Inoue Hirofumi 井上博文

Researcher Number	10639305
Affiliation *help	2013 – 2018 : 東京農業大学, 応用生物科学部, 助教
Review Section/Research Field	Principal Investigator Applied health science / Eating habits Except Principal Investigator Eating habits
Keywords	Principal Investigator 鉄欠乏 / オートファジー / 金属トランスポーター / 活性酸素 / 脂溶性ビタミン / 骨代謝 / 酸化ストレス / 細胞老化 / 老化 / 炎症性疾患 … More Except Principal Investigator … More

慢性的な鉄欠乏状態がビタミン類代謝産物の体内動態と加齢性疾患に及ぼす影響Principal InvestigatorOngoing
- Principal Investigator
  
  井上博文
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo University of Agriculture
Mechanisms of inflammation control in functional phytochemicals: Counterplans against lifestyle-related diseases based on chronic inflammation
- Principal Investigator
  
  上原万里子
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Eating habits
- Research Institution
  Tokyo University of Agriculture
Effects of mineral deficiency diet on between aging-disease and reactive oxygen signalPrincipal Investigator
- Principal Investigator
  
  Inoue Hirofumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits
- Research Institution
  Tokyo University of Agriculture

All 2018 2017 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Down-regulation of senescence marker protein 30 by iron-specific chelator deferoxamine drives cell senescence.2018
- Author(s)
  H. Inoue, N. Hanawa, S. Katsumata, R. Katsumata-Tsuboi, N. Takahashi, M. Uehara
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume : 82 Pages : 900-903
- DOI
  10.1080/09168451.2018.1440190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K16609
[Journal Article] Extracts of black and brown rice powders improve hepatic lipid accumulation via the activation of PPARα in obese and diabetic model mice.2017
- Author(s)
  Felix AD, Takahashi N, Takahashi M, Katsumata-Tsuboi R, Satoh R, Soon Hui T, Miyajima K, Nakae D, Inoue H, Uehara M.
- Journal Title
  
  Biosci Biotechnol Biochem.
  
  Volume : 81 Pages : 2209-2211
- DOI
  10.1080/09168451.2017.1372178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H01767
[Journal Article] Sulforaphene attenuates multinucleation of pre-osteoclasts by suppressing expression of cell-cell fusion-associated genes DC-STAMP, OC-STAMP, and Atp6v0d2.2017
- Author(s)
  Takagi T, Inoue H, Takahashi N, Katsumata-Tsuboi R, Uehara M.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume : 81 Pages : 1220-1223
- DOI
  10.1080/09168451.2017.1281729
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H01767
[Journal Article] Sulforaphane inhibits osteoclast differentiation by suppressing the cell-cell fusion molecules DC-STAMP and OC-STAMP.2017
- Author(s)
  Takagi T, Inoue H, Takahashi N, Katsumata-Tsuboi R, Uehara M.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 483 Pages : 718-724
- DOI
  10.1016/j.bbrc.2016.12.075
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H01767
[Journal Article] Iron deficiency induces autophagy and activates Nrf2 signal through modulating p62/SQSTM.2017
- Author(s)
  Inoue H, Hanawa N, Katsumata SI, Katsumata-Tsuboi R, Takahashi N, Uehara M.
- Journal Title
  
