ICHIMURA ATSUHIKO 市村敦彦

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Ichimura Atsuhiko 市村敦彦

ICHIMURA Atsuhiko 市村敦彦

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Researcher Number	10609209
Other IDs
Affiliation (Current)	2025: 立命館大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 立命館大学, 薬学部, 准教授 2020 – 2023: 京都大学, 薬学研究科, 助教 2016 – 2018: 京都大学, 薬学研究科, 特定助教 2015: 京都大学, 薬学研究科(研究院), 助教 2014: 京都大学, 健康長寿社会の総合医療開発ユニット, 助教 … More 2014: 京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 2014: 東北大学, 医学系研究科, 非常勤講師 2012 – 2013: 東北大学, 医学(系)研究科(研究院), 助教 2011 – 2012: 東北大学, 大学院・医学系研究科, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56020:Orthopedics-related / Pathological medical chemistry / General pharmacology / Endocrinology Except Principal Investigator Basic Section 59020:Sports sciences-related / Basic Section 56020:Orthopedics-related / Basic Section 59040:Nutrition science and health science-related / Applied pharmacology
Keywords	Principal Investigator 細胞内Ca2+ / 軟骨内骨化 / 薬理学 / 骨関連疾患 / イオンチャネル / 軟骨細胞 / 細胞内カルシウム / 肥満 / 糖尿病 / 分子薬理学 … More / 炎症 / 空間遺伝子発現 / スクリーニング / 骨伸長 / 軟骨無形成症 / C型ナトリウム利尿ペプチド / 細胞内シグナル / 内軟骨骨化 / シグナル経路 / 細胞死 / Ca2+ストア / 小胞体 / 小胞体ストレス / 栄養学 / 代謝異常 / 遺伝子多型 / ゲノム薬理学 / ゲノム / 脂質 / 薬学 / 生体分子 / 遊離脂肪酸 / 脂肪酸受容体 / エネルギー代謝 / GPCR / 受容体 / 脂肪酸 / 代謝 / 創薬 / 線溶系 / 抗炎症 / 免疫細胞遊走 / PAI-1 / マクロファージ / 免疫学 … More Except Principal Investigator 筋肉 / MG23 / カルシウム / 骨格筋 / 細胞内Ca2+ / 軟骨細胞 / 骨系統疾患 / 関節軟骨 / マッピング / イメージング / 生理学 / 軟骨組織 / カルシウムシグナル / 生体分子 / 生理活性 / 薬理学 Less

細胞内Ca2+動態と空間遺伝子発現の統合解析による軟骨内骨化制御の解明Principal Investigator
- Principal Investigator
  
  市村敦彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Ritsumeikan University
  Kyoto University
Molecular mechanisms of control of ca2+ in chondrocytes in cartilage development and in the repair of articular cartilages
- Principal Investigator
  
  伊藤宣
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Clinical Research Center Kurashiki Central Hospital
Muscle contraction and calcium signaling
- Principal Investigator
  
  西美幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Kyoto University
Study on novel methods to promote bone elongation through intracellular Ca2+ in chondrocytes and treatment of bone system diseasesPrincipal Investigator
- Principal Investigator
  
  Ichimura Atsuhiko
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto University
Study on intracellular Ca2+ regulation in endochondral ossification and its application to bone-related diseasesPrincipal Investigator
- Principal Investigator
  
  Ichimura Atsuhiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kyoto University
胎児期軟骨組織カルシウムシグナルマッピング
- Principal Investigator
  
  武井大祐
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyoto University
Analyses of regulatory mechanisms of energy homeostasis via free fatty acids receptorsPrincipal Investigator
- Principal Investigator
  
  Atsuhiko Ichimura
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
Molecular pharmacological analysis of anti-inflammatory effects of PAI-1 inhibitorPrincipal Investigator
- Principal Investigator
  
  ATSUHIKO Ichimura
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
  Tohoku University
The development of a novel mechanism therapeutic drug for rare intractable inflammatory diseases
- Principal Investigator
  
  MIYATA Toshio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University
The analysis of molecular mechanisms of the inflammatory macrophage migration by using a small molecule inhibitor to plasminogen activator inhibitor 1.Principal Investigator
- Principal Investigator
  
  ICHIMURA Atsuhiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Endocrinology
- Research Institution
  Tohoku University

