Seki Yuta 関優太

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SEKI Yuta 関優太

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Researcher Number	10615636
Other IDs
Affiliation (Current)	2022: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員 2022: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
Affiliation (based on the past Project Information) *help	2020: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員 2015 – 2019: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 2012: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 2011: 財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology / Laboratory animal science Except Principal Investigator Laboratory animal science
Keywords	Principal Investigator 難聴 / モデルマウス / 遺伝学 / ゲノム編集 / ミオシン6 / 遺伝子 / ゲノム / 遺伝性難聴 / 難聴モデルマウス / Myosin VI … More / 実験動物学 / ミオシンVI / ゲノム多型 / 有毛細胞 / 機能ゲノム多型 / ヒト変異模倣マウス / 進行性難聴 / アイソフォーム / 内耳有毛細胞 / 不動毛 / 遺伝子治療 … More Except Principal Investigator 実験動物学 / 遺伝学 / 難聴 / ゲノム編集 / アレル発現量比較 / コンソミックマウス / カドヘリン23 / 遺伝子発現 / 対立遺伝子発現量 Less

ミオシン6のミスセンス変異ヘテロ型で生じる進行性難聴の遺伝子治療Principal Investigator
- Principal Investigator
  
  関優太
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Mechanisms of stereocilia formation defined by myosin vi isoform highly expressed in the inner earPrincipal Investigator
- Principal Investigator
  
  SEKI Yuta
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Identification of the functional genomic polymorphisms affecting mouse progressive hearing lossPrincipal Investigator
- Principal Investigator
  
  SEKI Yuta
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Identification of genetic risk factors and phenotypic rescue of deaf mutant mice based on technological innovations of the forward genetics approach
- Principal Investigator
  
  KIKKAWA Yoshiaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Responsible gene identification and elucidation of molecular interaction to participate in the stereocilia formation based on mouse forward geneticsPrincipal Investigator
- Principal Investigator
  
  SEKI Yuta
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Otorhinolaryngology
- Research Institution
  公益財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research

All 2019 2017 2016 2015 2013 2012 2011

All Journal Article Presentation

[Journal Article] A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells.2017
- Author(s)
  Seki Yuta、Miyasaka Yuki、Suzuki Sari、Wada Kenta、Yasuda Shumpei P.、Matsuoka Kunie、Ohshiba Yasuhiro、Endo Kentaro、Ishii Rie、Shitara Hiroshi、Kitajiri Shin-ichiro、Nakagata Naomi、Takebayashi Hirohide、Kikkawa Yoshiaki
- Journal Title
  
