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Fujino Naoya  藤野 直也

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FUJINO Naoya  藤野 直也

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Researcher Number 10633670
Other IDs
Affiliation (Current) 2023: 東北大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help 2017 – 2023: 東北大学, 大学病院, 助教
2016: 東北大学, 東北メディカル・メガバンク機構, 非常勤講師
2012 – 2013: 東北大学, 医学(系)研究科(研究院), 非常勤講師
Review Section/Research Field
Principal Investigator
Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine
Except Principal Investigator
Basic Section 55040:Respiratory surgery-related
Keywords
Principal Investigator
組織幹細胞 / 気道上皮細胞 / 炎症 / Axl受容体チロシンキナーゼ / 慢性閉塞性肺疾患 / 自己複製 / 分化 / 肺上皮前駆細胞 / マイクロRNA / 上皮間葉移行 … More / 修復 / 肺胞上皮前駆細胞 / II型肺胞上皮細胞 / microRNA / 気道上皮 / リモデリング / 受容体チロシンキナーゼ / 細胞・組織 / シグナル伝達 / 再生医学 / 発現制御 / 重症喘息 / 好酸球性気道炎症 / 基底細胞 / アポトーシス細胞認識 / Axlキナーゼ / 気道上皮炎症制御 / 喘息 / COPD / 肺胞II型上皮細胞 / 幹細胞 / 肺胞上皮II型細胞 / 肺胞上皮細胞 / ストレス応答機構 / 細胞間相互作用 / クロスプレゼンテーション … More
Except Principal Investigator
肺移植 / 虚血・再灌流傷害 / 加齢 / RNAシークエンス / 高齢ドナー / 高齢 / マウス / 慢性拒絶反応 / マイクロアレイ Less
  • Research Projects

    (6 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (13 People)
  •  慢性閉塞性肺疾患における新規病原性肺胞マクロファージの同定と機能解析Principal Investigator

    • Principal Investigator
      藤野 直也
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Tohoku University
  •  Molecular mechanisms on how alveolar epithelial cells respond to exogenous stress in COPDPrincipal Investigator

    • Principal Investigator
      藤野 直也
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Tohoku University
  •  Why is prognosis of lung transplant recipient from elderly donors poor? –Elucidation of mechanisms and establishment of therapeutic intervention strategy-

    • Principal Investigator
      岡田 克典
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Tohoku University
  •  Apototic cell-induced supression of inflammation in the airwayPrincipal Investigator

    • Principal Investigator
      Fujino Naoya
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Tohoku University
  •  Investigation of Axl receptor tyrosine kinase in COPD airwaysPrincipal Investigator

    • Principal Investigator
      Fujino Naoya
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tohoku University
  •  Identification of microRNAs that regulate differentiation of human lung progenitor cellsPrincipal Investigator

    • Principal Investigator
      FUJINO Naoya
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tohoku University

All 2022 2021 2020 2019 2017 2013 2012

All Journal Article Presentation

  • [Journal Article] Increased LHX9 expression in alveolar epithelial type 2 cells of patients with chronic obstructive pulmonary disease2022

    • Author(s)
      Okutomo K. Fujino N, Yamada M, Saito T,Ono Y,Okada Y, Ichinose M, Sugiura H
    • Journal Title

      Respir Investig

      Volume: 60 Pages: 119-119

    • DOI

      10.1016/j.resinv.2021.08.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03684, KAKENHI-PROJECT-20K08558
  • [Journal Article] Axl kinase drivers immune checkpoint and chemokine signaling pathwaus in lung adenocarcinomas.2019

    • Author(s)
      Tsukita Yoko、Fujino Naoya、Miyauchi Eisaku、Saito Ryoko、Fujishima Fumiyoshi、Itakura Koji、Kyogoku Yorihiko、Okutomo Koji、Yamada Mitsuhiro、Okazaki Tatsuma、Sugiura Hisatoshi、Inoue Akira、Okada Yoshinori、Ichinose Masakazu
    • Journal Title

      Molecular Cancer

      Volume: 18 Pages: 24-24

    • DOI

      10.1186/s12943-019-0953-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K21266, KAKENHI-PROJECT-18K08134, KAKENHI-PROJECT-17H04149, KAKENHI-PROJECT-17H04180, KAKENHI-PROJECT-17K19785, KAKENHI-PROJECT-18K15942
  • [Journal Article] Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases.2019

