AOYAMA Ken-ichi 青山謙一

Researcher Number	10647530
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2019: 東海大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry Except Principal Investigator Morphological basic dentistry / Surgical dentistry
Keywords	Principal Investigator 分子生物学的解析 / 遺伝子解析 / NOTCH経路の腫瘍原性 / NOTCH1変異 / 大規模遺伝子解析 / 口腔扁平上皮癌 / FAT1 / NOTCH1 / 口腔がん Except Principal Investigator 遺伝子解析 … More / Dgcr2ノックアウトマウス / 顎顔面形態形成 / BMP / 軟骨細胞 / DGCR2遺伝子 / TGF-beta / 初代軟骨細胞 / TBX1 / TGF-betaシグナル / X型コラーゲン / 初代培養軟骨細胞 / Dgcr2 / Df1 / Tbx1 / Sez12 / ノックアウトマウス / 肥大軟骨細胞 / 頭蓋底軟骨結合 / 22q11.2欠失症候群 / DGCR2 / HRAS / 変異解析 / HRAS変異 / NOTCH1変異 / 大規模遺伝子解析 / 口腔扁平上皮癌 / Mutation analysis / Oral cancer / NOTCH1 Less

臨床標本に高頻度変異がみられたNOTCHとFAT1による口腔扁平上皮癌の病態解析Principal Investigator
- Principal Investigator
  
  青山謙一
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Tokai University
The Sez12, mouse homolog of DGCR2 gene encoding within 22q11.2, contributes to enchondral ossification in skull base
- Principal Investigator
  
  KAJIWARA Kagemasa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokai University
Functional analysis of NOTCH1 variantsPrincipal Investigator
- Principal Investigator
  
  AOYAMA Ken-ichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokai University
Oral cancer model of functional mutations in NOTCH1 and HRAS
- Principal Investigator
  
  OTA Yoshihide
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokai University

All 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] The mouse homolog of DGCR2 gene encoding within 22q11.2 contributes to enchondral ossification in skull base and its defect causes the severity in 22q11.2 deletion syndrome2018
- Author(s)
  Kajiwara, K., Aoyama, K., Uchibori, M., Ota, Y., Kimura, M., Tanigaki, K. and Elizabeth Illingworth
- Journal Title
  
  Journal of Oral and Maxillofacial Surgery
  
  Volume: 76 (10) Issue: 10 Pages: e71-e72
- DOI
  10.1016/j.joms.2018.06.152
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11460
[Journal Article] Longitudinal changes in the quality of life of oral cancer patients during the perioperative period2018
- Author(s)
  Aoki Takayuki、Ota Yoshihide、Suzuki Takatsugu、Denda Yuya、Aoyama Ken-Ichi、Akiba Takeshi、Naito Mariko、Arai Toshihiro
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 23 Issue: 6 Pages: 1038-1045
- DOI
  10.1007/s10147-018-1322-3
- Data Source
  KAKENHI-PROJECT-16K20614
[Journal Article] Trousseau syndrome in a patient with advanced oral squamous cell carcinoma: a case report2018
- Author(s)
  Aoyama Ken-ichi、Tamura Masashi、Uchibori Masahiro、Nakanishi Yasuhiro、Arai Toshihiro、Aoki Takayuki、Osawa Yuko、Kaneko Akihiro、Ota Yoshihide
- Journal Title
  
  Journal of Medical Case Reports
  
  Volume: 13 Issue: 1 Pages: 1833-1836
- DOI
  10.1186/s13256-018-1833-6
- Data Source
  KAKENHI-PROJECT-16K20614
[Journal Article] Lateral retropharyngeal lymph node metastasis from squamous cell carcinoma of the upper gingiva: a case report2018
- Author(s)
  Yamazaki H, Sasaki M, Aoyama K, Suzuki T, Denda Y, Uchibori M, Nakanishi Y, Kojima R, Ota Y
- Journal Title
  
  MOLECULAR AND CLINICAL ONCOLOGY
  
  Volume: 8 Pages: 68-72
- DOI
  10.3892/mco.2017.1496
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11732, KAKENHI-PROJECT-16K20614, KAKENHI-PROJECT-15K11302
[Journal Article] Kikuchi-Fujimoto Disease with 18F-Fludeoxyglucose Uptake in Cervical Lymph Nodes on Dual Time-point Imaging Positron Emission Tomography/Computed Tomography Mimicking Malignant Disease2017
- Author(s)
  Ken-ichi Aoyama, Mitsunobu Otsuru, Masahiro Uchibori, Yoshihide Ota
- Journal Title
  
