Asahina Yuya 朝比奈雄也

Researcher Number	10737232
Other IDs
Affiliation (based on the past Project Information) *help	2021: 大阪大学, 蛋白質研究所, 助教 2018 – 2019: 大阪大学, 蛋白質研究所, 助教 2015 – 2016: 大阪大学, たんぱく質研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Biomolecular chemistry
Keywords	Principal Investigator ペプチド化学 / 可溶化 / 糖タンパク質 / 糖ペプチド / 糖鎖化学 / 酸感受性保護基 / フコース / 膜タンパク質 / 可溶化タグ / ペプチド … More / ピコリン骨格 / 難溶性 / ペプチド合成 / ピコリン / 難溶性ペプチド / N-アルキルシステイン / O-結合型糖鎖 / 極性反転保護 / 親水性保護基 / チオエステル法 / シアル酸 / インターロイキン－２ / 4-ピコリル基（Pic） / ペプチドライゲーション / 極性反転 Less

Novel protecting strategy for the synthesis of fucosylated glycoproteinsPrincipal Investigator
- Principal Investigator
  
  朝比奈雄也
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Osaka University
Study of a novel peptide solubilizing tag based on picoline derivativePrincipal Investigator
- Principal Investigator
  
  Asahina Yuya
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Osaka University
Synthetic study of the O-glycoprotein using the solubilizing methodPrincipal Investigator
- Principal Investigator
  
  Asahina Yuya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka University

All 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Other

[Journal Article] FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers2021
- Author(s)
  Nakano Mikito、Hanashima Shinya、Hara Toshiaki、Kabayama Kazuya、Asahina Yuya、Hojo Hironobu、Komura Naoko、Ando Hiromune、Nyholm Thomas K.M.、Slotte J. Peter、Murata Michio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1863 Issue: 8 Pages: 183623-183623
- DOI
  10.1016/j.bbamem.2021.183623
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05275, KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-18H03942, KAKENHI-PROJECT-21H04707
[Journal Article] Glycopeptide synthesis based on a TFA-labile protection strategy and one-pot four-segment ligation for the synthesis of O-glycosylated histone H2A2019
- Author(s)
  Y. Asahina, T. Kawakami, H. Hojo
- Journal Title
  
  Eur. J. Org. Chem.
  
  Volume: - Issue: 9 Pages: 1915-1920
- DOI
  10.1002/ejoc.201801885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05316, KAKENHI-PROJECT-18K14336, KAKENHI-PROJECT-16H04180
[Journal Article] One Step Synthesis of Fmoc-Aminoacyl-N-alkylcysteine via the Ugi Four-Component Condensation Reaction2019
- Author(s)
  Asahina Yuya、Hojo Hironobu
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 85 Issue: 3 Pages: 1458-1465
- DOI
  10.1021/acs.joc.9b02433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14336
[Journal Article] Analysis of electrostatic interaction between ganglioside GM3 and transmembrane peptide2019
- Author(s)
  Nimura Yuka、Kabayama Kazuya、Asahina Yuya、Hanashima Shinya、Hojo Hironobu、Murata Michio、Fukase Koichi
- Journal Title
  
  AIP Conference Proceedings
  
  Volume: - Pages: 020020-020020
- DOI
  10.1063/1.5089453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14336, KAKENHI-PROJECT-18K05356
[Journal Article] Sialyl Tn Unit with TFA-Labile Protection Realizes Efficient Synthesis of Sialyl Glycoprotein2018
- Author(s)
  Takeda Naoki、Takei Toshiki、Asahina Yuya、Hojo Hironobu
- Journal Title
  
  Chemistry - A European Journal
  
  Volume: 24 Issue: 11 Pages: 2593-2597
- DOI
  10.1002/chem.201706127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-18K14336
[Journal Article] One-pot native chemical ligation by combination of two orthogonal thioester precursors2017
- Author(s)
  Y. Asahina, Toru Kawakami and Hironobu Hojo
- Journal Title
  