All 2023 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012 2011

All Journal Article Presentation Patent

[Journal Article] Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice2023
- Author(s)
  Ichimura Atsuhiko、Miyazaki Yuu、Nagatomo Hiroki、Kawabe Takaaki、Nakajima Nobuhisa、Kim Ga Eun、Tomizawa Masato、Okamoto Naoki、Komazaki Shinji、Kakizawa Sho、Nishi Miyuki、Takeshima Hiroshi
- Journal Title
  
  Cell Death and Disease
  
  Volume: 14 Issue: 12 Pages: 848-848
- DOI
  10.1038/s41419-023-06285-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18456, KAKENHI-PROJECT-23K06012, KAKENHI-PROJECT-23K10634, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K27378
[Journal Article] Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and orthodontic tooth movement through GPR1202023
- Author(s)
  Jinghan Ma, Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Kayoko Kanou, Akiko Kishikawa, Atsuhiko Ichimura, Itaru Mizoguchi
- Journal Title
  
  Front Immunol.
  
  Volume: eCollection 2022. Pages: 929690-929690
- DOI
  10.3389/fimmu.2022.929690
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03802, KAKENHI-PROJECT-23K19681, KAKENHI-PROJECT-22K10236, KAKENHI-PROJECT-21K10178, KAKENHI-PROJECT-22K17223, KAKENHI-PROJECT-22K17244
[Journal Article] Atypical cell death in the growth plate chondrocytes of Tric-b-knockout mice.2023
- Author(s)
  Atsuhiko Ichimura, Yuu Miyazaki, Hiroki Nagatomo, Masato Tomizawa, Takaaki Kawabe, Nobuhisa Nakajima, Naoki Okamoto, Shinji Komazaki, Sho Kakizawa, Miyuki Nishi, Hiroshi Takeshima
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.02.28.530410
- Open Access
- Data Source
  KAKENHI-PROJECT-20H03802, KAKENHI-PROJECT-21K19565
[Journal Article] Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding2023
- Author(s)
  Yasuda Takuma、Harada Norio、Hatoko Tomonobu、Ichimura Atsuhiko、Ikeguchi-Ogura Eri、Murata Yuki、Wada Naoki、Kiyobayashi Sakura、Yamane Shunsuke、Hirasawa Akira、Inagaki Nobuya
- Journal Title
  
  American Journal of Physiology-Endocrinology and Metabolism
  
  Volume: - Issue: 5 Pages: E449-E460
- DOI
  10.1152/ajpendo.00329.2022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03731, KAKENHI-PROJECT-20H03802, KAKENHI-PROJECT-22K08668, KAKENHI-PROJECT-23K27378
[Journal Article] FFAR (free fatty acid receptor, 遊離脂肪酸受容体) の生理的および薬理的作用2022
- Author(s)
  市村　敦彦
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 40 Pages: 146-147
- Data Source
  KAKENHI-PROJECT-20H03802
[Journal Article] C-type natriuretic peptide facilitates autonomic Ca 2+ entry in growth plate chondrocytes for stimulating bone growth2022
- Author(s)
  Yuu Miyazaki#, Atsuhiko Ichimura#, Ryo Kitayama, Naoki Okamoto, Tomoki Yasue, Feng Liu, Takaaki Kawabe, Hiroki Nagatomo, Yohei Ueda, Ichiro Yamauchi, Takuro Hakata, Kazumasa Nakao, Sho Kakizawa, Miyuki Nishi, Yasuo Mori, Haruhiko Akiyama, Kazuwa Nakao, Hiroshi Takeshima
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.71931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03802, KAKENHI-PROJECT-21H02663, KAKENHI-PROJECT-21K19565, KAKENHI-PROJECT-19K06955, KAKENHI-PROJECT-20K11306, KAKENHI-PROJECT-21K19752
[Journal Article] FFAR (free fatty acid receptor, 遊離脂肪酸受容体) の臨床応用2022
- Author(s)
  市村　敦彦
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 40 Pages: 284-287
- Data Source
  KAKENHI-PROJECT-20H03802
[Journal Article] FFAR (free fatty acid receptor, 遊離脂肪酸受容体) の種類2022
- Author(s)
  市村　敦彦
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 40 Pages: 8-10
- Data Source
  KAKENHI-PROJECT-20H03802
[Journal Article] Enhanced Ca2+ handling in thioglycolate-elicited peritoneal macrophages2021
- Author(s)
  Liu Feng、Xu Luxin、Nishi Miyuki、Ichimura Atsuhiko、Takeshima Hiroshi
- Journal Title
  
