oohara hiroki 大原浩貴

… Alternative Names

OOHARA Hirotaka 大原浩貴

OHARA Hiroki 大原浩貴

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Researcher Number	10609225
Other IDs
Affiliation (Current)	2022: 島根大学, 学術研究院医学・看護学系, 講師
Affiliation (based on the past Project Information) *help	2018 – 2019: 島根大学, 学術研究院医学・看護学系, 助教 2017: 島根大学, 医学部, 助教 2011 – 2015: 島根大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Kidney internal medicine / Experimental pathology / General physiology Except Principal Investigator Pathological medical chemistry
Keywords	Principal Investigator 疾患モデル / コンジェニックラット / 高血圧 / ストレス / 交感神経 / 脳卒中易発症高血圧自然発症ラット / 脳卒中 / ストレス性高血圧 / 脳卒中感受性遺伝子 / Stim1 … More / CRISPR/Cas9 / 脳卒中易発症高血圧自然発症ラット(SHRSP) / SHRSP / コンジェニック系統 / 疾患モデル動物 … More Except Principal Investigator BBB / 内皮細胞 / SHRSP / タイトジャンクション / アストロサイト / ペリサイト / 血液脳関門 Less

Dysfunction of STIM1 and Hypertesnion: evaluation using a novel genome-edited SHRSPPrincipal Investigator
- Principal Investigator
  
  Ohara Hiroki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shimane University
Is the Blood-Brain Barrier Weakened in Genetic Stroke Model Rats? A Study Utilizing in vitro Models System
- Principal Investigator
  
  YAMAGATA Kazuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
Identification of stroke susceptible genes in the stroke-spontaneously hypertensive rats and evaluation of its molecular pathogenesisPrincipal Investigator
- Principal Investigator
  
  Hiroki Ohara
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
  Experimental pathology
- Research Institution
  Shimane University
A novel approach for identification of the genes responsible for hypertensive phenotype in SHRSPPrincipal Investigator
- Principal Investigator
  
  OHARA Hiroki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Shimane University
高血圧責任遺伝子同定への新規アプローチ：ストレス応答遺伝子と高血圧をつなぐPrincipal Investigator
- Principal Investigator
  
  大原浩貴
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General physiology
- Research Institution
  Shimane University

All 2019 2018 2017 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] BIO Clinica 2015年11月号2015
- Author(s)
  大原浩貴、松尾裕之、新谷薫、並河徹
- Total Pages
  5
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-26870376
[Journal Article] Focal Ischemic Injury with Complex Middle Cerebral Artery in Stroke-Prone Spontaneously Hypertensive Rats with Loss-Of-Function in NADPH Oxidases.2015
- Author(s)
  Yao H, Ferdaus MZ, Zahid HM, Ohara H, Nakahara T, Nabika T
- Journal Title
  
  PLoS One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0138551
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461098, KAKENHI-PROJECT-26870376, KAKENHI-PROJECT-26290067
[Journal Article] Identification of Stim1 as a candidate gene for exaggerated sympathetic response to stress in the stroke-prone spontaneously hypertensive rat.2014
- Author(s)
  Mohammed Zubaerul Ferdaus, Bing Xiao, Hiroki Ohara, Kiyomitsu Nemoto, Yuji Harada, Kathrin Saar, Norbert Hubner, Minoru Isomura, Toru Nabika
- Journal Title
  
  PLoS One
  
  Volume: 9
- DOI
  10.1371/journal.pone.0095091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790846, KAKENHI-PROJECT-26290067
[Journal Article] Identification of Stim1 as a candidate gene for exaggerated sympathetic response to stress in the stroke-prone spontaneously hypertensive rat2014
- Author(s)
  Ferdaus MZ, Xiao B, Ohara H, Nemoto K, Harada Y, Saar K, Hubner N, Isomura M, Nabika T
- Journal Title
  
  PLoS ONE
  
  Volume: 9(4)
- Data Source
  KAKENHI-PROJECT-24790846
[Journal Article] The stroke-prone spontaneously hypertensive rat : still a useful model for post-GWAS genetic studies?2012
- Author(s)
  Nabika T
- Journal Title
  
