Morimoto Soyoko 森本創世子

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MORIMOTO Soyoko 森本創世子

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Researcher Number	10649023
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 招へい教員
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 大学院医学系研究科, 寄附講座助教 2016 – 2021: 大阪大学, 医学系研究科, 寄附講座助教 2014 – 2015: 大阪大学, 医学(系)研究科(研究院), 研究員 2013: 大阪大学, 医学(系)研究科(研究院), 特任研究員
Review Section/Research Field	Principal Investigator Tumor therapeutics / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator memory / CRISPR-guide RNA library / メモリー / TCR / WT1 / single cell定量PCR / WT1特異的CTL / TCF-1 / NGS / 増殖能 … More / エピジェネティック制御 / 免疫逃避 / CRISPR-gRNA library / CD27 / CD8T cell / Cas9 / T細胞受容体 / TCR avidity / TCR functional avidity / single cell / WT1 specific CTLs / single cell RT-PCR … More Except Principal Investigator がんワクチン / 膵臓がん / 細胞傷害性T細胞 / がん免疫療法 / high-avidity TCR / CTL / WT1 Less

癌免疫応答ロバストネスの維持を基盤とする癌免疫療法の開発Principal Investigator
- Principal Investigator
  
  森本創世子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka University
難治がんに有望ながん免疫effector T細胞特性の基盤的解明と細胞治療開発
- Principal Investigator
  
  西田純幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka University
CRISPR/Cas9 genome-wide knockout screening for identifying the novel gene to overcome the tumor-immune escapePrincipal Investigator
- Principal Investigator
  
  Morimoto Soyoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka University
Development of novel cancer immunotherapy based on memory-oriented TCRPrincipal Investigator
- Principal Investigator
  
  Morimoto Soyoko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Osaka University
Identification of T cells that exhibit cytotoxic activity against tumor based on the single-cell gene expression profiles and control their functionPrincipal Investigator
- Principal Investigator
  
  Morimoto Soyoko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Osaka University
Identification of key genes that is correlated with long-term maintenance of cytotoxic activity in WT1 specific cytotoxic T lymphocytesPrincipal Investigator
- Principal Investigator
  
  MORIMOTO Soyoko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Osaka University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Establishment of a novel NFAT-GFP reporter platform useful for the functional avidity maturation of HLA class II-restricted TCRs2023
- Author(s)
  Fujiki Fumihiro、Morimoto Soyoko、Nishida Yuya、Tanii Satoe、Aoyama Nao、Inatome Miki、Inoue Kento、Katsuhara Akiko、Nakajima Hiroko、Nakata Jun、Nishida Sumiyuki、Tsuboi Akihiro、Oka Yoshihiro、Oji Yusuke、Sogo Shinji、Sugiyama Haruo
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: in press Issue: 7 Pages: 2347-2356
- DOI
  10.1007/s00262-023-03420-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07251, KAKENHI-PROJECT-23K06761, KAKENHI-PROJECT-23K21389
[Journal Article] Enhanced antitumor activity of a novel, oral, helper epitope-containing WT1 protein vaccine in a model of murine leukemia2023
- Author(s)
  Minagawa Hikaru、Hashii Yoshiko、Nakajima Hiroko、Fujiki Fumihiro、Morimoto Soyoko、Nakata Jun、Shirakawa Toshiro、Katayama Takane、Tsuboi Akihiro、Ozono Keiichi
- Journal Title
  