  PLoS One
  
  Volume: 12
- DOI
  10.1371/journal.pone.0183477
- NAID
  120007099799
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293369, KAKENHI-PROJECT-16H04688, KAKENHI-PROJECT-15K06818, KAKENHI-PROJECT-15K18393
[Journal Article] Heterozygous mutation of Ush1g/Sans in mice causes early-onset progressive hearing loss, which is recovered by reconstituting the strain-specific mutation in Cdh23.2016
- Author(s)
  Miyasaka Y, Shitara H, Suzuki S, Yoshimoto S, Seki Y, Ohshiba Y, Okumura K, Taya C, Tokano H, Kitamura K, Takada T, Hibino H, Shiroishi T, Kominami R, Yonekawa H, Kikkawa Y
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 印刷中 Pages: 2045-2059
- DOI
  10.1093/hmg/ddw078
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-14J06119, KAKENHI-PROJECT-25430097, KAKENHI-PROJECT-25293058, KAKENHI-PROJECT-15H04291, KAKENHI-PROJECT-16H04688, KAKENHI-PROJECT-25290038, KAKENHI-PROJECT-15K18393
[Presentation] 3残基挿入ミオシンVIの蝸牛有毛細胞における特徴的な役割2019
- Author(s)
  関　優太，設樂浩志，吉川欣亮
- Organizer
  モロシヌス研究会
- Data Source
  KAKENHI-PROJECT-18K16913
[Presentation] カドヘリン23 のc.753 遺伝子型が異なるC57BL/6Jマウス間の加齢に伴う聴力表現型の比較2017
- Author(s)
  鈴木沙理，宮坂勇輝，関　優太，安田俊平，松岡邦枝，設楽浩志，吉川欣亮
- Organizer
  第64回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-15H04291
[Presentation] マウスにおけるミオシンVIのスプライス部位変異は蝸牛有毛細胞の頂部領域におけるアクチンネットワーク破綻に起因した感覚毛融合へと導く2017
- Author(s)
  関　優太，宮坂勇輝，鈴木沙理，吉川欣亮
- Organizer
  第64回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-15K18393
[Presentation] 早発性難聴モデルマウスの遺伝要因の解析2017
- Author(s)
  鈴木沙理，松岡邦枝，関　優太，安田俊平，吉川欣亮
- Organizer
  生理学研究所研究会
- Data Source
  KAKENHI-PROJECT-15H04291
[Presentation] Myosin VI変異ヘテロ接合体が発症する進行性難聴の病態.2016
- Author(s)
  関　優太, 宮坂勇輝, 鈴木沙理, 吉川欣亮.
- Organizer
  第63回日本実験動物学会総会
- Place of Presentation
  ミューザ川崎シンフォニーホール（神奈川県川崎市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K18393
[Presentation] Ush1gヘテロマウスの聴覚障害はCdh23の1塩基置換により回復する2016
- Author(s)
  宮坂勇輝，設楽浩志，鈴木沙理，関　優太，多屋長治，高田豊行，城石俊彦，木南　凌，米川博通，吉川欣亮
- Organizer
  第63回日本実験動物学会総会
- Place of Presentation
  ミューザ川崎シンフォニーホール（神奈川県・川崎市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15H04291
[Presentation] マウス成熟内耳におけるLrrc30の高発現と加齢性難聴抑制効果の関連を探る!2015
- Author(s)
  宮坂勇輝，安田俊平，関　優太，松岡邦枝，日比野浩，木南　凌，吉川欣亮
- Organizer
  第62回実験動物学会総会
- Place of Presentation
  京都テルサ（京都府・京都市）
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-15H04291
[Presentation] Myosin VI変異体の感覚毛－細胞間融合プロセスと機能低下型アレルに起因した難聴発症2015
- Author(s)
  関　優太，宮坂勇輝，鈴木沙理，吉川欣亮
- Organizer
  第12回北海道実験動物研究会総会・学術集会
- Place of Presentation
  北海道大学（北海道，札幌市）
- Year and Date
  2015-07-11
- Data Source
  KAKENHI-PROJECT-15K18393
[Presentation] Myosin VI新規機能低下型アレルの解析で明らかとなった感覚毛－細胞間融合プロセスとハプロ不全2015
- Author(s)
  関　優太，宮坂勇輝，鈴木沙理，吉川欣亮
- Organizer
  第29回モロシヌス研究会
- Place of Presentation
  かんぽの宿有馬（兵庫県，神戸市）
- Year and Date
  2015-07-03
- Data Source
  KAKENHI-PROJECT-15K18393
[Presentation] A new spontaneous mutation in the mouse Myosin VI gene2013
- Author(s)
  Yuta Seki, Kunie Matsuoka, Sari Suzuki, Yuki Miyasaka, Yasuhiro Oshiba, Kenta Wada, Hirohide Takebayashi, Yoshiaki Kikkawa
- Organizer
  9th Molecular Biology of Hearing & Deafness Conference
- Place of Presentation
  Stanford School of Medicine
- Data Source
  KAKENHI-PROJECT-23890253
[Presentation] 内耳有毛細胞の不動毛形成・維持に必須なMyosin VIアイソフォームの存在2012
- Author(s)
  関優太
- Organizer
  日本実験動物科学・技術九州2012(第59回日本実験動物学会総会、第46回日本実験動物技術者協会総会)
- Place of Presentation
  別府国際コンベンションセンター
- Year and Date
  2012-05-24
- Data Source
  KAKENHI-PROJECT-23890253
[Presentation] 内耳有毛細胞のstereocilia形成・維持に異常を示す2つのMyosin VI突然変異アレルの同定2012
- Author(s)
  関優太
- Organizer
  第26回モロシヌス研究会
- Place of Presentation
  東京大学
- Year and Date
  2012-06-15
- Data Source
  KAKENHI-PROJECT-23890253
[Presentation] 内耳有毛細胞の不動毛形成・維持に必須なMyosin VIアイソフォームの存在.2012
- Author(s)
  関　優太，鈴木沙理，和田健太，若菜茂晴，中潟直己，竹林浩秀，吉川欣亮
- Organizer
  第59回日本実験動物学会総会
- Place of Presentation
  別府国際コンベンションセンター
- Data Source
  KAKENHI-PROJECT-23890253
[Presentation] 行動異常および難聴を示す新規マウス突然変異体の原因遺伝子の同定2011
- Author(s)
  関優太
- Organizer
  北海道実験動物研究会・日本実験動物技術者協会北海道支部合同学術集会
- Place of Presentation
  北海道大学
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-23890253
[Presentation] 行動異常および難聴を示す新規マウス突然変異体の原因遺伝子の同定2011
- Author(s)
  関優太
- Organizer
  北海道実験動物研究会・日本実験動物技術者協会北海道支部合同学術集会
- Place of Presentation
  北海道大学
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-23890253

