Sakamori Ryotaro 阪森亮太郎

… Alternative Names

Researcher Number	10644685
Other IDs	https://orcid.org/0000-0002-1580-607X
Affiliation (Current)	2022: 大阪大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2016 – 2020: 大阪大学, 医学系研究科, 助教 2014 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 細胞内輸送 / 脂肪細胞 / 脂肪肝 / Rab11a / 国際情報交換 / アメリカ合衆国 / 細胞極性 / 脂肪生成 / 癌 / 肝細胞 … More Except Principal Investigator … More

Intracellular transport in the progress of chronic liver diseasePrincipal Investigator
- Principal Investigator
  
  阪森亮太郎
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
Elucidation of regulatory mechanism of cancer microenvironment through stromal cell autophagy in hepatocellular carcinoma
- Principal Investigator
  
  疋田隼人
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
Cell-to-cell communication and pathogenesis triggered by hepatocyte cell death in the liver
- Principal Investigator
  
  Tetsuo Takehara
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
Elucidation of the effect of mitochondrial DNA release by Bak/Bax activation on chronic liver disease
- Principal Investigator
  
  Hikita Hayato
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Intracellular trafficking in liver diseasePrincipal Investigator
- Principal Investigator
  
  Sakamori Ryotaro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Development of genetically-defined hepatocarcinogenesis animal model and establishment of personalized cancer immunotherapy
- Principal Investigator
  
  Tatsumi Tomohide
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Examination of the mechanisms of which radiation induces liver disorder for expanding radiation therapy
- Principal Investigator
  
  Tatsumi Tomohide
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Intracellular trafficking in the liverPrincipal Investigator
- Principal Investigator
  
  Ryotaro Sakamori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University

All 2021 2020 2019 2018 2017 2015 2014

All Journal Article Presentation

[Journal Article] Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production.2021
- Author(s)
  Myojin Y, Hikita H, Sugiyama M, Sasaki Y, Fukumoto K, Sakane S, Makino Y, Takemura N, Yamada R, Shigekawa M, Kodama T, Sakamori R, Kobayashi S, Tatsumi T, Suemizu H, Eguchi H, Kokudo N, Mizokami M, Takehara T.
- Journal Title
  
  Gastroenterology
  
  Volume: 160 Pages: 1741-1754
- DOI
  10.1053/j.gastro.2020.12.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-19K17489
[Journal Article] Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration.2021
- Author(s)
  Nozaki Y, Hikita H, Tanaka S, Fukumoto K, Urabe M, Sato K, Myojin Y, Doi A, Murai K, Sakane S, Saito Y, Kodama T, Sakamori R, Tatsumi T, Takehara T.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Pages: 3363-3363
- DOI
  10.1038/s41598-021-83082-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661
[Journal Article] Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis and tumorigenesis.2021
- Author(s)
  Mizutani N, Hikita H, Saito Y, Myojin Y, Sato K, Urabe M, Kurahashi T, Shiode Y, Sakane S, Murai K, Nozaki Y, Kodama T, Sakamori R, Yoshida Y, Tatsumi T, Takehara T.
- Journal Title
  
  American Journal of Physiology-Gastrointestinal and Liver Physiology
  
  Volume: in press
- DOI
  10.1152/ajpgi.00370.2020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661
[Journal Article] Hepatocellular carcinoma occurrence does not differ between interferon‐based and interferon‐free treatment with liver histological assessment2020
- Author(s)
  Tahata Yuki、Sakamori Ryotaro、Urabe Ayako、Yamada Ryoko、Ohkawa Kazuyoshi、Hiramatsu Naoki、Hagiwara Hideki、Oshita Masahide、Hijioka Taizo、Tamura Shinji、Imai Yasuharu、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Hepatology Research
  