  World J Nucl Med
  
  Volume: 16 Pages: 68-70
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20614
[Journal Article] Saliva pH affects the sweetness sense2017
- Author(s)
  Ken-ichi Aoyama, Yuichiro Okino, Hiroshi Yamazaki, Rena Kojima, Masahiro Uchibori, Yasuhiro Nakanishi, Yoshihide Ota
- Journal Title
  
  Nutrition
  
  Volume: 35 Pages: 51-55
- DOI
  10.1016/j.nut.2016.10.018
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11302, KAKENHI-PROJECT-16K20614
[Journal Article] Kikuchi-Fujimoto Disease with 18F-Fludeoxyglucose Uptake in Cervical Lymph Nodes on Dual Time-point Imaging Positron Emission Tomography/Computed Tomography Mimicking Malignant Disease2017
- Author(s)
  Ken-ichi Aoyama, Mitsunobu Otsuru, Masahiro Uchibori, Yoshihide Ota
- Journal Title
  
  World J Nucl Med
  
  Volume: 16 Pages: 68-70
- Open Access
- Data Source
  KAKENHI-PROJECT-15K11302
[Journal Article] A mutation in NOTCH1 ligand binding region detected in patients with oral squamous cell carcinoma reduces NOTCH1 oncogenic effect2017
- Author(s)
  M. Uchibori, Ken-ichi Aoyama, Y. Ota, K. Kajiwara, M. Tanaka, M. Kimura
- Journal Title
  
  Oncology Reports
  
  Volume: 38 Issue: 4 Pages: 2237-2242
- DOI
  10.3892/or.2017.5870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20614, KAKENHI-PROJECT-15K11302
[Presentation] The Mouse Homolog of DGCR2 Gene Encoding within 22q11.2 Contributes to Enchondral Ossification in Skull Base and Its Defect Causes the Severity in 22q11.2 Deletion Syndrome2018
- Author(s)
  Kagemasa Kajiwara, Kenichi Aoyama, Masahiro Uchibori, Yoshihide Ota, Minoru Kimura, Kenji Tanigaki and Elisabeth Anne Illingworth
- Organizer
  100th AAOMS Annual Meeting. Scientific Sessions and Exhibition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11460
[Presentation] Dgcr2は軟骨内骨化過程における肥大軟骨細胞への分化過程でTGF-betaシグナルを抑制性に制御する2018
- Author(s)
  梶原景正, 渡部聡, 青山謙一, 内堀雅博, 大澤侑子, 太田嘉英, 木村穣
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K11460
[Presentation] Mutational landscape of Japanese oral squamous cell carcinoma2017
- Author(s)
  青山謙一、太田嘉英、内堀雅博、梶原景正、木村穣
- Organizer
  日本口腔外科学会
- Data Source
  KAKENHI-PROJECT-15K11302
[Presentation] Mutational landscape of Japanese oral squamous cell carcinoma2017
- Author(s)
  青山謙一、太田嘉英、内堀雅博、梶原景正、木村穣
- Organizer
  日本口腔外科学会総会
- Data Source
  KAKENHI-PROJECT-16K20614
[Presentation] 22q11.2欠失症候群の骨格異常に関するDGCR2のTGF-betaシグナル制御メカニズム2017
- Author(s)
  梶原景正, 青山謙一, 内堀雅博, 斎藤雅幸, 弥栄聡介, 太田嘉英, 木村穣
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-16K11460
[Presentation] 口腔扁平上皮癌由来の変異NOTCH1を導入したHEK293はNICDの発現と細胞増殖が低下する2016
- Author(s)
  内堀雅博, 青山謙一, 太田嘉英, 梶原景正, 田中正史, 木村穣
- Organizer
  日本癌学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K11302
[Presentation] 22q11.2欠失症候群の骨格異常に関するDGCR2遺伝子のノックアウトマウスを用いた病因解析2016
- Author(s)
  梶原　景正, 青山　謙一, 内堀　雅博, 渡部聡, 金澤花帆, 太田　嘉英, 木村　穣
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  神奈川県　パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K11460
[Presentation] 日本人口腔扁平上皮癌に見いだされた変異型NOTCH1分子の発現解析2016
- Author(s)
  内堀雅博, 太田嘉英, 青山謙一, 梶原景正, 木村穣
- Organizer
  日本生化学会大会・日本分子生物学会年会合同大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K11302
[Presentation] 口腔扁平上皮癌由来の変異NOTCH1を導入したHEK293はNICDの発現と細胞増殖が低下する2016
- Author(s)
  内堀雅博, 青山謙一, 太田嘉英, 梶原景正, 田中正史, 木村穣
- Organizer
  日本癌学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K20614
[Presentation] 生化学データとアンケート調査による、味覚感度の予測システムの開発2016
- Author(s)
  青山謙一、沖野雄一郎
- Organizer
  日本公衆衛生学会
- Place of Presentation
  グランキューブ大阪（大阪府大阪市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16K20614
[Presentation] The functional analysis of NOTCH1 mutations found in Japanese oral carcinom2015
- Author(s)
  KI Aoyama, Y Ota, M Uchibori, K Kajiwara, M kimura
- Organizer
  日本癌学会学術大会
- Place of Presentation
  名古屋国際会議場（愛知県、名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K11302
[Presentation] NOTCH1 mutation found in Japanese oral carcinoma2015
- Author(s)
  KI Aoyama, Y Ota, M Uchibori, K Kajiwara, M kimura
- Organizer
  European Cancer Congress 2015
- Place of Presentation
  Wien Exhibition and Congress Center （オーストリア・ウィーン）
- Year and Date
  2015-10-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11302