  Cell Calcium
  
  Volume: 96 Pages: 102381-102381
- DOI
  10.1016/j.ceca.2021.102381
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11306, KAKENHI-PROJECT-18H02597, KAKENHI-PROJECT-20H03802, KAKENHI-PROJECT-21H02663
[Journal Article] Elucidation of the Physiological Functions of Membrane Proteins as Novel Drug Target Candidate Molecules2021
- Author(s)
  Atsuhiko Ichimura
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 9 Pages: 1167-1173
- DOI
  10.1248/bpb.b21-00296
- NAID
  130008082446
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-09-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-20H03802
[Journal Article] TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development.2019
- Author(s)
  Qian N, Ichimura A, Takei D, Sakaguchi R, Kitani A, Nagaoka R, Tomizawa M, Miyazaki Y, Miyachi H, Numata T, Kakizawa S, Nishi M, Mori Y, Takeshima H.
- Journal Title
  
  Science signaling
  
  Volume: 12 Issue: 576 Pages: 4847-4847
- DOI
  10.1126/scisignal.aaw4847
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845, KAKENHI-PROJECT-18H02597, KAKENHI-PROJECT-15K06774, KAKENHI-PROJECT-18K11044, KAKENHI-PROJECT-18K06864, KAKENHI-PROJECT-19K06955, KAKENHI-PROJECT-19K22834, KAKENHI-PUBLICLY-18H04695, KAKENHI-PROJECT-16K05843, KAKENHI-PLANNED-26111004, KAKENHI-PROJECT-17H06228
[Journal Article] Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-12018
- Author(s)
  Kawaguchi Shin-Ichi, Gonda Yuhei, Yamamoto Takuya, Sato Yuki, Shinohara Hiroyuki, Kobiki Yohsuke, Ichimura Atsuhiko, Dan Takashi, Sonoda Motohiro, Miyata Toshio, Ogawa Akiya, Tsujita Tadayuki
- Journal Title
  
  Molecules
  
  Volume: 23 Issue: 4 Pages: 885-885
- DOI
  10.3390/molecules23040885
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04138, KAKENHI-PROJECT-15H05652, KAKENHI-PROJECT-16K14049, KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-17K19881
[Journal Article] The natural flavonoid myricetin inhibits gastric H + , K + -ATPase2018
- Author(s)
  Miyazaki Yuu、Ichimura Atsuhiko、Sato Shun、Fujii Takuto、Oishi Shinya、Sakai Hideki、Takeshima Hiroshi
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 820 Pages: 217-221
- DOI
  10.1016/j.ejphar.2017.12.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08531, KAKENHI-PROJECT-15H05652
[Journal Article] Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.2017
- Author(s)
  Honjo K, Munakata S, Tashiro Y, Salama Y, Shimazu H, Eiamboonsert S, Dhahri D, Ichimura A, Dan T, Miyata T, Takeda K, Sakamoto K, Hattori K, Heissig B.
- Journal Title
  
  FASEB Journal
  
  Volume: - Issue: 6 Pages: 2625-2637
- DOI
  10.1096/fj.201600871rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05652, KAKENHI-PROJECT-26461415, KAKENHI-PROJECT-16K09821, KAKENHI-PROJECT-15K21373, KAKENHI-PROJECT-16K19956, KAKENHI-PROJECT-16K10476, KAKENHI-PROJECT-17K09941
[Journal Article] Gm7325 is MyoD-dependently expressed in activated muscle satellite cells 2017
- Author(s)
 Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura A, Takeshima H.
- Journal Title
 
 Biomed. Res.
 