  Chem. Commun
  
  Volume: 53 Issue: 13 Pages: 2114-2117
- DOI
  10.1039/c6cc10243c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-15K21124, KAKENHI-PROJECT-15K05565
[Journal Article] Development of the One-pot Ligation by Using Two Orthogonal Thioesterification Devices2017
- Author(s)
  Yuya Asahina, Toru Kawakami, Hironobu Hojo
- Journal Title
  
  Peptide Science (Proceeding)
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21124
[Journal Article] Synthesis of O-Linked Glycopeptide Thioester by the 4-Methylbenzyl Protection Strategy2016
- Author(s)
  Naoki Takeda, Yuya Asahina, Rina Fujimoto, Akemi Suzuki, Hironobu Hojo
- Journal Title
  
  Peptide Science 2015: H. Hojo, T. Inazu, H. Katayama (Eds.)
  
  Volume: - Pages: 123-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21124
[Journal Article] Study on a Preparation of Prolyl Thioester by the N-Alkylcysteine Method2016
- Author(s)
  Ami Ohagi, Yuya Asahina, Hironobu Hojo
- Journal Title
  
  Peptide Science 2015: H. Hojo, T. Inazu, H. Katayama (Eds.)
  
  Volume: - Pages: 135-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21124
[Journal Article] Synthesis of Interleukin-2 Having Core 1 Type Disaccharide by the Reverse Polarity Protection Strategy2016
- Author(s)
  Rina Fujimoto, Yuya Asahina, Shinobu Komiya, Ami Ohagi, Hiroko Tamagaki, Katsuhiro Nakagawa, Takashi Sato, Shizuo Akira, Toshifumi Takao, Akira Ishii, Yohsiaki Nakahara, Hironobu, Hojo
- Journal Title
  
  Peptide Science 2015: H. Hojo, T. Inazu, H. Katayama (Eds.)
  