    • Author(s)
      Fujino Naoya、Brand Oliver J.、Morgan David J.、Fujimori Toshifumi、Grabiec Aleksander M.、Jagger Christopher P.、Maciewicz Rose A.、Yamada Mitsuhiro、Itakura Koji、Sugiura Hisatoshi、Ichinose Masakazu、Hussell Tracy
    • Journal Title

      J Exp Med

      Volume: 216 Pages: 2184-2201

    • DOI

      10.1084/jem.20171978

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08134, KAKENHI-PROJECT-17H04180, KAKENHI-PROJECT-18K15942
  • [Journal Article] Increased severity of H1N1 pandemic influenza virus infection in alveolar type II cells from patients with pulmonary fibrosis2013

    • Author(s)
      Fujino N, Kubo H, Ota C, Suzuki T, Takahashi T, Yamada M, Suzuki S, Kondo T, Nagatomi R, Tando Y, Yamaya M
    • Journal Title

      J Infect Dis

      Volume: 207 Pages: 692-692

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890016
  • [Journal Article] Gene expression profiles of alveolar type II cells of chronic obstructive pulmonary disease: A case-control study.2012

    • Author(s)
      Fujino N, Ota C, Takahashi T, Suzuki T, Suzuki S, Yamada M, Nagatomi R, Kondo T, Yamaya M, Kubo H
    • Journal Title

      BMJ Open

      Volume: 2

    • DOI

      10.1136/bmjopen-2012-001553

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-23890020, KAKENHI-PROJECT-24890016
  • [Presentation] 慢性閉塞性肺疾患の増悪における肺胞マクロファージのSiglec-1発現低下2021

    • Author(s)
      齋藤拓矢,藤野直也,京極自彦,山田充啓,杉浦久敏
    • Organizer
      第61回 日本呼吸器学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K08558
  • [Presentation] Siglec-1-negative Alveolar Macrophages May Represent Pro-inflammatory Phenotypes And Are Associated With COPD Exacerbation2021

    • Author(s)
      Takuya Saito, Naoya Fujino, Yorihiko Kyogoku, Koji Okutomo, Mitsuhiro Yamada, Hisatoshi Sugiura
    • Organizer
      ATS 2021 International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08558
  • [Presentation] Sialic Acid-binding Immunoglobulin-type Lectin1 (Siglec1) Is Important For Bacterial Engulfment By Alveolar Macrophages And Is Down- regulated In COPD Patients2020

    • Author(s)
      N. Fujino, A. Tanno, M. Yamada, H. Sugiura, T. Hirano, R. Tanaka, H. Sano, M. Ichinose
    • Organizer
      American Thoracic Society 2020 International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08558
  • [Presentation] Axl receptor tyrosine kinase suppresses eosinophilic airway inflammation in allergen-induced asthma2019

    • Author(s)
      Koji Itakura, Naoya Fujino, Mitsuhiro Yamada, Yosuke Kamide, Ikuo Saito, Hisatoshi Sugiura, Masami Taniguchi, Masakazu Ichinose
    • Organizer
      American Thoracic Society International Conference 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15942
  • [Presentation] Negative regulation of eosinophilic inflammation by Axl receptor tyrosine kinase in a house-dust mite-induced asthma model2019

    • Author(s)
      Koji Itakura, Naoya Fujino, Mitsuhiro Yamada, Yosuke Kamide, Ikuo Saito, Hisatoshi Sugiura, Masami Taniguchi, Masakazu Ichinose
    • Organizer
      第68回日本アレルギー学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K15942
  • [Presentation] Axl受容体チロシンキナーゼによる重症喘息の好酸球性気道炎症制御機構2019

    • Author(s)
      板倉康司,藤野直也,山田充啓,上出庸介,齋藤生朗, 杉浦久敏,谷口正実,一ノ瀬正和
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Data Source
      KAKENHI-PROJECT-18K15942
  • [Presentation] Sensing of Apoptotic Cells Via Axl Kinase Triggers Cell Cycle Re-Entry of Airway Basal Cells in Mice2017

    • Author(s)
      Fujino N, Fujimori T, Grabiec AM, Maciewicz RA, Hussell T
    • Organizer
      Annual Congress of American Thoracic Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06641
  • 1.  岡田 克典 (90323104)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  松田 安史 (00455833)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  大河内 眞也 (40375035)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  大石 久 (60451580)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  野田 雅史 (70400356)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  兼平 雅彦 (90374941)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  早坂 一希 (40964739)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SUGIURA Hisatoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 9.  SUZUKI Takaya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  突田 容子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  山田 充啓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 12.  井上 彰
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  久保 裕司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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