Nakahara Naoya 中原直哉

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NAKAHARA Naoya 中原直哉

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Researcher Number	10632193
Other IDs
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 東京慈恵会医科大学, 医学部, 助教 2019 – 2023: 東京慈恵会医科大学, 医学部, 助教 2012: 東京慈恵会医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Basic Section 52040:Radiological sciences-related Except Principal Investigator Basic Section 59010:Rehabilitation science-related / Basic Section 56060:Ophthalmology-related / Mechanobiology
Keywords	Principal Investigator 骨格筋 / 筋萎縮 / in vivo / X線回折法 / 筋タンパク / MR信号 / 水 / DSC Except Principal Investigator 骨格筋 / X線回折 … More / リハビリテーション / サルコペニア / 筋肥大 / 伸張性収縮 / 筋線維 / サテライト細胞 / 胎児型ミオシン / 筋損傷 / 新生筋線維 / 筋新生 / 外眼筋 / 筋節長 / DNAマイクロアレイ / 術後の戻り / 斜視 / 筋原性前駆細胞 / ブタンジオンモノオキシム / Spring8 / アクチン / サルコメア / ミオシン / ゲルゾリン / 心筋 / スキンドファイバー / 筋節 / 収縮 / エックス線回折 / 横紋筋 Less

筋萎縮過程の解明を目指したin vivo解析～分子レベルから個体レベルまで～Principal Investigator
- Principal Investigator
  
  中原直哉
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Jikei University School of Medicine
筋萎縮過程の解明を目指した構造・機能同時測定～in vivo骨格筋2次元X線回折Principal Investigator
- Principal Investigator
  
  中原直哉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Jikei University School of Medicine
血流と代謝状態を維持した骨格筋のX線回折法による伸張性収縮後の筋節内微細構造評価
- Principal Investigator
  
  平野和宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Jikei University School of Medicine
筋原性前駆細胞に対する伸展誘導信号の抑制による「戻り」のない新規斜視治療法の開発
- Principal Investigator
  
  飯田貴絵
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Jikei University School of Medicine
新生筋線維の機能獲得過程：サテライト細胞が胎児型筋線維を経て成熟筋線維になるまで
- Principal Investigator
  
  山口眞紀
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Jikei University School of Medicine
Evaluation of interaction enthalpy between water and myoproteins in skeletal muscle for theoretical interpretation of MR signalsPrincipal Investigator
- Principal Investigator
  
  Nakahara Naoya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Jikei University School of Medicine
Stretch of muscle sarcomere induces protrusion of myosinheads toward actin so as to facilitate formation of contractile cross-bridges.
- Principal Investigator
  
  TAKEMORI Shigeru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Mechanobiology
- Research Institution
  Jikei University School of Medicine

All 2024 2023 2022 2021 2020 2019 2012 2011

All Journal Article Presentation

[Journal Article] Myosin and tropomyosin-troponin complementarily regulate thermal activation of muscles2023
- Author(s)
  Shuya Ishii, Kotaro Oyama, Fuyu Kobirumaki-Shimozawa, Tomohiro Nakanishi, Naoya Nakahara, Madoka Suzuki, Shin’ichi Ishiwata, Norio Fukuda
- Journal Title
  