1. KIKKAWA Yoshiaki (20280787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. SHITARA Hiroshi (90321885)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. YASUDA Shumpei (50534012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 高田豊行 (20356257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 宮坂勇輝 (30778098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. OBARA Yo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUZUKI Sari

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. KITAJIRI Shinichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. WADA Kenta

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. YASAKA TAKU

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 松岡邦枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 日比野浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 米川博通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Seki Yuta 関 優太

SEKI Yuta 関 優太

Research Projects

Research Products

Co-Researchers

ミオシン6のミスセンス変異ヘテロ型で生じる進行性難聴の遺伝子治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of stereocilia formation defined by myosin vi isoform highly expressed in the inner earPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of the functional genomic polymorphisms affecting mouse progressive hearing lossPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of genetic risk factors and phenotypic rescue of deaf mutant mice based on technological innovations of the forward genetics approach

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Responsible gene identification and elucidation of molecular interaction to participate in the stereocilia formation based on mouse forward geneticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Heterozygous mutation of Ush1g/Sans in mice causes early-onset progressive hearing loss, which is recovered by reconstituting the strain-specific mutation in Cdh23.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 3残基挿入ミオシンVIの蝸牛有毛細胞における特徴的な役割2019

Author(s)

Organizer

Data Source

[Presentation] カドヘリン23 のc.753 遺伝子型が異なるC57BL/6Jマウス間の加齢に伴う聴力表現型の比較2017

Author(s)

Organizer

Data Source

[Presentation] マウスにおけるミオシンVIのスプライス部位変異は蝸牛有毛細胞の頂部領域におけるアクチンネットワーク破綻に起因した感覚毛融合へと導く2017

Author(s)

Organizer

Data Source

[Presentation] 早発性難聴モデルマウスの遺伝要因の解析2017

Author(s)

Organizer

Data Source

[Presentation] Myosin VI変異ヘテロ接合体が発症する進行性難聴の病態.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Ush1gヘテロマウスの聴覚障害はCdh23の1塩基置換により回復する2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] マウス成熟内耳におけるLrrc30の高発現と加齢性難聴抑制効果の関連を探る!2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Seki Yuta 関優太

SEKI Yuta 関優太

[Presentation] 行動異常および難聴を示す新規マウス突然変異体の原因遺伝子の同定2011