Uehara Shotaro 上原正太郎

… Alternative Names

上原正太郎ウエハラショウタロウ

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Researcher Number	10733123
Other IDs
Affiliation (Current)	2023: 公益財団法人実験動物中央研究所, 実験動物応用研究部, 室長代理
Affiliation (based on the past Project Information) *help	2023: 公益財団法人実験動物中央研究所, 実験動物応用研究部, 室長代理 2021: 公益財団法人実験動物中央研究所, 実験動物応用研究部, 研究員 2020: 公益財団法人実験動物中央研究所, 実験動物研究部, 研究員 2017 – 2018: 公益財団法人実験動物中央研究所, 実験動物研究部, 研究員 2015 – 2016: 昭和薬科大学, 薬学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Medical pharmacy
Keywords	Principal Investigator チトクロムP450 / ヒト肝キメラマウス / 薬物代謝 / マーモセット / 代謝的活性化 / 肝毒性 / ワルファリン代謝 / チトクロムP450酸化還元酵素 / S-ワルファリン / CYP2B6 … More / プロパフェノン / プロゲステロン / P450 2C19 / P450 2D6 / P450 3A4 / シトクロムP450 / 薬物代謝における動物種差 / Marmoset / P450 / チロクロムP450 Less

Establishment of drug-induced liver injury evaluation system in vivo using humanized liver chimeric micePrincipal Investigator
- Principal Investigator
  
  上原正太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Central Institute for Experimental Animals
新規の肝臓ヒト化薬物性肝障害モデルマウスによるヒト特異的薬物肝毒性の発現機序解明Principal Investigator
- Principal Investigator
  
  上原正太郎
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Central Institute for Experimental Animals
The functional characterization of cytochrome P450 enzymes from preclinical speciesPrincipal Investigator
- Principal Investigator
  
  Uehara Shotaro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Central Institute for Experimental Animals
The functional chacterization of marmoset cytochrome P450 2C enzymesPrincipal Investigator
- Principal Investigator
  
  Uehara Shotaro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals2022
- Author(s)
  Uehara Shotaro、Higuchi Yuichiro、Yoneda Nao、Kawai Kenji、Yamamoto Masafumi、Kamimura Hidetaka、Iida Yuichi、Oshimura Mitsuo、Kazuki Yasuhiro、Yamazaki Hiroshi、Hikita Hayato、Takehara Tetsuo、Suemizu Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 42 Pages: 100410-100410
- DOI
  10.1016/j.dmpk.2021.100410
- NAID
  210000173085
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03150, KAKENHI-PROJECT-20K06463
[Journal Article] Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes.2021
- Author(s)
  Uehara S, Yoneda N, Higuchi Y, Yamazaki H, Suemizu H.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 41 Pages: 100419-100419
- DOI
  10.1016/j.dmpk.2021.100419
- NAID
  210000185812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06463
[Journal Article] Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes2021
- Author(s)
  Miura Tomonori、Uehara Shotaro、Shimizu Makiko、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 7 Pages: 311-317
- DOI
  10.2131/jts.46.311
- NAID
  130008060479
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-20K06463
[Journal Article] Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 12021
- Author(s)
  Uehara Shotaro、Uno Yasuhiro、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 39 Pages: 100398-100398
- DOI
  10.1016/j.dmpk.2021.100398
- NAID
  210000169422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20K06463
[Journal Article] In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice2021
- Author(s)
  Shimizu Makiko、Uehara Shotaro、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 37 Pages: 100369-100369
- DOI
  10.1016/j.dmpk.2020.11.004
- NAID
  210000164669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205, KAKENHI-PROJECT-20K06463
[Journal Article] UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers.2021
- Author(s)
  Uehara S, Higuchi Y, Yoneda N, Yamazaki H, Suemizu H.
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 10 Pages: 1146-1154
- DOI
  10.1080/00498254.2021.1972492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06463
[Journal Article] Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models.2021
- Author(s)
  Miura T, Kamiya Y, Uehara S, Murayama N, Shimizu M, Suemizu H, Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Pages: 636-642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06463
[Journal Article] Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling.2021
- Author(s)
  Toda A, Shimizu M, Uehara S, Sasaki T, Miura T, Mogi M, Utoh M, Suemizu H, Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 3 Pages: 316-323
- DOI
  10.1080/00498254.2020.1849872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06463
[Journal Article] Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes.2021
- Author(s)
  Uehara S, Yoneda N, Higuchi Y, Yamazaki H, Suemizu H.
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 5 Pages: 582-589
- DOI
  10.1080/00498254.2021.1875515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06463
[Journal Article] Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice2021
- Author(s)
  Miura Tomonori、Uehara Shotaro、Shimizu Makiko、Murayama Norie、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 11 Pages: 525-530
- DOI
  10.2131/jts.46.525
- NAID
  130008110376
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164
[Journal Article] Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes.2020
- Author(s)
  Uehara S, Yoneda N, Higuchi Y, Yamazaki H, Suemizu H.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 48 Issue: 7 Pages: 580-586
- DOI
  10.1124/dmd.120.091090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06463
[Journal Article] Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes.2020
- Author(s)
  Uehara S, Yoneda N, Higuchi Y, Yamazaki H, Suemizu H.
- Journal Title
  