 Volume: 38 Issue: 3 Pages: 215-219
- DOI
 10.2220/biomedres.38.215
- NAID
 130006865614
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-17K01845, KAKENHI-PLANNED-15H05933, KAKENHI-PROJECT-15H01843, KAKENHI-PROJECT-17H01524, KAKENHI-PROJECT-15H04676, KAKENHI-PROJECT-15H05652
[Journal Article] Polymorphic Variation in FFA Receptors: Functions and Consequences.2017
- Author(s)
  Ichimura A.
- Journal Title
  
  Handbook of Experimental Pharmacology
  
  Volume: 236 Pages: 133-158
- DOI
  10.1007/164_2016_57
- ISBN
  9783319506920, 9783319506937
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05652
[Journal Article] Nutritional Signaling via Free Fatty Acid Receptors2016
- Author(s)
  J. Miyamoto, S. Hasegawa, M. Kasubuchi, A. Ichimura, A. Nakajima, and I. Kimura
- Journal Title
  
  Int J Mol Sci
  
  Volume: 17 Issue: 4 Pages: 450-450
- DOI
  10.3390/ijms17040450
- NAID
  120005947125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05344, KAKENHI-PROJECT-15H05652, KAKENHI-PROJECT-14J06559
[Journal Article] TRIC-B Mutations Causing Osteogenesis Imperfecta.2016
- Author(s)
  Ichimura A, Takeshima H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Pages: 1743-1747
- NAID
  130005268698
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05652
[Journal Article] Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.2016
- Author(s)
  C.Zhao, A.Ichimura, N.Qian, T.Iida, D.Yamazaki, N.Noma, M.Asagiri, K.Yamamoto, S.Komazaki, C.Sato, F.Aoyama, A.Sawaguchi, S.Kakizawa, M.Nishi, and H.Takeshima.
- Journal Title
  
  science signaling
  
  Volume: 9 Issue: 428
- DOI
  10.1126/scisignal.aad9055
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01562, KAKENHI-PROJECT-15H04676, KAKENHI-PROJECT-15H04698, KAKENHI-PROJECT-15H05652, KAKENHI-PROJECT-14J06672, KAKENHI-PROJECT-15K06774, KAKENHI-PROJECT-15K14499
[Journal Article] Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis.2015
- Author(s)
  Pelisch N, Dan T, Ichimura A, Sekiguchi H, Vaughan DE, van Ypersele de Strihou C, Miyata T.
- Journal Title
  
  PloS One
  
  Volume: 10 Issue: 4 Pages: e0124510-e0124510
- DOI
  10.1371/journal.pone.0124510
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05652
[Journal Article] Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.2015
- Author(s)
  Van B, Nishi M, Komazaki S, Ichimura A, Kakizawa S, Nakanaga K, Aoki J, Park KH, Ma J, Ueyama T, Ogata T, Maruyama N, Takeshima H.
- Journal Title
  
  FEBS Lett.
  
  Volume: in press Issue: 10 Pages: 1095-1104
- DOI
  10.1016/j.febslet.2015.03.028
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500470, KAKENHI-PROJECT-15K06774, KAKENHI-PROJECT-15H04676, KAKENHI-PROJECT-15H05652
[Journal Article] Editorial: Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors.2015
- Author(s)
  Ichimura A, Kimura I.
- Journal Title
  
  Front Endocrinology
  
  Volume: 6 Pages: 178-178
- DOI
  10.3389/fendo.2015.00178
- NAID
  120005946997
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05652
[Journal Article] A Novel Antidiabetic Therapy: free Fatty Acids Receptors as Potential Druggable Targets.2015
- Author(s)
  Sekiguchi H, Kasubuchi M, Hasegawa S, Pelisch N, Kimura I, Ichimura A.
- Journal Title
  
  Curr Diabetes Rev.
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860185
[Journal Article] Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation.2015
- Author(s)
  Kasubuchi M, Hasegawa S, Hiramatsu T, Ichimura A, Kimura I.
- Journal Title
  
  Nutrients
  
  Volume: 7 Issue: 4 Pages: 2839-2849
- DOI
  10.3390/nu7042839
- NAID
  120005663309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05652
[Journal Article] Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and　Axonal Degeneration in a Mice Model of Multiple Sclerosis2015
- Author(s)
  Pelisch N, Dan T, Ichimura A, Sekiguchi H, Vaughan DE, van Ypersele C, Miyata T.
- Journal Title
  
  PLoS One.
  
  Volume: 掲載確定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249033
[Journal Article] Small Molecule Inhibitors of PAI-1 TM5275 and TM5441 Elicit Anti-Angiogenic and Anti-tumorigenic.2015
- Author(s)
  Placencio VR, Ichimura A, Miyata T, DeClerck YA.
- Journal Title
  
  Journal Molecular Cancer Therapeutics.
  
