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Kojima Kaname  小島 要

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Kaname Kojima  小島 要

KOJIMA Kaname  小島 要

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Researcher Number 10646988
Other IDs
Affiliation (Current) 2026: 東北大学, 東北メディカル・メガバンク機構, 講師
Affiliation (based on the past Project Information) *help 2017 – 2025: 東北大学, 東北メディカル・メガバンク機構, 講師
2014: 東北大学, 東北メディカル・メガバンク機構, 講師
2013: 東北大学, 東北メディカル・メガバンク機構, 助教
Review Section/Research Field
Principal Investigator
Basic Section 62010:Life, health and medical informatics-related / Life / Health / Medical informatics / Statistical science
Except Principal Investigator
Basic Section 90130:Medical systems-related / Basic Section 53050:Dermatology-related / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Gastroenterology
Keywords
Principal Investigator
深層学習 / 関連解析 / 機序解明 / AI / HLA / ゲノムワイド関連解析 / アレルギー疾患 / 臨床画像 / 状態空間モデル / 紫外線肌ダメージ … More / スマートフォン / 皮膚がん / 紫外線曝露 / cycleGAN / pix2pix / 敵対的生成ネットワーク / 紫外線写真 / 色素斑 / 肌ダメージ / 予防医療 / ゲノム解析 / SNPアレイ / ハイスループットシークエンサ / 機械学習 / シークエンスデータ解析 / インピュテーション / ハイスループットシークエンサー / 遺伝子型インピューテーション / マイクロサテライト / 遺伝子発現量定量 / 変異コール / 遺伝子制御ネットワーク / 次世代シークエンサ / 遺伝子発現 / 次世代シークエンサー / エピジェネティクス / 細胞内制御ネットワーク … More
Except Principal Investigator
腎病理 / 糸球体疾患 / 深層学習 / メラノサイト / GWAS / 白斑 / ゲノムワイド連鎖解析 / メラニン色素 / 紫外線 / スキンタイプ / Klotho遺伝子 / 遺伝環境因子 / 光干渉断層計(OCT) / アルツハイマー病前臨床期 / 環境因子 / 遺伝因子 / 網膜層厚変化 / 網膜断層画像撮像 / 光干渉断層計 / ApoE / 網膜層厚測定 / 晩期発症型アルツハイマー型認知症 / 網羅的遺伝子発現解析 / 統合解析 / トランスクリプトーム / 分子標的 / 疾患発症経路 / 疾患感受性遺伝子 / ゲノムワイド関連解析 / 原発性胆汁性胆管炎 Less
  • Research Projects

    (8 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (21 People)
  •  Deep learning based glomerular disease pathological assessment algorism

    • Principal Investigator
      岡本 好司
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 90130:Medical systems-related
    • Research Institution
      Tohoku University
  •  アレルギー疾患機序解明のためのHLA多型を考慮した解釈可能AIゲノム解析基盤構築Principal Investigator

    • Principal Investigator
      小島 要
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 62010:Life, health and medical informatics-related
    • Research Institution
      Tohoku University
  •  Development of a prediction program for vitiligo onset based on UV-sensitive nucleic acid polymorphisms

    • Principal Investigator
      Yamasaki Kenshi
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Tohoku University
  •  Establishing a diagnostic method for the preclinical stage of sporadic late-onset Alzheimer's disease based on retinal layer thickness and genetic and environmental factors

    • Principal Investigator
      Taira Makiko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
    • Research Institution
      Tohoku University
  •  Establishment of Time Series UV Skin Damage Prediction Methods Based on Deep Learning and Deep State Space ModelsPrincipal Investigator

    • Principal Investigator
      Kojima Kaname
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 62010:Life, health and medical informatics-related
    • Research Institution
      Tohoku University
  •  Exhaustive discovery of disease related variants by the construction of integrated analysis methods of microsatellites from genome dataPrincipal Investigator

    • Principal Investigator
      Kaname Kojima
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Life / Health / Medical informatics
    • Research Institution
      Tohoku University
  •  GWAS-based integrated analysis of PBC to dissect the mechanism of development and progression of primary biliary cholangitis

    • Principal Investigator
      Nakamura Minoru
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
  •  Modeling of genes and epigenome intracellular regulatory network and analysis of cellular differentiation mechanismsPrincipal Investigator

    • Principal Investigator
      KOJIMA Kaname
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Statistical science
    • Research Institution
      Tohoku University

All 2025 2024 2023 2021 2020 2019 2018 2017 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases2025

    • Author(s)
      Suzuki N, Kojima K, Malvica S, Yamasaki K, Chikamatsu Y, Oe Y, Nagasawa T, Kondo E, Sanada S, Aiba S, Sato H, Miyazaki M, Ito S, Sato M, Tanaka T, Kinoshita K, Asano Y, Rosenberg AZ, Okamoto K, Shido K.
    • Journal Title

      Commun Med (Lond).

