Ohka Fumiharu 大岡史治

Researcher Number	10725724
Other IDs
Affiliation (Current)	2023: 名古屋大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 名古屋大学, 医学系研究科, 講師 2016 – 2019: 名古屋大学, 医学系研究科, 助教 2015: 名古屋大学, 医学部附属病院, 病院助教 2014: 名古屋大学, 医学(系)研究科(研究院), 特別研究員(PD)
Review Section/Research Field	Principal Investigator Neurosurgery / Basic Section 56010:Neurosurgery-related Except Principal Investigator Basic Section 56010:Neurosurgery-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator 悪性脳腫瘍 / 神経膠腫 / EZH2 / 脳腫瘍学 / エピゲノム異常 / 脳腫瘍マウスモデルの樹立 / 悪性神経膠腫 / エピゲノム治療 / スーパーエンハンサー異常 / 異常エンハンサー / 脳腫瘍のエピゲノム異常 / オルガノイドモデル … More Except Principal Investigator … More 脳腫瘍 / シングルセル解析 / アフリカツメガエル / Neurod4 / 上位細胞 / 脱分化 / グリア瘢痕 / 脊髄損傷 / 神経再生 / エピゲノム制御 / ハイブリッドベクター / 上衣細胞 / 神経幹細胞 / 神経転写因子 / マウスモデル / 染色体構造異常 / エピゲノム異常 / 悪性脳腫瘍 / CRISPR/Cas9 / 神経膠腫 / 数理モデル / DNAバーコードラベル / CRISPR/Cas9ノックアウト / シングルセル / もやもや病 / 下垂体腫瘍 / エクソソーム / リアルタイムPCR Less

オルガノイドモデルを用いた脳腫瘍の悪性転化を誘導する分子メカニズムの解明Principal Investigator
- Principal Investigator
  
  大岡史治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nagoya University
New molecular diagnostic technique for pituitary neuroendocrine tumors
- Principal Investigator
  
  竹内和人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nagoya University
もやもや病脳動脈COL15A1発現低下のエピゲノム制御機構と病態生理の解明
- Principal Investigator
  
  荒木芳生
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nagoya University
The evolutional trajection and precision-medicine to gliomas
- Principal Investigator
  
  夏目敦至
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nagoya University
Xenopus由来因子のエピゲノム制御による神経系細胞の系譜転換と神経再生
- Principal Investigator
  
  西村由介
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nagoya University
スーパーエンハンサー形成が誘導する悪性脳腫瘍の異常クロマチンリモデリングの解明Principal Investigator
- Principal Investigator
  
  大岡史治
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nagoya University
Novel treatment strategy targeting neoantigen induced by epigenetic alterations in malignant glioma formation
- Principal Investigator
  
  夏目敦至
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Nagoya University
Remodeling of altered epigenetic regulation via targeting epigenetic factor during glioma formationPrincipal Investigator
- Principal Investigator
  
  Ohka Fumiharu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Nagoya University
Identification of a novel epigenetic modifier in gliomagenesisPrincipal Investigator
- Principal Investigator
  
  Ohka Fumiharu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Nagoya University

All 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Urinary MicroRNA-Based Diagnostic Model for Central Nervous System Tumors Using Nanowire Scaffolds2021
- Author(s)
  Kitano Yotaro、Aoki Kosuke、Ohka Fumiharu、Yamazaki Shintaro、Motomura Kazuya、Tanahashi Kuniaki、Hirano Masaki、Naganawa Tsuyoshi、Iida Mikiko、Shiraki Yukihiro、Nishikawa Tomohide、Shimizu Hiroyuki、Yamaguchi Junya、Maeda Sachi、Suzuki Hidenori、Wakabayashi Toshihiko、Baba Yoshinobu、Yasui Takao、Natsume Atsushi
- Journal Title
  
  ACS Applied Materials & Interfaces
  
  Volume: 13 Issue: 15 Pages: 17316-17329
- DOI
  10.1021/acsami.1c01754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21124, KAKENHI-PROJECT-17K10862, KAKENHI-PLANNED-17H06354, KAKENHI-PROJECT-18H02911, KAKENHI-PROJECT-19KK0228
[Journal Article] Newly established patient-derived organoid model of intracranial meningioma2021
- Author(s)
  Yamazaki Shintaro、Ohka Fumiharu、Hirano Masaki、Shiraki Yukihiro、Motomura Kazuya et al
- Journal Title
  