  Hypertension Research
  
  Volume: 35 Pages: 477-484
- DOI
  10.1038/hr.2012.30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590911, KAKENHI-PROJECT-24790846
[Presentation] E3ユビキチンリガーゼCBLCを介したSHRSPにおける食塩誘発性脳卒中の新規分子メカニズムの探索2019
- Author(s)
  大原浩貴、Yao Na、並河徹
- Organizer
  第42回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K08787
[Presentation] In vivo functional evaluation of STIM1 as a candidate gene responsible for exaggerated sympathetic response to stresses in SHRSP: establishment of Stim1 knock-in SHRSP2018
- Author(s)
  Hiroki Ohara, Batbayar Odongoo, Davis Ngarashi, Toru Nabika
- Organizer
  28th European Meeting on Hypertesion and Cardiovascular Protection
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08787
[Presentation] STIM1機能異常はSHRSPにおける高血圧成因の一つか？2018
- Author(s)
  大原浩貴、Batbayar Odongoo、 Davis Ngarashi、並河徹
- Organizer
  第53回高血圧関連疾患モデル学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08787
[Presentation] SHRSPにおけるカルシウム貯蔵センサーSTIM1の機能異常は高血圧発症に2018
- Author(s)
  大原浩貴、Batbayar Odongoo、 Davis Ngarashi、並河徹
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K08787
[Presentation] WKY/IzmとSHRSP/Izmの血液脳関門機能比較：In vitro BBBモデルを用いた検討2017
- Author(s)
  中川慎介、大原浩貴、有賀純、山形一雄、並河徹
- Organizer
  第53回高血圧関連疾患モデル学会
- Data Source
  KAKENHI-PROJECT-15K08321
[Presentation] 早期に脳卒中を自然発症するSHRSPコンジェニックラットの病態生理学的性質と2017
- Author(s)
  大原浩貴、Davis L. Ngarashi、並河徹
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K08787
[Presentation] Evaluation of pathological basis of a SHRSP-based congenic strain characterized by early stroke occurrence2017
- Author(s)
  Hiroki Ohara, Davis L. Ngarashi, Toru Nabika
- Organizer
  2017 ASH Annual Scientific Meeting with the AHA Council on Hypertension Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08787
[Presentation] SHRSPの脳卒中自然発症を促進する遺伝性憎悪因子の探索2017
- Author(s)
  大原浩貴、Davis L. Ngarashi、並河徹
- Organizer
  第53回高血圧関連疾患モデル学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08787
[Presentation] SHRSPで発現する変異型STIM1の機能評価：培養アストロサイトを用いたカルシウムシグナル経路への影響の検証2015
- Author(s)
  大原浩貴、並河徹
- Organizer
  第38回日本高血圧学会総会
- Place of Presentation
  愛媛県松山市、ひめぎんホール
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26870376
[Presentation] SHRSPにおけるStim1遺伝子変異とそのカルシウムシグナル経路への影響に関する検討2015
- Author(s)
  大原浩貴、並河徹
- Organizer
  第51回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  大阪府豊中市、千里ライフサイエンスセンター
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-26870376
[Presentation] A 1.2-MBP REGION ON RAT CHROMOSOME 1 IS INVOLVED IN EXAGGERATED SYMPATHETIC STRESS RESPONSE IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT: IDENTIFICATION OF STIM1 AS A CANDIDATE GENE2014
- Author(s)
  Hiroki Ohara, Mohammed Zubaerul Ferdaus, Minoru Isomura, Toru Nabika
- Organizer
  The 16th International SHR Symposium
- Place of Presentation
  Roma, Italy, Sant'Andrea Hospital
- Year and Date
  2014-06-18
- Data Source
  KAKENHI-PROJECT-26870376
[Presentation] ストレス性高血圧原因遺伝子としてのStim1の同定 : 高血圧モデルラットSHRSPを用いた研究2014
- Author(s)
  大原浩貴,磯村実,並河徹
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島市
- Invited
- Data Source
  KAKENHI-PROJECT-24790846
[Presentation] ストレス性高血圧原因遺伝子としてのStim1の同定：高血圧モデルラットSHRSPを用いた研究2014
- Author(s)
  大原　浩貴、磯村　実、並河　徹
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学・鹿児島
- Invited
- Data Source
  KAKENHI-PROJECT-24790846
[Presentation] 遺伝的高血圧モデルラットSHRSPにおけるストレス性高血圧原因遺伝子の探索.2013
- Author(s)
  大原浩貴,並河徹
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-24790846
[Presentation] ラット第1染色体に潜むストレス感受性と高血圧をつなぐ遺伝子の探索 : ストレス性高血圧の原因遺伝子同定を目指して2013
- Author(s)
  大原浩貴、磯村実、並河徹
- Organizer
  第49回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-24790846
[Presentation] 遺伝的高血圧モデルラットSHRSPにおけるストレス性高血圧原因遺伝子の探索2013
- Author(s)
  大原　浩貴、並河　徹
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪国際会議場・大阪
- Data Source
  KAKENHI-PROJECT-24790846
[Presentation] ラット第1染色体に潜むストレス感受性と高血圧をつなぐ遺伝子の探索：ストレス性高血圧の原因遺伝子同定を目指して2013
- Author(s)
  大原　浩貴、磯村　実、並河　徹
- Organizer
  第49回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  日本大学・東京
- Data Source
  KAKENHI-PROJECT-24790846
[Presentation] Search for the genes responsible for exaggerated sympathetic response to stress in stroke-prone spontaneously hypertensive rat: genetic and molecular biological approach using congenic strains2012
- Author(s)
  Hiroki Ohara, Mohammed Zubaerul Ferdaus, Minoru Isomura, Toru Nabika
- Organizer
  第15回国際SHRシンポジウム＆第48回高血圧関連疾患モデル学会
- Place of Presentation
  メルボルン大学（メルボルン、オーストラリア）
- Data Source
  KAKENHI-PROJECT-24790846
[Presentation] Search for the genes responsible for exaggerated sympathetic response to stress in stroke-prone spontaneously hypertensive rat : genetic and molecular biological approach using congenic strains.2012
- Author(s)
  Ohara H, Ferdaus MZ, Isomura M, Nabika T
- Organizer
  15th International SHR Symposium/48th Japanese SHR Meeting
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-24790846
[Presentation] ストレス感受性から見たSHRSPにおける高血圧原因遺伝子の探索2012
- Author(s)
  大原浩貴,並河徹
- Organizer
  第35回日本高血圧学会総会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-24790846
[Presentation] ストレス感受性から見たSHRSPにおける高血圧原因遺伝子の探索2012
- Author(s)
  大原浩貴、並河徹
- Organizer
  第35回日本高血圧学会総会
- Place of Presentation
  ウェスティンナゴヤキャッスル（名古屋市）
- Data Source
  KAKENHI-PROJECT-24790846
[Presentation] A 0.9-Mbp fragment on chromosome 1 affects sympathetic response to stresses-Congenic strategy for identification hypertension-responsible genes2011
- Author(s)
  大原浩貴
- Organizer
  Rat Genomics & Models Meeting
- Place of Presentation
  Cold Spring Harbor Laboratory (New York) (USA)
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-23890115
[Presentation] SHRSPで発現する変異型STIM1の機能解析
- Author(s)
  大原　浩貴、市川　純、並河　徹
- Organizer
  第50回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  和歌山、和歌山県立医科大学・紀三井寺キャンパス　生涯研修センター
- Year and Date
  2014-12-05 – 2014-12-06
- Data Source
  KAKENHI-PROJECT-26870376
[Presentation] 酸化ストレスの心血管系疾患への影響評価：p22phox欠損SHRSP
- Author(s)
  大原　浩貴、Hasan M. Zahid、元永　早希恵、八尾　博史、並河　徹
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-26870376

