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Yokota Mutsumi  横田 睦美

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… Alternative Names

横田 睦美  ヨコタ ムツミ

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Researcher Number 10647415
Other IDs
Affiliation (Current) 2022: 順天堂大学, 大学院医学研究科, 助教
2022: 国立研究開発法人国立精神・神経医療研究センター, その他部局等, 研究員(移行)
Affiliation (based on the past Project Information) *help 2022: 順天堂大学, 医学(系)研究科(研究院), 助教
2018 – 2020: 順天堂大学, 医学(系)研究科(研究院), 助教
2015: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第二部, 科研費研究員
2013 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第二部, 流動研究員
Review Section/Research Field
Principal Investigator
Basic Section 52020:Neurology-related / Neurology
Keywords
Principal Investigator
iPS細胞 / m.3243A>G / ミトコンドリア機能異常 / 細胞初期化 / 分化 / 神経細胞 / 心筋細胞 / m.3243A>G変異 / 神経系細胞 / 心血管系細胞 … More / 造血系細胞 / ミトコンドリア病 / PRKN変異 / ドーパミン神経細胞 / ミトコンドリアスフェロイド化 / CLEM / ミトコンドリア / CRISPR/Cas9 / GFP標識 / PARK2 iPS細胞 / 超微形態学的解析 Less
  • Research Projects

    (3 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (2 People)
  •  ミトコンドリアスフェロイド化不全を起点としたドーパミン神経細胞死の機序解明Principal Investigator

    • Principal Investigator
      横田 睦美
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Juntendo University
  •  パーキンソン病におけるドーパミン神経細胞特異的な新たな病態発症機構の解明Principal Investigator

    • Principal Investigator
      横田 睦美
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Juntendo University
  •  Genetic and biochemical studies of mitochondrial dysfunction in cellular reprogramming and differentiationPrincipal Investigator

    • Principal Investigator
      Yokota Mutsumi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry

All 2021 2020 2016 2015 2014 Other

All Journal Article Presentation

  • [Journal Article] Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons2021

    • Author(s)
      Yokota Mutsumi、Kakuta Soichiro、Shiga Takahiro、Ishikawa Kei-ichi、Okano Hideyuki、Hattori Nobutaka、Akamatsu Wado、Koike Masato
    • Journal Title

      Molecular Brain

      Volume: 14 Pages: 58-58

    • DOI

      10.1186/s13041-021-00771-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07743, KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-18K15466
  • [Journal Article] Mitochondrial respiratory dysfunction caused by a heteroplasmic mitochondrial DNA mutation blocks cellular reprogramming.2015

    • Author(s)
      Yokota M, Hatakeyama H, Okabe S, Ono Y, Goto Y
    • Journal Title

      Human Molecular Genetics

      Volume: 24 Pages: 4698-4709

    • DOI

      10.1093/hmg/ddv201

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25860732
  • [Presentation] PARK2 iPS細胞由来ドーパミン神経細胞における酸化ストレス下ミトコンドリア形態変化の電子顕微鏡観察2021

    • Author(s)
      横田睦美、角田宗一郎、吉野佑太朗、志賀孝宏、石川景一、岡野栄之、服部信孝、赤松和土、小池正人
    • Organizer
      第126回日本解剖学会総会
    • Data Source
      KAKENHI-PROJECT-18K15466
  • [Presentation] iPS細胞由来GFP標識ドパミン神経細胞の光顕-電顕相関観察2020

    • Author(s)
      横田睦美、角田宗一郎、志賀孝宏、石川景一、服部信孝、赤松和土、小池正人
    • Organizer
      日本解剖学会第108回関東支部学術集会
    • Data Source
      KAKENHI-PROJECT-18K15466
  • [Presentation] Tyrosine HydroxylaseレポーターPARK2 iPS細胞を用いた光顕-電顕相関観察2020

    • Author(s)
      横田睦美、角田宗一郎、志賀孝宏、服部信孝、赤松和土、小池正人
    • Organizer
      第125回日本解剖学会
    • Data Source
      KAKENHI-PROJECT-18K15466
  • [Presentation] Mitochondrial respiratory dysfunction inhibits maturation and survival of iPSC-derived neurons and cardiomyocytes2016

    • Author(s)
      Yokota M, Hatakeyama H, Ono Y, Kanazawa M, Goto Y
    • Organizer
      CiRA/ISSCR 2016 International Symposia
    • Place of Presentation
      Kyoto University Clock Tower Centennial Hall, Kyoto, Japan
    • Year and Date
      2016-03-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860732
  • [Presentation] ミトコンドリア機能異常は細胞初期化過程における障壁となる2014

    • Author(s)
      畠山英之,横田睦美,後藤雄一
    • Organizer
      CREST 「iPS細胞」研究領域ミーティング2014
    • Place of Presentation
      淡路夢舞台国際会議場, 淡路, 日本
    • Year and Date
      2014-10-28
    • Data Source
      KAKENHI-PROJECT-25860732
  • [Presentation] Generation of patient-derived isogenic iPSCs each carrying “all-or-none” mtDNA mutations toward disease modeling and drug screening

    • Author(s)
      Hatakeyama H, Yokota M, Ono Y, Kanazawa M, Goto Y
    • Organizer
      The 18th Takeda Science Foundation Symposium on Bioscience “iPS Cells for Regenerative Medicine”
    • Place of Presentation
      Center for Learning and Innovation Takeda Pharmaceutical Company Ltd., Osaka, Japan
    • Year and Date
      2015-01-15 – 2015-01-17
    • Data Source
      KAKENHI-PROJECT-25860732
  • [Presentation] Molecular pathogenesis and iPS-cell-based disease modeling of MELAS caused by a mutation in anticodon-stem of MTTW gene

    • Author(s)
      Hatakeyama H, Yokota M, Okabe S, Ono Y, Goto Y
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      Roppongi Academyhills 49, Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-25860732
  • [Presentation] 疾患特異的iPS細胞を活用したミトコンドリア病の病態解明・治療法開発研究

    • Author(s)
      畠山英之,横田睦美,後藤雄一
    • Organizer
      JST戦略的創造研究推進事業「iPS細胞」研究支援3制度合同シンポジウム2014 ~iPS細胞研究の今~
    • Place of Presentation
      日本科学未来館(東京都)
    • Data Source
      KAKENHI-PROJECT-25860732
  • [Presentation] in vitro neuronal modeling of various mitochondrial disorders using patient-derived iPS cells

    • Author(s)
      Hatakeyama H, Yokota M, Okabe S, Ono Y, Goto Y
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      Roppongi Academyhills 49, Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-25860732
  • [Presentation] Mitochondrial dysfunction is the barrier against cellular reprogramming, but not the maintenance of pluripotency

    • Author(s)
      Yokota M, Hatakeyama H, Okabe S, Ono Y, Goto Y
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      Roppongi Academyhills 49, Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-25860732
  • 1.  小池 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  石川 景一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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