Yokota Mutsumi 横田睦美

… Alternative Names

横田睦美ヨコタムツミ

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Researcher Number	10647415
Other IDs
Affiliation (Current)	2023: 順天堂大学, 大学院医学研究科, 助教 2023: 国立研究開発法人国立精神・神経医療研究センター, その他部局等, 研究員(移行)
Affiliation (based on the past Project Information) *help	2021 – 2022: 順天堂大学, 大学院医学研究科, 助教 2018 – 2020: 順天堂大学, 医学(系)研究科(研究院), 助教 2015: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第二部, 科研費研究員 2013 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第二部, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology
Keywords	Principal Investigator iPS細胞 / PRKN変異 / ドーパミン神経細胞死 / m.3243A>G / ミトコンドリア機能異常 / 細胞初期化 / 分化 / 神経細胞 / 心筋細胞 / m.3243A>G変異 … More / 神経系細胞 / 心血管系細胞 / 造血系細胞 / ミトコンドリア病 / ミトコンドリアスフェロイド化 / RNAシーケンス解析 / ドーパミン神経細胞 / CLEM / ミトコンドリア / CRISPR/Cas9 / GFP標識 / PARK2 iPS細胞 / 超微形態学的解析 / TH-GFP iPS細胞 / 光顕・電顕相関観察 / トランスクリプトーム Less

ミトコンドリアスフェロイド化不全を起点としたドーパミン神経細胞死の機序解明Principal Investigator
- Principal Investigator
  
  横田睦美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
パーキンソン病におけるドーパミン神経細胞特異的な新たな病態発症機構の解明Principal Investigator
- Principal Investigator
  
  横田睦美
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
Genetic and biochemical studies of mitochondrial dysfunction in cellular reprogramming and differentiationPrincipal Investigator
- Principal Investigator
  
  Yokota Mutsumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry

All 2022 2021 2020 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons2021
- Author(s)
  Yokota Mutsumi、Kakuta Soichiro、Shiga Takahiro、Ishikawa Kei-ichi、Okano Hideyuki、Hattori Nobutaka、Akamatsu Wado、Koike Masato
- Journal Title
  
  Molecular Brain
  
  Volume: 14 Pages: 58-58
- DOI
  10.1186/s13041-021-00771-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07743, KAKENHI-PROJECT-18K15466, KAKENHI-PROJECT-19K16930, KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-21K07301
[Journal Article] Mitochondrial respiratory dysfunction caused by a heteroplasmic mitochondrial DNA mutation blocks cellular reprogramming.2015
- Author(s)
  Yokota M, Hatakeyama H, Okabe S, Ono Y, Goto Y
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 24 Pages: 4698-4709
- DOI
  10.1093/hmg/ddv201
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860732
[Presentation] TH-GFP iPS細胞を用いたGFP陽性ドパミン神経細胞のRNA-seq解析2022
- Author(s)
  横田睦美、角田宗一郎、吉野佑太朗、志賀孝宏、石川景一、岡野栄之、服部信孝、赤松和土、小池正人
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-18K15466
[Presentation] PRKN変異患者ドパミン神経細胞におけるミトコンドリアスフェロイド化応答の電子顕微鏡解析2021
- Author(s)
  横田睦美、角田宗一郎、吉野佑太朗、志賀孝宏、石川景一、岡野栄之、服部信孝、赤松和土、小池正人
- Organizer
  日本解剖学会第109回関東支部学術集会
- Data Source
  KAKENHI-PROJECT-18K15466
[Presentation] PARK2 iPS細胞由来ドーパミン神経細胞における酸化ストレス下ミトコンドリア形態変化の電子顕微鏡観察2021
- Author(s)
  横田睦美、角田宗一郎、吉野佑太朗、志賀孝宏、石川景一、岡野栄之、服部信孝、赤松和土、小池正人
- Organizer
  第126回日本解剖学会総会
- Data Source
  KAKENHI-PROJECT-18K15466
[Presentation] Ultrastructural analysis of GFP-labeled dopaminergic neurons derived from control and PRKN-mutated patient TH-GFP iPSC lines. (PRKN変異患者TH-GFP iPS細胞由来ドパミン神経細胞の超微形態学的解析)2021
- Author(s)
  横田睦美、角田宗一郎、吉野佑太朗、志賀孝宏、石川景一、岡野栄之、服部信孝、赤松和土、小池正人
- Organizer
  第44回日本神経科学大会 CJK第1回国際会議
- Data Source
  KAKENHI-PROJECT-18K15466
[Presentation] iPS細胞由来GFP標識ドパミン神経細胞の光顕-電顕相関観察2020
- Author(s)
  横田睦美、角田宗一郎、志賀孝宏、石川景一、服部信孝、赤松和土、小池正人
- Organizer
  日本解剖学会第108回関東支部学術集会
- Data Source
  KAKENHI-PROJECT-18K15466
[Presentation] Tyrosine HydroxylaseレポーターPARK2 iPS細胞を用いた光顕-電顕相関観察2020
- Author(s)
  横田睦美、角田宗一郎、志賀孝宏、服部信孝、赤松和土、小池正人
- Organizer
  第125回日本解剖学会
- Data Source
  KAKENHI-PROJECT-18K15466
[Presentation] Mitochondrial respiratory dysfunction inhibits maturation and survival of iPSC-derived neurons and cardiomyocytes2016
- Author(s)
  Yokota M, Hatakeyama H, Ono Y, Kanazawa M, Goto Y
- Organizer
  CiRA/ISSCR 2016 International Symposia
- Place of Presentation
  Kyoto University Clock Tower Centennial Hall, Kyoto, Japan
- Year and Date
  2016-03-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860732
[Presentation] ミトコンドリア機能異常は細胞初期化過程における障壁となる2014
- Author(s)
  畠山英之，横田睦美，後藤雄一
- Organizer
  CREST ｢iPS細胞｣研究領域ミーティング2014
- Place of Presentation
  淡路夢舞台国際会議場, 淡路, 日本
- Year and Date
  2014-10-28
- Data Source
  KAKENHI-PROJECT-25860732
[Presentation] Generation of patient-derived isogenic iPSCs each carrying “all-or-none” mtDNA mutations toward disease modeling and drug screening
- Author(s)
  Hatakeyama H, Yokota M, Ono Y, Kanazawa M, Goto Y
- Organizer
  The 18th Takeda Science Foundation Symposium on Bioscience “iPS Cells for Regenerative Medicine”
- Place of Presentation
  Center for Learning and Innovation Takeda Pharmaceutical Company Ltd., Osaka, Japan
- Year and Date
  2015-01-15 – 2015-01-17
- Data Source
  KAKENHI-PROJECT-25860732
[Presentation] Molecular pathogenesis and iPS-cell-based disease modeling of MELAS caused by a mutation in anticodon-stem of MTTW gene
- Author(s)
  Hatakeyama H, Yokota M, Okabe S, Ono Y, Goto Y
- Organizer
  International Symposium on Mitochondria 2013
- Place of Presentation
  Roppongi Academyhills 49, Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-25860732
[Presentation] 疾患特異的iPS細胞を活用したミトコンドリア病の病態解明・治療法開発研究
- Author(s)
  畠山英之，横田睦美，後藤雄一
- Organizer
  JST戦略的創造研究推進事業「iPS細胞」研究支援3制度合同シンポジウム2014 ～iPS細胞研究の今～
- Place of Presentation
  日本科学未来館（東京都）
- Data Source
  KAKENHI-PROJECT-25860732
[Presentation] Mitochondrial dysfunction is the barrier against cellular reprogramming, but not the maintenance of pluripotency
- Author(s)
  Yokota M, Hatakeyama H, Okabe S, Ono Y, Goto Y
- Organizer
  International Symposium on Mitochondria 2013
- Place of Presentation
  Roppongi Academyhills 49, Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-25860732
[Presentation] in vitro neuronal modeling of various mitochondrial disorders using patient-derived iPS cells
- Author(s)
  Hatakeyama H, Yokota M, Okabe S, Ono Y, Goto Y
- Organizer
  International Symposium on Mitochondria 2013
- Place of Presentation
  Roppongi Academyhills 49, Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-25860732

1. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 志賀孝宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 石川景一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yokota Mutsumi 横田 睦美

横田 睦美 ヨコタ ムツミ

Research Projects

Research Products

Co-Researchers

ミトコンドリアスフェロイド化不全を起点としたドーパミン神経細胞死の機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

パーキンソン病におけるドーパミン神経細胞特異的な新たな病態発症機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genetic and biochemical studies of mitochondrial dysfunction in cellular reprogramming and differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondrial respiratory dysfunction caused by a heteroplasmic mitochondrial DNA mutation blocks cellular reprogramming.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] TH-GFP iPS細胞を用いたGFP陽性ドパミン神経細胞のRNA-seq解析2022

Author(s)

Organizer

Data Source

[Presentation] PRKN変異患者ドパミン神経細胞におけるミトコンドリアスフェロイド化応答の電子顕微鏡解析2021

Author(s)

Organizer

Data Source

[Presentation] PARK2 iPS細胞由来ドーパミン神経細胞における酸化ストレス下ミトコンドリア形態変化の電子顕微鏡観察2021

Author(s)

Organizer

Data Source

[Presentation] Ultrastructural analysis of GFP-labeled dopaminergic neurons derived from control and PRKN-mutated patient TH-GFP iPSC lines. (PRKN変異患者TH-GFP iPS細胞由来ドパミン神経細胞の超微形態学的解析)2021

Author(s)

Organizer

Data Source

[Presentation] iPS細胞由来GFP標識ドパミン神経細胞の光顕-電顕相関観察2020

Author(s)

Organizer

Data Source

[Presentation] Tyrosine HydroxylaseレポーターPARK2 iPS細胞を用いた光顕-電顕相関観察2020

Author(s)

Organizer

Data Source

[Presentation] Mitochondrial respiratory dysfunction inhibits maturation and survival of iPSC-derived neurons and cardiomyocytes2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ミトコンドリア機能異常は細胞初期化過程における障壁となる2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Generation of patient-derived isogenic iPSCs each carrying “all-or-none” mtDNA mutations toward disease modeling and drug screening

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Molecular pathogenesis and iPS-cell-based disease modeling of MELAS caused by a mutation in anticodon-stem of MTTW gene

Author(s)

Organizer

Place of Presentation

Data Source

Yokota Mutsumi 横田睦美

横田睦美ヨコタムツミ