  Xenobiotica
  
  Volume: 50 Issue: 6 Pages: 733-740
- DOI
  10.1080/00498254.2019.1688892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06463
[Journal Article] Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model2020
- Author(s)
  Miura Tomonori、Uehara Shotaro、Shigeta Kazuki、Yoshizawa Manae、Kamiya Yusuke、Murayama Norie、Shimizu Makiko、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 34 Issue: 2 Pages: 522-528
- DOI
  10.1021/acs.chemrestox.0c00358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164
[Journal Article] Survey of Drug Oxidation Activities in Liver and Intestine Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model.2019
- Author(s)
  Uehara S, Oshio T, Nakanishi K, Tomioka E, Suzuki M, Inoue T, Uno Y, Sasaki E, Yamazaki H.
- Journal Title
  
  Curr Drug Metab.
  
  Volume: 20 Issue: 2 Pages: 103-113
- DOI
  10.2174/1389200219666181003143312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Polymorphisms of cytochrome P450 2B6 (CYP2B6) in cynomolgus and rhesus macaques.2019
- Author(s)
  Uno Y, Uehara S, and Yamazaki H. Polymorphisms of cytochrome P450 2B6 (CYP2B6) in cynomolgus and rhesus macaques.
- Journal Title
  
  J Med Primatol.
  
  Volume: 印刷中 Issue: 4 Pages: 232-237
- DOI
  10.1111/jmp.12336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6.2019
- Author(s)
  Uehara S, Murayama N, Yamazaki H, and Suemizu H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中 Issue: 11 Pages: 1323-1331
- DOI
  10.1080/00498254.2018.1564401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanized livers.2019
- Author(s)
  Uehara S, Higuchi Y, Yoneda N, Yamazaki H, and Suemizu H.
- Journal Title
  
  Xenobiotica
  
  Volume: 49 Issue: 6 Pages: 678-687
- DOI
  10.1080/00498254.2018.1495346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Marmoset Cytochrome P450 2B6, a Propofol Hydroxylase Expressed in Liver.2019
- Author(s)
  Oshio T, Uehara S, Uno Y, Inoue T, Sasaki E, and Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 49 Issue: 3 Pages: 265-269
- DOI
  10.1080/00498254.2018.1439204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Cytochrome P450 1A1, 2C9, 2C19, and 3A4 Polymorphisms Account for Interindividual Variability of Toxicological Drug Metabolism in Cynomolgus Macaques.2018
- Author(s)
  Uno Y, Uehara S, Murayama N, and Yamazaki H.
- Journal Title
  
  Chem Res Toxicol.
  