  Volume: 掲載確定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249033
[Journal Article] Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.2015
- Author(s)
  Mashiko S, Kitatani K, Toyoshima M, Ichimura A, Dan T, Usui T, Ishibashi M, Shigeta S, Nagase S, Miyata T, Yaegashi N.
- Journal Title
  
  Cancer Biol Ther.
  
  Volume: 16 Pages: 253-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249033
[Journal Article] Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity.2015
- Author(s)
  Placencio VR, Ichimura A, Miyata T, DeClerck YA.
- Journal Title
  
  PloS One
  
  Volume: 10 Issue: 7 Pages: e0133786-e0133786
- DOI
  10.1371/journal.pone.0133786
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05652
[Journal Article] Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.2015
- Author(s)
  Mashiko S, Kitatani K, Toyoshima M, Ichimura A, Dan T, Usui T, Ishibashi M, Shigeta S, Nagase S, Miyata T, Yaegashi N
- Journal Title
  
  Cancer Biology & Therapy
  
  Volume: 16 Issue: 2 Pages: 253-260
- DOI
  10.1080/15384047.2014.1001271
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390375, KAKENHI-PROJECT-24592498, KAKENHI-PROJECT-25860185, KAKENHI-PROJECT-26462509, KAKENHI-PROJECT-26670710
[Journal Article] Plasminogen activator inhibitor-1 (PAI-1) molecule: new physiological roles and clinical applications.2014
- Author(s)
  Dan T, Ichimura A, Pelisch N, Miyata K, Akahori K, Miyata T.
- Journal Title
  
  Rinsho Ketsueki.
  
  Volume: 55 Pages: 396-404
- NAID
  130004920665
- Data Source
  KAKENHI-PROJECT-25860185
[Journal Article] The role of free fatty acid receptors in the regulation of energy metabolism2014
- Author(s)
  T. Hara, D. Kashihara, A. Ichimura, I. Kimura, G. Tsujimoto, and A. Hirasawa.
- Journal Title
  
  Biochem Biophys Acta
  
  Volume: 1841 Issue: 9 Pages: 1292-1300
- DOI
  10.1016/j.bbalip.2014.06.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590077, KAKENHI-PROJECT-25860185
[Journal Article] Regulation of Energy Homeostasis via GPR120.2014
- Author(s)
  Ichimura A, Hara T, Hirasawa A.
- Journal Title
  
  Front Endocrinol
  
  Volume: 11 Pages: 111-111
- DOI
  10.3389/fendo.2014.00111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860185
[Journal Article] Therapeutic role and ligands of medium- to long-chain Fatty Acid receptors.2014
- Author(s)
  Hara T, Ichimura A, Hirasawa A.
- Journal Title
  
  Front Endocrinol
  
  Volume: 5 Pages: 83-83
- DOI
  10.3389/fendo.2014.00083
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860185
[Journal Article] Free fatty acids receptors as therapeutic target for treatment of diabetes.2014
- Author(s)
  A. Ichimura, S. Hasegawa, M. Kasubuchi, and I. Kimura*
- Journal Title
  
  Front Pharmacol.
  
  Volume: 5 Pages: 236-236
- DOI
  10.3389/fphar.2014.00236
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590077, KAKENHI-PROJECT-25860185
[Journal Article] The PAI-1 antagonist TM5441 attenuates L-NAME-induced hypertension and vascular senescence2013
- Author(s)
  Boe A, Eren M, Murphy S, Kamide1 C, Ichimura A, Terry D, McAnally D, Smith LH, Miyata T, Vaughan DE
- Journal Title
  
  Circulation
  
  Volume: 128 Issue: 21 Pages: 2318-2324
- DOI
  10.1161/circulationaha.113.003192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249033, KAKENHI-PROJECT-25860185
[Journal Article] A smoll molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.2013
- Author(s)
  Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF, Vaughan DE, van Ypersele de Strihou S, Miyata T.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 33 Issue: 5 Pages: 935-942
- DOI
  10.1161/atvbaha.113.301224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590219, KAKENHI-PROJECT-23890019, KAKENHI-PROJECT-24249033, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487
[Journal Article] A Small Molecule Inhibitor to Plasminogen Activator Inhibitor 1 Inhibits Macrophage Migration.2013
- Author(s)
  Ichimura A
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 掲載確定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249033
[Journal Article] Free Fatty Acid Receptors and Their Role in Regulation of Energy Metabolism.2013
- Author(s)
  Hara Takafumi, et al.
- Journal Title
  
