KANO YOSHIHITO 加納嘉人

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Kano Yoshihito 加納嘉人

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Researcher Number	10633125
Other IDs	https://orcid.org/0000-0001-7511-7009
Affiliation (Current)	2023: 東京医科歯科大学, 大学院医歯学総合研究科, 講師
Affiliation (based on the past Project Information) *help	2019 – 2022: 東京医科歯科大学, 大学院医歯学総合研究科, 特任助教 2021: 東京医科歯科大学, 大学院医歯学総合研究科, 講師
Review Section/Research Field	Principal Investigator 0901:Oncology and related fields / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator クリニカルシークエンス / KRAS / SHP2阻害 / Q61変異 / チロシンリン酸化 / リキッドバイオプシー / 膵臓癌 / SHP2 / 分子標的治療 / がん個別化医療 / RAS-MAPK経路 / 頭頸部癌 … More Except Principal Investigator … More ゲノム検査 / 遺伝子変異 / 口腔癌 / 多発癌 / がんゲノム医療 / がんゲノム / プレシジョンメディシン / 腫瘍環境 Less

新規RASシグナル阻害剤の頭頸部癌治療応答基盤解明Principal Investigator
- Principal Investigator
  
  加納嘉人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Tokyo Medical and Dental University
Analysis of specific gene mutations in multiple oral cancer cases using genomic test.
- Principal Investigator
  
  平井秀明
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Tokyo Medical and Dental University
Molecular and clinical characterization of sensivity to SHP2 inhibition in KRAS-mutant cancersPrincipal Investigator
- Principal Investigator
  
  Kano Yoshihito
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Tokyo Medical and Dental University

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] MYC-PDL1 axis reduces sensitivity to nivolumab in recurrent head and neck squamous cell carcinoma2022
- Author(s)
  Noji Rika、Kano Yoshihito、Hirai Hideaki、Onishi Iichiroh、Nishii Naoto、Yoshimura Ryoichi、Miyake Satoshi、Ikeda Sadakatsu、Harada Hiroyuki
- Journal Title
  
  Oral Oncology
  
  Volume: 124 Pages: 105666-105666
- DOI
  10.1016/j.oraloncology.2021.105666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23909, KAKENHI-PROJECT-21K10134
[Journal Article] Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study2022
- Author(s)
  Aoyagi Yasuko、Kano Yoshihito et.al
- Journal Title
  
  PLOS ONE
  
  Volume: 17
- DOI
  10.1371/journal.pone.0266112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23909
[Journal Article] Primary pulmonary choriocarcinoma with a genomic sequence2021
- Author(s)
  Onishi Iichiroh、Kirimura Susumu、Wakejima Ryo、Okubo Kenichi、Odai Tamami、Kakuta Ryota、Kano Yoshihito、Ikeda Sadakatsu、Akashi Takumi、Kitagawa Masanobu
- Journal Title
  
  Pathology International
  
  Volume: 72 Pages: 141-143
- DOI
  10.1111/pin.13193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23909
[Journal Article] Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm.2021
- Author(s)
  Katsukura Nobuhiro、Watanabe Sho、Shirasaki Tomoaki、Hibiya Shuji、Kano Yoshihito、Akahoshi Keiichi、Tanabe Minoru、Kirimura Susumu、Akashi Takumi、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru、Tsuchiya Kiichiro
- Journal Title
  
  Cancer Sci.
  
  Volume: 112 Pages: 932-944
- DOI
  10.1111/cas.14755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23909, KAKENHI-PROJECT-20K22867, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19K17425, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19675
[Journal Article] ASO Author Reflections: Impact of Liquid Biopsy Using Plasma Cell-Free DNA in Solid Tumors in Japan2021
- Author(s)
  Matsudera Shotaro、Kano Yoshihito、Ikeda Sadakatsu
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 28 Pages: 8506-8507
- DOI
  10.1245/s10434-021-09858-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23909
[Journal Article] Hormonal tumor mapping for liver metastases of gastroenteropancreatic neuroendocrine neoplasms: a novel therapeutic strategy2021
- Author(s)
  Matsudera S、Kano Y、Aoyagi Y、Tohyama K、Takahashi K、Kumaki Y、Mitsumura T、Kimura K、Onishi I、Takemoto A、Ban D、Ono H、Kudo Atsushi、et.al.
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology
  
