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Ikoma Takeharu  生駒 丈晴

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IKOMA Takeharu  生駒 丈晴

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Researcher Number 10638290
Other IDs
Affiliation (Current) 2022: 神奈川歯科大学, 歯学部, 助教
Affiliation (based on the past Project Information) *help 2015 – 2020: 神奈川歯科大学, 大学院歯学研究科, 助教
2014 – 2015: 神奈川歯科大学, 歯学研究科(研究院), 助教
2013: 神奈川歯科大学, 歯学部附属病院, その他
Review Section/Research Field
Principal Investigator
Surgical dentistry / Basic Section 57060:Surgical dentistry-related
Except Principal Investigator
Surgical dentistry
Keywords
Principal Investigator
CXCL14 / サイトカイン / BRAK / 血管新生抑制 / 転写因子 / 細胞分化 / 血管新生阻害 / 抗腫瘍効果 / 血管新生 / VEGF … More / BOSS/GPRC5B / 扁平上皮癌 / ケトン食 / GPRC5B / 頭頸部扁平上皮癌 … More
Except Principal Investigator
CXCL14 / BRAK / 頭頚部癌 / メチル化 / 頭頸部癌 / メチル化異常 / セツキシマブ Less
  • Research Projects

    (5 results)
  • Research Products

    (10 results)
  • Co-Researchers

    (12 People)
  •  細胞膜エネルギーセンサーGPRC5Bに着目した頭頸部扁平上皮癌へのケトン食の導入Principal Investigator

    • Principal Investigator
      生駒 丈晴
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kanagawa Dental College
  •  Clinical significance of CXCL14, a cytokine that normalizes cancer neovascularizationPrincipal Investigator

    • Principal Investigator
      Ikoma Takeharu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kanagawa Dental College
  •  Clinical application of BRAK that is anti-angiogenic agentPrincipal Investigator

    • Principal Investigator
      Ikoma Takeharu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kanagawa Dental College
  •  Elucidation of Epigenetics in Head and Neck Squamous Cell Carcinoma.

    • Principal Investigator
      Kubota Eiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kanagawa Dental College
  •  Search of transcription factor for BRAK by using new method in Head and neck carcinomaPrincipal Investigator

    • Principal Investigator
      IKOMA Takeharu
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kanagawa Dental College

All 2019 2016 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression2019

    • Author(s)
      Xiao-Yan Yang,Shigeyuki Ozawa, Yasumasa Kato, Yojiro Maehata, Kazuhito Izukuri1, Takeharu Ikoma, Keisuke Kanamori, Tetsu Akasaka, Kenji Suzuki, Hiroshi Iwabuchi, Shun-Ichi Kurata, Iyoko Katoh,, Takashi Sakurai, Tohru Kiyono, Ryu-Ichiro Hata
    • Journal Title

      International Journal o f Molecular Sciences

      Volume: 20 Pages: 1-13

    • DOI

      10.3390/ijms20081872

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11707, KAKENHI-PROJECT-17K17112, KAKENHI-PROJECT-19K10074, KAKENHI-PROJECT-19K10080, KAKENHI-PROJECT-17K11860
  • [Journal Article] Expression of the chemokine CXCL14 and cetuximab-dependent tumour suppression in head and neck squamous cell carcinoma.2016

    • Author(s)
      Kondo T, Ozawa S, Ikoma T, Yang XY, Kanamori K, Suzuki K, Iwabuchi H, Maehata Y, Miyamoto C, Taguchi T, Kiyono T, Kubota E, Hata RI
    • Journal Title

      Oncogenesis

      Volume: 5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K20567
  • [Journal Article] Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.2014

    • Author(s)
      Miyamoto C1, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC.
    • Journal Title

      Biomedical Research

      Volume: 35 Pages: 381-388

    • NAID

      130004903867

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25861982
  • [Journal Article] Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma2014

    • Author(s)
      Chihiro MIYAMOTO, Yojiro MAEHATA, Kazuhiko MOTOHASHI, Shigeyuki OZAWA, Takeharu IKOMA, Kouki HIDAKA, Satoko WADA-TAKAHASHI, Shun-Suke TAKAHASHI, Fumihiko YOSHINO, Ayaka YOSHIDA, Eiro KUBOTA, Ryu-Ichiro HATA, Masaichi-Chang-il LEE
    • Journal Title

      Biomedical Research

      Volume: 35 Pages: 381-388

    • NAID

      130004903867

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25293414
  • [Presentation] エネルギーセンサーGPRC5Bは頭頚部扁平上皮癌細胞の無糖培養下での細胞死を抑制する2019

    • Author(s)
      金森慶亮, 小澤重幸, 生駒丈晴, 鈴木健司, 岩渕博史, 小林優
    • Organizer
      第64回日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-17K11860
  • [Presentation] Is chemokine CXCL14, a multi-step tumor suppressor, a differentiation regulator of squamous epithelial cells ?2016

    • Author(s)
      T. Ikoma, X. Yang, S. Ozawa, Y. Maehata, R. Hata
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-25
    • Data Source
      KAKENHI-PROJECT-15K20567
  • [Presentation] Expression of the chemokine CXCL14 is a predictive biomarker for Cetuximab-dependent tumor supression.2015

    • Author(s)
      生駒 丈晴
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Data Source
      KAKENHI-PROJECT-15K20567
  • [Presentation] セツキシマブによる抗腫瘍性ケモカインBRAKの発現上昇メカニズムの解明2013

    • Author(s)
      小澤重幸、近藤忠稚、生駒丈晴、鈴木健司、久保田英朗
    • Organizer
      日本口腔外科学会
    • Place of Presentation
      福岡国際会議場
    • Data Source
      KAKENHI-PROJECT-25861982
  • [Presentation] CXCL14のメチル化異常に着目したセツキシマブの抗腫瘍効果判定のための基礎研究

    • Author(s)
      近藤忠稚、小澤重幸、生駒丈晴、鈴木健司、久保田英朗
    • Organizer
      日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉 (幕張メッセ)
    • Year and Date
      2014-10-17 – 2014-10-19
    • Data Source
      KAKENHI-PROJECT-25861982
  • [Presentation] CXCL14のメチル化異常に着目したセツキシマブの抗腫瘍効果判定のための基礎研究

    • Author(s)
      近藤忠稚、小澤重幸、生駒丈晴、鈴木健司、久保田英朗
    • Organizer
      日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉 (幕張メッセ)
    • Year and Date
      2014-10-17 – 2014-10-19
    • Data Source
      KAKENHI-PROJECT-25293414
  • 1.  OZAWA SHIGEYUKI (40434394)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  Kubota Eiro (50170030)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  KONDO TADANORI (00587727)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  SUZUKI KENJI (80350536)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  MAEHATA YOUJIRO (80410009)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  小林 優 (00162024)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  畑 隆一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  陽 暁艶
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  加藤 靖正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  鈴木 厚子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  加藤 伊陽子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  倉田 俊一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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