      Volume: 5 Issue: 1 Pages: 3-3

    • DOI

      10.1038/s43856-024-00708-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07713, KAKENHI-PROJECT-23K11314
  • [Journal Article] Convolutional neural network-based skin image segmentation model to improve classification of skin diseases in conventional and non-standardized picture images2023

    • Author(s)
      Yanagisawa Yuta、Shido Kosuke、Kojima Kaname、Yamasaki Kenshi
    • Journal Title

      Journal of Dermatological Science

      Volume: 109 Issue: 1 Pages: 30-36

    • DOI

      10.1016/j.jdermsci.2023.01.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K08422
  • [Journal Article] Facial UV photo imaging for skin pigmentation assessment using conditional generative adversarial networks2021

    • Author(s)
      Kojima Kaname、Shido Kosuke、Tamiya Gen、Yamasaki Kenshi、Kinoshita Kengo、Aiba Setsuya
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 1213-1213

    • DOI

      10.1038/s41598-020-79995-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K12058, KAKENHI-PROJECT-19K08765
  • [Journal Article] A genotype imputation method for de-identified haplotype reference information by using recurrent neural network2020

    • Author(s)
      Kojima Kaname、Tadaka Shu、Katsuoka Fumiki、Tamiya Gen、Yamamoto Masayuki、Kinoshita Kengo
    • Journal Title

      PLOS Computational Biology

      Volume: 16 Issue: 10 Pages: e1008207-e1008207

    • DOI

      10.1371/journal.pcbi.1008207

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K12058
  • [Journal Article] POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.332019

    • Author(s)
      Hitomi, Y. Ueno, K. Kawai, Y. Nishida, N. , Umemura, T. et al
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 102-102

    • DOI

      10.1038/s41598-018-36490-1

    • NAID

      120007179055

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09416, KAKENHI-PROJECT-17K15924, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-17H04169, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-17H04168, KAKENHI-PROJECT-17K09448, KAKENHI-PROJECT-17K09449
  • [Journal Article] Population-scale whole genome sequencing identifies 271 highly polymorphic short tandem repeats from Japanese population2018

    • Author(s)
      Hirata, S., Kojima, K., Misawa, K., Gervais, O., Kawai, Y., and Nagasaki, M.
    • Journal Title

      Heliyon

      Volume: 4 Issue: 5 Pages: 1-19

    • DOI

      10.1016/j.heliyon.2018.e00625

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K17590
  • [Journal Article] NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population2018

    • Author(s)
      Nishida Nao、Aiba Yoshihiro、Hitomi Yuki、Nagasaki Masao、Tokunaga Katsushi、Nakamura Minoru et al.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 8071-8071

    • DOI

      10.1038/s41598-018-26369-6

    • NAID

      120006551764

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09449, KAKENHI-PROJECT-17K15924, KAKENHI-PROJECT-17H04169
  • [Journal Article] NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional Variants.2018

    • Author(s)
      Hitomi Y, Nakatani K, Kojima K, Nishida N, Kawai Y, Kawashima M, Aiba Y, Nagasaki M, Nakamura M, Tokunaga K.
    • Journal Title

      Cell Mol Gastroenterol Hepatol

      Volume: 7 Issue: 3 Pages: 515-532

    • DOI

      10.1016/j.jcmgh.2018.11.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K15924, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-17H04169, KAKENHI-PROJECT-17H04168, KAKENHI-PROJECT-17K09449
  • [Journal Article] Cathepsin Z variants are associated with progression to end-stage hepatic failure in Japanese patients with primary biliary cholangitis.2017

    • Author(s)
      Nishida N, Aiba Y, Kawashima M, Hitomi Y, Kojima K, Komori A, Nagasaki M,Tokunaga K, Nakamura M
    • Journal Title

      J Hepatol

      Volume: 66(1, Suppl)

    • Data Source
      KAKENHI-PROJECT-17H04169
  • [Journal Article] Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis2017

    • Author(s)
      Hitomi Yuki、Kojima Kaname、Kawashima Minae、Kawai Yosuke、Nishida Nao、Aiba Yoshihiro、Yasunami Michio、Nagasaki Masao、Nakamura Minoru、Tokunaga Katsushi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 2904-2904

    • DOI

      10.1038/s41598-017-03067-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293076, KAKENHI-PROJECT-17H04169, KAKENHI-PROJECT-15K06908
  • [Journal Article] Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population.2017

    • Author(s)
      Kawashima M, Honda M, Nakamura M. et al.
    • Journal Title

      Hum Mol Genet.