  Journal of General Physiology
  
  Volume: 155 Issue: 12
- DOI
  10.1085/jgp.202313414
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19929, KAKENHI-PROJECT-21K06789, KAKENHI-PROJECT-22K09434, KAKENHI-PROJECT-22K19273, KAKENHI-PROJECT-22K15367, KAKENHI-PLANNED-22H05053, KAKENHI-PLANNED-22H05054
[Journal Article] Gene Transfer of Skeletal Muscle-Type Myosin Light Chain Kinase via Adeno-Associated Virus 6 Improves Muscle Functions in an Amyotrophic Lateral Sclerosis Mouse Model2022
- Author(s)
  Oya Ryohei、Tsukamoto Osamu、Hitsumoto Tatsuro、Nakahara Naoya、Okamoto Chisato、Matsuoka Ken、Kato Hisakazu、Inohara Hidenori、Takashima Seiji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1747-1747
- DOI
  10.3390/ijms23031747
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17180, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-20K07338
[Journal Article] X-ray Diffraction Analysis to Explore Molecular Traces of Eccentric Contraction on Rat Skeletal Muscle Parallelly Evaluated with Signal Protein Phosphorylation Levels2021
- Author(s)
  Hirano Kazuhiro、Yamauchi Hideki、Nakahara Naoya、Kinoshita Kazuo、Yamaguchi Maki、Takemori Shigeru
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 23 Pages: 12644-12644
- DOI
  10.3390/ijms222312644
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17180
[Journal Article] Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers2020
- Author(s)
  Yamaguchi Maki、Kimura Masako、Ohno Tetsuo、Nakahara Naoya、Akiyama Nobutake、Takemori Shigeru、Yagi Naoto
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 10 Pages: 3520-3520
- DOI
  10.3390/ijms21103520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17180
[Presentation] Sarcomere structure analysis of in vivo slow-twitch muscle with retained blood supply: an x-ray diffraction study.2024
- Author(s)
  中原直哉、山内秀樹、山口眞紀、林友則、平野和宏、竹森重
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-22K09434
[Presentation] Sarcomere structure analysis of in vivo slow-twitch muscle with retained blood supply: an x-ray diffraction study.2024
- Author(s)
  Naoya Nakahara, Hideki Yamauchi, Maki Yamaguchi, Tomonori Hayashi, Kazuhiro Hirano, Shigeru Takemori
- Organizer
  日本生理学会　第101回大会
- Data Source
  KAKENHI-PROJECT-22K11378
[Presentation] Effects of contraction mode and intensity on signal protein activity and sarcomere structure in mildly atrophic muscle.2024
- Author(s)
  Kazuhiro Hirano, Hideki Yamauchi, Naoya Nakahara, Maki Yamaguchi, Tomonori Hayashi, Shigeru Takemori
- Organizer
  日本生理学会　第101回大会
- Data Source
  KAKENHI-PROJECT-22K11378
[Presentation] Physical activity of mice after denervation - application of deep learning-based detection system2024
- Author(s)
  寺西奈保美、中原直哉、竹森重
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-22K09434
[Presentation] 除神経後の自発運動量変化を自動測定評価する～深層学習システムの試用2023
- Author(s)
  寺西奈保美、中原直哉、竹森重
- Organizer
  第175回日本体力医学会関東地方会
- Data Source
  KAKENHI-PROJECT-22K09434
[Presentation] 萎縮筋に対する収縮様式と収縮強度がシグナルタンパク活性と筋節内微細構造に及ぼす影響2023
- Author(s)
  平野和宏、山内秀樹、中原直哉、山口眞紀、竹森重
- Organizer
  第28回　日本基礎理学療法学会学術大会
- Data Source
  KAKENHI-PROJECT-22K11378
[Presentation] X線回折法と張力測定法によるウサギ外眼筋の構造・機能特性2023
- Author(s)
  山口眞紀、栗原貫、中原直哉、山内秀樹、平野和宏、山口舞、山澤徳志子、竹森重、八木直人
- Organizer
  第61回生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K11249
[Presentation] Effects of contraction mode and intensity on sarcomere structure of skeletal muscle2023
- Author(s)
  Kazuhiro Hirano, Hideki Yamauchi, Naoya Nakahara, Maki Yamaguchi, Tomonori Hayashi, Shigeru Takemori
- Organizer
  日本生理学会　第100回記念大会
- Data Source
  KAKENHI-PROJECT-22K11378
[Presentation] Structural stability of sarcomere structure of in vivo muscle with maintained blood supply2023
- Author(s)
  中原直哉、山内秀樹、山口眞紀、林友則、平野和宏、竹森重
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-22K09434
[Presentation] In vivoで収縮する骨格筋の二次元X線回折解析2022
- Author(s)
  中原直哉、山内秀樹、山口眞紀、林友則、平野和宏、竹森重
- Organizer
  第139回成医会総会
- Data Source
  KAKENHI-PROJECT-22K09434
[Presentation] 外眼筋サルコメアにおけるミオシン重鎖アイソフォームの機能的特徴2022
- Author(s)
  山口舞，山口眞紀，中原直哉，竹森重
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-21K11249
[Presentation] 低ATP濃度条件での外眼筋線維の張力発揮特性2022
- Author(s)
  山口舞，山口眞紀，山澤德志子，中原直哉，竹森重
- Organizer
  第77回日本体力医学会大会
- Data Source
  KAKENHI-PROJECT-21K11249
[Presentation] In vivo skeletal muscle x-ray diffraction study on the cause of reduced contractility after blood flow interruption2022
- Author(s)
  中原直哉、山内秀樹、山口眞紀、林友則、平野和宏、竹森重
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K17180
[Presentation] 眼位の安定を左右する安静時外眼筋群の力学作用～斜視手術後を含む検討2021
- Author(s)
  飯田貴絵、山口眞紀、中原直哉、山澤徳志子,竹森重,久保寛之,仲泊聡,中野匡
- Organizer
  第125回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-21K09755
[Presentation] X線回折法による血流を保った骨格筋の除神経後の変化2021
- Author(s)
  中原直哉、山内秀樹、山口眞紀、平野和宏、竹森重
- Organizer
  2020年度量子ビームサイエンスフェスタ
- Data Source
  KAKENHI-PROJECT-19K17180
[Presentation] Development of x-ray diffraction methods for in vivo skeletal muscle with maintained blood supply2021
- Author(s)
  中原直哉、山内秀樹、山口眞紀、平野和宏、竹森重
- Organizer
  第126回日本解剖学会総会・全国学術集会、第98回日本生理学会大会　合同大会
- Data Source
  KAKENHI-PROJECT-19K17180
[Presentation] Strategy of extraocular muscle to achieve super-fast shortening velocity: an x-ray diffraction study.2021
- Author(s)
  Maki Yamaguchi, Toru Kurihara, Naoya Nakahara, Hideki Yamauchi, Kazuhiro Hirano, Tetsuo Ohno, Toshiko Yamazawa, Mai Yamaguchi, Shigeru Takemori.
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K11249
[Presentation] Actin filaments render considerable heat capacity to skeletal muscle sa陀omere2020
- Author(s)
  中原直哉
- Organizer
  日本生理学会
- Data Source
  KAKENHI-PROJECT-19K17180
[Presentation] 熱測定で評価した骨格筋内の水と筋タンパクの相互作用2019
- Author(s)
  中原直哉、大野哲生、木村雅子、木村澄子、竹森重
- Organizer
  成医会
- Data Source
  KAKENHI-PROJECT-19K17180
[Presentation]2012
- Author(s)
  Takemori S, Kimura M, Yamaguchi M, Ohno T, Nakahara N, Yokomizo S
- Organizer
  日本生物物理学会
- Place of Presentation
  名古屋
- Year and Date
  2012-09-23
- Data Source
  KAKENHI-PROJECT-22616008
[Presentation] 細いフィラメント除去筋線維内でのミオシン頭部の振る舞い2011
- Author(s)
  山口眞紀,竹森重,木村雅子,大野哲生,中原直哉,八木直人
- Organizer
  日本生理学会大会・日本解剖学会総会合同大会
- Place of Presentation
  紙上開催
- Data Source
  KAKENHI-PROJECT-22616008

