Arai Seiji 新井誠二

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ARAI SEIJI 新井誠二

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Researcher Number	10636210
Other IDs	https://orcid.org/0000-0002-9514-735X
Affiliation (Current)	2026: 群馬大学, 大学院医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2026: 群馬大学, 大学院医学系研究科, 講師 2022 – 2024: 群馬大学, 大学院医学系研究科, 講師 2020 – 2021: 群馬大学, 大学院医学系研究科, 助教 2013 – 2016: 群馬大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Urology Except Principal Investigator Urology
Keywords	Principal Investigator アポトーシス / 前立腺癌 / 耐性メカニズム / FGFR3阻害剤 / 尿路上皮癌 / BH3ミメティクス / MCL1 / MARCH5 / 癌細胞初代培養 / 去勢抵抗性前立腺癌 … More / 組織内アンドロゲン代謝 / アンドロゲン / スフェロイド / CTOS法 / CRPC … More Except Principal Investigator 時計遺伝子 / 前立腺 / 日内変動 / ホルモン Less

遺伝子共欠失が誘発する癌特異的脆弱性を標的とした前立腺癌新規治療法の開発Principal Investigator
- Principal Investigator
  
  新井誠二
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Gunma University
Novel targeted therapy for FGFR inhibitor-resistant urothelial cancer and apoptosis based therapy for urothelial cancerPrincipal Investigator
- Principal Investigator
  
  新井誠二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Gunma University
Targeting apoptosis pathway as novel therapeutic strategy for prostate cancerPrincipal Investigator
- Principal Investigator
  
  Arai Seiji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Gunma University
Circadian variation of serum hormone concentration in relation with serum melatonin level and tissue clock gene expression in patients receiving prostate needle biopsy
- Principal Investigator
  
  Shibata Yasuhiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Gunma University
Maintenance of intratumoral androgens and possibility of personalized medicine in prostate cancer by using cancer tissue-originated spheroid methodPrincipal Investigator
- Principal Investigator
  
  ARAI SEIJI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Gunma University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth2023
- Author(s)
  Wang Keshan、Ma Fen、Arai Seiji、Wang Yun、Varkaris Andreas、Poluben Larysa、Voznesensky Olga、Xie Fang、Zhang Xiaoping、Yuan Xin、Balk Steven P.
- Journal Title
  
  Cancer Research
  
  Volume: 83 Issue: 7 Pages: 1016-1030
- DOI
  10.1158/0008-5472.can-22-3003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09518
[Journal Article] Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer2022
- Author(s)
  Ma Fen、Arai Seiji、Wang Keshan、Calagua Carla、Yuan Amanda R.、Poluben Larysa、Gu Zhongkai、Russo Joshua W.、Einstein David J.、Ye Huihui、He Meng Xiao、Liu Yu、Van Allen Eliezer、Sowalsky Adam G.、Bhasin Manoj K.、Yuan Xin、Balk Steven P.
- Journal Title
  
  Cancer Research
  
  Volume: 82 Issue: 8 Pages: 1518-1533
- DOI
  10.1158/0008-5472.can-21-1807
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09518
[Journal Article] Metastatic Castration-Resistant Prostate Cancer Remains Dependent on Oncogenic Drivers Found in Primary Tumors2021
- Author(s)
  Einstein David J.、Arai Seiji、Calagua Carla、Xie Fang、Voznesensky Olga、Capaldo Brian J.、Luffman Christina、Hecht Jonathan L.、Balk Steven P.、Sowalsky Adam G.、Russo Joshua W.
- Journal Title
  
  JCO Precision Oncology
  
  Volume: 5 Issue: 5 Pages: 1514-1522
- DOI
  10.1200/po.21.00059
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09518
[Journal Article] Androgen receptor and MYC equilibration centralizes on developmental super-enhancer2021
- Author(s)
  Guo Haiyang、Wu Yiming、Nouri Mannan、Spisak Sandor、Russo Joshua W.、Sowalsky Adam G.、Pomerantz Mark M.、Wei Zhao、Korthauer Keegan、Seo Ji-Heui、Wang Liyang、Arai Seiji、Freedman Matthew L.、He Housheng Hansen、Chen Shaoyong、Balk Steven P.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 7308-7308
- DOI
  10.1038/s41467-021-27077-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09518
[Journal Article] Androgen receptor splice variant 7 functions independently of the full length receptor in prostate cancer cells2021
- Author(s)
  Liang Jiaqian、Wang Liyang、Poluben Larysa、Nouri Mannan、Arai Seiji、Xie Lisha、Voznesensky Olga S.、Cato Laura、Yuan Xin、Russo Joshua W.、Long Henry W.、Brown Myles、Chen Shaoyong、Balk Steven P.
- Journal Title
  