  BMC Cancer
  
  Volume: 23 Issue: 1 Pages: 167-167
- DOI
  10.1186/s12885-023-10547-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07841, KAKENHI-PROJECT-23K06761
[Journal Article] WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT12023
- Author(s)
  Oji Y, Kagawa N, Arita H, Naka N, Hamada KI, Outani H, Shintani Y, Takeda Y, Morii E, Shimazu K, Suzuki M, Nishida S, Nakata J, Tsuboi A, Iwai M, Hayashi S, Imanishi R, Ikejima S, Kanegae M, Iwamoto M, Ikeda M, Yagi K, Shimokado H, Nakajima H, Hasegawa K, Morimoto S, Fujiki F　他
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 2 Pages: 393-393
- DOI
  10.3390/cancers15020393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07251, KAKENHI-PROJECT-19K08650, KAKENHI-PROJECT-20K08732, KAKENHI-PROJECT-22K09283, KAKENHI-PROJECT-23K06761, KAKENHI-PROJECT-19K09457
[Journal Article] Cellular and Humoral Immune Responses Induced by an HLA Class I-restricted Peptide Cancer Vaccine Targeting WT1 Are Associated With Favorable Clinical Outcomes in Advanced Ovarian Cancer.2022
- Author(s)
  Nishida S, Morimoto S, Oji Y, Morita S, Shirakata T, Enomoto T, Tsuboi A, Ueda Y, Yoshino K, Shouq A, Kanegae M, Ohno S, Fujiki F, Nakajima H, Nakae Y, Nakata J, Hosen N, Kumanogoh A, Oka Y, Kimura T, Sugiyama H.
- Journal Title
  
  J Immunother.
  
  Volume: 45 Issue: 1 Pages: 55-66
- DOI
  10.1097/cji.0000000000000405
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07729, KAKENHI-PROJECT-20K07695
[Journal Article] T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy2022
- Author(s)
  Fujiki Fumihiro、Morimoto Soyoko、Katsuhara Akiko、Okuda Akane、Ogawa Saeka、Ueda Eriko、Miyazaki Maki、Isotani Ayako、Ikawa Masahito、Nishida Sumiyuki、Nakajima Hiroko、Tsuboi Akihiro、Oka Yoshihiro、Nakata Jun、Hosen Naoki、Kumanogoh Atsushi、Oji Yusuke、Sugiyama Haruo
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 935465-935465
- DOI
  10.3389/fimmu.2022.935465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07251, KAKENHI-PROJECT-23K21389
[Journal Article] An oral WT1 protein vaccine composed of WT1-anchored, genetically engineered Bifidobacterium longum allows for intestinal immunity in mice with acute myeloid leukemia2022
- Author(s)
  Nakagawa Natsuki、Hashii Yoshiko、Kayama Hisako、Okumura Ryu、Nakajima Hiroko、Minagawa Hikaru、Morimoto Soyoko、Fujiki Fumihiro、Nakata Jun、Shirakawa Toshiro、Katayama Takane、Takeda Kiyoshi、Tsuboi Akihiro、Ozono Keiichi
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 1 Pages: 39-53
- DOI
  10.1007/s00262-022-03214-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07841, KAKENHI-PROJECT-23K06761
[Journal Article] Identification of two distinct populations of WT1-specific cytotoxic T lymphocytes in co-vaccination of WT1 killer and helper peptides.2021
- Author(s)
  Fujiki F, Tsuboi A, Morimoto S, Hashimoto N, Inatome M, Nakajima H, Nakata J, Nishida S, Hasegawa K, Hosen N, Oka Y, Oji Y, Sogo S, Sugiyama H.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 70 Issue: 1 Pages: 253-263
- DOI
  10.1007/s00262-020-02675-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07729, KAKENHI-PROJECT-20K07695
[Journal Article] Reader-free ELISPOT assay for immuno-monitoring in peptide-based cancer vaccine immunotherapy2020
- Author(s)
  Hayashi Sae、Imanishi Rin、Adachi Mayuko、Ikejima Sayaka、Nakata Jun、Morimoto Soyoko、Fujiki Fumihiro、Nishida Sumiyuki、Tsuboi Akihiro、Hosen Naoki、Nakajima Hiroko、Hasegawa Kana、Oka Yoshihiro、Sugiyama Haruo、Oji Yusuke
- Journal Title
  
  Biomedical Reports
  
  Volume: 12 Pages: 244-250
- DOI
  10.3892/br.2020.1289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-20K07695
[Journal Article] Immune adjuvant therapy using Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments.2019
- Author(s)
  Nishida S, Tsuboi A, Tanemura A, Ito T, Nakajima H, Shirakata T, Morimoto S, Fujiki F, Hosen N, Oji Y, Kumanogoh A, Kawase I, Oka Y, Azuma I, Morita S, Sugiyama H.
- Journal Title
  
  Medicine (Baltimore)
  
