の最前線2017
- Author(s)
  岡田尚子、堺裕輔、江口晋
- Journal Title
  
  PHARMSTAGE
  
  Volume: 17 Pages: 10-16
- Data Source
  KAKENHI-PROJECT-16H05908
[Journal Article] Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice.2017
- Author(s)
  Ikuko Takahara, Yuko Akazawa, Maiko Tabuchi, Katsuya Matsuda, Hisamitsu Miyaaki, Youko Kido, Yasuko Kanda, Naota Taura, Ken Ohnita, Fuminao Takeshima, Yusuke Sakai, Susumu Egushi, Masahiro Nakashima, Kazuhiko Nakao
- Journal Title
  
  PLOS ONE
  
  Volume: 12
- DOI
  10.1371/journal.pone.0170591
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05908, KAKENHI-PROJECT-16K09362, KAKENHI-PROJECT-26461916, KAKENHI-PROJECT-16K08714
[Journal Article] Up-regulated extracellular matrix components and inflammatory chemokines may impair the regeneration of cholestatic liver.2016
- Author(s)
  Shuai Zhang, Tao-Sheng Li, Akihiko Soyama, Takayuki Tanaka, Chen Yan, Yusuke Sakai, Masaaki Hidaka, Ayaka Kinoshita, Koji Natsuda, Mio Fujii, Tota Kugiyama, Zhassulan Baimakhanov, Tamotsu Kuroki, Weili Gu, Susumu Eguchi
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Pages: 26540-26540
- DOI
  10.1038/srep26540
- Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05908, KAKENHI-PROJECT-15K01295, KAKENHI-PROJECT-26461916, KAKENHI-PROJECT-15K15509, KAKENHI-PROJECT-26861087
[Journal Article] Equal distribution of mesenchymal stem cells after hepatic ischemia-reperfusion injury.2016
- Author(s)
  Askhat Isbambetov, Zhassulan Baimakhanov, Akihiko Soyama, Masaaki Hidaka, Yusuke Sakai, Mitsuhisa Takatsuki, Tamotsu Kuroki, Susumu Eguchi
- Journal Title
  
  J Surg Res.
  
  Volume: 203 Pages: 360-367
- DOI
  10.1016/j.jss.2016.03.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05908, KAKENHI-PROJECT-26461916, KAKENHI-PROJECT-26861087
[Journal Article] Efficacy of multi-layered hepatocyte sheet transplantation for radiation-induced liver damage and partial hepatectomy in a rat model2016
- Author(s)
  Baimakhanov Z, Yamanouchi K, Sakai Y, Koike M, Soyama A, Hidaka M, Takatsuki M, Fujita F, Kanetaka K, Kuroki T, Eguchi S.
- Journal Title
  
  Cell Transplant.
  
  Volume: 25 Pages: 549-558
- DOI
  10.3727/096368915x688669
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462097, KAKENHI-PROJECT-26461916, KAKENHI-PROJECT-26861087
[Journal Article] Rapid production of engineered human primary hepatocyte/fibroblast sheets.2015
- Author(s)
  Yusuke Sakai, Makiko Koike, Akihiko Soyama, Masaaki Hidaka, Tamotsu Kuroki, Susumu Eguchi
- Journal Title
  
  Data Brief.
  
  Volume: 5 Pages: 498-501
- DOI
  10.1016/j.dib.2015.09.044
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461916, KAKENHI-PROJECT-26861087
[Journal Article] 組織工学による低侵襲な肝疾患治療2015
- Author(s)
  堺裕輔、江口晋
- Journal Title
  
  細胞
  
  Volume: 47 Pages: 18-21
- Data Source
  KAKENHI-PROJECT-26461916
[Journal Article] Vascularized subcutaneous human liver tissue from engineered hepatocyte/fibroblast sheets in mice.2015
- Author(s)
  Yusuke Sakai, Kosho Yamanouchi, Kazuo Ohashi, Makiko Koike, Rie Utoh, Hideko Hasegawa, Izumi Muraoka, Takashi Suematsu, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, Susumu Eguchi
- Journal Title
  
  Biomaterials.
  
