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KANO YOSHIHITO  加納 嘉人

… Alternative Names

Kano Yoshihito  加納 嘉人

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Researcher Number 10633125
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-7511-7009
Affiliation (Current) 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 講師
Affiliation (based on the past Project Information) *help 2019 – 2022: 東京医科歯科大学, 大学院医歯学総合研究科, 特任助教
2021: 東京医科歯科大学, 大学院医歯学総合研究科, 講師
Review Section/Research Field
Principal Investigator
0901:Oncology and related fields / Basic Section 56050:Otorhinolaryngology-related
Except Principal Investigator
Basic Section 57060:Surgical dentistry-related
Keywords
Principal Investigator
クリニカルシークエンス / KRAS / SHP2阻害 / Q61変異 / チロシンリン酸化 / リキッドバイオプシー / 膵臓癌 / SHP2 / 分子標的治療 / がん個別化医療 / RAS-MAPK経路 / 頭頸部癌 … More
Except Principal Investigator
… More ゲノム検査 / 遺伝子変異 / 口腔癌 / 多発癌 / がんゲノム医療 / がんゲノム / プレシジョンメディシン / 腫瘍環境 Less
  • Research Projects

    (3 results)
  • Research Products

    (22 results)
  • Co-Researchers

    (12 People)
  •  新規RASシグナル阻害剤の頭頸部癌治療応答基盤解明Principal Investigator

    • Principal Investigator
      加納 嘉人
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Analysis of specific gene mutations in multiple oral cancer cases using genomic test.

    • Principal Investigator
      平井 秀明
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Molecular and clinical characterization of sensivity to SHP2 inhibition in KRAS-mutant cancersPrincipal Investigator

    • Principal Investigator
      Kano Yoshihito
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0901:Oncology and related fields
    • Research Institution
      Tokyo Medical and Dental University

All 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] MYC-PDL1 axis reduces sensitivity to nivolumab in recurrent head and neck squamous cell carcinoma2022

    • Author(s)
      Noji Rika、Kano Yoshihito、Hirai Hideaki、Onishi Iichiroh、Nishii Naoto、Yoshimura Ryoichi、Miyake Satoshi、Ikeda Sadakatsu、Harada Hiroyuki
    • Journal Title

      Oral Oncology

      Volume: 124 Pages: 105666-105666

    • DOI

      10.1016/j.oraloncology.2021.105666

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23909, KAKENHI-PROJECT-21K10134
  • [Journal Article] Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study2022

    • Author(s)
      Aoyagi Yasuko、Kano Yoshihito et.al
    • Journal Title

      PLOS ONE

      Volume: 17

    • DOI

      10.1371/journal.pone.0266112

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Journal Article] Primary pulmonary choriocarcinoma with a genomic sequence2021

    • Author(s)
      Onishi Iichiroh、Kirimura Susumu、Wakejima Ryo、Okubo Kenichi、Odai Tamami、Kakuta Ryota、Kano Yoshihito、Ikeda Sadakatsu、Akashi Takumi、Kitagawa Masanobu
    • Journal Title

      Pathology International

      Volume: 72 Pages: 141-143

    • DOI

      10.1111/pin.13193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Journal Article] Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm.2021

    • Author(s)
      Katsukura Nobuhiro、Watanabe Sho、Shirasaki Tomoaki、Hibiya Shuji、Kano Yoshihito、Akahoshi Keiichi、Tanabe Minoru、Kirimura Susumu、Akashi Takumi、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru、Tsuchiya Kiichiro
    • Journal Title

      Cancer Sci.

      Volume: 112 Pages: 932-944

    • DOI

      10.1111/cas.14755

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K23909, KAKENHI-PROJECT-20K22867, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19K17425, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19675
  • [Journal Article] ASO Author Reflections: Impact of Liquid Biopsy Using Plasma Cell-Free DNA in Solid Tumors in Japan2021

    • Author(s)
      Matsudera Shotaro、Kano Yoshihito、Ikeda Sadakatsu
    • Journal Title

      Annals of Surgical Oncology

      Volume: 28 Pages: 8506-8507

    • DOI

      10.1245/s10434-021-09858-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Journal Article] Hormonal tumor mapping for liver metastases of gastroenteropancreatic neuroendocrine neoplasms: a novel therapeutic strategy2021

    • Author(s)
      Matsudera S、Kano Y、Aoyagi Y、Tohyama K、Takahashi K、Kumaki Y、Mitsumura T、Kimura K、Onishi I、Takemoto A、Ban D、Ono H、Kudo Atsushi、et.al.
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: - Pages: 697-706

    • DOI

      10.1245/s10434-021-09856-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09041, KAKENHI-PROJECT-19K23909
  • [Journal Article] PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells2021

    • Author(s)
      Liotti Federica、Kumar Narender、Prevete Nella、Marotta Maria、Sorriento Daniela、Ieran? Caterina、Ronchi Andrea、Marino Federica Zito、Moretti Sonia、Colella Renato、Puxeddu Efiso、Paladino Simona、Kano Yoshihito、Ohh Michael、Scala Stefania、Melillo Rosa Marina
    • Journal Title

      Journal of Experimental & Clinical Cancer Research

      Volume: 40 Pages: 22-22

    • DOI

      10.1186/s13046-020-01818-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Journal Article] The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors2021

    • Author(s)
      Gebregiworgis Teklab, Kano Yoshihito et. al
    • Journal Title

      Nature Communications

      Volume: 12

    • DOI

      10.1038/s41467-021-26526-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Journal Article] NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS-MAPK Pathway in Neuroblastoma2020

