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NIIZUMA KUNIYASU  新妻 邦泰

… Alternative Names

Niizuma Kuniyasu  新妻 邦泰

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Researcher Number 10643330
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-9282-6499
Affiliation (Current) 2025: 東北大学, 医工学研究科, 教授
Affiliation (based on the past Project Information) *help 2018 – 2024: 東北大学, 医工学研究科, 教授
2017: 東北大学, 大学病院, 講師
2016: 東北大学, 医学(系)研究科(研究院), 助教
2016: 東北大学, 医学系研究科, 助教
2014 – 2016: 東北大学, その他の研究科, 助教
2014 – 2015: 東北大学, 医工学研究科, 助教
2013: 東北大学, 医学(系)研究科(研究院), 非常勤講師
Review Section/Research Field
Principal Investigator
Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 51030:Pathophysiologic neuroscience-related / Medical systems / Science and Engineering / Neurosurgery
Except Principal Investigator
Basic Section 56010:Neurosurgery-related / Neurosurgery / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Medium-sized Section 21:Electrical and electronic engineering and related fields / Basic Section 90110:Biomedical engineering-related … More / Basic Section 50010:Tumor biology-related / Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related / Basic Section 90140:Medical technology assessment-related / Basic Section 90130:Medical systems-related / Basic Section 59010:Rehabilitation science-related / Basic Section 62010:Life, health and medical informatics-related / Medical systems Less
Keywords
Principal Investigator
脳動脈瘤 / 数値流体力学 / くも膜下出血 / iPS細胞 / RNF213 / 血管平滑筋 / 血管内皮 / もやもや病 / 細胞治療 / 認知症 … More / 幹細胞 / Muse細胞 / 血流解析 / 数値流体力学解析 / 血行力学 / 脳血管障害 / 磁気共鳴血管撮影 / 血流 / シミュレーション / 多元計算解剖 / 動脈硬化 / 脳神経外科学 / 脳血管障害学 / 数値流体解析 … More
Except Principal Investigator
もやもや病 / 脳動脈瘤 / Muse細胞 / 再生医療 / 数値流体力学 / RNF213 / 流体解析 / 脊髄損傷 / 幹細胞移植 / 血管新生 / MRI / 脳梗塞 / 造影MRI / 瘤壁造影効果 / AI / sphingosine-1-phosphate / blood brain barrier / S1P / バイオマーカー / 機械学習 / ラット / 多能性幹細胞 / 頭蓋外内バイパス術 / 数値流体解析 / 内皮化 / コイル後の内皮化促進 / NETs / nanoparticle / 再開通療法 / 免疫血栓 / vessel wall imaging / artificial intelligence / モヤモヤ病 / 生体磁気計測 / カテーテル / 磁界センサ / 虚血再灌流 / 微小血管網 / マイクロ流体デバイス / 計測融合シミュレーション / 血液脳関門 / 生物・生体工学 / 細胞・組織 / マイクロ・ナノデバイス / Ferroptosis / mRNA translation / Codon bias / Glioma / tRNA / マイクロ波 / 経頭蓋イメージング / 熱音響イメージング / 未破裂脳動脈瘤 / 脊髄腫瘍 / 頭蓋内動脈瘤 / 破裂点予測 / 血管壁イメージング / 脳卒中 / 脳循環予備能 / tRNA由来物 / 神経損傷 / 手術 / 血管内治療 / 脳循環 / 内皮細胞 / 血流 / 勃起障害 / 性機能 / 早期変化 / 内頚動脈終末部 / RNF213多型 / machine learning / MRA / 中大脳動脈 / 内頚動脈 / 人工知能 / 血管リモデリング / RNF213 p.R4810K / 内頚動脈終末部径 / 血行再建術 / 血管新生療法 / sphingossine-1-phosphate / functional antagonist / SEW2871 / S1PR1 / subarachnoid hemorrhage / エボラタン / ドラッグ・リポジショニング / 急性期脳損傷 / ドラッグリポジショニング / GSK-3b / Akt / アポトーシス / エダラボン / 早期脳損傷 / くも膜下出血 / isodesmosine / desmosine / エラスチン / コンピュータ / 医用画像 / シミュレーション / 海馬光けいれんモデル / 難治てんかん / optogenetics / regenerative medicine / status epilepticus / hippocampus / seizure model / epilepsy / Cell therapy / Optogenetics / 幹細胞 / けいれん / 海馬 / オプトジェネティクス / 細胞治療 / てんかん / 血管内皮障害 / 慢性脳虚血後過灌流モデル / エストロゲン / 動脈内皮障害 / 再灌流 / 過灌流 / 血行再建 / 慢性脳低灌流 / 慢性脳虚血 / 中枢神経疾患 / 細胞移植治療 / 組織修復 / 流体力学 / ステント / 脳血管内治療 / 穿通枝 / 脳動脈解離 / ドラッグ・デリバリー・デリバリー / 神経再生 / ドラッグデリバリー / cell therapy / drug delivery / OSI / WSS / CFD / プラーク / 頸動脈 / 血行動態 / コンピュータ・シミュレーション / CED法 / 神経外傷 / 脳低温療法 / 外科 / 頭部外傷 / 脳・神経 / 再生療法 / MUSE細胞 / moyamoya disease / 脳血管障害学 / 脳神経外科学 / 脳血管撮影 / 集学的治療 / 脳動静脈奇形 Less
  • Research Projects

    (38 results)
  • Research Products

    (110 results)
  • Co-Researchers

    (58 People)
  •  血管壁MRイメージングと数値流体解析を駆使した脳動脈瘤増大予測モデルの開発

    • Principal Investigator
      面高 俊介
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  A novel therapeutic approach for cerebral infarction via blood brain barrier protection by S1PR1 agonist

    • Principal Investigator
      伊藤 明
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  脳カテーテル用生体磁気センサシステムの開発と神経磁界の検出

    • Principal Investigator
      薮上 信
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 21:Electrical and electronic engineering and related fields
    • Research Institution
      Tohoku University
  •  Elucidation of the pathogenesis of moyamoya disease through Endothelial-Smooth Muscle Interaction and RNF213Principal Investigator

    • Principal Investigator
      新妻 邦泰
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Tohoku University
  •  Transcranial Whole Brain Imaging by Microwave-induced Thermoacoustics

    • Principal Investigator
      西條 芳文
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90130:Medical systems-related
      Basic Section 90140:Medical technology assessment-related
      Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related
    • Research Institution
      Tohoku University
  •  Elucidating the role of tRNA epitranscriptome in Glioma pathology and development of novel therapies

    • Principal Investigator
      Rashad Sherif
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Tohoku University
  •  Development of vascular permeability control method by integration of blood-brain barrier-on-a-chip and measurement-integrated simulation

    • Principal Investigator
      船本 健一
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Tohoku University
  •  人工知能を用いたもやもや病における病期進行予測モデルの開発

    • Principal Investigator
      遠藤 英徳
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  急性期脳梗塞における免疫血栓を標的とした新規治療法の開発