1. YAMAGATA Kazuo (10299323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 並河徹 (50180534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 中川慎介 (10404211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 八尾博史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

oohara hiroki 大原 浩貴

OOHARA Hirotaka 大原 浩貴

OHARA Hiroki 大原 浩貴

Research Projects

Research Products

Co-Researchers

Dysfunction of STIM1 and Hypertesnion: evaluation using a novel genome-edited SHRSPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Is the Blood-Brain Barrier Weakened in Genetic Stroke Model Rats? A Study Utilizing in vitro Models System

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of stroke susceptible genes in the stroke-spontaneously hypertensive rats and evaluation of its molecular pathogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel approach for identification of the genes responsible for hypertensive phenotype in SHRSPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

高血圧責任遺伝子同定への新規アプローチ：ストレス応答遺伝子と高血圧をつなぐPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] BIO Clinica 2015年11月号2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Focal Ischemic Injury with Complex Middle Cerebral Artery in Stroke-Prone Spontaneously Hypertensive Rats with Loss-Of-Function in NADPH Oxidases.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Stim1 as a candidate gene for exaggerated sympathetic response to stress in the stroke-prone spontaneously hypertensive rat.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Stim1 as a candidate gene for exaggerated sympathetic response to stress in the stroke-prone spontaneously hypertensive rat2014

Author(s)

Journal Title

Data Source

[Journal Article] The stroke-prone spontaneously hypertensive rat : still a useful model for post-GWAS genetic studies?2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] E3ユビキチンリガーゼCBLCを介したSHRSPにおける食塩誘発性脳卒中の新規分子メカニズムの探索2019

Author(s)

Organizer

Data Source

[Presentation] In vivo functional evaluation of STIM1 as a candidate gene responsible for exaggerated sympathetic response to stresses in SHRSP: establishment of Stim1 knock-in SHRSP2018

Author(s)

Organizer

Data Source

[Presentation] STIM1機能異常はSHRSPにおける高血圧成因の一つか？2018

Author(s)

Organizer

Data Source

[Presentation] SHRSPにおけるカルシウム貯蔵センサーSTIM1の機能異常は高血圧発症に2018

Author(s)

Organizer

Data Source

[Presentation] WKY/IzmとSHRSP/Izmの血液脳関門機能比較：In vitro BBBモデルを用いた検討2017

Author(s)

Organizer

Data Source

oohara hiroki 大原浩貴

OOHARA Hirotaka 大原浩貴

OHARA Hiroki 大原浩貴