  Neuro-Oncology
  
  Volume: 23 Issue: 11 Pages: 1936-1948
- DOI
  10.1093/neuonc/noab155
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10862, KAKENHI-PROJECT-21K16645, KAKENHI-PROJECT-20H03789, KAKENHI-PROJECT-18H02911, KAKENHI-PROJECT-20H03511, KAKENHI-PROJECT-20J01889, KAKENHI-PROJECT-20K20598
[Journal Article] Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury2021
- Author(s)
  Fukuoka Toshiki、Kato Akira、Hirano Masaki、Ohka Fumiharu、Aoki Kosuke、Awaya Takayuki、Adilijiang Alimu、Sachi Maeda、Tanahashi Kuniaki、Yamaguchi Junya、Motomura Kazuya、Shimizu Hiroyuki、Nagashima Yoshitaka、Ando Ryo、Wakabayashi Toshihiko、Lee-Liu Dasfne、Larrain Juan、Nishimura Yusuke、Natsume Atsushi
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 2 Pages: 102074-102074
- DOI
  10.1016/j.isci.2021.102074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10862, KAKENHI-PROJECT-18H02911, KAKENHI-PROJECT-19K09453
[Journal Article] H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant.2020
- Author(s)
  Maeda S, Ohka F, Okuno Y, Aoki K, Motomura K, Takeuchi K, Kusakari H, Yanagisawa N, Sato S, Yamaguchi J, Tanahashi K, Hirano M, Kato A, Shimizu H, Kitano Y, Yamazaki S, Yamashita S, Takeshima H, Shinjo K, Kondo Y, Wakabayashi T, Natsume A.
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 8 Issue: 1 Pages: 8-19
- DOI
  10.1186/s40478-020-0882-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09478, KAKENHI-PROJECT-19KK0228, KAKENHI-PROJECT-17H03582, KAKENHI-PROJECT-17K16643, KAKENHI-PROJECT-17K17792, KAKENHI-PROJECT-17K10862, KAKENHI-PROJECT-20K20598
[Journal Article] Trautmann-focused mastoidectomy for a simple, safe presigmoid approach: technical note.2020
- Author(s)
  Tanahashi K, Uda K, Araki Y, Takeuchi K, Choo J, Chalise L, Motomura K, Ohka F, Wakabayashi T, Natsume A.
- Journal Title
  
  J Neurosurg.
  
  Volume: 3 Issue: 3 Pages: 1-5
- DOI
  10.3171/2020.1.jns193179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0228, KAKENHI-PROJECT-17K16639, KAKENHI-PROJECT-17K10862
[Journal Article] Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas2019
- Author(s)
  Ohka Fumiharu、Shinjo Keiko、Deguchi Shoichi、Matsui Yusuke et al.
- Journal Title
  
  Cancer Research
  
  Volume: 79 Issue: 19 Pages: 4814-4827
- DOI
  10.1158/0008-5472.can-19-1272
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18151, KAKENHI-PROJECT-19KK0228, KAKENHI-PLANNED-17H06356, KAKENHI-PUBLICLY-18H04798, KAKENHI-PUBLICLY-18H04899, KAKENHI-PUBLICLY-19H05210, KAKENHI-PROJECT-17H03582, KAKENHI-PROJECT-18H03207, KAKENHI-PROJECT-17K07247
[Journal Article] Neurocognitive and functional outcomes in patients with diffuse frontal lower-grade gliomas undergoing intraoperative awake brain mapping.2019
- Author(s)
  Motomura K, Chalise L, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Yamaguchi J, Shimizu H, Wakabayashi T, Natsume A.
- Journal Title
  
  J Neurosurg.
  