    • Principal Investigator
      坂田 洋之
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  脳動脈瘤コイル塞栓術後の内皮形成促進:Muse細胞による新しい治療アプローチ

    • Principal Investigator
      高橋 佑介
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Akita University
  •  男性性機能を改善させる再生医療の開発

    • Principal Investigator
      山下 慎一
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      Tohoku University
  •  血流解剖に基づく未破裂脳動脈瘤分類および新規画像診断システムの提案

    • Principal Investigator
      杉山 慎一郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  脊髄悪性腫瘍に対する光刺激インプラントデバイスを用いた新規治療法の開発

    • Principal Investigator
      遠藤 俊毅
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Tohoku University
  •  慢性期脊髄損傷に対するMuse細胞を用いた新規治療法の開発

    • Principal Investigator
      遠藤 俊毅
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku Medical and Pharmaceutical University
  •  Elucidation of moyamoya disease pathophysiology through an interaction of hemodynamics and endothelial cells

    • Principal Investigator
      Tominaga Teiji
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Tohoku University
  •  MRI・バイオマーカーによる脳循環自動調節能メカニズム解明及びAIによるその評価

    • Principal Investigator
      井上 敬
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  Prediction of aneurysm rupture point using vessel wall MR imaging and CFD analysis

    • Principal Investigator
      Omodaka Shunsuke
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  A study to reduce early brain damage after subarachnoid hemorrhage: edaravone drug repositioning Drug Repositioning of Edaravone

    • Principal Investigator
      Haryu Shinya
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  Novel therapeutic approaches for subarachnoid hemorrhage via blood brain barrier protection by S1PR1 signaling pathway

    • Principal Investigator
      Ito Akira
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  Cilostazol may enhance the endogenous stem cell activity and thereby increase pial synangiosis after revascularization surgery for Moyamoya disease

    • Principal Investigator
      Miki Fujimura
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Hokkaido University
      Tohoku University
  •  Analysis of latent imaging findings in healthy subjects with moyamoya disease susceptibility gene RNF213 polymorphism using artificial intelligence

    • Principal Investigator
      Sonobe Shinya
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 62010:Life, health and medical informatics-related
    • Research Institution
      Tohoku University
  •  Development of Muse cell therapy for dementiaPrincipal Investigator

    • Principal Investigator
      Niizuma Kuniyasu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Tohoku University
  •  Muse cell transplantation for Spinal cord injury

    • Principal Investigator
      Toshiki Endo
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  エラスチン架橋アミノ酸に着目したもやもや病バイオマーカー診断法の確立

    • Principal Investigator
      井上 智夫
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Kitasato University
  •  Development of a new experimental model of chronic cerebral ischemia with vascular endothelial impairment and elucidation of hyperperfusion following vascular reconstruction

    • Principal Investigator
      Shimizu Hiroaki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Akita University
  •  Muse cell therapy for the cure of epileptogenesis

    • Principal Investigator
      Osawa Shin-ichiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  Hemodynamic predictors for the growth of unruptured intracranial aneurysms

    • Principal Investigator
      Sugiyama Shinichiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  Neo-angiogenesis induction by pluripotent stem cell Muse as a new therapeutic strategy for severer form of moyamoya disease

    • Principal Investigator
      Miki Fujimura
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  Platform for regenerative therapy of central nervous system using Muse cells

    • Principal Investigator
      TOMINAGA TEIJI
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  Development of risk evaluation system of cerebral aneurysms based on the computational fluid dynamicsPrincipal Investigator

    • Principal Investigator
      NIIZUMA KUNIYASU
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Medical systems
    • Research Institution
      Tohoku University
  •  Computational fluid dynamics in plaque formation of carotid artery

    • Principal Investigator
      Saito Atsushi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  New concept of local chemo- and cell-therapy for spinal cord injury using convection-enhanced drug delivery

    • Principal Investigator
      Sugiyama Shinichiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  正常から病態へ ~脳動脈瘤の発生に関する多元計算解剖学的アプローチ~Principal Investigator

    • Principal Investigator
      新妻 邦泰
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      Tohoku University
  •  Multidisciplinary Approach for Arteriovenous Malformation Based on Computational Fluid Dynamics

    • Principal Investigator
      Shimizu Hiroaki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical systems
    • Research Institution
      Akita University
  •  Establishment of the stem cell transplantation therapy by MUSE for moyamoya disease

    • Principal Investigator
      Miki Fujimura
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  Brain protection by local hypothermia in the acute phase of traumatic brain injury

    • Principal Investigator
      Tominaga Teiji
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  Development of stent to treat vertebral artery dissection: achievement of curability and functional preservation

    • Principal Investigator
      ENDO Hidenori
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  Prediction of the wall property and rupture risk of cerebral aneurysms based on the computational fluid dynamicsPrincipal Investigator

    • Principal Investigator
      Niizuma Kuniyasu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Patent

  • [Journal Article] The prognostic values of plasma desmosines, crosslinking molecules of elastic fibers, in the disease progression of Moyamoya disease2024

    • Author(s)
      Tashiro Ryosuke、Anzawa Riki、Inoue Tomoo、Mikagi Ayame、Ozaki Dan、Tominaga Keita、Inoue Takashi、Ishida Tomohisa、Fujimura Miki、Usuki Toyonobu、Endo Hidenori、Niizuma Kuniyasu、Tominaga Teiji
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 100 Pages: 117602-117602

    • DOI

      10.1016/j.bmc.2024.117602

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19KK0420, KAKENHI-PROJECT-21K09092, KAKENHI-PROJECT-21H04835
  • [Journal Article] Translational response to mitochondrial stresses is orchestrated by tRNA modifications2024

    • Author(s)
      Sherif Rashad, Shadi Al-Mesitef, Abdulrahman Mousa, Yuan Zhou, Daisuke Ando, Guangxin Sun, Tomoko Fukuuchi, Yuko Iwasaki, Jingdong Xiang, Shane R Byrne, Jingjing Sun, Masamitsu Maekawa, Daisuke Saigusa, Thomas J Begley, Peter C Dedon, Kuniyasu Niizuma
    • Journal Title

      Biorxiv preprint

      Volume: 00 Pages: 00-00

    • DOI

      10.1101/2024.02.14.580389

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27432
  • [Journal Article] Angiogenin regulates mitochondrial stress and function via tRNA-derived fragments generation and impacting tRNA modifications2024

    • Author(s)
      Shadi Al-Mesitef, Keita Tominaga, Abdulrahman Mousa, Thomas J Begley, Peter C Dedon, Sherif Rashad, Kuniyasu Niizuma
    • Journal Title

      Biorxiv preprint

      Volume: 00 Pages: 00-00

    • DOI

      10.1101/2024.02.13.580206

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27432
  • [Journal Article] Six-month Outcomes after PulseRider- and Conventional Single Stent-assisted Embolization for Bifurcation Aneurysms: A Propensity-adjusted Comparison2023