  Reviews of Physiology, Biochemistry and Pharmacology
  
  Volume: - Pages: 77-116
- DOI
  10.1007/112_2013_13
- ISBN
  9783319009957, 9783319009964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790249, KAKENHI-PROJECT-25860185
[Journal Article] A Small Molecule Inhibitor to Plasminogen Activator Inhibitor 1 Inhibits Macrophage Migration.2013
- Author(s)
  Ichimura Atsuhiko
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 掲載確定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890019
[Journal Article] Physiological functions of fatty acid receptors andtheir therapeutic potential2012
- Author(s)
  Hara T, Hirasawa A, Ichimura A, Kimura I, Tsujimoto G.
- Journal Title
  
  Nihon Yakurigaku Zasshi
  
  Volume: 140 Pages: 275-279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890019
[Journal Article] Early Treatment With Olmesartan Prevents Juxtamedullary Glomerular Podocyte Injury and the Onset of Microalbuminuria in Type 2 Diabetic Rats2012
- Author(s)
  Sofue T, 他
- Journal Title
  
  Am J Hypertens
  
  Volume: 34(3)(In Press) Issue: 5 Pages: 604-11
- DOI
  10.1038/ajh.2012.1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390259, KAKENHI-PROJECT-23390224, KAKENHI-PROJECT-23659442, KAKENHI-PROJECT-23890019, KAKENHI-PROJECT-24591204
[Journal Article] Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human2012
- Author(s)
  Ichimura A
- Journal Title
  
  Nature
  
  Volume: 483 Issue: 7389 Pages: 350-354
- DOI
  10.1038/nature10798
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117008, KAKENHI-PROJECT-21390021, KAKENHI-PROJECT-23659038, KAKENHI-PROJECT-23890019, KAKENHI-PROJECT-24590327
[Journal Article] Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)2011
- Author(s)
  Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 108 Pages: 8030-8035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890019
[Journal Article] Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders2011
- Author(s)
  Hara T, Hirasawa A, et al
- Journal Title
  
  J Pharm Sci
  
  Volume: 100(9) Issue: 9 Pages: 3594-3601
- DOI
  10.1002/jps.22639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390021, KAKENHI-PROJECT-23890019
[Journal Article] miRNAs and regulation of cell signaling2011
- Author(s)
  Ichimura A, Ruike Y, Terasawa K, Tsujimoto G
- Journal Title
  
  FEBS Journal
  
  Volume: 278 Pages: 1610-1618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890019
[Journal Article] Free fatty acid receptors and their physiological role in metabolic regulation2011
- Author(s)
  Hirasawa A, Hara T, Ichimura A, Tsujimoto G
- Journal Title
  
  Yakugaku Zasshi
  
  Volume: 131 Pages: 1683-1689
- NAID
  130001871764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890019
[Journal Article] 創薬標的としての遊離脂肪酸受容体:循環器疾患とメタボリックシンドローム2011
- Author(s)
  市村敦彦, 原貴史, 木村郁夫, 平津明, 辻本豪三
- Journal Title
  