  Biomedical research
  
  Volume : 38 Pages : 343-350
- DOI
  10.2220/biomedres.38.343
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K16609
[Journal Article] A combination of soy isoflavones and cello-oligosaccharides changes equol/O-desmethylangolensin production ratio and attenuates bone fragility in ovariectomized mice.2016
- Author(s)
  Fujii S, Takahashi N, Inoue H, Katsumata S, Kikkawa Y, Machida M, Ishimi Y, Uehara M.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume : 80 Pages : 1632-1635
- DOI
  10.1080/09168451.2016.1184559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H01767
[Journal Article] Activation of Nrf2/Keap1 signaling and autophagy induction against oxidative stress in heart in iron deficiency.2015
- Author(s)
  Hirofumi Inoue, Ken-Ichi Kobayashi, Moussa Ndong, Yuji Yamamoto, Shi-Ichi Katsumata, Kazuharu Suzuki, Mariko Uehara
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume : 60 Pages : 1-3
- DOI
  10.1080/09168451.2015.1018125
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25750057, KAKENHI-PROJECT-15H01767, KAKENHI-PROJECT-25450181
[Presentation] 骨粗鬆症予防におけるフィトケミカルの有効性2017
- Author(s)
  井上博文
- Organizer
  第15回日本機能性食品医用学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] レスベラトロールの食後高脂血症に対する作用メカニズムの解析2017
- Author(s)
  高橋真美、佐藤綾、勝間田理恵、井上博文、中田理恵子、井上裕康、河田照雄、室田佳恵子、上原万里子、高橋信之
- Organizer
  第71回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] 鉄欠乏状態はERK1/2を介して抗加齢タンパク質SMP30の発現を抑制する2017
- Author(s)
  井上博文、塙信彰、勝間田真一、勝間田(坪井) 理恵、高橋信之、上原万里子
- Organizer
  第71回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-16K16609
[Presentation] 鉄欠乏状態における活性酸素種と抗加齢タンパク質SMP30の生理的役割2017
- Author(s)
  井上博文、勝間田真一、勝間田(坪井) 理恵、高橋信之、上原万里子
- Organizer
  第39回日本臨床栄養学会総会・第38回日本臨床栄養協会総会　第15回大連合大会
- Data Source
  KAKENHI-PROJECT-16K16609
[Presentation] DNAマイクロアレイ法を用いた鉄欠乏状態と酸化ストレスを結ぶ新規分子の探索2017
- Author(s)
  井上博文、塙信彰、勝間田真一、勝間田(坪井) 理恵、高橋信之、上原万里子
- Organizer
  第10回食香粧研究会
- Data Source
  KAKENHI-PROJECT-16K16609
[Presentation] 僕がこの研究をはじめた理由：必須微量元素とフードファクターを結ぶ2016
- Author(s)
  井上博文
- Organizer
  フードサイエンスフォーラム第22回学術集会
- Place of Presentation
  岡山県美作市　美春閤
- Year and Date
  2016-09-08
- Invited
- Data Source
  KAKENHI-PROJECT-16K16609
[Presentation] Sulforaphaneの続発性骨粗鬆症に対する有効性および作用機序の検討2016
- Author(s)
  髙木智弘、井上博文、高橋信之、牛田悠介、菅沼大行、上原万里子
- Organizer
  第70回日本栄養・食糧学会大会
- Place of Presentation
  神戸ポートピアホテル・武庫川女子大学中央キャンパス（兵庫県・神戸市および西宮市）
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] オレウロペイン代謝産物hydroxytyrosolによる破骨細胞分化抑制メカニズム2016
- Author(s)
  井上博文、勝間田(坪井) 理恵、高橋信之、上原万里子
- Organizer
  第10回日本ポリフェノール学会学術集会
- Place of Presentation
  芝浦工業大学豊洲キャンパス（東京都・江東区）
- Year and Date
  2016-08-04
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] Equol鏡像異性体の再吸収動態と骨量減少抑制作用の差異2016
- Author(s)
  藤井俊吾、生城真一、室田佳恵子、太田篤胤、井上博文、高橋信之、上原万里子
- Organizer
  第21回日本フードファクター学会学術集会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Year and Date
  2016-11-19
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] SulforaphaneはSTAT1を介して破骨細胞融合因子(DC-STAMP，OC-STAMP)を阻害する2016
- Author(s)
  髙木智弘、井上博文、勝間田(坪井)理恵、高橋信之、上原万里子
- Organizer
  第21回日本フードファクター学会学術集会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Year and Date
  2016-11-19
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] 鉄欠乏状態が細胞老化と細胞内浄化機構オートファジーに及ぼす影響2016
- Author(s)
  井上博文、小林謙一、鈴木司、山本祐司、勝間田真一、勝間田(坪井) 理恵、高橋信之、上原万里子
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25750057
[Presentation] 鉄欠乏状態は活性酸素シグナルを介して細胞老化を促進する2016
- Author(s)
  井上博文、勝間田(坪井)理恵、高橋信之、上原万里子
- Organizer
  第27回日本微量元素学会学術集会
- Place of Presentation
  京都府京都市　京都大学医学部創立百周年記念施設　芝蘭会館
- Year and Date
  2016-07-30
- Data Source
  KAKENHI-PROJECT-16K16609
[Presentation] 鉄欠乏状態は酸化ストレスを惹起することで細胞老化を誘導する2016
- Author(s)
  井上博文、小林謙一、鈴木司、山本祐司、勝間田真一、勝間田(坪井)理恵、高橋信之、上原万里子
- Organizer
  第70回日本栄養食糧学会大会
- Place of Presentation
  兵庫県西宮市　武庫川女子大学　中央キャンパス
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-16K16609
[Presentation] 鉄欠乏状態における異常タンパク質分解システム活性化機構に関する研究2015
- Author(s)
  井上博文、塙信彰、勝間田真一、坪井理恵、高橋信之、上原万里子
- Organizer
  日本食生活学会第50回大会
- Place of Presentation
  東京農業大学
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-25750057
[Presentation] Beyond antioxidative and anti-inflammatory activities of phytochemicals inhibit osteoclastogenesis.2015
- Author(s)
  Uehara M, Inoue H, Takahashi N.
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
- Place of Presentation
  Sheraton Waikiki Hotel, Honolulu, Hawaii, USA.
- Year and Date
  2015-12-15
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] Comparative activities of isoflavone metabolites on osteoclastogenesis in vitro and bone loss in vivo.2015
- Author(s)
  Uehara M, Inoue H, Takahashi N.
- Organizer