    • Author(s)
      Shunsuke Omodaka , Yasushi Matsumoto , Takeshi Fujimori , Hiroyuki Sakata, Kenichi Sato , Kuniyasu Niizuma , Hidenori Endo , Teiji Tominaga
    • Journal Title

      Neurol. Med. Chir.(Tokyo)

      Volume: 63 Issue: 11 Pages: 512-518

    • DOI

      10.2176/jns-nmc.2023-0082

    • ISSN
      0470-8105, 1349-8029
    • Year and Date
      2023-11-15
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09117
  • [Journal Article] Mammalian tissue specific translation regulation; role of tRNA epitranscriptome in regulating codon optimality patterns across tissues2023

    • Author(s)
      Daisuke Ando, Sherif Rashad, Thomas J Begley, Hidenori Endo, Masashi Aoki, Peter C Dedon, Kuniyasu Niizuma
    • Journal Title

      Biorxiv preprint

      Volume: 00 Pages: 00-00

    • DOI

      10.1101/2023.10.24.563884

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27432
  • [Journal Article] Intravenous Administration of Human Muse Cells Ameliorates Deficits in a Rat Model of Subacute Spinal Cord Injury2023

    • Author(s)
      Takahashi Yoshiharu、Kajitani Takumi、Endo Toshiki、Nakayashiki Atsushi、Inoue Tomoo、Niizuma Kuniyasu、Tominaga Teiji
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 19 Pages: 14603-14603

    • DOI

      10.3390/ijms241914603

    • Data Source
      KAKENHI-PROJECT-23K24439
  • [Journal Article] Plasma tRNA derivatives concentrations for detecting early brain damage in patients with acute large vessel occlusion and predicting clinical outcomes after endovascular thrombectomy2022

    • Author(s)
      Ishida Tomohisa、Inoue Takashi、Niizuma Kuniyasu、Inoue Tomoo、Sasaki Keisuke、Sakata Hiroyuki、Ezura Masayuki、Uenohara Hiroshi、Abe Takaaki、Tominaga Teiji
    • Journal Title

      Clinical Neurology and Neurosurgery

      Volume: 220 Pages: 107358-107358

    • DOI

      10.1016/j.clineuro.2022.107358

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09092
  • [Journal Article] RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses2022

    • Author(s)
      Zhang Liyin、Rashad Sherif、Zhou Yuan、Niizuma Kuniyasu、Tominaga Teiji
    • Journal Title

      Journal of Cerebral Blood Flow & Metabolism

      Volume: 42 Issue: 11 Pages: 2107-2122

    • DOI

      10.1177/0271678x221110679

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04835, KAKENHI-PROJECT-20K16323
  • [Journal Article] Isotope-dilution LC-MS/MS analysis of the elastin crosslinkers desmosine and isodesmosine in acute cerebral stroke patients2022

    • Author(s)
      Mikagi Ayame、Tashiro Ryosuke、Inoue Tomoo、Anzawa Riki、Imura Akiho、Tanigawa Takahiro、Ishida Tomohisa、Inoue Takashi、Niizuma Kuniyasu、Tominaga Teiji、Usuki Toyonobu
    • Journal Title

      RSC Advances

      Volume: 12 Issue: 49 Pages: 31769-31777

    • DOI

      10.1039/d2ra06009d

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09092, KAKENHI-PROJECT-19KK0420, KAKENHI-PROJECT-20K05734
  • [Journal Article] Wall enhancement in unruptured posterior communicating aneurysms with oculomotor nerve palsy on magnetic resonance vessel wall imaging2022

    • Author(s)
      Omodaka Shunsuke、Endo Hidenori、Niizuma Kuniyasu、Endo Toshiki、Sato Kenichi、Saito Atsushi、Uchida Hiroki、Matsumoto Yasushi、Tominaga Teiji
    • Journal Title

      Journal of Neurosurgery

      Volume: - Issue: 3 Pages: 1-7

    • DOI

      10.3171/2021.11.jns212249

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09117
  • [Journal Article] Association between RNF213 c.14576G>A Variant (rs112735431) and Peripheral Pulmonary Artery Stenosis in Moyamoya Disease.2021

    • Author(s)
      Ozaki Dan、Endo Hidenori、Tashiro Ryosuke、Sugimura Koichiro、Tatebe Shunsuke、Yasuda Satoshi、Tomata Yasutake、Endo Toshiki、Tominaga Keita、Niizuma Kuniyasu、Fujimura Miki、Tominaga Teiji
    • Journal Title

      Cerebrovascular Diseases

      Volume: - Issue: 3 Pages: 1-6

    • DOI

      10.1159/000519717

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H04835, KAKENHI-PROJECT-19K08531, KAKENHI-PROJECT-20K09362
  • [Journal Article] Brain Temperature Measured by Magnetic Resonance Spectroscopy to Predict Clinical Outcome in Patients with Infarction2021

    • Author(s)
      Ishida Tomohisa、Inoue Takashi、Inoue Tomoo、Endo Toshiki、Fujimura Miki、Niizuma Kuniyasu、Endo Hidenori、Tominaga Teiji
    • Journal Title

      Sensors

      Volume: 21 Issue: 2 Pages: 490-490

    • DOI

      10.3390/s21020490

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09092
  • [Journal Article] Association of intravenous administration of human Muse cells with deficit amelioration in a rat model of spinal cord injury.2021

    • Author(s)
      Kajitani T, Endo T, Iwabuchi N, Inoue T, Takahashi Y, Abe T, Niizuma K, Tominaga T.
    • Journal Title

      J Neurosurg Spine.

      Volume: Jan 1 Issue: 4 Pages: 1-8

    • DOI

      10.3171/2020.7.spine20293

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09448
  • [Journal Article] Muse細胞を用いたてんかん原性治癒手法の確立2020

    • Author(s)
      大沢伸一郎 新妻邦泰 冨永悌二
    • Journal Title

      Medical Science Digest

      Volume: 46 Pages: 56-57

    • Data Source
      KAKENHI-PROJECT-18K08960
  • [Journal Article] Muse細胞によるてんかん原性治癒手法の確立.2020

    • Author(s)
      大沢伸一郎 新妻邦泰 冨永悌二
    • Journal Title

      Med Sci Digest.

      Volume: 25 Pages: 56-58

    • Data Source
      KAKENHI-PROJECT-18K08960
  • [Journal Article] Intravenously Transplanted Human Multilineage-Differentiating Stress-Enduring Cells Afford Brain Repair in a Mouse Lacunar Stroke Model.2020

    • Author(s)
      Abe T, Aburakawa D, Niizuma K, Iwabuchi N, Kajitani T, Wakao S, Kushida Y, Dezawa M, Borlongan CV, Tominaga T.
    • Journal Title

      Stroke.