  Volume: 65 Pages: 66-75
- DOI
  10.1016/j.biomaterials.2015.06.046
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461916, KAKENHI-PROJECT-26861087, KAKENHI-PROJECT-26670587
[Journal Article] Efficacy of multi-layered hepatocyte sheet transplantation for radiation-induced liver damage and partial hepatectomy in a rat model2015
- Author(s)
  Zhassulan Baimakhanov, Kosho Yamanouchi, Yusuke Sakai, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Fumihiko Fujita, Kengo Kanetaka, Tamotsu Kuroki, Susumu Eguchi
- Journal Title
  
  Journal of the American College of Surgeons
  
  Volume: 221
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461916
[Journal Article] Micropatterned culture of HepG2 spheroids using microwell chip with honeycomb-patterned polymer film2014
- Author(s)
  Hidekazu Yamazaki, Shun Goto, Koju Ito, Souichi Kohashi, Yuki Goto, Yukiko Yoshiura, Yusuke Sakai, Hiroshi Yabu, Masatsugu Shimomura, and Kohji Nakazawa
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 118 Issue: 4 Pages: 455-460
- DOI
  10.1016/j.jbiosc.2014.03.006
- ISSN
  1389-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861161
[Journal Article] Detachably assembled microfluidic device for perfusion culture and post-culture analysis of a spheroid array2014
- Author(s)
  Yusuke Sakai, Koji Hattori, Fumiki Yanagawa, Shinji Sugiura, Toshiyuki Kanamori, and Kohji Nakazawa
- Journal Title
  
  Biotechnology Journal
  
  Volume: 9 Pages: 971-979
- DOI
  10.1002/biot.201300559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861161
[Journal Article] Rapid fabrication of engineered liver tissue using novel fibroblast system2014
- Author(s)
  Yusuke Sakai, Makiko Koike, Hideko Hasegawa, Kosho Yamanouchi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, Teruo Okano, and Susumu Eguchi
- Journal Title
  
  ALTEX Proceedings
  
  Volume: 3 Pages: 44-44
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591868
[Journal Article] Rapid fabrication of engineered liver tissue using novel fibroblast system2014
- Author(s)
  1.Yusuke Sakai, Makiko Koike, Hideko Hasegawa, Kosho Yamanouchi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, Teruo Okano, and Susumu Eguchi
- Journal Title
  
  ALTEX Proceedings
  
  Volume: 3 Pages: 44-44
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861161
[Journal Article] Rapid fabricating technique for multi-layered human hepatic cell sheets by forceful contraction of the fibroblast monolayer2014
- Author(s)
  Sakai Y, Koike M, Hasegawa H, Yamanouchi K, Soyama A, Takatsuki M, Kuroki T, Ohashi K, Okano T, Eguchi S.
- Journal Title
  
  PLoS One
  
  Volume: 26
- DOI
  10.1371/journal.pone.0070970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300174, KAKENHI-PROJECT-23591868, KAKENHI-PROJECT-25861161
[Journal Article] Rapid fabrication of engineered liver tissue using novel fibroblast system2014
- Author(s)
  1.Yusuke Sakai, Makiko Koike, Hideko Hasegawa, Kosho Yamanouchi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, Teruo Okano, and Susumu Eguchi
- Journal Title
  
  ALTEX Proceedings
  
  Volume: 3 Pages: 44-44
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461916
[Journal Article] Construction of liver tissue in vivo with preparative partial hepatic irradiation and growth stimulus: investigations of less invasive techniques and progenitor cells.2013
- Author(s)
  Kensuke Miyazaki, Kosho Yamanouchi, Yusuke Sakai, Izumi Yamaguchi, Mitsuhisa Takatsuki, Tamotsu Kuroki, Chandan Guha, and Susumu Eguchi
- Journal Title
  