  血管
  
  Volume: 34 Pages: 145-152
- NAID
  10030334780
- Data Source
  KAKENHI-PROJECT-23890019
[Patent] 骨伸長促進剤2023
- Inventor(s)
  市村敦彦、竹島浩
- Industrial Property Rights Holder
  市村敦彦、竹島浩
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-026255
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K27378
[Patent] 骨伸長促進剤2023
- Inventor(s)
  市村敦彦、竹島浩
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-026255
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21K19565
[Presentation] Tric-b遺伝子欠損は成長板軟骨細胞において非典型的な細胞死を引き起こす2023
- Author(s)
  長友宏樹, 市村敦彦, 川邊隆彰, 中嶋将久, 安江智生, 竹島浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03802
[Presentation] 成長板におけるTric-b遺伝子欠損は非典型的な細胞死と不完全な細胞外基質構築を引き起こす2023
- Author(s)
  長友宏樹、市村敦彦、川邊隆彰、中嶋将久、金佳垠、竹島浩
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-23K27378
[Presentation] 成長板軟骨細胞におけるホスホジエステラーゼ3(PDE3)の阻害は細胞内Ca2+シグナル経路を活性化し骨伸長を促進する2023
- Author(s)
  川邊隆彰, 市村敦彦, 安江智生, 竹島浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03802
[Presentation] Tric-b遺伝子欠損は成長板軟骨細胞において非典型的な細胞死を引き起こす2023
- Author(s)
  長友宏樹, 市村敦彦, 川邊隆彰, 中嶋将久, 安江智生, 竹島浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K19565
[Presentation] 成長板軟骨細胞におけるホスホジエステラーゼ3(PDE3)の阻害は細胞内Ca2+シグナル経路を活性化し骨伸長を促進する2023
- Author(s)
  川邊隆彰, 市村敦彦, 安江智生, 竹島浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K19565
[Presentation] 肝臓特異的Ccdc47欠損マウスの作出とツニカマイシン誘導性小胞体ストレスへの応答の検討2023
- Author(s)
  中嶋将久、山形史音、市村敦彦、竹島浩
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-23K27378
[Presentation] C 型ナトリウム利尿ペプチドによる軟骨細胞内 Ca2+シグナルの活性化と骨伸長促進作用: 分子機序に基づく小児骨系統疾患に対する創薬戦略2022
- Author(s)
  市村敦彦
- Organizer
  「子どもの薬を創る会」第5回セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21K19565
[Presentation] C型ナトリウム利尿ペプチドは成長板軟骨細胞において自発的なCa2+流入を介して骨伸長を促進する2022
- Author(s)
  宮崎侑、市村敦彦、北山諒、岡本直樹、安江智生、劉楓、川邊隆彰、長友宏樹、西美幸、柿澤昌、竹島浩
- Organizer
  日本薬理学会95回年会
- Data Source
  KAKENHI-PROJECT-20H03802
[Presentation] C 型ナトリウム利尿ペプチドによる軟骨細胞内 Ca2+シグナルの活性化と骨伸長促進作用: 分子機序に基づく小児骨系統疾患に対する創薬戦略2022
- Author(s)
  市村　敦彦
- Organizer
  「子どもの薬を創る会」第5回セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20H03802
[Presentation] C型ナトリウム利尿ペプチドは軟骨細胞内Ca2+シグナル経路を活性化し骨伸長を促進する2022
- Author(s)
  岡本直樹、市村敦彦、宮崎侑、北山諒、安江智己、劉楓、川邊隆彰、長友宏樹、柿澤昌、西美幸、竹島浩
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K19565
[Presentation] C型ナトリウム利尿ペプチドは軟骨細胞内Ca2+シグナル経路を活性化し骨伸長を促進する2022
- Author(s)
  岡本直樹、市村敦彦、宮崎侑、北山諒、安江智己、劉楓、川邊隆彰、長友宏樹、柿澤昌、西美幸、竹島浩
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-20H03802
[Presentation] C型ナトリウム利尿ペプチドは成長板軟骨細胞において自発的なCa2+流入を介して骨伸長を促進する2022
- Author(s)
  宮崎侑、市村敦彦、北山諒、岡本直樹、安江智生、劉楓、川邊隆彰、長友宏樹、西美幸、柿澤昌、竹島浩
- Organizer
  日本薬理学会95回年会
- Data Source
  KAKENHI-PROJECT-21K19565
[Presentation] 遊離脂肪酸受容体の新たな生理機能2021
- Author(s)
  市村　敦彦
- Organizer
  日本薬理学会第94回年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03802
[Presentation] フラボノイドミリセチンは胃のH+, K+-ATPaseを抑制する2018
- Author(s)
  宮崎侑, 市村敦彦, 佐藤駿, 藤井拓人, 大石真也、酒井秀紀、竹島浩
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-15H05652
[Presentation] Spontaneous Ca2+ fluctuations mediated by TRPM7 channels in growth plate chondrocytes2018
- Author(s)
  Nianchao Qian, Atsuhiko Ichimura, Daisuke Takei, Hua Zhu, Miyuki Nishi, Hiroshi Takeshima,
- Organizer
  Biophysical society 62nd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05652
[Presentation] TRIC-Bチャネルの骨形成と破骨細胞における生理機能の解析2016
- Author(s)
  銭年超, 市村敦彦, 朝霧成挙, 竹島浩
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H05652
[Presentation] TRIC-Bチャネルの骨形成と骨芽細胞における生理機能の解析2016
- Author(s)
  趙成珠, 市村敦彦, 山本浩司, 竹島浩
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H05652
[Presentation] Drug development of Plasminogen Activator Inhibitor 1 (PAI-1) inhibitor2015
- Author(s)
  市村敦彦
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  甲府市総合市民会館
- Year and Date
  2015-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-15H05652
[Presentation] Generation of Glyoxalase 1-deficient mouse2012
- Author(s)
  Atsuhiko Ichimura
- Organizer
  11th International Symposium on the Maillard Reaction
- Place of Presentation
  Nancy, France
- Data Source
  KAKENHI-PROJECT-24249033
[Presentation] Generation of Glyoxalase 1-deficient mouse2012
- Author(s)
  Atsuhiko Ichimura
- Organizer
  11th International Symposium on the Maillard Reaction
- Place of Presentation
  Nancy, France
- Data Source
  KAKENHI-PROJECT-23890019
[Presentation] International Symposium on the Maillard Reaction2012
- Author(s)
 Atsuhiko Ichimura, Takashi Dan, Tadayuki Tsujita, Miyata Toshio
- Organizer
 Generation of Glyoxalase 1-deficient mice 11^<th>
- Place of Presentation
 Nacy France
- Year and Date
 2012-09-18
- Data Source
 KAKENHI-PROJECT-23890019
[Presentation] グリオキサラーゼ1欠損マウスの創出2011
- Author(s)
  市村敦彦、段孝、宮田敏男
- Organizer
  第21回日本メイラード学会
- Place of Presentation
  東京ステーションコンファレンス602,東京
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-23890019