    • Author(s)
      Valencia-Sama Ivette、Ladumor Yagnesh、Kee Lynn、Adderley Teresa、Christopher Gabriella、Robinson Claire M.、Kano Yoshihito、Ohh Michael、Irwin Meredith S.
    • Journal Title

      Cancer Research

      Volume: 80 Pages: 3413-3423

    • DOI

      10.1158/0008-5472.can-19-3822

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] がんゲノム解析によりニボルマブ耐性機構が示唆された再発頬粘膜癌の一例2021

    • Author(s)
      野地理夏,加納嘉人,平井秀明,山下大和,工藤亮,富岡寛文,島本裕彰,道泰之,大西威一郎,三浦雅彦,吉村亮一,三宅智,池田貞勝,原田浩之
    • Organizer
      第45回日本頭頸部癌学会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] 進行肝癌に対するがんゲノム診療における臨床的問題点とリアルワールドデータ解析2021

    • Author(s)
      加納嘉人、朝比奈靖浩、岡本隆一
    • Organizer
      第108回 日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] がんゲノム解析によりニボルマブ耐性機構が示唆された再発頬粘膜癌の一例2021

    • Author(s)
      野地理夏,加納嘉人,平井秀明,山下大知,工藤 亮,富岡寛文,島本裕彰,道 泰之,大西威一郎,三浦雅彦,吉村亮一,三宅 智,池田貞勝,原田浩之
    • Organizer
      第45回日本頭頸部癌学会
    • Data Source
      KAKENHI-PROJECT-21K10134
  • [Presentation] 肝内胆管癌の臨床的問題点と網羅的がんゲノム解析の有用性検討2021

    • Author(s)
      加納嘉人、北畑富貴子、村川美也子、柿沼晴、東正新、中川美奈、 井津井康浩、新田沙由梨、三好正人、田邉稔、三宅智、池田貞勝、 岡本隆一、朝比奈靖浩
    • Organizer
      第57回肝癌研究会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] 進行肝細胞癌に対するがんゲノム診療における網羅的遺伝子パネル検査の有用性とバイオマーカー探索.2020

    • Author(s)
      加納嘉人、北畑富貴子、村川美也子、柿沼晴、東正新、中川美奈、 井津井康浩、新田沙由梨、三好正人、青柳康子、松寺翔太郎、遠山皓基、 田邉稔、三宅智、池田貞勝、朝比奈靖浩.
    • Organizer
      第56回日本肝癌研究会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] Detection of RAS mutation in solid cancers using NGS-based genome profiling tests.2020

    • Author(s)
      加納嘉人、野地理夏、山下大和、工藤亮、大西威一郎、谷本幸介、宮冬樹、中川剛士、石川敏昭、植竹宏之、絹笠祐介、田邉稔、朝蔭孝宏、原田浩之、岡本隆一、三宅智、池田貞勝
    • Organizer
      第18回日本臨床腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] Clinical utility of tumor-profiling multiplex gene panel testing in advanced head and neck cancer at TMDU.2020

    • Author(s)
      加納 嘉人,野地 理夏, 山下 大和, 工藤 亮, 田崎 彰久, 大野 十央, 有泉 陽介, 平井 秀明, 富岡 寛文, 島本 裕彰, 道 泰之, 三浦 雅彦, 吉村 亮一, 朝蔭 孝宏, 原田 浩之, 岡本 隆一, 三宅 智, 池田 貞勝
    • Organizer
      第18回日本臨床腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] Evasion of KRASQ61H regulation by tyrosine phosphorylation renders cancer cells resistant to SHP2 inhibitor.2020

    • Author(s)
      Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Mitsuhiko Ikura, Michael Ohh.
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] KRAS Q61H mutation evades the regulation of tyrosyl phosphorylation and renders cancer cells resistant to SHP2 inhibitor.2020

    • Author(s)
      YOSHIHITO KANO, Teklab Gebregiworgis, Christopher Marshall, Mitsuhiko Ikura, Satoshi Miyake, Michael Ohh.
    • Organizer
      第18回日本臨床腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] Inhibition of SHP2 promotes the tyrosyl phosphorylation of KRAS and suppresses the pancreatic cancer growth.2019

    • Author(s)
      Yoshihito Kano, Teklab Gebregiworgis, Christopher Marshall,Mitsuhiko Ikura, Michael Ohh
    • Organizer
      第78回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] Drugging the Undruggable ~新規分子標的治療による難治癌克服への挑戦~.2019

    • Author(s)
      加納嘉人
    • Organizer
      第25回東京西部消化器先端医療勉強会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] チロシンリン酸化モデルに基づくKRAS制御機構の解明と治療応用の可能性.2019

    • Author(s)
      加納嘉人
    • Organizer
      大阪大学蛋白質研究所セミナー「がん研究の新機軸」
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] KRASチロシンリン酸化モデルに基づく膵癌新規分子機構と治療戦略2019

    • Author(s)
      加納嘉人,Teklab Gebregiworgis, Christopher Marshall, 伊倉 光彦, Michael Ohh.
    • Organizer
      第17回日本臨床腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • 1.  原田 浩之 (40343149)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  朝蔭 孝宏 (50361481)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  岡本 隆一 (50451935)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  平井 秀明 (60598895)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  渡辺 翔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  渡辺 守
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  土屋 輝一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  赤星 径一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  日比谷 秀爾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  工藤 篤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  田中 真二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  田辺 稔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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