      Volume: - Pages: 650-659

    • DOI

      10.1093/hmg/ddw406

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26293076, KAKENHI-PROJECT-26293181, KAKENHI-PROJECT-26460416, KAKENHI-PROJECT-26460996, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-15K06908, KAKENHI-PROJECT-15K19314, KAKENHI-PROJECT-16K21069, KAKENHI-PROJECT-17H04058, KAKENHI-PROJECT-17H04169, KAKENHI-PROJECT-16H05283, KAKENHI-PROJECT-15K19357
  • [Journal Article] HLA-VBSeq: accurate HLA typing at full resolution from whole-genome sequencing data2015

    • Author(s)
      Naoki Nariai, Kaname Kojima, Sakae Saito, Takahiro Mimori, Yukuto Sato, Yosuke Kawai, Yumi Yamaguchi-Kabata, Jun Yasuda, and Masao Nagasaki
    • Journal Title

      BMC Genomics

      Volume: 16(Suppl 2) Pages: 1-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25730011
  • [Journal Article] Estimating copy numbers of alleles from population-scale high-throughput sequencing data2015

    • Author(s)
      Takahiro Mimori, Naoki Nariai, Kaname Kojima, Yukuto Sato, Yosuke Kawai, Yumi Yamaguchi-Kabata, and Masao Nagasaki
    • Journal Title

      BMC Bioinformatics

      Volume: 16(Suppl 1) Pages: 1-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25730011
  • [Journal Article] HapMonster: a statistically unified approach for variant calling and haplotyping based on phase-informative reads2014

    • Author(s)
      Kaname Kojima, Naoki Nariai, Takahiro Mimori, Yumi Yamaguchi-Kabata, Yukuto Sato, Yosuke Kawai, and Masao Nagasaki
    • Journal Title

      Lecture Notes in Computer Science

      Volume: 8542 Pages: 107-118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25730011
  • [Journal Article] TIGAR2: sensitive and accurate estimation of transcript isoform expression with longer RNA-Seq reads2014

    • Author(s)
      Naoki Nariai, Kaname Kojima, Takahiro Mimori, Yukuto Sato, Yosuke Kawai, Yumi Yamaguchi-Kabata, and Masao Nagasaki
    • Journal Title

      BMC Genomics

      Volume: 15(Suppl 9) Pages: 1-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25730011
  • [Journal Article] SVEM: a structural variant estimation method using multi-mapped reads on breakpoints2014

    • Author(s)
      Tomohiko Ohtsuki, Naoki Nariai, Kaname Kojima, Takahiro Mimori, Yukuto Sato, Yosuke Kawai, Yumi Yamaguchi-Kabata, and Masao Nagasaki
    • Journal Title

      Lecture Notes in Computer Science

      Volume: 8542 Pages: 208-219

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25730011
  • [Journal Article] A statistical variant calling approach from pedigree information and local haplotyping with phase informative reads2013

    • Author(s)
      Kaname Kojima, Naoki Nariai, Takahiro Mimori, Mamoru Takahashi, Yumi Yamaguchi-Kabata, Yukuto Sato, and Masao Nagasaki
    • Journal Title

      Bioinformatics

      Volume: 29 (22) Issue: 22 Pages: 2835-2843

    • DOI

      10.1093/bioinformatics/btt503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25730011
  • [Journal Article] TIGAR : transcript isoform abundance estimation method with gapped alignment of RNA-Seq data by variational Bayesian inference2013

    • Author(s)
      Naoki Nariai, Osamu Hirose, Kaname Kojima, Masao Nagasaki
    • Journal Title

      Bioinformatics

      Volume: 29 (18) Issue: 18 Pages: 2292-2299

    • DOI

      10.1093/bioinformatics/btt381

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24810010, KAKENHI-PROJECT-25730011
  • [Presentation] Ribosomal protein RPS10 plays a crucial role in melanin transportation and skin pigmentation2024