  6th International Conference on Food Factors (ICoFF2015)
- Place of Presentation
  Coex, Seoul, Korea
- Year and Date
  2015-11-22
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] Iron deficiency regulates oxidative stress via inducing anti-oxidant enzymes and activating autophagy2015
- Author(s)
  H. Inoue, N. Hanawa, N. Takahashi, M. Uehara
- Organizer
  12th Asian Congress of Nutrition・第69回日本栄養・食糧学会大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-05-14
- Data Source
  KAKENHI-PROJECT-25750057
[Presentation] Sulforaphene, sulforaphene and erucin, sulfur containing compounds, inhibit osteoclasts differentiation via down-regulating cell-cell fusion molecules associated to osteoclast differentiation.2015
- Author(s)
  Takagi T, Inoue H, Takahashi N, Uehara M.
- Organizer
  12th Asian Congress of Nutrition (ACN2015)
- Place of Presentation
  Pacifico Yokohama, Kanagawa, Japan
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] Differences in effects of equol enantiomers in vivo and in vitro.2015
- Author(s)
  Fujii S, Inoue H, Takahashi N, Uehara M.
- Organizer
  12th Asian Congress of Nutrition (ACN2015)
- Place of Presentation
  Pacifico Yokohama, Kanagawa, Japan
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] Isothiocyanates suppressed the osteoclast differentiation by decreasing master regulator of osteoclast fusion factor DC-STAMP.2015
- Author(s)
  Takagi T, Inoue H, Takahashi N, Uehara M.
- Organizer
  6th International Conference on Food Factors (ICoFF2015)
- Place of Presentation
  Coex, Seoul, Korea
- Year and Date
  2015-11-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] Bone-sparing effects of phytochemicals in vitro and in rodent models of osteoporosis.2015
- Author(s)
  Uehara M, Inoue H, Takahashi N.
- Organizer
  12th Asian Congress of Nutrition (ACN2015)
- Place of Presentation
  Pacifico Yokohama, Kanagawa, Japan
- Year and Date
  2015-05-14
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] 鉄欠乏状態における異常タンパク質分解システム活性化機構に関する研究2015
- Author(s)
  井上博文、塙信彰、勝間田真一、坪井理恵、高橋信之、上原万里子
- Organizer
  日本食生活学会第50回記念大会
- Place of Presentation
  東京農業大学
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-25750057
[Presentation] 鉄欠乏状態が活性酸素シグナルとタンパク質品質機構に及ぼす影響2015
- Author(s)
  井上博文、小林謙一、鈴木司、山本祐司、勝間田(坪井) 理恵、勝間田真一、高橋信之、上原万里子
- Organizer
  第96回日本栄養・食糧学会関東支部大会
- Place of Presentation
  新潟大学
- Year and Date
  2015-09-05
- Data Source
  KAKENHI-PROJECT-25750057
[Presentation] Iron deficiency induces autophagy through activation of Nrf2/Keap1 system and phosphorylation of p62 (Thr351) against oxidative stress2015
- Author(s)
  H. Inoue, KI. Kobayashi, T. Suzuki, Y. Yamamoto, SI. Katsumata, R. Katsumata-Tsuboi, N. Takahashi, M Uehara
- Organizer
  第6回国際フードファクター学会
- Place of Presentation
  ソウル市(韓国)
- Year and Date
  2015-11-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25750057
[Presentation] 鉄欠乏状態が加齢疾患リスクと活性酸素シグナルに与える影2015
- Author(s)
  井上博文、勝間田(坪井)理恵、高橋信之、上原万里子
- Organizer
  BMB2015(第38回日本分子生物学会年会・第88回日本生化学会大会合同大会)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25750057
[Presentation] A combination of soy isoflavones and cellooligosaccharides improves equol production and bone fragility in ovariectomized mice.2015
- Author(s)
  Fujii S, Inoue H, Takahashi N, Kikkawa Y, Machida M, Uehara M.
- Organizer
  6th International Conference on Food Factors (ICoFF2015)
- Place of Presentation
  Coex, Seoul, Korea
- Year and Date
  2015-11-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01767
[Presentation] Dietary iron deficiency induces expression of metal-ion transporters and anti-oxidant enzymes in mouse heart2013
- Author(s)
  Hirofumi Inoue, Shin-Ichi Katsumata, Ken-Ichi Kobayashi, Yuji Yamamoto, Kazuharu Suzuki, Mariko Uehara
- Organizer
  The 8th Asia Pacific Conference on Clinical Nutrition
- Place of Presentation
  TOKYO BAY, MAIHAMA
- Data Source
  KAKENHI-PROJECT-25750057
[Presentation] Iron deficiency regulates oxidative stress via inducing anti-oxidant enzymes and activating autophagy.
- Author(s)
  Hirofumi Inoue, Nobuaki Hanawa, Nobuyuki Takahashi, Mariko Uehara
- Organizer
  ACN2015・第69回日本栄養・食糧学会大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-05-14 – 2015-05-17
- Data Source
  KAKENHI-PROJECT-25750057
[Presentation] 鉄欠乏時では活性酸素シグナルセンサーとオートファジーを活性化することで細胞内恒常性を維持する
- Author(s)
  井上博文、勝間田真一、高橋信之、上原万里子
- Organizer
  2015年度日本農芸化学会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25750057
[Presentation] 鉄欠乏によるオートファジー誘導と生体防御機構
- Author(s)
  井上博文、塙信彰、勝間田真一、高橋信之、上原万里子
- Organizer
  第19回ニホンフードファクター学会学術集会
- Place of Presentation
  鹿児島大学
- Year and Date
  2014-11-08 – 2014-11-09
- Data Source
  KAKENHI-PROJECT-25750057