      Volume: 51(2) Issue: 2 Pages: 601-611

    • DOI

      10.1161/strokeaha.119.026589

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22648, KAKENHI-PROJECT-17H01583, KAKENHI-PROJECT-17K15540, KAKENHI-PROJECT-20K07218
  • [Journal Article] What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review2020

    • Author(s)
      Saqr Khalid M、Rashad Sherif、Tupin Simon、Niizuma Kuniyasu、Hassan Tamer、Tominaga Teiji、Ohta Makoto
    • Journal Title

      Journal of Cerebral Blood Flow & Metabolism

      Volume: - Issue: 5 Pages: 1021-1039

    • DOI

      10.1177/0271678x19854640

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04745
  • [Journal Article] Prolonged/delayed cerebral hyperperfusion in adult patients with moyamoya disease with RNF213 gene polymorphism c.14576G>A (rs112735431) after superficial temporal artery middle cerebral artery anastomosis2020

    • Author(s)
      Tashiro Ryosuke、Fujimura Miki、Katsuki Masahito、Nishizawa Taketo、Tomata Yasutake、Niizuma Kuniyasu、Tominaga Teiji
    • Journal Title

      Journal of Neurosurgery

      Volume: - Issue: 2 Pages: 1-8

    • DOI

      10.3171/2020.6.jns201037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09362
  • [Journal Article] Optimal Timing of Extracranial-Intracranial Bypass with Microsurgical Trapping for Ruptured Blister Aneurysms of the Internal Carotid Artery.2020

    • Author(s)
      Endo H, Fujimura M, Shimizu H, Endo T, Omodaka S, Inoue T, Sato K, Niizuma K, Tominaga T.
    • Journal Title

      World Neurosurg

      Volume: 136 Pages: e567-e577

    • DOI

      10.1016/j.wneu.2020.01.081

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08934
  • [Journal Article] The hemodynamic complexities underlying transient ischemic attacks in early-stage Moyamoya disease: an exploratory CFD study2020

    • Author(s)
      Rashad Sherif、Saqr Khalid M.、Fujimura Miki、Niizuma Kuniyasu、Tominaga Teiji
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 3700-3700

    • DOI

      10.1038/s41598-020-60683-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04745, KAKENHI-PROJECT-17K10815, KAKENHI-PROJECT-20K09362
  • [Journal Article] Significance of quantitative cerebral blood flow measurement in the acute stage after revascularization surgery for adult moyamoya disease: Implication for the pathological threshold of local cerebral hyperperfusion2019

    • Author(s)
      Kameyama M, Fujimura M, Tashiro R, Sato K, Endo H, Niizuma K, Mugikura S, Tominaga T
    • Journal Title

      Cerebrovasc Dis

      Volume: 48 Issue: 3-6 Pages: 217-225

    • DOI

      10.1159/000504835

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Journal Article] Circumferential wall enhancement in evolving intracranial aneurysms on magnetic resonance vessel wall imaging2019

    • Author(s)
      Omodaka Shunsuke、Endo Hidenori、Niizuma Kuniyasu、Fujimura Miki、Inoue Takashi、Endo Toshiki、Sato Kenichi、Sugiyama Shin-ichiro、Tominaga Teiji
    • Journal Title

      Journal of Neurosurgery

      Volume: 131 Issue: 4 Pages: 1262-1268

    • DOI

      10.3171/2018.5.jns18322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04745
  • [Journal Article] 脳梗塞におけるMuse細胞を用いた治用戦略2019

    • Author(s)
      新妻邦泰、冨永悌二
    • Journal Title

      血液フロンティア

      Volume: 29 Pages: 47-57

    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Journal Article] Incidence and risk factors of the watershed shift phenomenon after superficial temporal artery-middle cerebral artery anastomosis for adult moyamoya disease2019

    • Author(s)
      Tashiro R, Fujimura M, Kameyama M, Mugikura S, Endo H, Takeuchi Y, Tomata Y, Niizuma K, Tominaga T
    • Journal Title

      Cerebrovasc Dis

      Volume: 47 Issue: 3-4 Pages: 178-187

    • DOI

      10.1159/000500802

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Journal Article] Genetic analysis of Ring Finger Protein 213 (RNF213) c.14576G>A polymorphism in patients with vertebral artery dissection: a comparative study with moyamoya disease2019

    • Author(s)
      Tashiro R, Fujimura M, Sakata H, Endo H, Tomata Y, Sato-Maeda M, Niizuma K, Tominaga T
    • Journal Title

      Neurol Res

      Volume: 41 Issue: 9 Pages: 811-816

    • DOI

      10.1080/01616412.2019.1615726

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Journal Article] Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study2019

    • Author(s)
      Tashiro R, Niizuma K, Khor SS, Tokunaga K, Fujimura M, Sakata H, Endo H, Inoko H, Ogasawara K, Tominaga T
    • Journal Title

      PLoS One

      Volume: 14 Issue: 8 Pages: e0220858-e0220858

    • DOI

      10.1371/journal.pone.0220858

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Journal Article] Biphasic development of focal cerebral hyperperfusion after revascularization surgery for adult moyamoya disease associated with autosomal dominant polycystic kidney disease2018

    • Author(s)
      Tashiro R, FUJIMURA M, Endo H, Endo T, Niizuma K, Tominaga T
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 27 Issue: 11 Pages: 3256-3260

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.07.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Journal Article] Stress-induced tRNA cleavage and tiRNA generation in rat neuronal PC12 cells2018

    • Author(s)
      Alaa E、Mishima E、Niizuma K、Akiyama Y、Fujimura M、Tominaga T、Abe T
    • Journal Title

      J Neurochem

      Volume: - Issue: 5 Pages: 560-569

    • DOI

      10.1111/jnc.14321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01583, KAKENHI-PROJECT-16K19474
  • [Journal Article] Application of Muse Cell Therapy to Stroke2018

    • Author(s)
      Niizuma K, Borlongan C V, Tominaga T.
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 1103 Pages: 167-186

    • DOI

      10.1007/978-4-431-56847-6_9

    • ISBN
      9784431568452, 9784431568476
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Journal Article] A Novel Chronic Cerebral Hypoperfusion Model with Cognitive Impairment and Low Mortality Rate in Rats2018

    • Author(s)
      Mansour A、Niizuma K、Rashad S、Sumiyoshi A、Endo H、Endo T、Sato K、Kawashima R、Tominaga
    • Journal Title

      J Neurosurg

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Journal Article] Increased serum production of soluble CD163 and CXCL5 in patients with moyamoya disease: Involvement of intrinsic immune reaction in its pathogenesis2018

    • Author(s)
      Fujimura M, Fujimura T, Kakizaki A, Sato-Maeda M, Niizuma K, Tomata Y, Aiba S, Tominaga T
    • Journal Title

      Brain Res

      Volume: 1679 Pages: 39-44

    • DOI

      10.1016/j.brainres.2017.11.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10815, KAKENHI-PROJECT-16K10143
  • [Journal Article] Paradoxical association of symptomatic local vasogenic edema with global cerebral hypoperfusion after direct revascularization surgery for adult moyamoya disease2018

    • Author(s)
      Tashiro R, Fujimura M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T
    • Journal Title