  Volume: 31 Issue: 12 Pages: 1373-1381
- DOI
  10.1021/acs.chemrestox.8b00257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes.2018
- Author(s)
  Nakanishi K, Uehara S, Uno Y, Inoue T, Sasaki E, Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models.2018
- Author(s)
  Kusama T, Toda A, Shimizu M, Uehara S, Inoue T, Uno Y, Utoh M, Sasaki E, and Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 48 Issue: 10 Pages: 1072-1077
- DOI
  10.1080/00498254.2017.1393121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans.2018
- Author(s)
  Uno Y, Uehara S, Yamazaki H.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 153 Pages: 184-195
- DOI
  10.1016/j.bcp.2017.12.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19.2018
- Author(s)
  Toda A, Uehara S, Inoue T, Utoh M, Kusama T, Shimizu M, Uno Y, Mogi M, Sasaki E, and Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 48 Issue: 7 Pages: 720-726
- DOI
  10.1080/00498254.2017.1353716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Molecular cloning and tissue distribution of a novel marmoset ABC transporter.2018
- Author(s)
  Uehara S, Uno Y, Inoue T, Sasaki E, and Yamazaki H.
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 39 Issue: 1 Pages: 59-63
- DOI
  10.1002/bdd.2111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants.2018
- Author(s)
  Nakanishi K, Uehara S, Kusama T, Inoue T, Shimura K, Kamiya Y, Murayama N, Shimizu M, Uno Y, Sasaki E, and Yamazaki H.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 152 Pages: 272-278
- DOI
  10.1016/j.bcp.2018.04.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques.2018
- Author(s)
  Uno Y, Uehara S, Mahadhi HMD, Ohura K, Hosokawa M, Imai T.
- Journal Title
  
  J Med Primatol.
  
  Volume: 47 Issue: 3 Pages: 185-191
- DOI
  10.1111/jmp.12342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08378, KAKENHI-PROJECT-17K15520
[Journal Article] Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes.2018
- Author(s)
  Nakanishi K, Uehara S, Uno Y, Inoue T, Sasaki E, and Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 48 Issue: 8 Pages: 757-763
- DOI
  10.1080/00498254.2017.1363444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Marmoset pulmonary cytochrome P450 2F1 oxidizes biphenyl and 7-ethoxycoumarin and hepatic human P450 substrates.2018
- Author(s)
  Uehara S, Uno Y, Oshio T, Inoue T, Sasaki E, and Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 48 Issue: 7 Pages: 656-662
- DOI
  10.1080/00498254.2017.1354138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Marmoset Cytochrome P450 2B6, a Propofol Hydroxylase Expressed in Liver.2018
- Author(s)
  Oshio T., Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase.2017
- Author(s)
  Uehara, S., Shimizu, M., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 45 Issue: 5 Pages: 497-500
- DOI
  10.1124/dmd.117.075184
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934, KAKENHI-PROJECT-16K08380
[Journal Article] Cloning and expression of a novel catechol-<i>O</i>-methyltransferase in common marmosets2017
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Sasaki, E. and Yamazaki H.
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 79 Issue: 2 Pages: 267-272
- DOI
  10.1292/jvms.16-0459
- NAID
  130005316105
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid ω-hydroxylase expressed in liver and kidney tissues.2017
- Author(s)
  Uehara, S., Uno, Y., Ishii, S., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中 Issue: 7 Pages: 553-561
- DOI
  10.1080/00498254.2016.1206673
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines.2017
- Author(s)
  Uehara, S., Yuki, Y., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中 Issue: 4 Pages: 342-347
- DOI
  10.1080/00498254.2017.1321811
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Strong induction of cytochrome P450 1A/3A, but not P450 2B, in cultured hepatocytes from common marmosets and cynomolgus monkeys by typical human P450 inducing agents.2017
- Author(s)
  Uehara, S., Uno, Y., Suzuki, T., Inoue, T., Utoh, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab Lett.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Hepatic expression of cytochrome P450 enzymes in non-human primate species.2017
- Author(s)
  Uehara, S., Uno, Y., and Yamazaki, H.
- Journal Title
  
  J Med Primatol.
  