1. YAMAGUCHI Maki (30271315)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. TAKEMORI Shigeru (20179675)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
3. 平野和宏 (40874821)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
4. 山内秀樹 (60220224)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
5. 山澤徳志子 (00282616)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KIMURA Masako (30328314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. OHNO Tetsuo (30233224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 飯田貴絵 (00897168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 秋山暢丈 (00338865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 高橋徳志子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
11. 福田紀男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakahara Naoya 中原 直哉

NAKAHARA Naoya 中原 直哉

Research Projects

Research Products

Co-Researchers

筋萎縮過程の解明を目指したin vivo解析～分子レベルから個体レベルまで～Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

筋萎縮過程の解明を目指した構造・機能同時測定～in vivo骨格筋2次元X線回折Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血流と代謝状態を維持した骨格筋のX線回折法による伸張性収縮後の筋節内微細構造評価

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

筋原性前駆細胞に対する伸展誘導信号の抑制による「戻り」のない新規斜視治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新生筋線維の機能獲得過程：サテライト細胞が胎児型筋線維を経て成熟筋線維になるまで

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of interaction enthalpy between water and myoproteins in skeletal muscle for theoretical interpretation of MR signalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Stretch of muscle sarcomere induces protrusion of myosinheads toward actin so as to facilitate formation of contractile cross-bridges.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Myosin and tropomyosin-troponin complementarily regulate thermal activation of muscles2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene Transfer of Skeletal Muscle-Type Myosin Light Chain Kinase via Adeno-Associated Virus 6 Improves Muscle Functions in an Amyotrophic Lateral Sclerosis Mouse Model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] X-ray Diffraction Analysis to Explore Molecular Traces of Eccentric Contraction on Rat Skeletal Muscle Parallelly Evaluated with Signal Protein Phosphorylation Levels2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Sarcomere structure analysis of in vivo slow-twitch muscle with retained blood supply: an x-ray diffraction study.2024

Author(s)

Organizer

Data Source

[Presentation] Sarcomere structure analysis of in vivo slow-twitch muscle with retained blood supply: an x-ray diffraction study.2024

Author(s)

Organizer

Data Source

[Presentation] Effects of contraction mode and intensity on signal protein activity and sarcomere structure in mildly atrophic muscle.2024

Author(s)

Organizer

Data Source

[Presentation] Physical activity of mice after denervation - application of deep learning-based detection system2024

Nakahara Naoya 中原直哉

NAKAHARA Naoya 中原直哉