1. 上原万里子 (20211071)

# of Collaborated Projects : 1results

# of Collaborated Products : 17results
2. 高橋信之 (50370135)

# of Collaborated Projects : 1results

# of Collaborated Products : 16results
3. 小林謙一

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

Inoue Hirofumi 井上 博文

Research Projects

Research Products

Co-Researchers

慢性的な鉄欠乏状態がビタミン類代謝産物の体内動態と加齢性疾患に及ぼす影響Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of inflammation control in functional phytochemicals: Counterplans against lifestyle-related diseases based on chronic inflammation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of mineral deficiency diet on between aging-disease and reactive oxygen signalPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Down-regulation of senescence marker protein 30 by iron-specific chelator deferoxamine drives cell senescence.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracts of black and brown rice powders improve hepatic lipid accumulation via the activation of PPARα in obese and diabetic model mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sulforaphene attenuates multinucleation of pre-osteoclasts by suppressing expression of cell-cell fusion-associated genes DC-STAMP, OC-STAMP, and Atp6v0d2.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sulforaphane inhibits osteoclast differentiation by suppressing the cell-cell fusion molecules DC-STAMP and OC-STAMP.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Iron deficiency induces autophagy and activates Nrf2 signal through modulating p62/SQSTM.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A combination of soy isoflavones and cello-oligosaccharides changes equol/O-desmethylangolensin production ratio and attenuates bone fragility in ovariectomized mice.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of Nrf2/Keap1 signaling and autophagy induction against oxidative stress in heart in iron deficiency.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] 骨粗鬆症予防におけるフィトケミカルの有効性2017

Author(s)

Organizer

Data Source

[Presentation] レスベラトロールの食後高脂血症に対する作用メカニズムの解析2017

Author(s)

Organizer

Data Source

[Presentation] 鉄欠乏状態はERK1/2を介して抗加齢タンパク質SMP30の発現を抑制する2017

Author(s)

Organizer

Data Source

[Presentation] 鉄欠乏状態における活性酸素種と抗加齢タンパク質SMP30の生理的役割2017

Author(s)

Organizer

Data Source

[Presentation] DNAマイクロアレイ法を用いた鉄欠乏状態と酸化ストレスを結ぶ新規分子の探索2017

Author(s)

Organizer

Data Source

[Presentation] 僕がこの研究をはじめた理由：必須微量元素とフードファクターを結ぶ2016

Author(s)

Organizer

Inoue Hirofumi 井上博文