  Volume: 46 Issue: 6 Pages: 347-351
- DOI
  10.1111/jmp.12288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15520
[Journal Article] Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone.2017
- Author(s)
  Uehara, S., Uno, Y., Nakanishi, K., Ishii, S., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 45 Issue: 5 Pages: 457-467
- DOI
  10.1124/dmd.116.074898
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Utility of non-human primates in drug development: comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes.2016
- Author(s)
  Uehara, S., Uno, Y., and Yamazaki, H.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 121 Pages: 1-7
- DOI
  10.1016/j.bcp.2016.06.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Molecular cloning, tissue distribution, and functional characterization of marmoset cytochrome P450 1A1, 1A2, and 1B1.2016
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 44 Issue: 1 Pages: 8-15
- DOI
  10.1124/dmd.115.067561
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.2016
- Author(s)
  Iwasaki, K., Kitsugi, Y., Ikeda, K., Yoshikawa, T., Hosaka, S., Uehara, S., Uno, Y., Utoh, M., and Yamazaki, H.
- Journal Title
  
  Biopharm. Drug Dispos.
  
  Volume: 37 Issue: 6 Pages: 379-383
- DOI
  10.1002/bdd.2021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] A new marmoset P450 4F12 enzyme expressed in small intestines and livers efficiently metabolizes an anti-histaminic drug ebastine.2016
- Author(s)
  Uehara, S., Uno, Y., Yuki, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol, and midazolam, in common marmosets (Callithrix jacchus).2016
- Author(s)
  Uehara, S., Inoue, T., Utoh, M., Toda, A., Shimizu, M., Uno, Y., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 46 Issue: 2 Pages: 163-168
- DOI
  10.3109/00498254.2015.1057270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets.2016
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Suzuki, T., Utoh, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 46 Issue: 7 Pages: 573-578
- DOI
  10.3109/00498254.2015.1096980
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets.2016
- Author(s)
  Uehara, S., Kawano, M., Murayama, N., Uno, Y., Utoh, M., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 120 Pages: 56-62
- DOI
  10.1016/j.bcp.2016.09.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine.2016
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Okamoto, E., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Individual differences in metabolic clearance of S-warfarin efficiently mediated by polymorphic marmoset cytochrome P450 2C19 in livers.2016
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling2015
- Author(s)
  Utoh, M., Suemizu, H., Mitsui, M., Kawao, M., Toda, A., Uehara, S., Uno, Y., Shimizu, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 46 Issue: 12 Pages: 1049-1055
- DOI
  10.3109/00498254.2016.1147102
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460206, KAKENHI-PROJECT-15K18934
[Journal Article] Substrate selectivities and catalytic activities of marmoset liver cytochrome P450 2A6 differed from those of human P450 2A6.2015
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 43 Issue: 7 Pages: 969-976
- DOI
  10.1124/dmd.115.063909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).2015
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 43 Issue: 5 Pages: 735-742
- DOI
  10.1124/dmd.115.063594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934, KAKENHI-PROJECT-25460198
[Journal Article] Novel marmoset cytochrome P450 2C19 in livers efficiently metabolizes human P450 2C9 and 2C19 substrates, S-warfarin, tolbutamide, flurbiprofen, and omeprazole.2015
- Author(s)
  Uehara, S., Uno, Y., Inoue, S., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 43 Issue: 10 Pages: 1408-1416
- DOI
  10.1124/dmd.115.066100
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol, and dextromethorphan.2015
- Author(s)
  Uehara, S., Uno, Y., Hagihira, Y., Murayama, N., Shimizu, M., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 45 Issue: 9 Pages: 757-765
- DOI
  10.3109/00498254.2015.1019595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] Evaluation of drug-induced hepatotoxicity using hepatocytes from chimeric TK-NOG mice with humanized liver.2021
- Author(s)
  Uehara S, Higuchi Y, Yoneda N, Yamazaki H, Suemizu H.
- Organizer
  36th JSSX Meeting
- Data Source
  KAKENHI-PROJECT-20K06463
[Presentation] マーモセット肝UDP-グルクロン酸転移酵素 (UGT) 触媒機能のサルとヒトとの比較2019
- Author(s)
  河村秀，村山典恵，小野関駿佑，上原正太郎，石井祐，上原正太郎，宇野泰広，生城真，山崎浩史
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15520
[Presentation] 生理学的薬物動態モデルとヒト肝移植マウスを用いた短長鎖フタル酸ジエステル類のヒト尿中予測排泄速度の差異2019
- Author(s)
  三浦智徳, 吉沢愛映, 水野紗和, 上原正太郎, 神矢佑輔, 村山典恵, 清水万紀子, 末水洋志, 山崎浩史
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15520
[Presentation] 医薬品等の抱合反応を触媒するマーモセット肝グルタチオンS-転移酵素分子種2019
- Author(s)
  田中佐季，村山典恵，加藤雅巳，上原正太郎，上原正太郎，宇野泰広，山崎浩史
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15520
