sasaki fumiyuki 佐々木文之

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佐々木文之ササキフミユキ

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Researcher Number	10706469
Other IDs
Affiliation (Current)	2026: 日本医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2026: 日本医科大学, 医学部, 助教 2022 – 2024: 日本医科大学, 医学部, 助教 2019 – 2020: 東京医科歯科大学, 大学院医歯学総合研究科, プロジェクト研究員
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Basic Section 59020:Sports sciences-related / Basic Section 56020:Orthopedics-related Except Principal Investigator Basic Section 49070:Immunology-related
Keywords	Principal Investigator イオンチャネル / メカノバイオロジー / 免疫応答 / マイオカイン / メカノセンサー / 炎症 / IL-6 / 骨格筋 / Piezo1 / スクレロスチン / 骨細胞 … More Except Principal Investigator … More 自然免疫 / ユビキチン化 / クラスリン / NLRP3 / トランスゴルジ網 / マイクロチューブ / インフラマソーム / 炎症 / エンドサイトーシス / マクロファージ Less

流産・早産に保護的に作用する子宮メカノバイオロジー分子機序の解明Principal Investigator
- Principal Investigator
  
  佐々木文之
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
Elucidating of molecular mechanism by which endocytosis regulates NLRP3 inflammasome formation and its phycological significance
- Principal Investigator
  
  Morita Rimpei
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Nippon Medical School
炎症・免疫応答を司る骨格筋特異的メカニカルストレス受容体の新規同定と機能解析Principal Investigator
- Principal Investigator
  
  佐々木文之
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Nippon Medical School
新規スクリーニング法を用いた骨細胞特異的なメカニカルストレス受容体の同定Principal Investigator
- Principal Investigator
  
  佐々木文之
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2020 2019

All Journal Article Presentation

[Journal Article] Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation.2024
- Author(s)
  Lee J, Sasaki F, Koike E, Cho M, Lee Y, Dho SH, Lee J, Lee E, Toyohara E, Sunakawa M, Ishibashi M, Hung HH, Nishioka S, Komine R, Okura C, Shimizu M, Ikawa M, Yoshimura A, Morita R, Kim LK.
- Journal Title
  
  Cell Death Differ.
  
