Watanabe Takahiro 渡辺崇広

Researcher Number	10624398
Other IDs
Affiliation (Current)	2023: 名古屋大学, 医学系研究科, 助教 2023: 藤田医科大学, 医学部, 客員助手
Affiliation (based on the past Project Information) *help	2017 – 2023: 名古屋大学, 医学系研究科, 助教 2016: 名古屋大学, 医学部付属病院, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Virology Except Principal Investigator Basic Section 49060:Virology-related
Keywords	Principal Investigator EBV / ウイルス学 / cGAS / EBV-LPD / STING / PAMPs / Epstein-Barr virus / リンパ増殖性疾患 / 自然免疫応答 / DNAセンサー … More / 遺伝子 / ウイルス / vPIC / がん / マウスモデル / CDK / LPD / 感染症 / 腫瘍ウイルス / ヒト化マウスモデル / EBV関連リンパ増殖症 / ウィルス / ヒト化マウス … More Except Principal Investigator リンパ腫 / 腫瘍原性 / EBウイルス / 欠失ウイルス / 悪性リンパ腫 / Epstein-Barrウイルス Less

欠失EBVによる腫瘍発生促進機構の解明
- Principal Investigator
  
  木村宏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Nagoya University
エンベロープウイルスの膜融合タンパク質に着目した自然免疫回避機構の解明Principal Investigator
- Principal Investigator
  
  渡辺崇広
- Project Period (FY)
  2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Nagoya University
EBウイルスの病原体認識回避機構の解明Principal Investigator
- Principal Investigator
  
  渡辺崇広
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Nagoya University
欠失EBVによるリンパ腫発生機構の解明
- Principal Investigator
  
  木村宏
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Nagoya University
Pathological analysis and evaluation of a novel therapeutic target using a humanized mouse model in EBV-associated lymphoproliferative disorderPrincipal Investigator
- Principal Investigator
  
  Watanabe Takahiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Nagoya University
Research for the pathogenic mechanism using transgenic EB virus and humanized micePrincipal Investigator
- Principal Investigator
  
  Watanabe Takahiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Virology
- Research Institution
  Nagoya University

All 2022 2021 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] PD-L1 upregulation by lytic induction of Epstein-Barr Virus2022
- Author(s)
  Yanagi Y, Hara Y, Mabuchi S, Watanabe T, Sato Y, Kimura H, Murata T
- Journal Title
  
  Virology
  
  Volume: 568 Pages: 31-40
- DOI
  10.1016/j.virol.2022.01.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07580, KAKENHI-PROJECT-20H03493
[Journal Article] Role of Epstein-Barr Virus C Promoter Deletion in Diffuse Large B Cell Lymphoma2021
- Author(s)
  Mabuchi Seiyo、Hijioka Fumiya、Watanabe Takahiro、Yanagi Yusuke、Okuno Yusuke、Masud H. M. Abdullah Al、Sato Yoshitaka、Murata Takayuki、Kimura Hiroshi
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 3 Pages: 561-561
- DOI
  10.3390/cancers13030561
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07580, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PUBLICLY-19H04829, KAKENHI-PROJECT-20H03493, KAKENHI-PROJECT-19K22560, KAKENHI-ORGANIZER-16H06429
[Journal Article] Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infection2021
- Author(s)
  Inagaki T, Sato Y, Ito J, Takaki M, Okuno Y, Yaguchi M, Masud MHAA, Watanabe T, Sato K, Iwami S, MurataT, Kimura H
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 11 Pages: 575255-575255
- DOI
  10.3389/fmicb.2020.575255
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PUBLICLY-19H04826, KAKENHI-PUBLICLY-19H04829, KAKENHI-PUBLICLY-19H04839, KAKENHI-PROJECT-18H02662, KAKENHI-PROJECT-20J22335, KAKENHI-PROJECT-18K15165, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-19J01713
[Journal Article] RNAseq analysis identifies involvement of EBNA2 in PD-L1 induction during Epstein-Barr virus infection of primary B cells2021
- Author(s)
  Yanagi Yusuke、Okuno Yusuke、Narita Yohei、Masud H.M. Abdullah Al、Watanabe Takahiro、Sato Yoshitaka、Kanda Teru、Kimura Hiroshi、Murata Takayuki
- Journal Title
  