  Volume: 98 Issue: 33 Pages: e16771-e16771
- DOI
  10.1097/md.0000000000016771
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07729, KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216
[Journal Article] A phase I clinical study of a cocktail vaccine of Wilms’ tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma2018
- Author(s)
  Tsuboi A, Hashimoto N, Fujiki F, Morimoto S, Kagawa N, Nakajima H, Hosen N, Nishida S, Nakata J, Morita S, Sakamoto J, Oji Y, Oka Y, Sugiyama H
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 68(2) Issue: 2 Pages: 331-340
- DOI
  10.1007/s00262-018-2274-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10331, KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216
[Journal Article] A versatile T cell-based assay to assess therapeutic antigen-specific PD-1-targeted approaches2018
- Author(s)
  Versteven Maarten、Bergh Johan M.J. Van den、Broos Katrijn、Fujiki Fumihiro、Campillo-Davo Diana、De Reu Hans、Morimoto Soyoko、Lecocq Quentin、Keyaerts Marleen、Berneman Zwi、Sugiyama Haruo、Van Tendeloo Viggo F.I.、Breckpot Karine、Lion Eva
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 45 Pages: 27797-27808
- DOI
  10.18632/oncotarget.25591
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216
[Journal Article] WT1 peptide-based immunotherapy for advanced thymic epithelial malignancies2018
- Author(s)
  Oji Y、Inoue M、Takeda Y、Hosen N、Shintani Y、Kawakami M、Harada T、Murakami Y、Iwai M、Fukuda M、Nishida S、Nakata J、Nakae Y、Takashima S、Shirakata T、Nakajima H、Hasegawa K、Kida H、Kijima T、Morimoto S、Fujiki F、Tsuboi A、Morii E、Morita S、Sakamoto J、Kumanogoh A、Oka Y、Okumura M、Sugiyama H
- Journal Title
  
  International Journal of Cancer
  
  Volume: 142 Issue: 11 Pages: 2375-2382
- DOI
  10.1002/ijc.31253
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09537, KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216, KAKENHI-PROJECT-15K09173, KAKENHI-PROJECT-15K09476
[Journal Article] Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity2018
- Author(s)
  Morimoto Soyoko、Fujiki Fumihiro、Kondo Kenta、Nakajima Hiroko、Kobayashi Yoshiki、Inatome Miki、Aoyama Nao、Nishida Yuya、Tsuboi Akihiro、Oka Yoshihiro、Nishida Sumiyuki、Nakata Jun、Hosen Naoki、Oji Yusuke、Sugiyama Haruo
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 75 Pages: 34132-34141
- DOI
  10.18632/oncotarget.26139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216, KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-17K15727
[Journal Article] Combination Gemcitabine and WT1 Peptide Vaccination Improves Progression-Free Survival in Advanced Pancreatic Ductal Adenocarcinoma: A Phase II Randomized Study.2018
- Author(s)
  Nishida S, Ishikawa T, Egawa S, Koido S, Yanagimoto H, Ishii J, Kanno Y, Kokura S, Yasuda H, Oba MS, Sato M, Morimoto S, Fujiki F, Eguchi H, Nagano H, Kumanogoh A, Unno M, Kon M, Shimada H, Ito K, Homma S, Oka Y, Morita S, Sugiyama H.
- Journal Title
  
  Cancer Immunol Res.
  
  Volume: 6 Issue: 3 Pages: 320-331
- DOI
  10.1158/2326-6066.cir-17-0386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216, KAKENHI-PROJECT-15K09050, KAKENHI-PROJECT-15K09173
[Journal Article] Wilms tumour 1 peptide vaccine as a cure-oriented post-chemotherapy strategy for patients with acute myeloid leukaemia at high risk of relapse.2017
- Author(s)
  Nakata J, Nakae Y, Kawakami M, Morimoto S, Motooka D, Hosen N, Fujiki F, Nakajima H, Hasegawa K, Nishida S, Tsuboi A, Oji Y, Oka Y, Kumanogoh A, Sugiyama H.
- Journal Title
  
  Br J Haematol.
  