  Volume: 31 Issue: 12 Pages: 1679-1694
- DOI
  10.1038/s41418-024-01367-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07140
[Journal Article] Mechanotransduction via the Piezo1-Akt Pathway Underlies Sost Suppression in Osteocytes2020
- Author(s)
  Sasaki F, Hayashi M, Mouri Y, Nakamura S, Adachi T, Nakashima T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 521 Issue: 3 Pages: 806-813
- DOI
  10.1016/j.bbrc.2019.10.174
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18452
[Journal Article] The regulation of RANKL by mechanical force2020
- Author(s)
  Sasaki Fumiyuki、Hayashi Mikihito、Ono Takehito、Nakashima Tomoki
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 39 Issue: 1 Pages: 34-44
- DOI
  10.1007/s00774-020-01145-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K17014, KAKENHI-PROJECT-19K18452
[Presentation] Gelsolin negatively regulates NLRP3 inflammasome activation by stabilizing mitochondria.2024
- Author(s)
  Rimpei Morita, Jiyeon Lee, Masumi Shimizu, Fumiyuki Sasaki, Akihiko Yoshimura, Lark Kyun Kim
- Organizer
  第52回日本免疫学会学術集会（千葉）
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] Gelsolin from macrophages promotes fibroblasts migration during skin wound healing.2024
- Author(s)
  Eri Toyohara, Fumiyuki Sasaki, Teruyuki Dohi, Rei Ogawa, Rimpei Morita.
- Organizer
  第53回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] NLRP3 and SGPL1 interaction plays a key role in priming event for inflammasome activation2024
- Author(s)
  Fumiyuki Sasaki, Masumi Shimizu, Misaki Wakasugi, Hinata Hirashima, Rimpei Morita.
- Organizer
  第53回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] Gelsolin from macrophages is required for fibroblast migration during skin wound healing2024
- Author(s)
  Eri Toyohara, Fumiyuki Sasaki, Teruyuki Dohi, Rei Ogawa, Rimpei Morita
- Organizer
  第52回日本免疫学会学術集会（千葉）
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] Gelsolin released from macrophages is required for fibroblast migration during skin wound healing2024
- Author(s)
  Eri Toyohara, Fumiyuki Sasaki, Teruyuki Dohi, Rimpei Morita, Rei Ogawa,
- Organizer
  International Plastic Surgery Research Council (IPSRC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] Gelsolin released from macrophages promotes fibroblasts migration during skin wound healing2024
- Author(s)
  Eri Toyohara, Fumiyuki Sasaki, Teruyuki Dohi, Rimpei Morita, Rei Ogawa
- Organizer
  The Fourth Congress of The Asia Pacific Society for Scar Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] SGPL1はNLRP3インフラマソームのプライミング場の形成に必須である2024
- Author(s)
  佐々木文之, 森田林平
- Organizer
  第45回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] マクロファージ死由来のゲルゾリンは皮膚創傷治癒において線維芽細胞の遊走能を促進する2024
- Author(s)
  豊原瑛理, 佐々木文之, 土肥輝之, 小川令, 森田林平
- Organizer
  第45回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] Sphingosine-1-phosphate lyase SGPL1 is required for NLRP3 inflammasome activation via the dynamic organization of endoplasmic reticulum and microtubules.2024
- Author(s)
  Fumiyuki Sasaki, Masumi Shimizu, Rimpei Morita
- Organizer
  第52回日本免疫学会学術集会（千葉）
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] NLRP3とスフィンゴシン1リン酸分解酵素の相互作用はインフラマソーム活性化に必須なプライミングイベントである2024
- Author(s)
  佐々木文之, 清水真澄, 若杉美咲, 平島ひなた, 森田林平
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] Clathrin heavy chain regulates NLRP3 inflammasome formation via endocytosis in macrophages.2024
- Author(s)
  Hung Hiep Huynh, Fumiyuki Sasaki, Masumi Shimizu, Akihiko Yoshimura, Rimpei Morita
- Organizer
  第52回日本免疫学会学術集会（千葉）
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] The gelsolin-actin axis orchestrates NLRP3 inflammasome activation.2023
- Author(s)
  Rimpei Morita, Jiyeon Lee, Mika Sunakawa, Eri Koike, Masumi Shimizu, Mariko Ishibashi, Fumiyuki Sasaki, Akihiko Yoshimura, Lark Kyun Kim
- Organizer
  Keystone Symposia. Innate Immunity: From Innate Sensing to Adaptive Responses (D2)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] Sphingosine-1-phosphate lyase promotes NLRP3 inflammasome activation via the development of endoplasmic reticulum and microtubules.2023
- Author(s)
  Fumiyuki Sasaki, Masumi Shimizu, Rimpei Morita
- Organizer
  Keystone Symposia. Innate Immunity: From Innate Sensing to Adaptive Responses (D2)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] phingosine-1-phosphate lyase promotes inflammasome activation via the development of endoplasmic reticulum network2022
- Author(s)
  Fumiyuki Sasaki, Masumi Shimizu and Rimpei Morita
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] Gelsolin-actin axis organizes NLRP3 inflammasome activation2022
- Author(s)
  Masumi SHIMIZU, Eri KOIKE, Jiyeon LEE, Fumiyuki SASAKI, Akihiko YOSHIMURA, Lark Kyun KIM, Rimpei MORITA
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07140
[Presentation] 骨メカニカルストレス受容機構の解明を目指して2019
- Author(s)
  佐々木文之、林幹人、中島友紀
- Organizer
  第５回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19K18452

1. Morita Rimpei (00362541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
2. 小野岳人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

sasaki fumiyuki 佐々木 文之

佐々木 文之 ササキ フミユキ

Research Projects

Research Products

Co-Researchers

流産・早産に保護的に作用する子宮メカノバイオロジー分子機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating of molecular mechanism by which endocytosis regulates NLRP3 inflammasome formation and its phycological significance

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

炎症・免疫応答を司る骨格筋特異的メカニカルストレス受容体の新規同定と機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規スクリーニング法を用いた骨細胞特異的なメカニカルストレス受容体の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanotransduction via the Piezo1-Akt Pathway Underlies Sost Suppression in Osteocytes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The regulation of RANKL by mechanical force2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Gelsolin negatively regulates NLRP3 inflammasome activation by stabilizing mitochondria.2024

Author(s)

Organizer

Data Source

[Presentation] Gelsolin from macrophages promotes fibroblasts migration during skin wound healing.2024

Author(s)

Organizer

Data Source

[Presentation] NLRP3 and SGPL1 interaction plays a key role in priming event for inflammasome activation2024

Author(s)

Organizer

Data Source

[Presentation] Gelsolin from macrophages is required for fibroblast migration during skin wound healing2024

Author(s)

Organizer

Data Source

[Presentation] Gelsolin released from macrophages is required for fibroblast migration during skin wound healing2024

Author(s)

Organizer

Data Source

[Presentation] Gelsolin released from macrophages promotes fibroblasts migration during skin wound healing2024

Author(s)

Organizer

Data Source

[Presentation] SGPL1はNLRP3インフラマソームのプライミング場の形成に必須である2024

Author(s)

Organizer

Data Source

[Presentation] マクロファージ死由来のゲルゾリンは皮膚創傷治癒において線維芽細胞の遊走能を促進する2024

Author(s)

Organizer

Data Source

[Presentation] Sphingosine-1-phosphate lyase SGPL1 is required for NLRP3 inflammasome activation via the dynamic organization of endoplasmic reticulum and microtubules.2024

Author(s)

Organizer

Data Source

sasaki fumiyuki 佐々木文之

佐々木文之ササキフミユキ