  Virology
  
  Volume: 557 Pages: 44-54
- DOI
  10.1016/j.virol.2021.02.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09184, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PUBLICLY-19H04829, KAKENHI-PROJECT-19K22560, KAKENHI-PROJECT-18K15165, KAKENHI-PROJECT-19K07580, KAKENHI-PROJECT-20H03493
[Journal Article] A STING inhibitor suppresses EBV‐induced B cell transformation and lymphomagenesis2021
- Author(s)
  Miyagi Shouhei、Watanabe Takahiro、Hara Yuya、Arata Masataka、Uddin Md. Kamal、Mantoku Keisuke、Sago Ken、Yanagi Yusuke、Suzuki Takeshi、Masud H. M. Abdullah Al、Kawada Jun‐ichi、Nakamura Shigeo、Miyake Yasuyuki、Sato Yoshitaka、Murata Takayuki、Kimura Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 12 Pages: 5088-5099
- DOI
  10.1111/cas.15152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03493, KAKENHI-PROJECT-21K07748, KAKENHI-PROJECT-21K15449
[Journal Article] The BOLF1 gene is necessary for effective Epstein?Barr viral infectivity2019
- Author(s)
  Masud H. M. Abdullah Al、Watanabe Takahiro、Sato Yoshitaka、Goshima Fumi、Kimura Hiroshi、Murata Takayuki
- Journal Title
  
  Virology
  
  Volume: 531 Pages: 114-125
- DOI
  10.1016/j.virol.2019.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15165, KAKENHI-PROJECT-17H04081, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PUBLICLY-19H04829
[Journal Article] Antitumor activity of cyclin‐dependent kinase inhibitor alsterpaullone in Epstein‐Barr virus‐associated lymphoproliferative disorders2019
- Author(s)
  Watanabe Takahiro、Sato Yoshitaka、Masud H. M. Abdullah Al、Takayama Masahiro、Matsuda Hiroki、Hara Yuya、Yanagi Yusuke、Yoshida Masahiro、Goshima Fumi、Murata Takayuki、Kimura Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 1 Pages: 279-287
- DOI
  10.1111/cas.14241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15165, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PUBLICLY-19H04829, KAKENHI-PROJECT-17H04081, KAKENHI-PROJECT-16H06231
[Journal Article] Defective Epstein-Barr virus in chronic active infection and haematological malignancy.2019
- Author(s)
  Okuno Y, Murata T, Sato Y,Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.
- Journal Title
  
  Nat Microbiol.
  
  Volume: 4 Issue: 3 Pages: 404-413
- DOI
  10.1038/s41564-018-0334-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-17K09934, KAKENHI-PROJECT-17K10107, KAKENHI-PROJECT-18K07816, KAKENHI-PROJECT-18K15165, KAKENHI-PLANNED-15H05912, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-17H04081
[Journal Article] S-Like-Phase Cyclin-Dependent Kinases Stabilize the Epstein-Barr Virus BDLF4 Protein To Temporally Control Late Gene Transcription2019
- Author(s)
  Sato Yoshitaka、Watanabe Takahiro、Suzuki Chihiro、Abe Yuichi、Masud H. M. Abdullah Al、Inagaki Tomoki、Yoshida Masahiro、Suzuki Takeshi、Goshima Fumi、Adachi Jun、Tomonaga Takeshi、Murata Takayuki、Kimura Hiroshi
- Journal Title
  
  Journal of Virology
  
  Volume: 93 Issue: 8
- DOI
  10.1128/jvi.01707-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15165, KAKENHI-PROJECT-17H04081, KAKENHI-PROJECT-16H06231
[Journal Article] Initial Characterization of the Epstein-Barr Virus BSRF1 Gene Product.2019
- Author(s)
  Yusuke Yanagi、H. M. bdullah Al Masud、Takahiro Watanabe、Yoshitaka Sato、Fumi Goshima、Hiroshi Kimura、Takayuki Murata
- Journal Title
  