  Journal of Surgical Research
  
  Volume: 185 (2) Pages: 889-895
- DOI
  10.1016/j.jss.2013.06.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591868, KAKENHI-PROJECT-25462097, KAKENHI-PROJECT-25861161
[Presentation] 効率的・移植可能な肝胆膵領域での再生医療2018
- Author(s)
  江口晋、黄宇、堺裕輔
- Organizer
  第17回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] 効率的・移植可能な肝胆膵領域での再生医療2018
- Author(s)
  江口晋、黄宇、堺裕輔
- Organizer
  第17回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05908
[Presentation] Unique cell morphologies and liver-specific gene expressions of chemically-induced liver progenitors2018
- Author(s)
  Yu Huang、Yusuke Sakai、Takanobu Hara、Takeshi Katsuda、Takahiro Ochiya、Susumu Eguchi
- Organizer
  第17回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16H05908
[Presentation] 細胞シート工学を利用した血管網を有する皮下培養型ヒト肝組織作製2017
- Author(s)
  堺裕輔、高槻光寿、江口晋
- Organizer
  第103回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16H05908
[Presentation] 術後急性肝不全予防のための迅速な肝細胞複合シート作製2017
- Author(s)
  堺裕輔、小池真章子、曽山明彦、日高匡章、高槻光寿、江口晋
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-16H05908
[Presentation] 術後急性肝不全予防のための迅速な肝細胞複合シート作製2017
- Author(s)
  堺裕輔、小池真章子、曽山明彦、日高匡章、高槻光寿、江口晋
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] 細胞シート工学を利用した血管網を有する皮下培養型ヒト肝組織作製2017
- Author(s)
  堺裕輔、高槻光寿、江口晋
- Organizer
  第103回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] 孔貫通型シリコーンフィルムを利用した肝類似パターニング2017
- Author(s)
  久賀千尋、堺裕輔、中澤浩二、江口晋
- Organizer
  第54回化学関連支部合同九州大会
- Data Source
  KAKENHI-PROJECT-16H05908
[Presentation] 皮下性ヒト肝組織構築に伴う血管網と肝特異機能発現の評価2016
- Author(s)
  堺裕輔、小池真章子、山之内孝彰、曽山明彦、日高匡章、黒木保、江口晋
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪国際会議場（大阪）
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] 安定した肝細胞複合シート作製のための線維芽細胞培養条件の検討2016
- Author(s)
  小池真章子、堺裕輔、川原大輔、高槻光寿、江口晋
- Organizer
  第23回肝細胞研究会
- Place of Presentation
  大阪大学中之島センター（大阪府、大阪市）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-16H05908
[Presentation] 肝特異的な特徴を有するヒト肝組織の皮下構築と機能発現解析2016
- Author(s)
  堺裕輔、小池真章子、長谷川英子、山之内孝彰、曽山明彦、日高匡章、高槻光寿、江口晋
- Organizer
  第23回肝細胞研究会
- Place of Presentation
  大阪大学中之島センター（大阪府、大阪市）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] 皮下性ヒト肝細胞/線維芽細胞シートによる肝再生医療2016
- Author(s)
  日高匡章, 堺裕輔, 曽山明彦, 小池真章子, 山之内孝彰, 夏田孔史, 大野慎一郎, 藤田文彦, 黒木保, 江口晋
- Organizer
  第24回 JDDW
- Place of Presentation
  兵庫県神戸市神戸コンベンションセンター
- Year and Date
  2016-11-03
- Data Source
  KAKENHI-PROJECT-15K01295
[Presentation] 安定した肝細胞複合シート作製のための線維芽細胞培養条件の検討2016
- Author(s)
  小池真章子、堺裕輔、川原大輔、高槻光寿、江口晋
- Organizer
  第23回肝細胞研究会
- Place of Presentation
  大阪大学中之島センター（大阪府、大阪市）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] 肝特異的な特徴を有するヒト肝組織の皮下構築と機能発現解析2016
- Author(s)
  堺裕輔、小池真章子、長谷川英子、山之内孝彰、曽山明彦、日高匡章、高槻光寿、江口晋
- Organizer
  第23回肝細胞研究会
- Place of Presentation
  大阪大学中之島センター（大阪府、大阪市）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-16H05908
[Presentation] 放射線性肝障害と肝切除を組み合わせたラットモデルに対する多層肝細胞シートの移植効果2016
- Author(s)
  Zhassulan Baimakhanov / 長崎大学　移植・消化器外科共著者：山之内孝彰、堺裕輔、曽山明彦、日高匡章、高槻光寿、藤田文彦、金高賢悟、黒木保、江口晋
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪国際会議場（大阪府・大阪市）
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-25462097
[Presentation] Zhassulan Baimakhanov, Kosho Yamanouchi, Yusuke Sakai, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Fumihiko Fujita, Kengo Kanetaka, Kazuma Kobayashi, Tamotsu Kuroki, Susumu Eguchi2015
- Author(s)
  Baimakhanov Z, Yamanouchi K, Sakai Y, Koike M, Soyama A, Hidaka M, Takatsuki M, Fujita F, Kanetaka K, Kuroki T, Eguchi S.
- Organizer
  American College of Surgeon, Clinical Congress 2015
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462097
[Presentation] Reconstruction of vascularized subcutaneous liver tissue for minimally invasive cell therapy2015
- Author(s)
  Yusuke Sakai, Makiko Koike, Kosho Yamanouchi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, Susumu Eguchi
- Organizer
  ASGCT 18th Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] 支持細胞密度による初代肝細胞の形態および機能発現制御2015
- Author(s)
  小池真章子、堺裕輔、川原大輔、黒木保、江口晋
