Maruo Tomohiko 丸尾知彦

… Alternative Names

TOMOHIKO Maruo 丸尾知彦

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Researcher Number	10625114
Other IDs
Affiliation (Current)	2025: 北里大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2024: 北里大学, 医学部, 講師 2016 – 2017: 神戸大学, 医学研究科, 医学研究員 2013 – 2014: 神戸大学, 医学(系)研究科(研究院), 特命助教
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 46020:Anatomy and histopathology of nervous system-related
Keywords	Principal Investigator アファディン / シナプス / マギン / ネクチン / アクチン / PAJ / 神経シナプス / パンクタアドヘレンティアジャンクション / 加齢 / 海馬苔状線維シナプス … More / パンクタアドヘレンティア / スプライスバリアント / パンクタアドヘレンシアジャンクション / グルタミン酸受容体 / 接着 Less

アファディンのスプライスバリアントが形成する微小領域による細胞機能制御の分子機構Principal Investigator
- Principal Investigator
  
  丸尾知彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Kitasato University
Synapse maintenance by afadin and its binding proteinsPrincipal Investigator
- Principal Investigator
  
  Maruo Tomohiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Molecular mechanisms in the synapse formation by afadin and nectinsPrincipal Investigator
- Principal Investigator
  
  TOMOHIKO Maruo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University

All 2018 2017 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Requirement of the F-actin-binding activity of l-afadin for enhancing the formation of adherens and tight junctions2018
- Author(s)
  Sakakibara Shotaro、Maruo Tomohiko、Miyata Muneaki、Mizutani Kiyohito、Takai Yoshimi
- Journal Title
  
  Genes to Cells
  
  Volume: 23 Issue: 3 Pages: 185-199
- DOI
  10.1111/gtc.12566
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-16J06236, KAKENHI-PROJECT-16K19036
[Journal Article] NGL-3-induced presynaptic differentiation of hippocampal neurons in an afadin-dependent, nectin-1-independent manner2017
- Author(s)
  Maruo Tomohiko、Mandai Kenji、Miyata Muneaki、Sakakibara Shotaro、Wang Shujie、Sai Kousyoku、Itoh Yu、Kaito Aika、Fujiwara Takeshi、Mizoguchi Akira、Takai Yoshimi
- Journal Title
  
  Genes to Cells
  
  Volume: 22 Issue: 8 Pages: 742-755
- DOI
  10.1111/gtc.12510
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-16J06236, KAKENHI-PROJECT-16K19036, KAKENHI-PLANNED-16H06463
[Journal Article] Roles of afadin in functional differentiations of hippocampal mossy fiber synapse2017
- Author(s)
  Geng Xiaoqi、Maruo Tomohiko、Mandai Kenji、Supriyanto Irwan、Miyata Muneaki、Sakakibara Shotaro、Mizoguchi Akira、Takai Yoshimi、Mori Masahiro
- Journal Title
  
  Genes to Cells
  
  Volume: 22 Issue: 8 Pages: 715-722
- DOI
  10.1111/gtc.12508
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-16J06236, KAKENHI-PROJECT-16K19036, KAKENHI-PLANNED-16H06463
[Journal Article] Aging-dependent expression of synapse-related proteins in the mouse brain.2017
- Author(s)
  Shiotani, H., Maruo, T., Sakakibara, S., Miyata, M., Mandai, K., Mochizuki, H., Takai, Y.
- Journal Title
  
  Genes to Cells
  
  Volume: 印刷中 Issue: 5 Pages: 472-484
- DOI
  10.1111/gtc.12489
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-16K19036, KAKENHI-PROJECT-16J06236, KAKENHI-PLANNED-16H06463
[Journal Article] Roles of afadin in the formation of the cellular architecture of the mouse hippocampus and dentate gyrus.2017
- Author(s)
  Miyata M, Maruo T, Kaito A, Wang S, Yamamoto H, Fujiwara T, Mizoguchi A, Mandai K, Takai Y
- Journal Title
  
  Mol Cell Neurosci
  
  Volume: 79 Pages: 34-44
- DOI
  10.1016/j.mcn.2016.12.007
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06463, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-16K19036
[Journal Article] Multiple Roles of Afadin in the Ultrastructural Morphogenesis of Mouse Hippocampal Mossy Fiber Synapses.2017
- Author(s)
  Sai K, Wang S, Kaito A, Fujiwara T, Maruo T, Itoh Y, Miyata M, Sakakibara S, Miyazaki N, Murata K, Yamaguchi Y, Haruta T, Nishioka H, Motojima Y, Komura M, Kimura K, Mandai K, Takai Y, Mizoguchi A.
- Journal Title
  
  J Comp Neurol
  
  Volume: - Issue: 12 Pages: 2719-2734
- DOI
  10.1002/cne.24238
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06463, KAKENHI-PROJECT-16K01514, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-16J06236, KAKENHI-PROJECT-16K19036
[Journal Article] Localization of nectin-2δ at perivascular astrocytic endfoot processes and degeneration of astrocytes and neurons in nectin-2 knockout mouse brain.2016
- Author(s)
  Miyata M, Mandai K, Maruo T, Sato J, Shiotani H, Kaito A, Itoh Y, Wang S, Fujiwara T, Mizoguchi A, Takai Y, Rikitake Y
- Journal Title
  
  Brain Res
  
  Volume: 1649 Pages: 90-101
- DOI
  10.1016/j.brainres.2016.08.023
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06463, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-16K19036
[Journal Article] Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3.2014
- Author(s)
  Shanks NF, Cais O, Maruo T, Savas JN, Zaika EI, Azumaya CM, Yates JR 3rd, Greger I, Nakagawa T.
- Journal Title
  