1. OTA Yoshihide (60233152)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. 木村穣 (10146706)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
3. KAJIWARA Kagemasa (00204397)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. 内堀雅博 (50749273)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. HOZUMI Katsuto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAJIMA Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HOSOMICHI Kazuyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OSAWA Yuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. ILLINGWORTH Elizabeth

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 山崎浩史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AOYAMA Ken-ichi 青山 謙一

Research Projects

Research Products

Co-Researchers

臨床標本に高頻度変異がみられたNOTCHとFAT1による口腔扁平上皮癌の病態解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Sez12, mouse homolog of DGCR2 gene encoding within 22q11.2, contributes to enchondral ossification in skull base

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of NOTCH1 variantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Oral cancer model of functional mutations in NOTCH1 and HRAS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The mouse homolog of DGCR2 gene encoding within 22q11.2 contributes to enchondral ossification in skull base and its defect causes the severity in 22q11.2 deletion syndrome2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Longitudinal changes in the quality of life of oral cancer patients during the perioperative period2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trousseau syndrome in a patient with advanced oral squamous cell carcinoma: a case report2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lateral retropharyngeal lymph node metastasis from squamous cell carcinoma of the upper gingiva: a case report2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kikuchi-Fujimoto Disease with 18F-Fludeoxyglucose Uptake in Cervical Lymph Nodes on Dual Time-point Imaging Positron Emission Tomography/Computed Tomography Mimicking Malignant Disease2017

Author(s)

Journal Title

Data Source

[Journal Article] Saliva pH affects the sweetness sense2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kikuchi-Fujimoto Disease with 18F-Fludeoxyglucose Uptake in Cervical Lymph Nodes on Dual Time-point Imaging Positron Emission Tomography/Computed Tomography Mimicking Malignant Disease2017

Author(s)

Journal Title

Data Source

[Journal Article] A mutation in NOTCH1 ligand binding region detected in patients with oral squamous cell carcinoma reduces NOTCH1 oncogenic effect2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] The Mouse Homolog of DGCR2 Gene Encoding within 22q11.2 Contributes to Enchondral Ossification in Skull Base and Its Defect Causes the Severity in 22q11.2 Deletion Syndrome2018

Author(s)

Organizer

Data Source

[Presentation] Dgcr2は軟骨内骨化過程における肥大軟骨細胞への分化過程でTGF-betaシグナルを抑制性に制御する2018

Author(s)

Organizer

Data Source

[Presentation] Mutational landscape of Japanese oral squamous cell carcinoma2017

Author(s)

Organizer

Data Source

[Presentation] Mutational landscape of Japanese oral squamous cell carcinoma2017

Author(s)

AOYAMA Ken-ichi 青山謙一