- Organizer
  第22回肝細胞研究会
- Place of Presentation
  米子コンベンションセンター（鳥取）
- Year and Date
  2015-06-04
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] 細胞シート工学を利用した血管誘導ヒト肝組織の迅速な自己構築2015
- Author(s)
  堺裕輔、小池真章子、長谷川英子、山之内孝彰、曽山明彦、日高匡章、高槻光寿、黒木保、江口晋
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-04-16
- Invited
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] Efficacy of multi-layered hepatocyte sheet transplantation for radiation-induced liver damage and partial hepatectomy in a rat model2015
- Author(s)
  Zhassulan Baimakhanov, Kosho Yamanouchi, Yusuke Sakai, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Fumihiko Fujita, Kengo Kanetaka, Tamotsu Kuroki, Susumu Eguchi
- Organizer
  Clinical Congress 2015, American College of Surgeons
- Place of Presentation
  Chicago, IL, USA
- Year and Date
  2015-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] 皮下性ヒト肝組織構築による肝疾患治療2015
- Author(s)
  堺裕輔、小池真章子、長谷川英子、山之内孝彰、曽山明彦、日高匡章、黒木保、江口晋
- Organizer
  第22回肝細胞研究会
- Place of Presentation
  米子コンベンションセンター（鳥取）
- Year and Date
  2015-06-04
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] Reversibly-assembled microfluidic device consists of microwells and microchannels for stable perfusion culture of spheroid array2012
- Author(s)
  Yusuke Sakai, Koji Hattori, Shinji Sugiura, Toshiyuki Kanamori, and Kohji Nakazawa
- Organizer
  2012 IEEE EMBS Micro and Nanotechnology in Medicine Conference, Hawaii, USA
- Place of Presentation
  アメリカ
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] Rapid fabrication of engineered liver tissue using novel fibroblast system
- Author(s)
  Yusuke Sakai, Makiko Koike, Hideko Hasegawa, Kosho Yamanouchi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, Teruo Okano, and Susumu Eguchi
- Organizer
  9th World Congress on Alternatives and Animal Use in the Life Sciences (WC9)
- Place of Presentation
  Prague, Czech Republic
- Year and Date
  2014-08-24 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] ヒト初代肝細胞複合シート移植における支持細胞の種類の効果
- Author(s)
  堺裕輔、小池真章子、長谷川英子、山之内孝彰、日高匡章、曽山明彦、高槻光寿、黒木保、岡野光夫、江口晋
- Organizer
  第13回日本再生医療学会総会
- Place of Presentation
  京都（国立京都国際会館）
- Data Source
  KAKENHI-PROJECT-25861161
[Presentation] 肝細胞／各種支持細胞共培養シートの構造と機能発現の評価
- Author(s)
  小池真章子、堺裕輔、黒木保、江口晋
- Organizer
  第13回日本再生医療学会総会
- Place of Presentation
  京都（国立京都国際会館）
- Data Source
  KAKENHI-PROJECT-25861161
[Presentation] 異所性肝組織構築のための再生医療デバイスの創成
- Author(s)
  堺裕輔、小池真章子、山之内孝彰、曽山明彦、高槻光寿、黒木保、鵜頭理恵、大橋一夫、岡野光夫、江口晋
- Organizer
  第68回日本消化器外科学会総会
- Place of Presentation
  宮崎（シーガイアコンベンションセンター）
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] Rapid fabrication of engineered liver tissue using novel fibroblast system
- Author(s)
  Yusuke Sakai, Makiko Koike, Hideko Hasegawa, Kosho Yamanouchi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, Teruo Okano, and Susumu Eguchi
- Organizer
  9th World Congress on Alternatives and Animal Use in the Life Sciences (WC9)
- Place of Presentation
  Prague, Czech Republic
- Year and Date
  2014-08-24 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-25861161
[Presentation] ヒト初代肝細胞/線維芽細胞複合シートが創造する第二の肝臓
- Author(s)
  堺裕輔、高槻光寿、江口晋
- Organizer
  JDDW2013
- Place of Presentation
  東京（グランドプリンスホテル新高輪）
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] 共培養技術に基づく重層化肝細胞シートの開発
- Author(s)
  堺裕輔、高槻光寿、山之内孝彰、曽山明彦、村岡いづみ、田中貴之、山口泉、木下綾華、原貴信、鵜頭理恵、大橋一夫、岡野光夫、黒木保、江口晋
- Organizer
  第11回日本再生医療学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] 肝細胞／各種支持細胞共培養シートの構造と機能発現の評価
- Author(s)
  小池真章子、堺裕輔、黒木保、江口晋
- Organizer
  第13回日本再生医療学会総会
- Place of Presentation
  京都（国立京都国際会館）
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] 再生医療のための肝細胞組織工学
- Author(s)
  堺裕輔、小池真章子、山之内孝彰、曽山明彦、高槻光寿、黒木保、江口晋
- Organizer
  第27回長崎DDS・再生医療研究会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] 線維芽細胞/肝細胞重層化シートの開発およびin vivo肝特異機能発現
- Author(s)
  堺裕輔、高槻光寿、山之内孝彰、曽山明彦、鵜頭理恵、大橋一夫、岡野光夫、黒木保、江口晋
- Organizer
  第19回肝細胞研究会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] Reconstruction of Vascularized Subcutaneous Liver Tissue for Minimally Invasive Cell Therapy