  Volume: 17 Issue: 6 Pages: 1-9
- DOI
  10.3171/2019.3.jns19211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10862, KAKENHI-PROJECT-19KK0228, KAKENHI-PLANNED-17H06356, KAKENHI-PROJECT-18H02911
[Journal Article] Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma2019
- Author(s)
  Ranjit Melissa、Hirano Masaki、Aoki Kosuke、Okuno Yusuke、Ohka Fumiharu、Yamamichi Akane、Kato Akira、Maeda Sachi、Motomura Kazuya、Matsuo Keitaro、Enomoto Atsushi、Ino Yasushi、Todo Tomoki、Takahashi Masahide、Wakabayashi Toshihiko、Kato Takuya、Natsume Atsushi
- Journal Title
  
  Cell Reports
  
  Volume: 26 Issue: 9 Pages: 2274-2281
- DOI
  10.1016/j.celrep.2019.01.109
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16643, KAKENHI-PLANNED-17H06356, KAKENHI-PROJECT-16H05436, KAKENHI-PROJECT-19K21262, KAKENHI-PROJECT-17K10862, KAKENHI-PROJECT-19K18386, KAKENHI-PROJECT-19KK0228
[Presentation] 診断困難な成人diffuse midline glioma, H3 K27M-mutantにおけるddPCRの有用性2019
- Author(s)
  前田紗知、大岡史治、平野雅規、青木恒介、竹内和人、本村和也、棚橋邦明、加藤彰、北野詳太郎、西川知秀、清水浩之、山口純矢、山﨑慎太郎、若林俊彦、夏目敦至
- Organizer
  第20回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-19K09478
[Presentation] マウスモデルを用いたIDH野生型グレードIIIグリオーマ形成に寄与するエピゲノム異常の解析2018
- Author(s)
  大岡史治、出口彰一、鈴木啓道、青木恒介、加藤　彰、山道　茜、勝島啓佑、新城恵子、若林俊彦、近藤豊、夏目敦至
- Organizer
  第19回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-16K20003
[Presentation] Epigenetic treatment for IDH-wildtype lower grade glioma, targeting dysregulation of EZH2-H3K27me32017
- Author(s)
  Fumiharu Ohka, Atsushi Natsume, Hiromichi Suzuki, Shoichi Deguchi, Keisuke Katsushima, Keiko Shinjo, Toshihiko Wakabayashi, Yutaka Kondo
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K20003
[Presentation] IDH野生型グレードIIIグリオーマ形成におけるエピゲノムリプログラミング2017
- Author(s)
  大岡史治、出口彰一、山道茜、鈴木啓道、青木恒介、加藤　彰、勝島啓佑、新城恵子、若林俊彦、近藤豊、夏目敦至
- Organizer
  第35回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-16K20003
[Presentation] Epigenetic treatment strategy for IDH-wildtype grade III glioma2017
- Author(s)
  Fumiharu Ohka, Shoichi Deguchi, Hiromichi Suzuki, Kosuke Aoki, Keisuke Katsushima, Keiko Shinjo, Toshihiko Wakabayashi, Yutaka Kondo, Atsushi Natsume  
- Organizer
  日本脳神経外科学会第76回学術総会
- Data Source
  KAKENHI-PROJECT-16K20003
[Presentation] Epigenomic treatment for IDH wild-type grade III glioma, targeting dysregulation of EZH2-H3K27me32016
- Author(s)
  Fumiharu Ohka, Atsushi Natsume, Hiromichi Suzuki, Kosuke Aoki, Shoichi Deguchi, Keisuke Katsushima, Keiko Shinjo, Toshihiko Wakabayashi, Yutaka Kondo
- Organizer
  2016 SNO annual meeting
- Place of Presentation
  米国アリゾナ州スコッツデール
- Year and Date
  2016-11-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861172
[Presentation] Epigenomic treatment for IDH wild-type grade III glioma, targeting dysregulation of EZH2-H3K27me32016
- Author(s)
  Fumiharu Ohka, Atsushi Natsume, Hiromichi Suzuki, Kosuke Aoki, Shoichi Deguchi, Keisuke Katsushima, Keiko Shinjo, Toshihiko Wakabayashi, Yutaka Kondo
- Organizer
  2016 SNO annual meeting
- Place of Presentation
  Scottsdale (USA)
- Year and Date
  2016-11-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20003
[Presentation] IDH野生型グレード3グリオーマに対する新規エピジェネティクス治療の開発2016
- Author(s)
  大岡史治, 出口彰一, 鈴木啓道, 青木恒介, 加藤　彰,勝島啓佑, 新城恵子, 若林俊彦, 近藤豊, 夏目敦至
- Organizer
  第34回日本脳腫瘍学会学術集会
- Place of Presentation
  甲府富士屋ホテル（山梨県甲府市）
- Year and Date
  2016-12-04
- Data Source
  KAKENHI-PROJECT-16K20003
[Presentation] IDH野生型グレード3グリオーマ形成に寄与するエピゲノム異常を標的とした新規治療2016
- Author(s)
  大岡史治, 出口彰一, 鈴木啓道, 青木恒介, 加藤　彰,勝島啓佑, 新城恵子, 若林俊彦, 近藤豊, 夏目敦至
- Organizer
  日本脳神経外科学会第75回学術総会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-16K20003
[Presentation] EZH2を標的としたIDH1野生型グリオーマの新規治療戦略2016
- Author(s)
  大岡史治, 夏目敦至, 鈴木啓道, 出口彰一,勝島啓佑, 新城恵子, 若林俊彦, 近藤豊
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K20003
[Presentation] クロマチンダイナミクスを誘導するEZH2を標的とした膠芽腫の新規治療戦略2015
- Author(s)
  大岡史治　出口彰一　鈴木啓道　勝島啓佑　新城恵子若林俊彦　近藤豊　夏目敦至
- Organizer
  日本脳神経外科学会第74回学術総会
- Place of Presentation
  北海道札幌市　ロイトン札幌
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-26861172
[Presentation] エピゲノム異常を誘導するEZH2を標的としたProneural GBMに対する新規治療戦略2015
- Author(s)
  大岡史治　出口彰一　鈴木啓道　勝島啓佑　新城恵子若林俊彦　近藤豊　夏目敦至
- Organizer
  第33回日本脳腫瘍学会学術集会
- Place of Presentation
  京都府京都市　グランドプリンスホテル京都
- Year and Date
  2015-12-07
- Data Source
  KAKENHI-PROJECT-26861172
[Presentation] Role of Dysregulation of EZH2-H3K27me3 in Gliomagenesis2015
- Author(s)
  大岡史治　夏目敦至　出口彰一　勝島啓佑　新城恵子　若林俊彦　近藤豊
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市　名古屋国際会議場
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-26861172
[Presentation] GBM形成に重要な役割を果たすエピゲノム異常の蓄積
- Author(s)
  大岡史治
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-26861172
[Presentation] 膠芽腫の悪性転化に関わるエピゲノム異常を標的とした新規治療戦略の検討
- Author(s)
  大岡史治
- Organizer
  日本脳神経外科学会第73回学術総会
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Year and Date
  2014-10-09 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-26861172
[Presentation] 二次性膠芽腫マウスにおける経時的なクロマチンリモデリングによるエピゲノム変化
- Author(s)
  大岡史治
- Organizer
  第32回日本脳腫瘍学会学術集会
- Place of Presentation
  シェラトン・グランデ・トーキョーベイホテル（千葉県浦安市）
- Year and Date
  2014-12-07 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-26861172

