KUME Kohei 久米浩平

Researcher Number	10609663
Other IDs	https://orcid.org/0000-0003-2856-5970
Affiliation (based on the past Project Information) *help	2015 – 2017: 岩手医科大学, 医学部, 助教 2015: 岩手医科大学, 医歯薬総合研究所・神経科学研究部門, 助教 2014: 岩手医科大学, 医学部, ポストドクター 2013 – 2014: 岩手医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Tumor therapeutics Except Principal Investigator Digestive surgery
Keywords	Principal Investigator RNAポリメラーゼ / RNAポリメラーゼ阻害 / 再発 / 化学療法 / シスプラチン / コロニー形成 / 薬剤寛容性細胞集団 / TAF15 / RNAポリメラーゼII / 逆相タンパク質マイクロアレイ / 癌性腹膜炎 / 抗癌剤耐性 … More Except Principal Investigator … More RNAポリメラーゼ / 薬剤耐性 / 化学療法 Less

RNAポリメラーゼ阻害による再発癌特異的治療法の開発Principal Investigator
- Principal Investigator
  
  久米浩平
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Iwate Medical University
Identification of compounds to suppress post-chemotherapeutic cancer relapse using drug-tolerant cancer subpopulations
- Principal Investigator
  
  Nishizuka Satoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Iwate Medical University
Analysis of cancer relapse mechanisms by proteomic profiling using drug-tolerant cell subpopulationPrincipal Investigator
- Principal Investigator
  
  KUME Kohei
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Iwate Medical University

All 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Patent

[Journal Article] Colony Lysate Arrays for Proteomic Profiling of Drug-Tolerant Persisters of Cancer Cell.2017
- Author(s)
  Kume K, Nishizuka SS.
- Journal Title
  
  Anal Chem
  
  Volume: 89 Issue: 17 Pages: 8626-8631
- DOI
  10.1021/acs.analchem.7b01215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15KK0317, KAKENHI-PUBLICLY-16H01578, KAKENHI-PROJECT-15K10114, KAKENHI-PROJECT-16K18458
[Journal Article] がん研究における定量生物学の重要性2017
- Author(s)
  久米浩平, 西塚哲
- Journal Title
  
  実験医学増刊
  
  Volume: 35 Pages: 81-85
- Data Source
  KAKENHI-PROJECT-16K18458
[Journal Article] Individualized Mutation Detection in Circulating Tumor DNA for Monitoring Colorectal Tumor Burden Using a Cancer-Associated Gene Sequencing Panel.2016
- Author(s)
  Sato KA, Hachiya T, Iwaya T, Kume K, Matsuo T, Kawasaki K, Abiko Y, Akasaka R, Matsumoto T, Otsuka K, Nishizuka SS
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 1 Pages: e0146275-e0146275
- DOI
  10.1371/journal.pone.0146275
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10114, KAKENHI-PROJECT-26461994, KAKENHI-PROJECT-25462034
[Journal Article] α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF152016
- Author(s)
  Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS
- Journal Title
  
  Sci Rep
  
  Volume: - Issue: 1 Pages: 25895-25895
- DOI
  10.1038/srep25895
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01578, KAKENHI-PROJECT-26461994, KAKENHI-PROJECT-16K18458, KAKENHI-PROJECT-16H06276
[Journal Article] Aipha-Amanitin restrains cancer relapse from drug-tolerant cell subpopulations via TAF-152016
- Author(s)
  Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Pages: 25895-25895
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25462034
[Journal Article] Systematic Protein Level Regulation via Degradation Machinery Induced by Genotoxic Drugs2016
- Author(s)
  Kume K, Ishida K, Ikeda M, Takemoto K, Shimura T, Young L, Nishizuka SS.
- Journal Title
  