      Tashiro R, FUJIMURA M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T

      Volume: - Issue: 8 Pages: e172-e176

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.03.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10815, KAKENHI-PROJECT-17H04255, KAKENHI-PROJECT-26461877
  • [Journal Article] Impact of bifurcation angle and inflow coefficient on the rupture risk of bifurcation type basilar artery tip aneurysms.2017

    • Author(s)
      Sherif Rashad, Shin-ichiro Sugiyama, Kuniyasu Niizuma, Kenichi Sato, Hidenori Endo, Shunsuke Omodaka, Yasushi Matsumoto, Miki Fujimura, Teiji Tominaga
    • Journal Title

      J Neurosurg

      Volume: in press Issue: 3 Pages: 723-730

    • DOI

      10.3171/2016.10.jns161695

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01102, KAKENHI-PROJECT-17H01583
  • [Journal Article] Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: Cerebral hyperperfusion and remote ischemia caused by the 'watershed shift'2017

    • Author(s)
      Tu XK, Fujimura M, Rashad S, Mugikura S, Sakata H, Niizuma K, Tominaga T
    • Journal Title

      Neurosurg Rev

      Volume: - Issue: 3 Pages: 507-512

    • DOI

      10.1007/s10143-017-0845-9

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-26461877, KAKENHI-PROJECT-17K10815, KAKENHI-PROJECT-17H04255
  • [Journal Article] De novo development of moyamoya disease in an adult female with a genetic variant of the RNF-213 gene: case report2017

    • Author(s)
      Tashiro R, Fujimura M, Niizuma K, Endo H, Sakata H, Sato-Maeda M, Tominaga T
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 26 Issue: 1 Pages: e8-e11

    • DOI

      10.1016/j.jstrokecerebrovasdis.2016.09.035

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Journal Article] Transient Global Cerebral Ischemia Induces RNF213, a Moyamoya Disease Susceptibility Gene, in Vulnerable Neurons of the Rat Hippocampus CA1 Subregion and Ischemic Cortex.2017

    • Author(s)
      Sato-Maeda M, Fujimura M, Rashad S, Morita-Fujimura Y, Niizuma K, Sakata H, Ikawa S, Tominaga T.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 26 Issue: 9 Pages: 1904-1911

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.06.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07152, KAKENHI-PROJECT-17K10815
  • [Journal Article] Embolization of ruptured arteriovenous malformations in the cerebellopontine angle cistern.2017

    • Author(s)
      Endo H, Osawa SI, Matsumoto Y, Endo T, Sato K, Niizuma K, Fujimura M, Tominaga T.
    • Journal Title

      Neurosurg Rev.

      Volume: 印刷中 Issue: 1 Pages: 173-182

    • DOI

      10.1007/s10143-017-0832-1

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26861138
  • [Journal Article] Prediction of the Initiation of Cerebral Aneurysms2017

    • Author(s)
      Kuniyasu Niizuma, Takanobu Yagi, Shin-ichiro Sugiyama, Atsuhiro Nakagawa, Teiji Tominaga
    • Journal Title

      The 3nd International Symposium on Multidisciplinary Computational Anatomy

      Volume: 3

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01102
  • [Journal Article] Navigation-guided clipping of a de novo aneurysm associated with superficial temporal artery-middle cerebral artery bypass combined with indirect pial synangiosis in a patient with moyamoya disease2017

    • Author(s)
      Aburakawa D, Fujimura M, Niizuma K, Sakata H, Endo H, Tominaga T
    • Journal Title

      Neurosurg Rev

      Volume: 40 Issue: 3 Pages: 517-521

    • DOI

      10.1007/s10143-017-0866-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Journal Article] Transient middle cerebral artery occlusion in mice induces neuronal expression of RNF213, a susceptibility gene for moyamoya disease.2016

    • Author(s)
      Sato-Maeda M, Fujimura M, Kanoke A, Morita-Fujimura Y, Niizuma K, Tominaga T.
    • Journal Title

      Brain Res

      Volume: 1630 Pages: 50-55

    • DOI

      10.1016/j.brainres.2015.10.055

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Journal Article] Temporal profile of magnetic resonance angiography and decreased ratio of regulatory T cells after immunological adjuvant administration to mice lacking RNF213, a susceptibility gene for moyamoya disease.2016

    • Author(s)
      Kanoke A, Fujimura M, Niizuma K, Fujimura T, Kakizaki A, Ito A, Sakata H, Sato-Maeda M, Kure S, Tominaga T.
    • Journal Title

      Brain Res

      Volume: in press Pages: 1-9

    • DOI

      10.1016/j.brainres.2016.03.009

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15H04871, KAKENHI-PROJECT-15K15385
  • [Journal Article] Prediction of the initiation of cerebral aneurysms2016

    • Author(s)
      Kuniyasu Niizuma, Takanobu Yagi, Shin-ichiro Sugiyama, Atsuhiro Nakagawa, and Teiji Tominaga
    • Journal Title

      The 2nd International Symposium on Multidisciplinary Computational Anatomy

      Volume: -

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01102
  • [Journal Article] Long-term follow-up of pediatric Moyamoya disease treated by combined direct-indirect revascularization surgery: Single institute experience with surgical and perioperative management.2016

    • Author(s)
      Rashad S, Fujimura M, Niizuma K, Endo H, Tominaga T.
    • Journal Title

      Neurosurg Rev

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Journal Article] Long-term follow-up of pediatric Moyamoya disease treated by combined direct-indirect revascularization surgery: Single institute experience with surgical and perioperative management2016

    • Author(s)
      Rashad S, Fujimura M, Niizuma K, Endo H, Tominaga T
    • Journal Title

      Neurosurg Rev

      Volume: 39 Issue: 4 Pages: 615-623

    • DOI

      10.1007/s10143-016-0734-7

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Journal Article] Prediction of the initiation of cerebral aneurysms2016

    • Author(s)
      Kuniyasu Niizuma, Takanobu Yagi, Shin-ichiro Sugiyama, Atsuhiro Nakagawa, and Teiji Tominaga
    • Journal Title

      The 2nd International Symposium on Multidisciplinary Computational Anatomy

      Volume: -

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25713051
  • [Journal Article] Quantitative analysis of early postoperative cerebral blood flow contributes to the prediction and diagnosis of cerebral hyperperfusion syndrome after revascularization surgery for moyamoya disease2015

    • Author(s)
      FUJIMURA M, Niizuma K, Endo H, Sato K, Inoue T, Shimizu H, Tominaga T
    • Journal Title

      Neurol Res

      Volume: 37 Issue: 2 Pages: 131-138

    • DOI

      10.1179/1743132814y.0000000432

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K10289
  • [Journal Article] もやもや病に対する血行再建術後・過灌流に対するミノサイクリンを用いた周術期管理の現状と問題点.2015

    • Author(s)
      藤村幹、新妻邦泰、遠藤英徳、佐藤健一、井上敬、冨永悌二.
    • Journal Title

      脳卒中の外科

      Volume: 43 Pages: 136-140

    • NAID

      130005072756

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Journal Article] Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease.2015