  Viruses
  
  Volume: 21 Issue: 3 Pages: 01707-18
- DOI
  10.3390/v11030285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15165, KAKENHI-PROJECT-17H04081
[Journal Article] Antitumor effects of duvelisib on Epstein-Barr virus-associated lymphoma cells2018
- Author(s)
  Kawada, J. Ando, S. Torii, Y. Watanabe, T. Sato, Y. Ito, Y. Kimura, H.
- Journal Title
  
  Cancer Med
  
  Volume: 印刷中 Issue: 4 Pages: 1275-1284
- DOI
  10.1002/cam4.1311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10107, KAKENHI-PROJECT-16H06231, KAKENHI-PROJECT-16H06867, KAKENHI-PROJECT-15J40217, KAKENHI-PROJECT-16K19638, KAKENHI-PROJECT-18K16172
[Journal Article] The C-terminus of Epstein-Barr virus BRRF2 is required for its proper localization and efficient virus production2017
- Author(s)
  Takahiro Watanabe, Keiya Sakaida, Masahiro Yoshida, H. M. Abdullah Al Masud, Yoshitaka Sato, Fumi Goshima, Hiroshi Kimura, and Takayuki Murata
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 8 Pages: 125-125
- DOI
  10.3389/fmicb.2017.00125
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H06231, KAKENHI-PROJECT-16H06867, KAKENHI-PROJECT-15K08494
[Journal Article] Epstein-Barr Virus BKRF4 Gene Product Is Required for Efficient Progeny Production.2017
- Author(s)
  H. M. Abdullah Al Masud、Takahiro Watanabe、 Masahiro Yoshida、 Yoshitaka Sato、 Fumi Goshima、 Hiroshi Kimura、 Takayuki Murata
- Journal Title
  