1. 植田洋平 (30848213)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 伊藤宣 (70397537)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. MIYATA Toshio (10222332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. DAN Takashi (00512451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 武井大祐 (60775766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 近藤武史 (60565084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 井貫晋輔 (70736272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 西美幸 (60183894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUJII Takuto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. HARADA Norio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. NAGASE Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. TOYOSHIMA Masafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小川昭弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 竹島美幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
15. 平澤明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 木村郁夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. 松尾理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 岡田清孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 柿澤昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 佐藤主税

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 原貴史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 稲垣暢也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 山根俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 八重樫伸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ICHIMURA ATSUHIKO 市村 敦彦

Ichimura Atsuhiko 市村 敦彦

ICHIMURA Atsuhiko 市村 敦彦

Research Projects

Research Products

Co-Researchers

細胞内Ca2+動態と空間遺伝子発現の統合解析による軟骨内骨化制御の解明Principal Investigator

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Molecular mechanisms of control of ca2+ in chondrocytes in cartilage development and in the repair of articular cartilages

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Muscle contraction and calcium signaling

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Study on novel methods to promote bone elongation through intracellular Ca2+ in chondrocytes and treatment of bone system diseasesPrincipal Investigator

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Study on intracellular Ca2+ regulation in endochondral ossification and its application to bone-related diseasesPrincipal Investigator

Principal Investigator

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胎児期軟骨組織カルシウムシグナルマッピング

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Analyses of regulatory mechanisms of energy homeostasis via free fatty acids receptorsPrincipal Investigator

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Molecular pharmacological analysis of anti-inflammatory effects of PAI-1 inhibitorPrincipal Investigator

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The development of a novel mechanism therapeutic drug for rare intractable inflammatory diseases

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The analysis of molecular mechanisms of the inflammatory macrophage migration by using a small molecule inhibitor to plasminogen activator inhibitor 1.Principal Investigator

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[Journal Article] Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice2023

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[Journal Article] Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and orthodontic tooth movement through GPR1202023

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[Journal Article] Atypical cell death in the growth plate chondrocytes of Tric-b-knockout mice.2023

Author(s)

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DOI

ICHIMURA ATSUHIKO 市村敦彦

Ichimura Atsuhiko 市村敦彦

ICHIMURA Atsuhiko 市村敦彦