1. 夏目敦至 (30362255)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. 青木恒介 (10759773)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 西村由介 (20447816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 平野雅規 (40823076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 日野原邦彦 (50549467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 荒木芳生 (80467290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 金森史哲 (00905979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 横山欣也 (90867904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 本村和也 (30467295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 竹内和人 (90710088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 永田雄一 (20834659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YASUI Takao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 松井佑介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohka Fumiharu 大岡 史治

Research Projects

Research Products

Co-Researchers

オルガノイドモデルを用いた脳腫瘍の悪性転化を誘導する分子メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New molecular diagnostic technique for pituitary neuroendocrine tumors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

もやもや病脳動脈COL15A1発現低下のエピゲノム制御機構と病態生理の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The evolutional trajection and precision-medicine to gliomas

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Xenopus由来因子のエピゲノム制御による神経系細胞の系譜転換と神経再生

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

スーパーエンハンサー形成が誘導する悪性脳腫瘍の異常クロマチンリモデリングの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel treatment strategy targeting neoantigen induced by epigenetic alterations in malignant glioma formation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Remodeling of altered epigenetic regulation via targeting epigenetic factor during glioma formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a novel epigenetic modifier in gliomagenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Urinary MicroRNA-Based Diagnostic Model for Central Nervous System Tumors Using Nanowire Scaffolds2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Newly established patient-derived organoid model of intracranial meningioma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant.2020

Author(s)

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[Journal Article] Trautmann-focused mastoidectomy for a simple, safe presigmoid approach: technical note.2020

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Ohka Fumiharu 大岡史治