  Cancer Letters
  
  Volume: 519 Pages: 172-184
- DOI
  10.1016/j.canlet.2021.07.013
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09518
[Journal Article] MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation2020
- Author(s)
  Arai Seiji、Varkaris Andreas、Nouri Mannan、Chen Sen、Xie Lisha、Balk Steven P
- Journal Title
  
  eLife
  
  Volume: 9 Pages: 1-24
- DOI
  10.7554/elife.54954
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09518
[Presentation] PI3K inhibitor may be effective on erdafitinib-resistant urothelial cancer cells2024
- Author(s)
  Seiji Arai, Tatsuhiro Sawada, Akira Ohtsu, Mai Kato, Yuta Maeno, Takanori Shimizu, Yoshitaka Sekine, Kazuhiro Suzuki
- Organizer
  2024 AACR Special Conference on Bladder Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08773
[Presentation] PIK3CA mutation as a resistant mechanism of an FGFR inhibitor erdafitinib in urothelial cancer cells2024
- Author(s)
  Seiji Arai, Tatsuhiro Sawada, Akira Ohtsu, Mai Kato, Yuta Maeno, Takanori Shimizu, Yoshitaka Sekine, Kazuhiro Suzuki
- Organizer
  2024年日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-23K08773
[Presentation] Combination therapies with BH3 mimetic drugs for prostate cancer2020
- Author(s)
  新井誠二、大津晃、鈴木和浩
- Organizer
  2020年日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-20K09518
[Presentation] Mitochondria E3 Ubiquitin Ligase MARCH5 Mediates StressInduced and NOXA-Dependent MCL1 Degradation2020
- Author(s)
  Seiji Arai, Akira Ohtsu, Tatsuhiro Sawada, Kazuhiro Suzuki
- Organizer
  2020年日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K09518
[Presentation] MCL１阻害剤とミトコンドリア標的薬の併用療法は前立腺癌細胞のアポトーシスを誘導する2020
- Author(s)
  大津晃、新井誠二、澤田達宏、鈴木和浩
- Organizer
  2020年日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K09518

1. Shibata Yasuhiro (90344936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Arai Seiji 新井 誠二

ARAI SEIJI 新井 誠二

Research Projects

Research Products

Co-Researchers

遺伝子共欠失が誘発する癌特異的脆弱性を標的とした前立腺癌新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel targeted therapy for FGFR inhibitor-resistant urothelial cancer and apoptosis based therapy for urothelial cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting apoptosis pathway as novel therapeutic strategy for prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Circadian variation of serum hormone concentration in relation with serum melatonin level and tissue clock gene expression in patients receiving prostate needle biopsy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Maintenance of intratumoral androgens and possibility of personalized medicine in prostate cancer by using cancer tissue-originated spheroid methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metastatic Castration-Resistant Prostate Cancer Remains Dependent on Oncogenic Drivers Found in Primary Tumors2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Androgen receptor and MYC equilibration centralizes on developmental super-enhancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Androgen receptor splice variant 7 functions independently of the full length receptor in prostate cancer cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] PI3K inhibitor may be effective on erdafitinib-resistant urothelial cancer cells2024

Author(s)

Organizer

Data Source

[Presentation] PIK3CA mutation as a resistant mechanism of an FGFR inhibitor erdafitinib in urothelial cancer cells2024

Author(s)

Organizer

Data Source

[Presentation] Combination therapies with BH3 mimetic drugs for prostate cancer2020

Author(s)

Organizer

Data Source

[Presentation] Mitochondria E3 Ubiquitin Ligase MARCH5 Mediates StressInduced and NOXA-Dependent MCL1 Degradation2020

Author(s)

Organizer

Arai Seiji 新井誠二

ARAI SEIJI 新井誠二