    • Author(s)
      Ito A, Fujimura M, Niizuma K, Kanoke A, Sakata H, Morita-Fujimura Y, Kikuchi A, Kure S, Tominaga T.
    • Journal Title

      Brain Res

      Volume: 16 Pages: 310-320

    • DOI

      10.1016/j.brainres.2014.11.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670470, KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K15385, KAKENHI-PROJECT-15H04871
  • [Journal Article] Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histological analysis in mice with the R4859K mutation of RNF213, the susceptibility gene for moyamoya disease.2015

    • Author(s)
      Kanoke A, Fujimura M, Niizuma K, Ito A, Sakata H, Sato-Maeda M, Morita-Fujimura Y, Kure S, and Tominaga T.
    • Journal Title

      Brain Res

      Volume: 1624 Pages: 497-505

    • DOI

      10.1016/j.brainres.2015.07.039

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K15385, KAKENHI-PROJECT-15H04871
  • [Journal Article] 脳動脈瘤壁の硬化性変化2014

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、松本康史、冨永悌二
    • Journal Title

      脳神経外科速報

      Volume: 24 Pages: 640-643

    • Data Source
      KAKENHI-PROJECT-25713051
  • [Journal Article] Increased vascular MMP-9 in mice lacking RNF213: moyamoya disease susceptibility gene.2014

    • Author(s)
      Sonobe S, Fujimura M, Niizuma K, Fujimura T, Furudate S, Nishijima Y, Kure S, Tominaga T.
    • Journal Title

      Neuroreport

      Volume: 1552 Issue: 18 Pages: 64-71

    • DOI

      10.1097/wnr.0000000000000289

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670470, KAKENHI-PROJECT-26462150
  • [Journal Article] Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a susceptibility gene2014

    • Author(s)
      FUJIMURA M, Sonobe S, Nishijima Y, Niizuma K, Sakata H, Kure S, Tominaga T
    • Journal Title

      J Stroke

      Volume: 16 Pages: 65-72

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Journal Article] Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213 : a susceptibility gene for moyamoya disease2014

    • Author(s)
      Sonobe S, Fujimura M, Niizuma K, Nishijima Y, Ito A, Shimizu H, Kikuchi A, Arai-Ichinoi N, Kure S, T ominaga T
    • Journal Title

      Brain Res

      Volume: 1552 Pages: 64-71

    • DOI

      10.1016/j.brainres.2014.01.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390267, KAKENHI-PROJECT-23390268, KAKENHI-PROJECT-24659486, KAKENHI-PROJECT-24659642, KAKENHI-PROJECT-25670470, KAKENHI-PROJECT-26462150
  • [Journal Article] Relative residence time prolongation in intracranial aneurysms: a possible association with atherosclerosis.2013

    • Author(s)
      Sugiyama S, Niizuma K, Nakayama T, Shimizu H, Endo H, Inoue T, Fujimura M, Ohta M, Takahashi A, Tominaga T.
    • Journal Title

      Neurosurgery

      Volume: 73 Issue: 5 Pages: 767-776

    • DOI

      10.1227/neu.0000000000000096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25713051
  • [Patent] 脳血管性認知症の治療または予防剤2022

    • Inventor(s)
      新妻邦泰、冨永悌二
    • Industrial Property Rights Holder
      国立大学法人東北大学、生命科学インスティテュート株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-539261
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-20H03560
  • [Patent] AGENT FOR TREATING OR PREVENTING CEREBROVASCULAR DEMENTIA2022

    • Inventor(s)
      新妻邦泰、冨永悌二
    • Industrial Property Rights Holder
      国立大学法人東北大学、生命科学インスティテュート株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20H03560
  • [Presentation] もやもや病の病期進行予測における膠原線維架橋アミノ酸エラスチン血中濃度測定 の有用性の検討2024

    • Author(s)
      田代亮介、安藤力、井上智夫、三ケ木彩芽、尾崎弾、冨永慶太、井上敬、石田朋久、藤村幹、臼杵豊展、遠藤英徳、新妻邦泰、冨永悌二
    • Organizer
      Stroke 2024
    • Data Source
      KAKENHI-PROJECT-21H04835
  • [Presentation] Neuronal sensitivity to oxidative stress is an epi and post transcriptional consequence to neuronal differentiation.2023

    • Author(s)
      Yuan Zhou, Sherif Rashad , Kuniyasu Niizuma;
    • Organizer
      RNA Japan meeting 2023
    • Data Source
      KAKENHI-PROJECT-23K27432
  • [Presentation] 亜急性期脊髄損傷モデルラットに対するMuse細胞移植治療2023

    • Author(s)
      高橋義晴、遠藤俊毅、梶谷卓未、中屋敷諄、井上智夫、新妻邦泰、冨永悌二
    • Organizer
      第83回日本脳神経外科学会 学術集会(シンポジウム)
    • Data Source
      KAKENHI-PROJECT-23K24439
  • [Presentation] 破裂脳動脈瘤の出血点予測における瘤壁造影効果の有用性2023

    • Author(s)
      面高俊介 遠藤英徳 杉山慎一郎 新妻邦泰 冨永悌二
    • Organizer
      Stroke2023
    • Data Source
      KAKENHI-PROJECT-21K09117
  • [Presentation] 動眼神経麻痺で発症した未破裂内頚動脈-後交通動脈分岐部動脈瘤の瘤壁造影効果2023

    • Author(s)
      面高俊介 坂田洋之 新妻邦泰 松本康史 遠藤英徳
    • Organizer
      第39回日本脳神経血管内治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K09117
  • [Presentation] tRNA Queuosine modifications regulate translationalresponse to mitochondrial stress2023

    • Author(s)
      Sherif Rashad , Shadi Al-Mesitef , Abdulrahman Mousa , Daisuke Saigusa , Thomas Begley , Peter Dedon , Kuniyasu Niizuma
    • Organizer
      Cell bio 2023 (American society for cell biology meeting)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27432
  • [Presentation] Ribosome collisions is targetable vulnerability inglioma during ferroptosis exposure2023

    • Author(s)
      Tianxiang Zhang, Sherif Rashad , Kuniyasu Niizuma;
    • Organizer
      Cell bio 2023 (American society for cell biology meeting)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27432
  • [Presentation] Optimal strategy for mechanical thrombectomy based on preoperative imaging diagnosis ofthrombus composition2023

    • Author(s)
      Hiroyuki Sakata, Masayuki Ezura, Kuniyasu Niizuma, Teiji Tominaga, Hidenori Endo
    • Organizer
      The 16th Korea-Japan Joint Conference on Surgery for Cerebral Stroke
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K08536
  • [Presentation] SAMD4A regulates neuronal differentiation andsensitivity to oxidative stress via altering mRNA stability2023