  Volume: - Pages: 697-706
- DOI
  10.1245/s10434-021-09856-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09041, KAKENHI-PROJECT-19K23909
[Journal Article] PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells2021
- Author(s)
  Liotti Federica、Kumar Narender、Prevete Nella、Marotta Maria、Sorriento Daniela、Ieran? Caterina、Ronchi Andrea、Marino Federica Zito、Moretti Sonia、Colella Renato、Puxeddu Efiso、Paladino Simona、Kano Yoshihito、Ohh Michael、Scala Stefania、Melillo Rosa Marina
- Journal Title
  
  Journal of Experimental & Clinical Cancer Research
  
  Volume: 40 Pages: 22-22
- DOI
  10.1186/s13046-020-01818-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23909
[Journal Article] The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors2021
- Author(s)
  Gebregiworgis Teklab, Kano Yoshihito et. al
- Journal Title
  
  Nature Communications
  
  Volume: 12
- DOI
  10.1038/s41467-021-26526-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23909
[Journal Article] NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS-MAPK Pathway in Neuroblastoma2020
- Author(s)
  Valencia-Sama Ivette、Ladumor Yagnesh、Kee Lynn、Adderley Teresa、Christopher Gabriella、Robinson Claire M.、Kano Yoshihito、Ohh Michael、Irwin Meredith S.
- Journal Title
  
  Cancer Research
  
  Volume: 80 Pages: 3413-3423
- DOI
  10.1158/0008-5472.can-19-3822
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] がんゲノム解析によりニボルマブ耐性機構が示唆された再発頬粘膜癌の一例2021
- Author(s)
  野地理夏，加納嘉人，平井秀明，山下大和，工藤亮，富岡寛文，島本裕彰，道泰之，大西威一郎，三浦雅彦，吉村亮一，三宅智，池田貞勝，原田浩之
- Organizer
  第45回日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] 進行肝癌に対するがんゲノム診療における臨床的問題点とリアルワールドデータ解析2021
- Author(s)
  加納嘉人、朝比奈靖浩、岡本隆一
- Organizer
  第108回　日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] がんゲノム解析によりニボルマブ耐性機構が示唆された再発頬粘膜癌の一例2021
- Author(s)
  野地理夏，加納嘉人，平井秀明，山下大知，工藤　亮，富岡寛文，島本裕彰，道　泰之，大西威一郎，三浦雅彦，吉村亮一，三宅　智，池田貞勝，原田浩之
- Organizer
  第45回日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-21K10134
[Presentation] 肝内胆管癌の臨床的問題点と網羅的がんゲノム解析の有用性検討2021
- Author(s)
  加納嘉人、北畑富貴子、村川美也子、柿沼晴、東正新、中川美奈、井津井康浩、新田沙由梨、三好正人、田邉稔、三宅智、池田貞勝、岡本隆一、朝比奈靖浩
- Organizer
  第57回肝癌研究会
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] 進行肝細胞癌に対するがんゲノム診療における網羅的遺伝子パネル検査の有用性とバイオマーカー探索.2020
- Author(s)
  加納嘉人、北畑富貴子、村川美也子、柿沼晴、東正新、中川美奈、井津井康浩、新田沙由梨、三好正人、青柳康子、松寺翔太郎、遠山皓基、田邉稔、三宅智、池田貞勝、朝比奈靖浩.
- Organizer
  第56回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] Detection of RAS mutation in solid cancers using NGS-based genome profiling tests.2020
- Author(s)
  加納嘉人、野地理夏、山下大和、工藤亮、大西威一郎、谷本幸介、宮冬樹、中川剛士、石川敏昭、植竹宏之、絹笠祐介、田邉稔、朝蔭孝宏、原田浩之、岡本隆一、三宅智、池田貞勝
- Organizer
  第18回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] Clinical utility of tumor-profiling multiplex gene panel testing in advanced head and neck cancer at TMDU.2020
- Author(s)
  加納嘉人,野地理夏, 山下大和, 工藤亮, 田崎彰久, 大野十央, 有泉陽介, 平井秀明, 富岡寛文, 島本裕彰, 道泰之, 三浦雅彦, 吉村亮一, 朝蔭孝宏, 原田浩之, 岡本隆一, 三宅智, 池田貞勝
- Organizer
  第18回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] Evasion of KRASQ61H regulation by tyrosine phosphorylation renders cancer cells resistant to SHP2 inhibitor.2020
- Author(s)
  Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Mitsuhiko Ikura, Michael Ohh.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] KRAS Q61H mutation evades the regulation of tyrosyl phosphorylation and renders cancer cells resistant to SHP2 inhibitor.2020
- Author(s)
  YOSHIHITO KANO, Teklab Gebregiworgis, Christopher Marshall, Mitsuhiko Ikura, Satoshi Miyake, Michael Ohh.
- Organizer
  第18回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] Inhibition of SHP2 promotes the tyrosyl phosphorylation of KRAS and suppresses the pancreatic cancer growth.2019
- Author(s)
  Yoshihito Kano, Teklab Gebregiworgis, Christopher Marshall,Mitsuhiko Ikura, Michael Ohh
- Organizer
  第78回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] Drugging the Undruggable　～新規分子標的治療による難治癌克服への挑戦～.2019
- Author(s)
  加納嘉人
- Organizer
  第25回東京西部消化器先端医療勉強会
- Invited
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] チロシンリン酸化モデルに基づくKRAS制御機構の解明と治療応用の可能性.2019
- Author(s)
  加納嘉人
- Organizer
  大阪大学蛋白質研究所セミナー「がん研究の新機軸」
- Invited
- Data Source
  KAKENHI-PROJECT-19K23909
[Presentation] KRASチロシンリン酸化モデルに基づく膵癌新規分子機構と治療戦略2019
- Author(s)
  加納嘉人,Teklab Gebregiworgis, Christopher Marshall, 伊倉光彦, Michael Ohh.
- Organizer
  第17回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23909