  Volume: XX Issue: 2 Pages: 287-290
- DOI
  10.1111/bjh.14768
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-17K07216, KAKENHI-PROJECT-15K09173, KAKENHI-PROJECT-15K09476, KAKENHI-PROJECT-15K19550
[Journal Article] Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis.2016
- Author(s)
  Hasegawa K, Tanaka S, Fujiki F, Morimoto S, Nakano K, Kinoshita H, Okumura A, Fujioka Y, Urakawa R, Nakajima H, Tatsumi N, Nakata J, Takashima S, Nishida S, Tsuboi A, Oka Y, Oji Y, Miyoshi E, Hirata T, Kumanogoh A, Sugiyama H, Hosen N.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 3 Pages: e0152326-e0152326
- DOI
  10.1371/journal.pone.0152326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-25460588, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-26461404
[Journal Article] An essential role of the avidity of T-cell receptor in differentiation of self-antigen-reactive CD8+ T cells2016
- Author(s)
  Kondo K, Fujiki F, Nakajima H, Yatsukawa E, Morimoto S, Tatsumi N, Nishida S, Nakata J, Oka Y, Tsuboi A, Hosen N, Oji Y, Sugiyama H
- Journal Title
  
  Journal of Immunotherapy
  
  Volume: 39 Issue: 3 Pages: 127-139
- DOI
  10.1097/cji.0000000000000114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09173, KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-15K19550, KAKENHI-PROJECT-25460685
[Journal Article] Syndecan-4 as a biomarker to predict clinical outcome for glioblastoma multiforme treated with WT1 peptide vaccine2016
- Author(s)
  Takashima S, Oka Y, Fujiki F, Morimoto S, Nakajima H, Nakae Y, Nakata J, Nishida S, Hosen N, Tatsumi N, Mizuguchi K, Hashimoto N, Oji Y, Tsuboi A, Kumanogoh A, Sugiyama H
- Journal Title
  
  Future Sci OA
  
  Volume: FSO96 Issue: 4
- DOI
  10.4155/fsoa-2015-0008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-15K09173, KAKENHI-PROJECT-15K19550
[Journal Article] A Zbtb7a proto-oncogene as a novel target for miR-125a.2016
- Author(s)
  Hojo N, Tatsumi N, Moriguchi N, Matsumura A, Morimoto S, Nakata J, Fujiki F, Nishida S, Nakajima H, Tsuboi A, Oka Y, Hosen N, Hayashi S, Sugiyama H, Oji Y.
- Journal Title
  
  Molecular Carcinogenesis
  
  Volume: - Issue: 12 Pages: 1-9
- DOI
  10.1002/mc.22446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-15K09476
[Journal Article] Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response2015
- Author(s)
  Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama
- Journal Title
  
  Cancer Immunology Immunotherapy
  
  Volume: - Issue: 6 Pages: 707-16
- DOI
  10.1007/s00262-015-1674-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830116, KAKENHI-PROJECT-26462180, KAKENHI-PROJECT-26462195, KAKENHI-PROJECT-15K10331, KAKENHI-PROJECT-24592160, KAKENHI-PROJECT-25462256
[Journal Article] An immunocompetent mouse model for MLL/AF9 leukemia reveals the potential of spontaneous cytotoxic T-cell response to an antigen expressed in leukemia cells2015
- Author(s)
  Kana Hasegawa, Satomi Tanaka, Fumihiro Fujiki, Soyoko Morimoto, Hiroko Nakajima, Naoya Tatsumi, Jun Nakata, Satoshi Takashima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama, Naoki Hosen
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 12 Pages: e0144594-e0144594
- DOI
  10.1371/journal.pone.0144594
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-25460685
[Journal Article] Two distinct effector memory cell populations of WT1 (Wilms' tumor gene 1)-specific cytotoxic T lymphocytes in acute myeloid leukemia patients2015
- Author(s)
  Nakae Y., Oka Y., Fujiki F., Morimoto S., Kamiya T., Takashima S., Nakata J., Nishida S., Nakajima H., Hosen N., Tsuboi A, Kyo T., Oji Y., Mizuguchi K., Kumanogoh A., Sugiyama H.
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: in press Issue: 7 Pages: 791-804
- DOI
  10.1007/s00262-015-1683-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591164, KAKENHI-PROJECT-25830116, KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K19550
[Journal Article] Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms.2015
- Author(s)
  Tatsumi N, Hojo N, Sakamoto H, Inaba R, Moriguchi N, Matsuno K, Fukuda M, Matsumura A, Hayashi S, Morimoto S, Nakata J, Fujiki F, Nishida S, Nakajima H, Tsuboi A, Oka Y, Hosen N, Sugiyama H, Oji Y.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 6 Pages: e0130578-e0130578
- DOI
  10.1371/journal.pone.0130578
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09476, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-25460685
[Journal Article] Transduction of a novel HLA-DRB1*04:05-restricted, WT1-specific TCR gene into human CD4+T cells confers killing activity against human leukemia cells2015
- Author(s)
  Akiko Katsuhara, Fumihiro Fujiki, Nao Aoyama, Satoe Tanii, Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Hiroko Nakajima, Kenta Kondo, Naoya Tatsumi, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Sumiyuki Nishida, Naoki Hosen, Shinji Sogo, Yusuke Oji, Haruo Sugiyama
- Journal Title
  