  J Proteome Res
  
  Volume: 15 Issue: 1 Pages: 205-15
- DOI
  10.1021/acs.jproteome.5b00759
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10114, KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-25462034, KAKENHI-PROJECT-25700030
[Patent] 腫瘍の再発を抑制する医薬2016
- Inventor(s)
  久米浩平, 西塚哲
- Industrial Property Rights Holder
  岩手医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-09-04
- Data Source
  KAKENHI-PROJECT-16K18458
[Patent] 腫瘍の再発を抑制する医薬2015
- Inventor(s)
  西塚　哲、久米浩平
- Industrial Property Rights Holder
  西塚　哲、久米浩平
- Industrial Property Rights Type
  特許
- Filing Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-25462034
[Patent] 微小細胞集団の発現プロファイル方法2015
- Inventor(s)
  西塚　哲、久米浩平
- Industrial Property Rights Holder
  西塚　哲、久米浩平
- Industrial Property Rights Type
  特許
- Filing Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-25462034
[Patent] 腫瘍の再発を抑制するための標的分子としてのTAF15遺伝子およびその産物2015
- Inventor(s)
  西塚　哲、久米浩平
- Industrial Property Rights Holder
  西塚　哲、久米浩平
- Industrial Property Rights Type
  特許
- Filing Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-25462034
[Presentation] Colony lysate arrays for proteomic profiling of drug-presistent cancer cell subpopulations2017
- Author(s)
  Kume K and Nishizuka SS
- Organizer
  AACR Annual Meeting 2017
- Place of Presentation
  Walter E. Washington Convention Center, Washington, DC (アメリカ合衆国)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18458
[Presentation] TAF15 as an important mediator of RNA polymerase II-dependent drug tolerance2016
- Author(s)
  Kume K, Ito K Iwaya T Nishizuka SS
- Organizer
  AACR2016
- Place of Presentation
  アーネスト N. メモリアルコンベンションセンター
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18458
[Presentation] α-Amanitin prevents stochastic emergence of drug-tolerant cancer cell subpopulations via TAF152016
- Author(s)
  Kume K, Nishizuka SS
- Organizer
  The 41st Naito Conference
- Place of Presentation
  Chateraise Gateaux Kingdom Sapporo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18458
[Presentation] Prevention of peritonitis carcinomatosa after adjuvant chemotherapy by the inhibition of RNA polymerase in drug-tolerant subpopulations2015
- Author(s)
  Nishizuka SS, Kume K, Sato K, Wakabayashi G
- Organizer
  2015 American Association for Cancer Research
- Place of Presentation
  米国
- Year and Date
  2015-04-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462034
[Presentation] Emergence of bimodal responses to etoposide in human cancer cell lines.2014
- Author(s)
  久米浩平, 西塚哲, 若林剛.
- Organizer
  The 15th International Conference on Systems Biology
- Place of Presentation
  コペンハーゲン
- Year and Date
  2014-09-15
- Data Source
  KAKENHI-PROJECT-25830121
[Presentation] Imaging cytometric analysis of cancer cell subpopulation accumulating p53 in response to etoposide2014
- Author(s)
  Kohei Kume
- Organizer
  The 37th Naito Conference
- Place of Presentation
  Niseko
- Data Source
  KAKENHI-PROJECT-25830121
[Presentation] Transcriptional and proteomic profiling of drug-tolerant cancer cell subpopulations using colonies that emerge in the presence of anticancer agents2014
- Author(s)
  Kohei Kume
- Organizer
  AACR2014
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-25830121
[Presentation] コロニー形成試験を用いた薬剤寛容性細胞集団の分子プロファイリング2014
- Author(s)
  久米浩平, 西塚哲, 池田めぐみ, 三浦佐和子, 若林剛.
- Organizer
  未来医療開発プロジェクトシンポジウム
- Place of Presentation
  盛岡
- Year and Date
  2014-08-07
- Data Source
  KAKENHI-PROJECT-25830121
[Presentation] Inhibition of RNA Pol II suppresses the emergence of drug-tolerant cell subpopulations.2014
- Author(s)
  久米浩平, 西塚哲, 遠藤史隆, 片桐弘勝, 前沢千早, 若林剛.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-25830121
[Presentation] Analysis of cancer cell populations by isolated single colonies for the identification of drug-tolerance inducing factor2013
- Author(s)
  Kohei Kume
- Organizer
  AACR2013
- Place of Presentation
  Washington, DC
- Data Source
  KAKENHI-PROJECT-25830121
[Presentation] Analysis of drug-tolerant phenotype by molecular profiling of single colonies2013
- Author(s)
  Kohei Kume
- Organizer
  JCA2013
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-25830121
[Presentation] Genotoxic drug-induced switch-like protein expression of nuclear p53 in human cancer cells2013
- Author(s)
  Kohei Kume
- Organizer
  ICSB2013
- Place of Presentation
  Copenhagen
- Data Source
  KAKENHI-PROJECT-25830121
[Presentation] Imaging cytometric analysis of cancer cell subpopulation accumulating p53 in the nucleous in response to etoposide.
- Author(s)
  久米浩平, 西塚哲, 前沢千早, 若林剛.
- Organizer
  37th The Naito Conference
- Place of Presentation
  ニセコ
- Year and Date
  2014-07-15 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25830121

1. Nishizuka Satoshi (50453311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. Iwaya Takeshi (70405801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 前沢千早 (10326647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 若林剛 (50175064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

KUME Kohei 久米 浩平

Research Projects

Research Products

Co-Researchers

RNAポリメラーゼ阻害による再発癌特異的治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of compounds to suppress post-chemotherapeutic cancer relapse using drug-tolerant cancer subpopulations

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cancer relapse mechanisms by proteomic profiling using drug-tolerant cell subpopulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Colony Lysate Arrays for Proteomic Profiling of Drug-Tolerant Persisters of Cancer Cell.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] がん研究における定量生物学の重要性2017

Author(s)

Journal Title

Data Source

[Journal Article] Individualized Mutation Detection in Circulating Tumor DNA for Monitoring Colorectal Tumor Burden Using a Cancer-Associated Gene Sequencing Panel.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF152016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aipha-Amanitin restrains cancer relapse from drug-tolerant cell subpopulations via TAF-152016

Author(s)

Journal Title

Data Source

[Journal Article] Systematic Protein Level Regulation via Degradation Machinery Induced by Genotoxic Drugs2016

Author(s)

Journal Title

DOI

Data Source

[Patent] 腫瘍の再発を抑制する医薬2016

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 腫瘍の再発を抑制する医薬2015

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 微小細胞集団の発現プロファイル方法2015

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 腫瘍の再発を抑制するための標的分子としてのTAF15遺伝子およびその産物2015

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] Colony lysate arrays for proteomic profiling of drug-presistent cancer cell subpopulations2017

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] TAF15 as an important mediator of RNA polymerase II-dependent drug tolerance2016

KUME Kohei 久米浩平