  Volume: 50 Pages: 313-320
- DOI
  10.1111/hepr.13454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04160
[Journal Article] Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.2020
- Author(s)
  Murai Kazuhiro、Hikita Hayato、Kai Yugo、Kondo Yasuteru、Fukuoka Makoto、Fukutomi Keisuke、Doi Akira、Yamai Takuo、Nakabori Tasuku、Fukuda Ryo、Takahashi Takeshi、Miyakawa Kei、Suemizu Hiroshi、Ryo Akihide、Yamada Ryoko、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Sci Rep
  
  Volume: 10 Pages: 941-941
- DOI
  10.1038/s41598-020-57603-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08374, KAKENHI-PROJECT-17K09424, KAKENHI-PROJECT-18H02368
[Journal Article] Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice.2020
- Author(s)
  Kurahashi Tomohide、Yoshida Yuichi、Ogura Satoshi、Egawa Mayumi、Furuta Kunimaro、Hikita Hayato、Kodama Takahiro、Sakamori Ryotaro、Kiso Shinichi、Kamada Yoshihiro、Wang I-Ching、Eguchi Hidetoshi、Morii Eiichi、Doki Yuichiro、Mori Masaki、Kalinichenko Vladimir V.、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Cell Mol Gastroenterol Hepatol.
  
  Volume: 9 Pages: 425-446
- DOI
  10.1016/j.jcmgh.2019.10.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K09424
[Journal Article] Hypovascular hepatic nodules as a predictive factor for transcatheter arterial chemoembolization refractoriness in hepatocellular carcinoma2019
- Author(s)
  Maesaka Kazuki、Sakamori Ryotaro、Yamada Ryoko、Tahata Yuki、Urabe Ayako、Shigekawa Minoru、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Hepatology Research
  
  Volume: 50 Pages: 365-373
- DOI
  10.1111/hepr.13446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04160
[Journal Article] Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients2019
- Author(s)
  Kegasawa Tadashi、Tatsumi Tomohide、Yoshioka Teppei、Suda Takahiro、Ikezawa Kenji、Nakabori Tasuku、Yamada Ryoko、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Takehara Tetsuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 517 Pages: 84-88
- DOI
  10.1016/j.bbrc.2019.07.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-17K09424
[Journal Article] CRISPR Loss-of-Function Screen Identifies the Hippo Signaling Pathway as the Mediator of Regorafenib Efficacy in Hepatocellular Carcinoma2019
- Author(s)
  Suemura Shigeki、Kodama Takahiro、Myojin Yuta、Yamada Ryoko、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Cancers
  
  Volume: 11 Pages: 1362-1362
- DOI
  10.3390/cancers11091362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K09424
[Journal Article] Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling2019
- Author(s)
  D'Agostino L, Nie Y, Goswami S, Tong K, Yu S, Bandyopadhyay S, Flores J, Zhang X, Balasubramanian I, Joseph I, Sakamori R, Farrell V, Li Q, Yang CS, Gao B, Ferraris RP, Yehia G, Bonder EM, Goldenring JR, Verzi MP, Zhang L, Ip YT, Gao N.
- Journal Title
  
  Cancer Research
  
  Volume: 79 Pages: 4099-4112
- DOI
  10.1158/0008-5472.can-18-4075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09424
[Journal Article] DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway.2019
- Author(s)
  Saito Yoshinobu、Hikita Hayato、Nozaki Yasutoshi、Kai Yugo、Makino Yuki、Nakabori Tasuku、Tanaka Satoshi、Yamada Ryoko、Shigekawa Minoru、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Cell Death Differ.
  