  Anticancer Research
  
  Volume: 35 Pages: 1251-1262
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830116
[Journal Article] Wilms tumor gene (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer.2014
- Author(s)
  Nishida S, Koido S et al
- Journal Title
  
  J Immunother
  
  Volume: 37 Issue: 2 Pages: 105-114
- DOI
  10.1097/cji.0000000000000020
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23501289, KAKENHI-PROJECT-24501334, KAKENHI-PROJECT-24591164, KAKENHI-PROJECT-25830116
[Journal Article] Functional human Th17 clones with WT1-specific helper activity.2013
- Author(s)
  Tachino S, Fujiki F, Oka Y, Tsuboi A, Morimoto S, Lin YH, Tamanaka T, Kondo K, Nakajima H, Nishida S, Hosen N, Oji Y, Kumanogoh A, Sugiyama H.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 62（4） Issue: 4 Pages: 801-10
- DOI
  10.1007/s00262-012-1385-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592123, KAKENHI-PROJECT-24591164, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-25462257, KAKENHI-PROJECT-25830116
[Journal Article] Maintenance of complete remission after allogeneic stem cell transplantation in leukemia patients treated with Wilms tumor 1 peptide vaccine2013
- Author(s)
  Maeda T, Hosen N, Fukushima K, Tsuboi A, Morimoto S, Matsui T, Sata H, Fujita J, Hasegawa K, Nishida S, Nakata J, Nakae Y, Takashima S, Nakajima H, Fujiki F, Tatsumi N, Kondo T, Hino M, Oji Y, Oka Y, Kanakura Y, Kumanogoh A, Sugiyama H
- Journal Title
  