[Presentation] グルクロン酸抱合活性の種差を考慮したフタル酸ジブチル経口投与後の生理学的薬物動態モデルによるヒト体内動態予測2019
- Author(s)
  水野紗和，三浦智徳，吉沢愛映，上原正太郎，神矢佑輔，村山典恵，清水万紀子，末水洋志，山崎浩史
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15520
[Presentation] Expression and inducibility of cytochrome P450 in human hepatocytes from humanized-liver TK-NOG mice.2018
- Author(s)
  Uehara S, Higuchi Y, Yoneda N, Yamazaki H, and Suemizu H
- Organizer
  2018MDO/JSSX
- Data Source
  KAKENHI-PROJECT-17K15520
[Presentation] EXPRESSION AND INDUCTION ABILITY OF CYTOCHROME P450 IN HUMAN HEPATOCYTES HARVESTED FROM CHIMERIC MICE WITH HUMANIZED LIVER.2018
- Author(s)
  Uehara S, Higuchi Y, Yoneda N, Yamazaki H, and Suemizu H
- Organizer
  22nd North American ISSX Meeting
- Data Source
  KAKENHI-PROJECT-17K15520
[Presentation] Activities of UDP-glucuronosyltransferase 1A/2B enzymes in marmoset liver microsomes: comparison with cynomolgus macaques and humans2018
- Author(s)
  Murayama N, Uehara S, Ishii Y, Onozeke S, Kawamura S, Ikushiro S, Uno Y, Yamazaki H
- Organizer
  2018MDO/JSSX
- Data Source
  KAKENHI-PROJECT-17K15520
[Presentation] マーモセット、カニクイザルおよびヒト肝および小腸P450酵素によるテルフェナジンの酸化的代謝2017
- Author(s)
  結城友香子、上原正太郎、宇野泰広、井上貴史、佐々木えりか、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県　仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] マーモセットP450 3A 酵素の臓器分布および薬物酸化酵素活性：ヒトP450 3Aとの類似性2017
- Author(s)
  上原正太郎、中西一志、石井さくら、宇野泰広、井上貴史、佐々木えりか、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県　仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] マーモセット、カニクイザルおよびヒト肝によるメトプロロール酸化的代謝の比較2017
- Author(s)
  石井さくら、上原正太郎、宇野泰広、井上貴史、佐々木えりか、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県　仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] 新規マーモセットP450 2F 酵素の同定および機能解析2017
- Author(s)
  上原正太郎、大塩徹、宇野泰広、井上貴史、佐々木えりか、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県　仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] マーモセット肝のワルファリン酸化的代謝の立体選択性2016
- Author(s)
  河野未来, 上原正太郎, 石井さくら, 宇野泰広, 井上貴史, 鵜藤雅裕, 佐々木えりか, 山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] 新規マーモセットP450 2J酵素の同定および機能解析2016
- Author(s)
  上原正太郎, 岡本絵里子, 宇野泰広, 井上貴史, 佐々木えりか, 山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] ヒト肝細胞移植マウスおよびマーモセット生理学的薬物動態モデルを活用したチトクロムP450カクテル基質のヒト血中濃度推移予測2016
- Author(s)
  清水万紀子, 三井満里奈, 河野未来, 上原正太郎, 宇野泰広, 鵜藤雅裕, 井上貴史, 佐々木えりか, 末水洋志, 山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] Pharmacokinetics of efavirenz after intravenous and oral administration of efavirenz to genotyped cynomolgus monkeys.2016
- Author(s)
  Kazuhide Iwasaki, Yusuke Kitsugi, Kanami Ikeda, Takahiro Yoshikawa, Shotaro Uehara, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki
- Organizer
  11th International ISSX Meeting
- Place of Presentation
  Busan（Korea）
- Year and Date
  2016-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] Identification and characterization of cytochrome P450 4F enzymes in marmosets.2016
- Author(s)
  Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki
- Organizer
  11th International ISSX Meeting
- Place of Presentation
  Busan（Korea）
- Year and Date
  2016-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] マーモセットあるいはカニクイザル肝細胞を用いた薬物暴露によるチトクロムP450誘導の評価2016
- Author(s)
  鈴木貴子, 上原正太郎, 村山典恵, 宇野泰広, 矢島加奈子, 鵜藤雅裕, 井上貴史, 佐々木えりか, 山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] マーモセットおよびカニクイザル小腸P450酵素によるエバスチン酸化的代謝2016
- Author(s)
  上原正太郎, 結城友香子, 宇野泰広, 井上貴史, 佐々木えりか, 山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] マーモセット肝のカフェイン代謝経路の解析2015
- Author(s)
  鈴木貴子, 上原正太郎, 宇野泰広, 鵜藤雅裕, 佐々木えりか, 山崎浩史
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部（千葉県・船橋市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] Molecular cloning, expression and functional characterization of marmoset cytochrome P450 2A6.2015
- Author(s)
  Shotaro Uehara, Yasuhiro Uno, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki
- Organizer
  19th International Conference on Cytochrome P450
- Place of Presentation
  国立オリンピック記念青少年総合センター(東京都・代々木)
- Year and Date
  2015-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] Cytochrome P450-dependent warfarin and caffeine metabolism in marmosets, monkeys, and humans.2015
- Author(s)
  Hiroshi Yamazaki, Shotaro Uehara, Yasuhiro Uno, and Erika Sasaki
- Organizer
  20th North American ISSX Meeting
- Place of Presentation
  Hilton Orlando Bonnet Creek (Orlando, USA）
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] Cytochrome P450-dependent xenobiotic metabolism in marmosets2015
- Author(s)
  Shotaro Uehara, Hiroshi Yamazaki
- Organizer
  2nd Symposium of SPU Innovative Project for Pharmaceutical Analyses of Covalent Modification in Biomolecules
- Place of Presentation
  昭和薬科大学(東京都・町田市)
- Year and Date
  2015-08-31
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] マーモセット肝のワルファリン代謝の解析2015
- Author(s)
  河野未来, 上原正太郎, 宇野泰広, 鵜藤雅裕, 佐々木えりか、山崎浩史
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部（千葉県・船橋市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K18934