  Volume: 26 Pages: 470-486
- DOI
  10.1038/s41418-018-0131-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09422, KAKENHI-PUBLICLY-17H05508, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-17K09423
[Journal Article] CEACAM1 Is Associated With the Suppression of Natural Killer Cell Function in Patients With Chronic Hepatitis C2018
- Author(s)
  Suda Takahiro、Tatsumi Tomohide、Nishio Akira、Kegasawa Tadashi、Yoshioka Teppei、Yamada Ryoko、Furuta Kunimaro、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Fukuhara Takasuke、Matsuura Yoshiharu、Takehara Tetsuo
- Journal Title
  
  Hepatology Communications
  
  Volume: 2 Pages: 1247-1258
- DOI
  10.1002/hep4.1240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04160
[Journal Article] Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice2018
- Author(s)
  Aono Satoshi、Tatsumi Tomohide、Yoshioka Teppei、Tawara Seiichi、Nishio Akira、Onishi Yoshiki、Fukutomi Keisuke、Nakabori Tasuku、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Takahashi Takeshi、Suemizu Hiroshi、Takehara Tetsuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Pages: 1457-1464
- DOI
  10.1016/j.bbrc.2018.07.063
- Data Source
  KAKENHI-PROJECT-17H04160
[Journal Article] Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.2015
- Author(s)
  Kai Y, Hikita H, Tatsumi T, Nakabori T, Saito Y, Morishita N, Tanaka S, Nawa T, Oze T, Sakamori R, Yakushijin T, Hiramatsu N, Suemizu H, Takehara T.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 50(11) Pages: 1145-1151
- DOI
  10.1007/s00535-015-1108-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461002, KAKENHI-PROJECT-26860503
[Journal Article] Plasmalemma Vesicle Associated Protein Truncation Causes Lethal Protein-Losing Enteropathy in Humans.2015
- Author(s)
  Sakamori R, Zhang L, Gao N.
- Journal Title
  
  Cell Mol Gastroenterol Hepatol.
  
  Volume: 1(4) Pages: 348-349
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461002
[Journal Article] Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche.2015
- Author(s)
  Das S, Yu S, Sakamori R, Vedula P, Feng Q, Flores J, Hoffman A, Fu J, Stypulkowski E, Rodriguez A, Dobrowolski R, Harada A, Hsu W, Bonder EM, Verzi MP, Gao N
- Journal Title
  
  Development
  
  Volume: 142(12) Pages: 2147-2162
- DOI
  10.1242/dev.121046
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461002, KAKENHI-PROJECT-15H04668, KAKENHI-PROJECT-25460269
[Journal Article] Activation of the Mitochondrial Apoptotic Pathway Produces Reactive Oxygen Species and Oxidative Damage in Hepatocytes That Contribute to Liver Tumorigenesis.2015
- Author(s)
  Hikita H, Kodama T, Tanaka S, Saito Y, Nozaki Y, Nakabori T, Shimizu S, Hayashi Y, Li W, Shigekawa M, Sakamori R, Miyagi T, Hiramatsu N, Tatsumi T, Takehara T.
- Journal Title
  
  Cancer Prev Res (Phila).
  
  Volume: 8(8) Pages: 693-701
- DOI
  10.1158/1940-6207.capr-15-0022-t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461002
[Journal Article] Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on γδT cells in mice.2015
- Author(s)
  Nishio K, Miyagi T, Tatsumi T, Mukai K, Yokoyama Y, Yoshioka T, Sakamori R, Hikita H, Kodama T, Shimizu S, Shigekawa M, Nawa T, Yoshihara H, Hiramatsu N, Yamanaka H, Seino K, Takehara T.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 50(11) Pages: 1124-1133
- DOI
  10.1007/s00535-015-1060-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461002
[Journal Article] The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice.2015
- Author(s)
  Yokoyama Y, Miyagi T, Hikita H, Yoshioka T, Mukai K, Nawa T, Sakamori R, Ohkawa K, Hiramatsu N, Takahashi T, Suemizu H, Ryo A, Tatsumi T, Takehara T.
- Journal Title
  
  PLOS One
  
  Volume: 10(12)
- DOI
  10.1371/journal.pone.0144775
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461002, KAKENHI-PROJECT-26290034
[Journal Article] TLR Sorting by Rab11 Endosome in Enterocyte Maintains Intestinal Epithelial-Microbial Homeostasis2014
- Author(s)
  Shiyan Yu, Yingchao Nie, Byron Knowles, Ryotaro Sakamori, Ewa Stypulkowski, Chirag Patel, Soumyashree Das, Veronique Douard, Ronaldo P. Ferraris, Edward M.Bonder, James R. Goldenring, Y. Tomy Ip, Nan Gao
- Journal Title
  