  J Neurosci
  
  Volume: 34 Issue: 36 Pages: 12104-12120
- DOI
  10.1523/jneurosci.0595-14.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860214
[Journal Article] Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons.2014
- Author(s)
  Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, Mori M, Takai Y.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 2 Pages: e89763-e89763
- DOI
  10.1371/journal.pone.0089763
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-21500372, KAKENHI-PROJECT-24590354, KAKENHI-PUBLICLY-25111716, KAKENHI-PUBLICLY-25127710, KAKENHI-PROJECT-25440107, KAKENHI-PROJECT-25860214, KAKENHI-PROJECT-26400205
[Journal Article] s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin.2014
- Author(s)
  Kobayashi R, Kurita S, Miyata M, Maruo T, Mandai K, Rikitake Y, Takai Y.
- Journal Title
  
  Genes Cells.
  
  Volume: 19 Issue: 12 Pages: 853-863
- DOI
  10.1111/gtc.12185
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-24590354, KAKENHI-PROJECT-24790283, KAKENHI-PROJECT-25860214, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013
[Journal Article] ネクチンによる細胞間接着の制御機構2013
- Author(s)
  丸尾知彦、萬代研二、高井義美
- Journal Title
  
  生体の科学
  
  Volume: 64巻 Pages: 206-215
- Data Source
  KAKENHI-PROJECT-25860214
[Presentation] 脳におけるネクチン－２の局在と機能2017
- Author(s)
  宮田宗明、萬代研二、丸尾知彦、佐藤淳哉、塩谷元、垣内愛加、伊藤優、王淑杰、藤原武志、溝口明、高井義美、力武良行
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K19036
[Presentation] マウス網膜におけるNectin-1を介したSelf-to-Self新規接着機構の解析2017
- Author(s)
  王淑杰、垣内愛加、崔煌植、萬代研二、丸尾知彦、高井義美、溝口明
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K19036
[Presentation] 海馬神経細胞のシナプス前部の分子的および機能的な分化におけるアファディンの関与2017
- Author(s)
  丸尾知彦、萬代研二、宮田宗明、榊原正太郎、王淑杰、崔煌植、伊藤優、垣内愛加、藤原武志、耿瀟奇、イルワンスプリヤント、溝口明、森正弘、高井義美
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K19036
[Presentation] 海馬苔状線維シナプス分化における２つのアファディンスプライスバリアントの役割.2016
- Author(s)
  丸尾知彦, 萬代研二, 榊原正太郎, 伊藤優, 藤原武志, 王淑杰, 崔煌植, 垣内愛加, 耿瀟奇, 森正弘, 溝口明, 高井義美.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16K19036
[Presentation] ネクチン-2αとマウス手綱核.2016
- Author(s)
  塩谷元, 萬代研二, 宮田宗明, 丸尾知彦, 垣内愛加, 王淑杰, 藤原武志, 溝口明, 望月秀樹, 高井義美.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16K19036
[Presentation] 海馬発生におけるアファディンの役割.2016
- Author(s)
  宮田宗明, 丸尾知彦, 山本昆明, 垣内愛加, 王淑杰, 藤原武志, 溝口明, 萬代研二, 高井義美.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16K19036
[Presentation] SBF-SEM 3D reconstitution analysis reveals alterations in composition and morphology of mouse hippocampal mossy fiber synapses by afadin knockout2015
- Author(s)
  Takeshi Fujiwara, Shujie Wang, Yu Itoh, Kousyoku Sai, Aika Kaito, Naoyuki Miyazaki, Kazuyoshi Murata, Tomohiko Maruo, Hideaki Yamamoto, Kenji Mandai, Yoshimi Takai, Akira Mizoguchi
- Organizer
  第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
- Place of Presentation
  神戸国際会議場・展示場
- Year and Date
  2015-03-21
- Data Source
  KAKENHI-PROJECT-25860214
[Presentation] アファディンの海馬神経細胞におけるシナプス形成への関与2013
- Author(s)
  丸尾知彦, 豊嶋大作, 萬代研二, 富樫英, 井上貴仁, 山本昆明, 三好淳, スプリヤントイルワン, 森正弘, 高井義美
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25860214

1. TOGASHI Hideru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. RIKITAKE Yoshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 高井義美

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
4. 萬代研二

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 栗田宗一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maruo Tomohiko 丸尾 知彦

TOMOHIKO Maruo 丸尾 知彦

Research Projects

Research Products

Co-Researchers

アファディンのスプライスバリアントが形成する微小領域による細胞機能制御の分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synapse maintenance by afadin and its binding proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms in the synapse formation by afadin and nectinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Requirement of the F-actin-binding activity of l-afadin for enhancing the formation of adherens and tight junctions2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NGL-3-induced presynaptic differentiation of hippocampal neurons in an afadin-dependent, nectin-1-independent manner2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of afadin in functional differentiations of hippocampal mossy fiber synapse2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aging-dependent expression of synapse-related proteins in the mouse brain.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of afadin in the formation of the cellular architecture of the mouse hippocampus and dentate gyrus.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiple Roles of Afadin in the Ultrastructural Morphogenesis of Mouse Hippocampal Mossy Fiber Synapses.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Localization of nectin-2δ at perivascular astrocytic endfoot processes and degeneration of astrocytes and neurons in nectin-2 knockout mouse brain.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ネクチンによる細胞間接着の制御機構2013

Author(s)

Journal Title

Data Source

[Presentation] 脳におけるネクチン－２の局在と機能2017

Author(s)

Organizer

Maruo Tomohiko 丸尾知彦

TOMOHIKO Maruo 丸尾知彦