1. YAMAZAKI Hiroshi (30191274)

# of Collaborated Projects: 2 results

# of Collaborated Products: 60 results
2. UNO Yasuhiro

# of Collaborated Projects: 2 results

# of Collaborated Products: 51 results
3. SUEMIZU Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 清水万紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 細川正清

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 神矢佑輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uehara Shotaro 上原 正太郎

上原 正太郎 ウエハラ ショウタロウ

Research Projects

Research Products

Co-Researchers

Establishment of drug-induced liver injury evaluation system in vivo using humanized liver chimeric micePrincipal Investigator

Principal Investigator

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新規の肝臓ヒト化薬物性肝障害モデルマウスによるヒト特異的薬物肝毒性の発現機序解明Principal Investigator

Principal Investigator

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The functional characterization of cytochrome P450 enzymes from preclinical speciesPrincipal Investigator

Principal Investigator

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The functional chacterization of marmoset cytochrome P450 2C enzymesPrincipal Investigator

Principal Investigator

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[Journal Article] An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals2022

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[Journal Article] Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes.2021

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[Journal Article] Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes2021

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[Journal Article] Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 12021

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[Journal Article] In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice2021

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NAID

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[Journal Article] UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers.2021

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[Journal Article] Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models.2021

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[Journal Article] Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling.2021

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[Journal Article] Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes.2021

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Uehara Shotaro 上原正太郎

上原正太郎ウエハラショウタロウ