  The EMBO Journal
  
  Volume: 33(17) Pages: 1882-1895
- DOI
  10.15252/embj.201487888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461002
[Journal Article] CDC42 inhibition suppresses progression of incipient intestinal tumors.2014
- Author(s)
  Ryotaro Sakamori, Shiyan Yu, Xiao Zhang, Andrew Hoffman, Jiaxin Sun, Soumyashree Das, Pavan Vedula, Guangxun Li, Jiang Fu, Francesca Walker, Chung S. Yang, Zheng Yi, Wei Hsu, Da-Hai Yu, Lanlan Shen, Alexis J. Rodriguez, Makoto M. Taketo, Edward M. Bonder, Michael P. Verzi, Nan Gao
- Journal Title
  
  Cancer Research
  
  Volume: 74(19) Pages: 5480-5492
- DOI
  10.1158/0008-5472.can-14-0267
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461002
[Journal Article] Global Ablation of Mouse Rab11a Impairs Early Embryogenesis and Matrix Metalloproteinase Secretion.2014
- Author(s)
  Shiyan Yu, Ghassan Yehia, Juanfei Wang, Ewa Stypulkowski, Ryotaro Sakamori, Ping Jiang, Edith B Hernandez-Enriquez, Tracy S. Tran, Edward M. Bonder, Wei Guo, Nan Gao
- Journal Title
  
  J Biol Chem.
  