- Author(s)
  Yusuke Sakai, Makiko Koike, Kosho Yamanouchi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, and Susumu Eguchi
- Organizer
  ASGCT 18th Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2015-05-13 – 2015-05-16
- Data Source
  KAKENHI-PROJECT-25861161
[Presentation] ヒト初代肝細胞/線維芽細胞複合シートが創造する第二の肝臓
- Author(s)
  堺裕輔、高槻光寿、江口晋
- Organizer
  JDDW2013
- Place of Presentation
  東京（グランドプリンスホテル新高輪）
- Data Source
  KAKENHI-PROJECT-25861161
[Presentation] 細胞シート工学を利用した血管誘導ヒト肝組織の迅速な自己構築
- Author(s)
  堺裕輔、小池真章子、長谷川英子、山之内孝彰、曽山明彦、日高匡章、高槻光寿、黒木保、江口晋
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-04-16 – 2015-04-18
- Data Source
  KAKENHI-PROJECT-25861161
[Presentation] 肝移植の代替または再生補助療法としてのヒト肝細胞シートを用いた再生医療デバイスの開発
- Author(s)
  高槻光寿、堺裕輔、江口晋
- Organizer
  第40回日本肝臓学会西部会
- Place of Presentation
  岐阜（長良川国際会議場）
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] 共培養型肝細胞シートにおける支持細胞の効果
- Author(s)
  小池真章子、堺裕輔、高槻光寿、曽山明彦、虎島泰洋、藤田文彦、金高賢悟、黒木保、江口晋
- Organizer
  第12回日本再生医療学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] Reconstruction of Vascularized Subcutaneous Liver Tissue for Minimally Invasive Cell Therapy
- Author(s)
  Yusuke Sakai, Makiko Koike, Kosho Yamanouchi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, and Susumu Eguchi
- Organizer
  ASGCT 18th Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2015-05-13 – 2015-05-16
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] ヒト肝細胞シートによる肝再生を目指して～ヒト肝細胞シート作製技術の確立～
- Author(s)
  堺裕輔、高槻光寿、山之内孝彰、曽山明彦、村岡いづみ、大橋一夫、江口晋
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  石川
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] Reconstruction of Vascularized Subcutaneous Liver Tissue for Minimally Invasive Cell Therapy
- Author(s)
  Yusuke Sakai, Makiko Koike, Kosho Yamanouchi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, and Susumu Eguchi
- Organizer
  ASGCT 18th Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2014-05-13 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] 細胞シート工学を利用した血管誘導ヒト肝組織の迅速な自己構築
- Author(s)
  堺裕輔、小池真章子、長谷川英子、山之内孝彰、曽山明彦、日高匡章、高槻光寿、黒木保、江口晋
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-04-16 – 2015-04-18
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] 肝移植の代替または再生補助療法としてのヒト肝細胞シートを用いた再生医療デバイスの開発
- Author(s)
  高槻光寿、堺裕輔、江口晋
- Organizer
  第40回日本肝臓学会西部会
- Place of Presentation
  岐阜（長良川国際会議場）
- Data Source
  KAKENHI-PROJECT-25861161
[Presentation] Development of a multilayered fibroblast/hepatocyte sheet for regenerative medicine
- Author(s)
  Yusuke Sakai, Mitsuhisa Takatsuki, Kosho Yamanouchi, Akihiko Soyama, Izumi Muraoka, Rie Utoh, Kazuo Ohashi, Teruo Okano, Tamotsu Kuroki, and Susumu Eguchi
- Organizer
  3rd TERMIS World Congress in Vienna
- Place of Presentation
  オーストリア
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] 異所性肝組織構築のための再生医療デバイスの創成
- Author(s)
  堺裕輔、小池真章子、山之内孝彰、曽山明彦、高槻光寿、黒木保、鵜頭理恵、大橋一夫、岡野光夫、江口晋
- Organizer
  第68回日本消化器外科学会総会
- Place of Presentation
  宮崎（シーガイアコンベンションセンター）
- Data Source
  KAKENHI-PROJECT-25861161
[Presentation] Rapid fabrication of engineered liver tissue using novel fibroblast system
- Author(s)
  Yusuke Sakai, Makiko Koike, Hideko Hasegawa, Kosho Yamanouchi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, Teruo Okano, and Susumu Eguchi
- Organizer
  9th World Congress on Alternatives and Animal Use in the Life Sciences (WC9)
- Place of Presentation
  Prague, Czech Republic
- Year and Date
  2014-08-24 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-26461916
[Presentation] ヒト初代肝細胞/線維芽細胞複合シートによる異所性肝組織構築
- Author(s)
  堺裕輔、小池真章子、長谷川英子、山之内孝彰、曽山明彦、高槻光寿、黒木保、鵜頭理恵、大橋一夫、岡野光夫、江口晋
- Organizer
  第12回日本再生医療学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591868
[Presentation] ヒト初代肝細胞複合シート移植における支持細胞の種類の効果
- Author(s)
  堺裕輔、小池真章子、長谷川英子、山之内孝彰、日高匡章、曽山明彦、高槻光寿、黒木保、岡野光夫、江口晋
- Organizer
  第13回日本再生医療学会総会
- Place of Presentation
  京都（国立京都国際会館）
- Data Source
  KAKENHI-PROJECT-23591868