  Blood Cancer J
  
  Volume: 3 Issue: 8 Pages: e130-e130
- DOI
  10.1038/bcj.2013.29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591423, KAKENHI-PROJECT-24591164, KAKENHI-PROJECT-24591395, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-25461419, KAKENHI-PROJECT-25461450, KAKENHI-PROJECT-25830116
[Presentation] Isolation of a novel high-avidity TCR in pancreatic cancer patients receiving the combination of WT1126 peptide vaccine plus gemcitabine2023
- Author(s)
  Soyoko Morimoto, Fumihiro Fujiki, Akinori Nagata, Satsuki Okafuji, Jun Nakata, Hiroko Nakajima, Akihiro Tsuboi, Yoshiko Hashii, Yoshihiro Oka, Yusuke Oji, Takeshi Ishikawa, Shinichi Egawa, Shingo Koido, Haruo Sugiyama, Sumiyuki Nishida
- Organizer
  The 10th International Conference on WT1 in human neoplasia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07251
[Presentation] GEM併用WT1ワクチン投与膵癌患者からのWT1126特異的high avidity TCRの単離2023
- Author(s)
  森本　創世子、藤木　文博、西田　純幸、永田　暁教、岡藤　咲月、中田　潤、中島　博子、岡　芳弘、尾路　祐介、杉山　治夫
- Organizer
  第15回日本血液疾患免疫療法学会
- Data Source
  KAKENHI-PROJECT-23K06761
[Presentation] GEM併用WT1ワクチン投与膵癌患者から単離したWT1126特異的high-avidity TCRのTCR-T細胞療法への応用2023
- Author(s)
  森本　創世子、藤木　文博、西田　純幸、永田　暁教、中田　潤、中島　博子、尾路　祐介、岡芳弘、杉山　治夫
- Organizer
  第51回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K06761
[Presentation] TCF1レポーターマウスを活用した腫瘍局所と所属リンパ節に存在する癌抗原特異的CD8+ T細胞の分類と解析2023
- Author(s)
  永田　暁教、藤木　文博、森本　創世子、中田　潤、西田　純幸、中島　博子、橋井　佳子、坪井　昭博、岡　芳弘、尾路　祐介、杉山　治夫
- Organizer
  第27回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K06761
[Presentation] GEM併用WT1ワクチン投与膵癌患者からのWT1126特異的high avidity TCRの単離2023
- Author(s)
  森本　創世子、藤木　文博、西田　純幸、永田　暁教、岡藤　咲月、中田　潤、中島　博子、岡　芳弘、尾路　祐介、杉山　治夫
- Organizer
  第15回日本血液疾患免疫療法学会
- Data Source
  KAKENHI-PROJECT-22K07251
[Presentation] TCF1レポーターマウスを活用した腫瘍局所と所属リンパ節に存在する癌抗原特異的CD8+ T細胞の分類と解析2023
- Author(s)
  永田　暁教、藤木　文博、森本　創世子、中田　潤、西田　純幸、中島　博子、橋井　佳子、坪井　昭博、岡　芳弘、尾路　祐介、杉山治夫
- Organizer
  第27回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-22K07251
[Presentation] Isolation of a novel high-avidity TCR in pancreatic cancer patients receiving the combination of WT1126 peptide vaccine plus gemcitabine2023
- Author(s)
  Soyoko Morimoto, Fumihiro Fujiki, Akinori Nagata, Satsuki Okafuji, Jun Nakata, Hiroko Nakajima, Akihiro Tsuboi, Yoshiko Hashii, Yoshihiro Oka, Yusuke Oji, Takeshi Ishikawa, Shinichi Egawa, Shingo Koido, Haruo Sugiyama, Sumiyuki Nishida
- Organizer
  The 10th International Conference on WT1 in human neoplasia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06761
[Presentation] TCF1レポーターマウスを活用した腫瘍局所と所属リンパ節に存在する癌抗原特異的CD8+ T細胞の分類と解析2023
- Author(s)
  永田　暁教、藤木　文博、森本　創世子、中田　潤、西田　純幸、中島　博子、橋井　佳子、坪井　昭博、岡　芳弘、尾路　祐介、杉山　治夫
- Organizer
  第15回日本血液疾患免疫療法学会
- Data Source
  KAKENHI-PROJECT-23K06761
[Presentation] GEM併用WT1ワクチン投与膵癌患者から単離したWT1126特異的high-avidity TCRのTCR-T細胞療法への応用2023
- Author(s)
  森本　創世子、藤木　文博、西田　純幸、永田　暁教、中田　潤、中島　博子、尾路　祐介、岡芳弘、杉山　治夫
- Organizer
  第51回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-22K07251
[Presentation] CD19キメラ抗原受容体のN末側領域の改変によるCAR-T細胞の機能増強2023
- Author(s)
  岡藤　咲月、森本　創世子、藤木　文博、竹内　杏樹、中田　潤、中島　博子、岡　芳弘、尾路　祐介、杉山　治夫
- Organizer
  第15回日本血液疾患免疫療法学会
- Data Source
  KAKENHI-PROJECT-23K06761
[Presentation] 1.GEM併用WT1ワクチン投与膵癌患者からのWT1^126特異的high-avidity TCRの単離2022
- Author(s)
  森本創世子, 藤木文博, 西田純幸, 永田暁教, 中田潤, 中島博子, 尾路祐介, 岡芳弘, 杉山治夫
- Organizer
  日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-22K07251
[Presentation] 脳腫瘍患者におけるWT1ヘルパーペプチド併用WT1ペプチドワクチン療法の免疫モニタリング解析2019
- Author(s)
  森本　創世子、坪井　昭博、藤木　文博、橋本　直哉、稲留　美希、中島　博子、中田　潤、保仙　直毅、尾路　祐介、岡　芳弘、杉山　治夫
- Organizer
  日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K07216
[Presentation] 癌抗原特異的T細胞受容体のfunctional avidityを効率よく正確に評価できるplatform細胞の作製とその応用例2019
- Author(s)
  森本　創世子、藤木　文博、近藤　健太、中島　博子、中田　潤、保仙　直毅、橋井　佳子、坪井　昭博、岡　芳弘、尾路　祐介、杉山　治夫
- Organizer
  日本血液疾患免疫療法学会
- Data Source
  KAKENHI-PROJECT-17K07216
[Presentation] Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity and its application2019
- Author(s)
  Soyoko Morimoto, Fumihiro Fujiki, Kenta Kondo, Hiroko Nakajima, Yoshiki Kobayashi, Miki Inatome, Nao Aoyama, Yuya Nishida, Akihiro Tsuboi, Yoshihiro Oka, Sumiyuki Nishida, Jun Nakata, Naoki Hosen, Yusuke Oji, and Haruo Sugiyama