  Volume: 289(46) Pages: 32030-32043
- DOI
  10.1074/jbc.m113.538223
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461002
[Presentation] 肝星細胞がオートファジー依存的に分泌するGDF15は肝細胞癌の進展に寄与する2020
- Author(s)
  明神悠太、疋田隼人、小玉尚宏、牧野祐紀、阪森亮太郎、巽智秀、溝上雅史、江口英利、竹原徹郎
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] GDF15 secreted by hepatic stellate cells accelerates HCC progression in an autophagy-dependent manner2020
- Author(s)
  Yuta Myojin, Hayato Hikita , Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
- Organizer
  The Liver Meeting Digital Experience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] アダプター蛋白Gab1は肝細胞アポトーシス・肝線維化・肝発癌を抑制する2020
- Author(s)
  水谷直揮、疋田隼人、齋藤義修、吉田雄一、小玉尚宏、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] GDF15 secreted by hepatic stellate cells accelerates HCC progression in an autophagy-dependent manner2020
- Author(s)
  Yuta Myojin, Hayato Hikita , Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
- Organizer
  The Liver Meeting Digital Experience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] Hepatic stellate cell autophagy promotes HCC progression via GDF152020
- Author(s)
  Yuta Myojin, Hayato Hikita, Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Tasuku Nakabori, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
- Organizer
  The Digital International Liver Congress of the European Association for the Study of the Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] 肝星細胞がオートファジー依存的に分泌するGDF15は肝細胞癌の進展に寄与する2020
- Author(s)
  明神悠太、疋田隼人、小玉尚宏、牧野祐紀、阪森亮太郎、巽智秀、溝上雅史、江口英利、竹原徹郎
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] Hepatic stellate cell autophagy promotes HCC progression via GDF152020
- Author(s)
  Yuta Myojin, Hayato Hikita, Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Tasuku Nakabori, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
- Organizer
  The Digital International Liver Congress of the European Association for the Study of the Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 肝細胞癌に対するレンバチニブの初期治療成績2019
- Author(s)
  前阪和城、阪森亮太郎、山田涼子、中堀輔、重川稔、小玉尚宏、疋田隼人、巽智秀、竹原徹郎
- Organizer
  第20回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-17H04160
[Presentation] 慢性肝疾患におけるマクロファージ由来TNF-αは肝細胞における非アポトーシス型の肝細胞死誘導と酸化ストレス誘導により肝発癌を促進する2019
- Author(s)
  齋藤　義修，疋田　隼人，工藤　慎之輔，野崎　泰俊，牧野　祐紀，中堀　輔，山田涼子，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] In vivo rapid genetic screen of efficacy biomarker for multi-kinase inhibitors in hepatocellular carcinoma2019
- Author(s)
  Takahiro Kodama, Yuta Myojin, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  JDDW2019
- Data Source
  KAKENHI-PROJECT-17H04160
[Presentation] 慢性肝疾患におけるマクロファージ由来TNF-αは肝細胞における非アポトーシス型の肝細胞死誘導と酸化ストレス誘導により肝発癌を促進する2019
- Author(s)
  齋藤　義修，疋田　隼人，工藤　慎之輔，野崎　泰俊，牧野　祐紀，中堀　輔，山田涼子，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 持続的肝細胞アポトーシスは、酸化ストレス依存的にジエチルニトロサミンによるDNA損傷を持続させ腫瘍形成を促進させる2019
- Author(s)
  野﨑泰俊、疋田隼人、田中聡司、水谷直揮、明神悠太、坂根貞嗣、牧野祐紀、中堀輔、齋藤義修、小玉尚宏、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] HCC promotes autophagy in hepatic stellate cells, leading to HCC progression via IL-6/STAT3 signaling2019
- Author(s)
  Yuta Myojin, Hayato Hikita ,Takahiro Kodama, Yuki Makino, Ryoko Yamada, Yoshinobu Saito, Tasuku Nakabori, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  The 54rd International Liver Congress of the European Association for the Study of the Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 持続的肝細胞アポトーシスは、酸化ストレス依存的にジエチルニトロサミンによるDNA損傷を持続させ腫瘍形成を促進させる2019
- Author(s)
  野﨑泰俊、疋田隼人、田中聡司、水谷直揮、明神悠太、坂根貞嗣、牧野祐紀、中堀輔、齋藤義修、小玉尚宏、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] The autophagy in hepatic stellate cell promotes carcinogenesis and fibrosis in liver via IL6-STAT3 pathway2019
- Author(s)
  Yuta Myojin, Hayato Hikita ,Takahiro Kodama, Yuki Makino, Ryoko Yamada, Tasuku Nakabori, Ryotaro Sakamori, Tomohide Tatsumi,Tetsuo Takehara
- Organizer
  The Liver Meeting 2019 (AASLD2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] The impact of TNF-α-induced non-apoptotic cell death on hepatocarcinogenesis related with continuous hepatocyte apoptosis2018
- Author(s)
  Yoshinobu Saito, Hayato Hikita, Yasutoshi Nozaki, Yuki Makino, Tasuku Nakabori, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  AASLD 2018　The Liver meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 肝細胞DNase IIはアポトーシス刺激下においてTLR9/IFN-β経路を介した非アポトーシス細胞死を制御する2018
- Author(s)
  齋藤　義修，疋田　隼人，甲斐　優吾，野崎　泰俊，牧野　祐紀，中堀　輔，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] Continuous hepatocyte apoptosis accelerates diethylnitrosamine-induced liver tumor development via oxidative stress2018
- Author(s)
  Yasutoshi Nozaki, Hayato Hikita, Satoshi Tanaka, Naoki Mizutani, Sadatsugu Sakane,　Yuki Makino, Tasuku Nakabori, Yoshinobu Saito, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  AASLD 2018　The Liver meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] Persistent hepatocyte apoptosis accelerates diethylnitrosamine(DEN)-induced liver tumor formation2018
- Author(s)
  Yasutoshi Nozaki, Hayato Hikita, Satoshi Tanaka, Yuta Myojin, Yuki Makino, Yoshinobu Saito, Takahiro Kodama, RYotaro Sakamori, Tomohide Tatsumi and Tetsuo Takehara
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 慢性肝疾患においてTNF-αが肝細胞死に及ぼす影響についての検討2018
- Author(s)
  齋藤　義修，疋田　隼人，野崎　泰俊，牧野　祐紀，中堀　輔，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第25回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 放射線肝限局照射モデルマウスを用いた肝再生能の検討2018
- Author(s)
  占部真貴子、疋田隼人、齋藤義修、小玉尚宏、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第54回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K15430
[Presentation] 肝細胞アポトーシスに起因する慢性肝疾患におけるTNF-αの役割についての検討2018
- Author(s)
  齋藤　義修，疋田　隼人，甲斐　優吾，野崎　泰俊，牧野　祐紀，中堀　輔，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] The impact of TNF-α on hepatocarcinogenesis related with continuous hepatocyte apoptosis2018
- Author(s)
  Yoshinobu Saito, Hayato Hikita, Yuta Myojin, Yasutoshi Nozaki, Yuki Makino, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] Suppression of DNase II activity in fatty livers contributes to induction of RIP1-dependent hepatocyte necrosis through TLR9-IFNβ pathway.2017
- Author(s)
  Yoshinobu Saito, Hayato Hikita, Yasutoshi Nozaki, Yugo Kai, Yuki Makino, Tasuku Nakabori, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  AASLD 2017　The Liver meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] NAFLDの病態における肝細胞DNaseIIの役割2017
- Author(s)
  齋藤　義修，疋田　隼人，甲斐　優吾，野崎　泰俊，牧野　祐紀，中堀　輔，田中　聡司，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第59回日本消化器病学会
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] Cdc42は腸管における癌幹細胞のニッチ形成に関与する2014
- Author(s)
  阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第56回日本消化器病学会大会
- Place of Presentation
  神戸
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-26461002
[Presentation] Colorectal cancer cells exploit the pleiotropic functions of Cell Division Cycle 42 for immediate pro-survival niche construction.2014
- Author(s)
  Ryotaro Sakamori, Shiyan Yu, Jiaxin Sun, Xiao Zhang, Nan Gao
- Organizer
  Digestive Disease Week 2014
- Place of Presentation
  アメリカ合衆国シカゴ
- Year and Date
  2014-05-04
- Data Source
  KAKENHI-PROJECT-26461002