  Journal of Virology
  
  Volume: 91 Issue: 23
- DOI
  10.1128/jvi.00975-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06231, KAKENHI-PROJECT-16H06867, KAKENHI-PROJECT-15K08494
[Journal Article] The Epstein-Barr Virus BRRF1 Gene Is Dispensable for Viral Replication in HEK293 cells and Transformation2017
- Author(s)
  Yoshida Masahiro、Watanabe Takahiro、Narita Yohei、Sato Yoshitaka、Goshima Fumi、Kimura Hiroshi、Murata Takayuki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 6044-6044
- DOI
  10.1038/s41598-017-06413-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06231, KAKENHI-PROJECT-16H06867, KAKENHI-PROJECT-15K08494
[Patent] Cyclin dependent kinase(CDK)阻害剤によるEpstein-Barrウイルスのウイルス産生抑制2017
- Inventor(s)
  佐藤好隆,木村宏,渡辺崇広
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Acquisition Date
  2017
- Data Source
  KAKENHI-PROJECT-16H06867
[Presentation] STING inhibitor suppresses EBV-induced B cell transformation and lymphomagenesis2021
- Author(s)
  Shouhei Miyagi, Takahiro Watanabe, Yuya Hara, Masataka Arata, Md. Kamal Uddin, Yusuke Yanagi, Yoshitaka Sato, Takayuki Murata, Hiroshi Kimura
- Organizer
  19th International Symposium on Epstein-Barr Virus and associated diseases (EBV2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15449
[Presentation] EBウイルス関連腫瘍のがん微小環境における炎症性細胞浸潤メカニズムの解析2021
- Author(s)
  渡辺崇広, 佐藤公治
- Organizer
  第66回公益社団法人日本口腔外科学会総会・学術大会,幕張メッセ国際会議場
- Data Source
  KAKENHI-PROJECT-21K15449
[Presentation] 慢性活動性EBV感染症およびEBV 関連リンパ腫における変異株の存在意義2019
- Author(s)
  渡辺崇広、村田貴之、佐藤好隆、成田洋平、MASUD H. M. Abdullah Al、五島典、奥野友介、木村宏
- Organizer
  第28回EBウイルス感染症研究会
- Data Source
  KAKENHI-PROJECT-18K15165
[Presentation] ヒト化マウスモデルを用いたEBV関連リンパ増殖症に対する新たな標的治療の評価2019
- Author(s)
  渡辺崇広, 木村宏
- Organizer
  第48回　東海乳酸菌研究会
- Data Source
  KAKENHI-PROJECT-18K15165
[Presentation] ヒト化マウスモデルを用いたEBV関連リンパ増殖症に対する新たな標的治療の評価2019
- Author(s)
  木村宏、渡辺崇広
- Organizer
  第48回東海乳酸菌研究会
- Data Source
  KAKENHI-PROJECT-18K15165
[Presentation] The presence of defective Epstein-Barr virus in patients with chronic active EBV infection and EBV-associated hematological malignancy2018
- Author(s)
  Takahiro Watanabe, Yusuke Okuno, Takayuki Murata, Yoshitaka Sato, Yoshinori Ito, H. M. Abdullah Al Masud, Fumi Goshima, Jun-ichi Kawada, Seiji Kojima, Seishi Ogawa, Hiroshi Kimura
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15165
[Presentation] S-phase CDKs stabilize the Epstein-Barr virus BDLF4 protein to temporally control late gene transcription2018
- Author(s)
  Takahiro Watanabe, Yoshitaka Sato, Chihiro Suzuki, Yuichi Abe, Fumi Goshima, Takayuki Murata, Hiroshi Kimura
- Organizer
  International Conference on EBV & KSHV 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15165
[Presentation] EBV BGLF4はEBV関連リンパ増殖症の進展に関与する2017
- Author(s)
  渡辺崇広、村田貴之、MASUD H.M. Abdullah Al、吉田全宏、佐藤好隆、五島典、木村宏
- Organizer
  第31回ヘルペスウイルス研究会
- Data Source
  KAKENHI-PROJECT-16H06867
[Presentation] Epstein-Barr Virus Protein Kinase Contributes to LPD Development in Mice Model2017
- Author(s)
  Takahiro Watanabe,Fumi Goshima, Hiroshi Kimura, Takayuki Murata
- Organizer
  第9回NAGOYAグローバルリトリート
- Place of Presentation
  あいち県健康プラザ(愛知県知多郡東浦町)
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H06867
[Presentation] 変異型EBウイルスを用いた抗ウイルス薬開発のための新規分子標的の同定2016
- Author(s)
  渡辺崇広、佐藤公治、水谷英樹
- Organizer
  第61回日本口腔外科学会総会・学術大会
- Place of Presentation
  幕張メッセ(千葉県千葉市)
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16H06867

1. KIMURA Hiroshi (30303621)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 奥野友介 (00725533)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 川田潤一 (20532831)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 伊藤嘉規 (20373491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. MURATA Takayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 佐藤好隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 渡辺登喜子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 神田輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 清井仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Takahiro 渡辺 崇広

Research Projects

Research Products

Co-Researchers

欠失EBVによる腫瘍発生促進機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エンベロープウイルスの膜融合タンパク質に着目した自然免疫回避機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

EBウイルスの病原体認識回避機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

欠失EBVによるリンパ腫発生機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathological analysis and evaluation of a novel therapeutic target using a humanized mouse model in EBV-associated lymphoproliferative disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for the pathogenic mechanism using transgenic EB virus and humanized micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] PD-L1 upregulation by lytic induction of Epstein-Barr Virus2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Epstein-Barr Virus C Promoter Deletion in Diffuse Large B Cell Lymphoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infection2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNAseq analysis identifies involvement of EBNA2 in PD-L1 induction during Epstein-Barr virus infection of primary B cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A STING inhibitor suppresses EBV‐induced B cell transformation and lymphomagenesis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The BOLF1 gene is necessary for effective Epstein?Barr viral infectivity2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor activity of cyclin‐dependent kinase inhibitor alsterpaullone in Epstein‐Barr virus‐associated lymphoproliferative disorders2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Defective Epstein-Barr virus in chronic active infection and haematological malignancy.2019

Author(s)

Journal Title

DOI

Data Source

Watanabe Takahiro 渡辺崇広