    • Author(s)
      Moyuka Wada-Irimada, Kenshi Yamasaki, Kosuke Shido, Kaname Kojima, Ikuko N. Motoike, Kengo Kinoshita, Yoshihide Asano
    • Organizer
      The 49th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08422
  • [Presentation] 新たなSTR8座位のマルチプレックスPCR法および全ゲノムシークエンスデータ解析によるSTRタイピング2018

    • Author(s)
      平田智士、関谷弥生、小島要、三澤 計治、Gervais Olivier、人見祐基、河合洋介、徳永勝士、長﨑正朗
    • Organizer
      日本DNA多型学会
    • Data Source
      KAKENHI-PROJECT-17K17590
  • [Presentation] Genome-wide Association Studies Identify PRKCB as A Novel Genetic Susceptibility Locus for Primary Biliary Cholangitis in the Japanese Population.2017

    • Author(s)
      Nakamura M, Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Komori A, Shimoda S, Tanaka A, Nagasaki M, Tokunaga K, PBC consortium in Japan.
    • Organizer
      The 26th Conference of the Asian Pacific Association for the Study of the Liver (APASL 2017).
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04169
  • [Presentation] GWAS polygenic model approach applied to primary biliary cholangitis (PBC) in a Japanese population.2017

    • Author(s)
      O. Gervais, Ueno K, Kojima K, Aiba Y, Kawashima M, Kawai Y, Hitomi Y, Tokunaga K, Nakamura M, Nagasaki M.
    • Organizer
      ASHG 2017(The 67th Annual Meeting of the American Society of Human Genetics)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04169
  • [Presentation] NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population.2017

    • Author(s)
      Kawashima M, Nishida N, Hitomi Y, Kojima K, Kawai Y, Aiba Y, Nakamura H, Nagasaki M, Tokunaga K, Nakamura M.
    • Organizer
      ASHG 2017(The 67th Annual Meeting of the American Society of Human Genetics)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04169
  • [Presentation] Identification of the primary functional variants in primary biliary cholangitis susceptibility gene loci NFKB1/MANBA.2017

    • Author(s)
      Hitomi Y, Nakatani K, Kojima K, Nishida N, Kawai Y, Kawashima M, Aiba Y, Nagasaki M, Nakamura M, Tokunaga K.
    • Organizer
      ASHG 2017(The 67th Annual Meeting of the American Society of Human Genetics).
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04169
  • [Presentation] Statistical methods for analyzing next generation sequencing data2014

    • Author(s)
      Kaname Kojima
    • Organizer
      International Statistical Symposium CSA-KSS-JSS Special Invited Sessions
    • Place of Presentation
      台湾、新竹市、交通大学
    • Year and Date
      2014-12-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-25730011
  • [Presentation] HapMonster: a Statistically Unified Approach for Variant Calling and Haplotyping Based on Phase-informative Reads2014

    • Author(s)
      Kaname Kojima, Naoki Nariai, Takahiro Mimori, Yumi Yamaguchi-Kabata, Yukuto Sato, Yosuke Kawai and Masao Nagasaki
    • Organizer
      1st International Conference on Algorithms for Computational Biology
    • Place of Presentation
      Tarragona, Spain
    • Data Source
      KAKENHI-PROJECT-25730011
  • [Presentation] Short tandem repeat number estimation from paired-end sequence reads by considering unobserved genealogy of multiple individuals

    • Author(s)
      Kaname Kojima, Yosuke Kawai, Naoki Nariai, Takahiro Mimori, Takanori Hasegawa, and Masao Nagasaki
    • Organizer
      11th International Symposium on Bioinformatics Research and Applications
    • Place of Presentation
      アメリカ合衆国、バージニア州ノーフォーク市、オールドドミニオン大学
    • Year and Date
      2015-06-07 – 2015-06-10
    • Data Source
      KAKENHI-PROJECT-25730011
  • 1.  Yamasaki Kenshi (40294798)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 2.  Nakamura Minoru (40217906)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 3.  Taira Makiko (60792140)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  川嶋 実苗 (00396706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 5.  人見 祐基 (10525819)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 6.  下田 慎治 (30279319)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  安波 道郎 (80244127)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  布施 昇男 (10302134)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  川崎 良 (70301067)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  三木 篤也 (30437404)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  田高 周 (60815463)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  元池 育子 (70347178)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  岡本 好司 (80572247)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  志藤 光介 (10976228)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  AIBA Yoshihiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  TANAKA Tetsuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  HIROSE Osamu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  伊東 正博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  川合 覚
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  本多 政夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  梅村 武司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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