1. Tatsumi Tomohide (20397699)

# of Collaborated Projects: 7 results

# of Collaborated Products: 28 results
2. Hikita Hayato (20623044)

# of Collaborated Projects: 7 results

# of Collaborated Products: 37 results
3. Tetsuo Takehara (70335355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
4. 小玉尚宏 (10623275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. GAO Nan

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. SAITO Yoshinobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. URABE Makiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KONDO Yasuteru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 高橋武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 小瀬嗣子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 明神悠太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 原田彰宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 吉武玲子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakamori Ryotaro 阪森 亮太郎

Ryotaro Sakamori 阪森 亮太郎

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Intracellular transport in the progress of chronic liver diseasePrincipal Investigator

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Elucidation of regulatory mechanism of cancer microenvironment through stromal cell autophagy in hepatocellular carcinoma

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Cell-to-cell communication and pathogenesis triggered by hepatocyte cell death in the liver

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Elucidation of the effect of mitochondrial DNA release by Bak/Bax activation on chronic liver disease

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Intracellular trafficking in liver diseasePrincipal Investigator

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Development of genetically-defined hepatocarcinogenesis animal model and establishment of personalized cancer immunotherapy

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Examination of the mechanisms of which radiation induces liver disorder for expanding radiation therapy

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Intracellular trafficking in the liverPrincipal Investigator

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[Journal Article] Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production.2021

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[Journal Article] Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration.2021

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[Journal Article] Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis and tumorigenesis.2021

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[Journal Article] Hepatocellular carcinoma occurrence does not differ between interferon‐based and interferon‐free treatment with liver histological assessment2020

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[Journal Article] Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.2020

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[Journal Article] Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice.2020

Author(s)

Sakamori Ryotaro 阪森亮太郎

Ryotaro Sakamori 阪森亮太郎