- Organizer
  International conference on WT1 biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07216
[Presentation] 癌抗原特異的T細胞受容体のfunctional avidityを効率よく正確に評価できるplatform細胞の作製2018
- Author(s)
  森本創世子
- Organizer
  第46回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K07216
[Presentation] Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity2018
- Author(s)
  Soyoko Morimoto
- Organizer
  The 9th International Conference on WT1 in Human Neoplasia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07216
[Presentation] 癌抗原特異的T細胞受容体のfunctional avidityを効率よく正確に評価できるplatform細胞の作製2018
- Author(s)
  森本創世子
- Organizer
  第22回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K07216
[Presentation] 切除不能進行膵癌に対するゲムシタビン併用HLA拘束性WT1ペプチドワクチン療法で誘導されたWT1特異的CTLの免疫学的機能解析2017
- Author(s)
  森本創世子
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K07216
[Presentation] 進行膵癌に対するゲムシタビン併用WT1ワクチン療法ランダム化第II創臨床試験：臨床効果と抗原特異的免疫反応の評価2016
- Author(s)
  西田　純幸、石川　剛、江川　新一、小井戸　薫雄、森本　創世子、石井　淳、菅野　良秀、柳本　泰明、大庭　真梨、古倉　聡、本間　定、島田　英昭、森田　智視、岡　芳弘、杉山　治夫
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2016-07-27
- Data Source
  KAKENHI-PROJECT-15K18446
[Presentation] Randamized phase II stuy of WT1 peptide vaccine plus gemcitabine for advanced pancreatic ductal adenocarcinoma (PDAC): Clinical efficacy and immune response2016
- Author(s)
  Sumiyuki Nishida, Takeshi Ishikawa, Satoshi Kokura, Shinichi Egawa, Shigeo Koido, Hiroaki Yasuda, Hiroaki Yanagimoto, Jun Ishii, Yoshihide Kanno, Mari Saito Oba, Maho Sato, Soyoko Morimoto, Hidetoshi Eguchi, Hiroaki Nagano, Sadamu Homma, Yoshihiro Oka, Satoshi Morita, Haruo Sugiyama
- Organizer
  2016 ASCO Annual Meeting
- Place of Presentation
  シカゴ（米国）
- Year and Date
  2016-06-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18446
[Presentation] HLA class II 拘束性WT1特異的T cell Receptor遺伝子導入によるヘルパー活性とキラー活性を有するCD+4 T細胞の作製2013
- Author(s)
  藤木文博，林ユウ宏，勝原晶子，岡芳弘，坪井昭博，青山奈央，谷井里江，中島博子，森本創世子，保仙直毅，尾路祐介，熊ノ郷淳，杉山治夫
- Organizer
  第41回　日本臨床免疫学会総会
- Place of Presentation
  海峡メッセ下関
- Data Source
  KAKENHI-PROJECT-25830116
[Presentation] Analysis of correlation of WT1-specific immune responses before WT1 peptide vaccination and clinical responses
- Author(s)
  Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Naoki Hosen, Sumiyuki Nishida, Fumihiro Fujiki, Hiroko Nakajima, Yusuke Oji, Haruo Sugiyama
- Organizer
  The 7th International Conference on WT1 in human neoplasia
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-04-22 – 2014-04-23
- Data Source
  KAKENHI-PROJECT-25830116
[Presentation] Gemcitabine plus WT1 peptide-based cancer vaccine versus gemcitabine alone for advanced pancreatic cancer: a randomized phase II clinical study in multi-centre-interim analysis
- Author(s)
  Sumiyuki Nishida, Shinichi Egawa, Satoshi Kokura, Takeshi Ishikawa, Shigeo Koido, Sadamu Homma, Soyoko Morimoto, Satoshi Morita, Yoshihiro Oka, Haruo Sugiyama
- Organizer
  The 7th International Conference on WT1 in human neoplasia
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-04-22 – 2014-04-23
- Data Source
  KAKENHI-PROJECT-25830116
[Presentation] Response assessments in WT1 peptide vaccination an long term results of combined temozolomide therapy
- Author(s)
  Naoya Hashimoto, Akihiro Tsuboi, Yasuyoshi Chiba, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Sumiyuki Nishida, Naoki Hosen, Naoki Kagawa, Yusuke Oji, Toshiki Yoshimine, Haruo Sugiyama
- Organizer
  The 7th International Conference on WT1 in human neoplasia
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-04-22 – 2014-04-23
- Data Source
  KAKENHI-PROJECT-25830116
[Presentation] Wilms' tumor gene 1 (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer
- Author(s)
  Shigeo Koido, Sumiyuki Nishida, Sadamu Homma, Yutaka Takeda, Hideo Komita, Satoshi Morita, Toshinori Ito, Soyoko Morimoto, Yoshihiro Oka, Satoru Yanagisawa, Yoichi Toyama, Masahiro Ikegami, Hiroaki Nagano, Toshifumi Ohkusa, Hisao Tajiri, Haruo Sugiyama
- Organizer
  AACR Annual Meeting
- Place of Presentation
  San Diego, CA
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25830116