1. EGUCHI Susumu (80404218)

# of Collaborated Projects: 5 results

# of Collaborated Products: 46 results
2. YAMANOUCHI Kosho (10448508)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
3. 曽山明彦 (10549447)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
4. KANEMATSU Takashi (40128004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 中澤浩二 (00304733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KOIKE Makiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
7. HASEGAWA Hideko

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. OHASHI Kazuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. TAKATSUKI Mitsuhisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
10. HIDAKA Masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
11. 日高匡章

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
12. 李桃生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 赤澤祐子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 中尾一彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 中島正洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAI Yusuke 堺 裕輔

Research Projects

Research Products

Co-Researchers

Reconstruction of liver from arranged-hepatocytes/liver sinusoidal endothelial cells/cholangiocytes tissuesPrincipal InvestigatorOngoing

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In vitro reconstruction of functional bile canaliculus-intrahepatic bile duct structurePrincipal InvestigatorOngoing

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Fabrication of human liver with mimicking hepatic lobule structures by alternately-arranged human hepatocyte/endotherial cell tissue transplantationPrincipal InvestigatorOngoing

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ハイブリッド人工胆管構築技術を基盤とした術後胆管狭窄予防Ongoing

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Acute liver failure treatment using rapid fabricated engineered hepatocyte sheets

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Construction of liver tissue in vivo with preparative partial hepatic irradiation and growth stimulus: investigations of less invasive techniques and progenitor cells.

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Construction of vascularized ectopic liver tissue from engineered human hepatocyte sheetPrincipal Investigator

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Reconstruction of human liver sheet for preclinical study of liver regenerative medicine

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[Book] 再生医療用語ハンドブック： 肝細胞移植2015

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[Journal Article] Controlled cell morphology and liver-specific function of engineered primary hepatocytes by fibroblast layer cell densities2018

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[Journal Article] Tissue Repair Promotion and Functional Tissue Fabrication of Digestive Organ by Cell Sheets2018

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[Journal Article] In vivo construction of liver tissue by implantation of a hepatic non-parenchymal/adipose-derived stem cell sheet.2018

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[Journal Article] Spontaneous hepatocyte migration towards an endothelial cell tube network2018

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[Journal Article] 細胞を用いた肝再生医療の最前線2017

SAKAI Yusuke 堺裕輔

[Book] 再生医療用語ハンドブック：　肝細胞移植2015