    • Author(s)
      Yuan Zhou, Sherif Rashad , Kuniyasu Niizuma;
    • Organizer
      Cell bio 2023 (American society for cell biology meeting)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27432
  • [Presentation] 造影MRIにおける瘤壁造影効果を用いた破裂脳動脈瘤の出血点予測2022

    • Author(s)
      面高俊介 遠藤英徳 杉山慎一郎 新妻邦泰 冨永悌二
    • Organizer
      第81回日本脳神経外科学会総会
    • Data Source
      KAKENHI-PROJECT-21K09117
  • [Presentation] The clinical utility of the RNF213 founder variant (rs112735431) in the management of patients with moyamoya disease2022

    • Author(s)
      Ryosuke Tashiro, Hidenori Endo, Dan Ozaki, Taketo Nishizawa, Keita Tominaga, Yasutake Tomata, Kuniyasu Niizuma, Miki Fujimura, Teiji Tominaga
    • Organizer
      WINC MOYAMOYA 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04835
  • [Presentation] RNF213 loss of function reshapes vascular transcriptome and spliceosome2022

    • Author(s)
      Sherif Rashad, Liyin Zhang, Kuniyasu Niizuma, Teiji Tominaga
    • Organizer
      Brain Japan 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04835
  • [Presentation] Rnf213遺伝子変異による抗原提示能低下は抗原特異的T細胞応答の低下に寄与する2022

    • Author(s)
      田代亮介、新妻邦泰、笠松純、奥山祐子、Sherif Rashad、菊池敦生、藤村幹、呉繁夫、石井直人、冨永悌二
    • Organizer
      Stroke 2022
    • Data Source
      KAKENHI-PROJECT-21H04835
  • [Presentation] 動眼神経麻痺で発症した未破裂内頚動脈-後交通動脈分岐部動脈瘤のMRI瘤壁造影効果2021

    • Author(s)
      面高俊介 遠藤英徳 新妻邦泰 松本康史 冨永悌二
    • Organizer
      第80回日本脳神経外科学会総会
    • Data Source
      KAKENHI-PROJECT-21K09117
  • [Presentation] 脳主幹動脈閉塞症に対し急性期緊急バイパスを施行した症例の検討2021

    • Author(s)
      井上敬、藤村幹、遠藤英徳、坂田洋之、江面正幸、上之原広司、新妻邦泰、冨永悌二
    • Organizer
      第39回The Mt. Fuji Workshop on CVD
    • Data Source
      KAKENHI-PROJECT-21K09092
  • [Presentation] CEA術中 ICG による術後過灌流予測2021

    • Author(s)
      井上敬、石田朋久、坂田洋之、遠藤英徳、江面正幸、上之原広司、斉藤敦志、新妻邦泰、冨永悌二
    • Organizer
      第44回日本脳神経CI学会
    • Data Source
      KAKENHI-PROJECT-21K09092
  • [Presentation] 成人もやもや病に対するバイパス術後の遅発性過灌流とRNF213遺伝子c.14576G>A多型の関連についての検討2020

    • Author(s)
      藤村幹、田代亮介、勝木将人、西澤威人、遠又靖丈、新妻邦泰、冨永悌二
    • Organizer
      第63回日本脳循環代謝学会総会
    • Data Source
      KAKENHI-PROJECT-20K09362
  • [Presentation] 成人もやもや病に対するバイパス術後の遅発性過灌流とRNF213遺伝子c.14576G>A多型の関連についての検討2020

    • Author(s)
      藤村幹、田代亮介、勝木将人、西澤威人、遠又靖丈、新妻邦泰、冨永悌二
    • Organizer
      第79回日本脳神経外科学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K09362
  • [Presentation] 脳動脈瘤に対する治療医シミュレーション・再発予測2020

    • Author(s)
      新妻邦泰
    • Organizer
      第43回脳神経CI学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04745
  • [Presentation] 幹細胞治療の基礎と臨床応用(Muse細胞):脳卒中2019

    • Author(s)
      新妻邦泰
    • Organizer
      創薬薬理フォーラム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] 脳梗塞に対するMuse細胞治療の開発2019

    • Author(s)
      新妻邦泰
    • Organizer
      第46回日本臓器保存生物医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] A rat model of venous sinus occlusion; impact on cerebral blood flow2019

    • Author(s)
      Hamasaki R,Shimizu H,Niizuma K,Tominaga T
    • Organizer
      第29回国際脳循環代謝学会総会(Brain&BrainPET 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08934
  • [Presentation] Muse細胞による再生医療について2019

    • Author(s)
      新妻邦泰
    • Organizer
      第1回日本スティミュレーションセラピー学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] Muse細胞による治療開発2019

    • Author(s)
      新妻邦泰
    • Organizer
      第10回日本ニューロリハビリテーション学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] Muse細胞を用いた脳梗塞再生治療2019

    • Author(s)
      新妻 邦泰
    • Organizer
      第44回日本脳卒中学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] 成人もやもや病に対するSTA-MCAバイパス術後急性期の脳循環動態と臨床像についての検討2019

    • Author(s)
      藤村幹、田代亮介、亀山昌幸、佐藤健一、遠藤英徳、新妻邦泰、冨永悌二
    • Organizer
      第62回 日本脳循環代謝学会総会 (仙台)
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Presentation] 脳梗塞に対する新規治療法の開発2019

    • Author(s)
      新妻邦泰
    • Organizer
      日本臨床化学会第59回年次集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] Computational hemodynamic analysis: towards clinical application in neuro-endovascular therapy2019

    • Author(s)
      杉山慎一郎 新妻邦泰 冨永悌二
    • Organizer
      第35回日本脳神経血管内治療学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K08961
  • [Presentation] An experimental model of hyperperfusion following chronic cerebral ischemia in rats: effect of estrogen deficiency and hypertension2019

    • Author(s)
      Hatakeyama J,Furuyama Y,Niizuma K,Tominaga T,Shimizu H
    • Organizer
      第29回国際脳循環代謝学会総会(Brain&BrainPET 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08934
  • [Presentation] Muse Cell Transplantation to Treat Cerebral Ischemia2019

    • Author(s)
      Niizuma K.
    • Organizer
      The 14th Korea-Japan Joint Conference on Surgery for Cerebral Stroke (KJJC2018)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] An experimental model of hyperperfusion following chronic cerebral ischemia in rats: effect of estrogen deficiency and hypertension.2019

    • Author(s)
      Junya Hatakeyama, Yosuke Furuyama, Kuniyasu Niizuma, Teiji Tominaga, Hiroaki Shimizu
    • Organizer
      BRAIN & BRAIN PET 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08934
  • [Presentation] Muse 細胞による脳梗塞治療2018

    • Author(s)
      新妻 邦泰
    • Organizer
      日本脳神経外科学会第77回総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] Muse Cell Treatment for Cerebral Ischemia2018

    • Author(s)
      Niizuma K、Tominaga T
    • Organizer
      Pan Pacific Symposium on Stem Cells and Cancer Research
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] コンピュータを用いた脳動脈瘤の可視化と定量化2018