1. 西田純幸 (00403189)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
2. HASHII Yoshiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. FUJIKI Fumihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
4. HOSEN Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. KAGAWA Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. KIDA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. TSUBOI Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 岡芳弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 小井戸薫雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 片山高嶺

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 白川利朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 皆川光

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 尾路祐介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 井上義一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 香山尚子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 日野雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morimoto Soyoko 森本 創世子

MORIMOTO Soyoko 森本 創世子

Research Projects

Research Products

Co-Researchers

癌免疫応答ロバストネスの維持を基盤とする癌免疫療法の開発Principal Investigator

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難治がんに有望ながん免疫effector T細胞特性の基盤的解明と細胞治療開発

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CRISPR/Cas9 genome-wide knockout screening for identifying the novel gene to overcome the tumor-immune escapePrincipal Investigator

Principal Investigator

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Development of novel cancer immunotherapy based on memory-oriented TCRPrincipal Investigator

Principal Investigator

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Identification of T cells that exhibit cytotoxic activity against tumor based on the single-cell gene expression profiles and control their functionPrincipal Investigator

Principal Investigator

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Identification of key genes that is correlated with long-term maintenance of cytotoxic activity in WT1 specific cytotoxic T lymphocytesPrincipal Investigator

Principal Investigator

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[Journal Article] Establishment of a novel NFAT-GFP reporter platform useful for the functional avidity maturation of HLA class II-restricted TCRs2023

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[Journal Article] Enhanced antitumor activity of a novel, oral, helper epitope-containing WT1 protein vaccine in a model of murine leukemia2023

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[Journal Article] WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT12023

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[Journal Article] Cellular and Humoral Immune Responses Induced by an HLA Class I-restricted Peptide Cancer Vaccine Targeting WT1 Are Associated With Favorable Clinical Outcomes in Advanced Ovarian Cancer.2022

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[Journal Article] T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy2022

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[Journal Article] An oral WT1 protein vaccine composed of WT1-anchored, genetically engineered Bifidobacterium longum allows for intestinal immunity in mice with acute myeloid leukemia2022

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[Journal Article] Identification of two distinct populations of WT1-specific cytotoxic T lymphocytes in co-vaccination of WT1 killer and helper peptides.2021

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[Journal Article] Reader-free ELISPOT assay for immuno-monitoring in peptide-based cancer vaccine immunotherapy2020

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Morimoto Soyoko 森本創世子

MORIMOTO Soyoko 森本創世子

[Journal Article] Immune adjuvant therapy using Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments.2019