1. 原田浩之 (40343149)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 朝蔭孝宏 (50361481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岡本隆一 (50451935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 平井秀明 (60598895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 渡辺翔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 渡辺守

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 土屋輝一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 赤星径一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 日比谷秀爾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 工藤篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 田中真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 田辺稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KANO YOSHIHITO 加納 嘉人

Kano Yoshihito 加納 嘉人

Research Projects

Research Products

Co-Researchers

新規RASシグナル阻害剤の頭頸部癌治療応答基盤解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of specific gene mutations in multiple oral cancer cases using genomic test.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular and clinical characterization of sensivity to SHP2 inhibition in KRAS-mutant cancersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] MYC-PDL1 axis reduces sensitivity to nivolumab in recurrent head and neck squamous cell carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Primary pulmonary choriocarcinoma with a genomic sequence2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ASO Author Reflections: Impact of Liquid Biopsy Using Plasma Cell-Free DNA in Solid Tumors in Japan2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hormonal tumor mapping for liver metastases of gastroenteropancreatic neuroendocrine neoplasms: a novel therapeutic strategy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS-MAPK Pathway in Neuroblastoma2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] がんゲノム解析によりニボルマブ耐性機構が示唆された再発頬粘膜癌の一例2021

Author(s)

Organizer

Data Source

[Presentation] 進行肝癌に対するがんゲノム診療における臨床的問題点とリアルワールドデータ解析2021

Author(s)

Organizer

Data Source

[Presentation] がんゲノム解析によりニボルマブ耐性機構が示唆された再発頬粘膜癌の一例2021

Author(s)

Organizer

Data Source

KANO YOSHIHITO 加納嘉人

Kano Yoshihito 加納嘉人

[Presentation] Drugging the Undruggable　～新規分子標的治療による難治癌克服への挑戦～.2019