    • Author(s)
      杉山慎一郎 新妻邦泰 冨永悌二 ほか
    • Organizer
      一般社団法人日本脳神経外科学会 第77回学術総会
    • Data Source
      KAKENHI-PROJECT-18K08961
  • [Presentation] Muse細胞による脳梗塞治療2018

    • Author(s)
      新妻邦泰 冨永悌二
    • Organizer
      Stroke2018
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] MUSE細胞2018

    • Author(s)
      新妻 邦泰
    • Organizer
      第2回日本神経細胞治療研究会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] Development of a New Thrombolytic Agent and Stem Cell Therapy for Cerebral Ischemia2017

    • Author(s)
      Niizuma K、Tominaga T
    • Organizer
      Ralph L. Nachman Vascular and Biology Seminar Series at Weill Cornell Medical College
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01583
  • [Presentation] もやもや病に対する直接間接複合血行再建術:頭蓋形成における生体性吸収性プレート併用法の長期成績2017

    • Author(s)
      藤村幹,遠藤英徳,新妻邦泰,坂田洋之,冨永悌二
    • Organizer
      第9回日本整容脳神経外科研究会(甲府)
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Presentation] Current status and limitation of the basic research of moyamoya disease using RNF213 mutant mice; Prospect for the future clinical application2017

    • Author(s)
      FUJIMURA M, Niizuma K, Kanoke A, Fujimura T, Kure S, Tominaga T
    • Organizer
      第76回日本脳神経外科学会 学術総会(名古屋)
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Presentation] The CFD rupture challenge 2013: Prediction of rupture status in intracranial aneurysms2016

    • Author(s)
      杉山慎一郎, 新妻邦泰, 遠藤英徳, 佐藤健一, 松本康史, 船本健一, 太田信, 冨永悌二
    • Organizer
      第38回日本脳神経CI学会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-02-13
    • Data Source
      KAKENHI-PROJECT-25713051
  • [Presentation] 脳動脈瘤のCFD2016

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、佐藤健一、藤村幹、松本康史、冨永悌二
    • Organizer
      第9回脳血管手術研究会
    • Place of Presentation
      名古屋
    • Invited
    • Data Source
      KAKENHI-PROJECT-26282141
  • [Presentation] Bifurcation configuration as a criterion affecting risk of aneurysm rupture in Basilar artery aneurysms2016

    • Author(s)
      Sherif Rashad, Shin-ichiro Sugiyama, Kuniyasu Niizuma, Kenichi Sato, Hidenori Endo, Yasushi Matsumoto, Miki Fujimura, Teiji Tominaga
    • Organizer
      European congress on computational methods in applied sciences and engineering
    • Place of Presentation
      Greece
    • Year and Date
      2016-06-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25713051
  • [Presentation] Prediction of the initiation of cerebral aneurysms2016

    • Author(s)
      Kuniyasu Niizuma, Takanobu Yagi, Shin-ichiro Sugiyama, Atsuhiro Nakagawa, and Teiji Tominaga
    • Organizer
      The 2nd International Symposium on Multidisciplinary Computational Anatomy
    • Place of Presentation
      Nagoya
    • Year and Date
      2016-02-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01102
  • [Presentation] Outcome of revascularization surgery for elderly patients with moyamoya disease over the age of 60 years: Single institute experience.2015

    • Author(s)
      Fujimura M, Niizuma K, Endo H, Sakata H, Tominaga T.
    • Organizer
      4th International Moyamoya Meeting.
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2015-07-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Presentation] Prophylactic blood pressure lowering with intravenous minocycline administration as secure and effective postoperative management after revascularization surgery for moyamoya disease.2015

    • Author(s)
      Fujimura M, Niizuma K, Endo H, Sakata H, Tominaga T.
    • Organizer
      15th Interim Meeting of the World Federation of Neurological Societies.
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2015-09-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Presentation] 脳疾患領域におけるComputational Fluid Dynamics: 最新の知見2015

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、佐藤健一、藤村幹、松本康史、冨永悌二
    • Organizer
      2015-02-25_SENDAI 脳・心血管疾患 JOINT Symposium 2015
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Year and Date
      2015-02-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-25713051
  • [Presentation] もやもや病の病態解明:もやもや病疾患感受性遺伝子RNF213遺伝子変異マウスを用いた検討.2015

    • Author(s)
      藤村幹、新妻邦泰、園部真也、伊藤明、鹿毛淳史、呉繁夫、冨永悌二.
    • Organizer
      日本脳神経外科学会第74回学術総会.
    • Place of Presentation
      札幌(ロイトン札幌)
    • Year and Date
      2015-10-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Presentation] 脳疾患領域におけるComputational Fluid Dynamics: 最新の知見2015

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、佐藤健一、藤村幹、松本康史、冨永悌二
    • Organizer
      SENDAI 脳・心血管疾患 JOINT Symposium 2015
    • Place of Presentation
      仙台
    • Year and Date
      2015-02-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-26282141
  • [Presentation] 脳動脈瘤に対する数値流体力学的アプローチ2014

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、清水宏明、藤村幹、井上敬、近藤竜史、松本康史、船本健一、冨永悌二
    • Organizer
      第43回日本脳卒中の外科学会学術総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-25713051
  • [Presentation] 破裂瘤の治療後早期に破裂した前交通動脈瘤の一例  ー 血行力学的変化の検討 ー2013

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、鈴木一郎、近藤竜史、松本康史、冨永悌二
    • Organizer
      第29回日本脳神経血管内治療学会学術総会
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-25713051
  • [Presentation] CFD解析による脳動脈瘤壁性状の予測2013

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、清水宏明、近藤竜史、松本康史、長嶺義秀、藤原悟、冨永悌二
    • Organizer
      第22回日本脳ドック学会総会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-25713051
  • [Presentation] Stagnant Blood Flow in Intracranial Aneurysms2013

    • Author(s)
      Shin-ichiro Sugiyama, Kuniyasu Niizuma, Kenichi Funamoto, Toshio Nakayama, TeijiTominaga
    • Organizer
      ICBME 2013
    • Place of Presentation
      Singapore, Singapore
    • Data Source
      KAKENHI-PROJECT-25713051
  • [Presentation] A Case of Anterior Communicating Artery Aneurysm Ruptured after the Treatment of Another Ruptured Aneurysm

    • Author(s)
      Niizuma K, Sugiyama S, Endo H, Sato K, Matsumoto Y, Fujimura M, Tominaga T
    • Organizer
      Asia Pacific Stroke Conference 2014
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2014-09-12 – 2014-09-14
    • Data Source
      KAKENHI-PROJECT-25713051
  • [Presentation] 破裂瘤の治療後早期に破裂した前交通動脈瘤の一例  ー 血行力学的変化の検討 ー

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、佐藤健一、松本康史、藤村幹、冨永悌二
    • Organizer
      第26回日本脳循環代謝学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2014-11-21 – 2014-11-22
    • Data Source
      KAKENHI-PROJECT-25713051
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