  Volume: - Pages: 119-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21124
[Journal Article] Chemoenzymatic Synthesis of Glycoprotein Using the Peptide Ligation Chemistry2015
- Author(s)
  Yuya Asahina
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 27 Issue: 157 Pages: E15-E19
- DOI
  10.4052/tigg.1414.4E
- NAID
  130005099230
- ISSN
  0915-7352, 1883-2113
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21124
[Journal Article] Chemical Synthesis of O-Glycosylated Human Interleukin-2 by the Reverse Polarity Protection Strategy2015
- Author(s)
  Yuya Asahina, Shinobu Komiya, Ami Ohagi, Rina Fujimoto,Hiroko Tamagaki, Katsuhiro Nakagawa, Takashi Sato,Shizuo Akira, Toshifumi Takao,Akira Ishii, Yoshiaki Nakahara, Hironobu Hojo
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 54 Issue: 28 Pages: 8226-8230
- DOI
  10.1002/anie.201501847
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K21124
[Journal Article] Chemoenzymatic Synthesis of Glycoprotein Using the Peptide Ligation Chemistry (Jpn. Ed.)2015
- Author(s)
  朝比奈雄也
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 27 Issue: 157 Pages: J15-J20
- DOI
  10.4052/tigg.1414.4J
- NAID
  130005099227
- ISSN
  0915-7352, 1883-2113
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21124
[Presentation] 新規保護様式を利用したフコース含有糖アミノ酸4糖の合成研究2022
- Author(s)
  朝比奈雄也、北條裕信
- Organizer
  日本農芸化学会年会２０２２年度大会
- Data Source
  KAKENHI-PROJECT-21K05275
[Presentation] Study for chemical synthesis of nanobody2021
- Author(s)
  Kazuki Ichihashi, Yuya Asahina, Hironobu Hojo
- Organizer
  The 59th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-21K05275
[Presentation] 新規保護様式を利用したフコース含有糖ペプチドの合成2021
- Author(s)
  安藤達也、朝比奈雄也、北條裕信
- Organizer
  第４０回日本糖質学会
- Data Source
  KAKENHI-PROJECT-21K05275
[Presentation] Synthesis of fucosylated glycopeptide by a novelprotection scheme of sugar alcohols2021
- Author(s)
  Tatsuya Ando, Yuya Asahina, Hironobu Hojo
- Organizer
  The 59th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-21K05275
[Presentation] ペプチド上のα-フコシル結合の安定性の検討2020
- Author(s)
  安藤達也、朝比奈雄也、北條裕信
- Organizer
  日本農芸化学会２０２０年度大会
- Data Source
  KAKENHI-PROJECT-18K14336
[Presentation] シアル酸を有する O-結合型糖アミノ酸の合成研究2020
- Author(s)
  伊藤駿、朝比奈雄也、北條裕信
- Organizer
  日本農芸化学会２０２０年度大会
- Data Source
  KAKENHI-PROJECT-18K14336
[Presentation] Facile synthesis of Fmoc-aminoacyl-N-alkylcysteine dipeptide by Ugi multi-component reaction2019
- Author(s)
  朝比奈雄也、北條裕信
- Organizer
  第56回日本ペプチド討論会
- Data Source
  KAKENHI-PROJECT-18K14336
[Presentation] 糖ペプチド合成のためのシアル酸カルボキシ基保護基の検討2019
- Author(s)
  伊藤駿、朝比奈雄也、北條裕信
- Organizer
  第38回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K14336
[Presentation] 糖タンパク質合成を志向した糖鎖合成法の開発2019
- Author(s)
  朝比奈雄也
- Organizer
  大阪大学蛋白質研究所セミナー、30代研究者が切り拓くタンパク質化学合成の新潮流
- Invited
- Data Source
  KAKENHI-PROJECT-18K14336
[Presentation] 糖ペプチド合成を志向したシアル酸カルボキシ保護基の検討2019
- Author(s)
  伊藤駿、朝比奈雄也、北條裕信
- Organizer
  日本農芸化学会２０１９年度大会
- Data Source
  KAKENHI-PROJECT-18K14336
[Presentation] ４－メチルベンジル保護とワンポットライゲーションを利用した糖付きヒストンH2Aの化学合成2018
- Author(s)
  朝比奈雄也、川上徹、北條裕信
- Organizer
  第37回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K14336
[Presentation] 精密有機化学による特異的修飾タンパク質の合成2018
- Author(s)
  朝比奈雄也
- Organizer
  第91回日本生化学会大会、シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K14336
[Presentation] Synthesis of histone H2A carrying O-(N-acetylglucosamine) by using novel GlcNAc-Ser unit and one-pot ligation method2018
- Author(s)
  Yuya Asahina, Toru Kawakami, Hironobu Hojo
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14336
[Presentation] カベオリン-1の化学合成研究及び細胞膜内ドメインの構造解析2017
- Author(s)
  藤本梨菜、武居俊樹、朝比奈雄也、佐藤毅、北條裕信
- Organizer
  日本農芸化学会２０１７年会
- Place of Presentation
  京都女子大学（京都府、京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K21124
[Presentation] 直交型チオエステル化素子を利用したヒトヒストンH4の化学合成2017
- Author(s)
  朝比奈雄也、川上徹、北條裕信
- Organizer
  日本農芸化学会２０１７年会
- Place of Presentation
  京都女子大学（京都府、京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K21124
[Presentation] TFA感受性保護基を用いたシアリル糖ペプチドの合成2017
- Author(s)
  竹田直樹、武居俊樹、朝比奈雄也、北條裕信
- Organizer
  日本農芸化学会２０１７年会
- Place of Presentation
  京都女子大学（京都府、京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K21124
[Presentation] 4-メチルベンジル基を用いたalpha-シアリル糖ペプチドの合成研究2016
- Author(s)
  竹田直樹、武居俊樹、朝比奈雄也、北條裕信
- Organizer
  第３５回日本糖質学会年会
- Place of Presentation
  高知市文化プラザ　かるぽーと（高知県高知市）
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-15K21124
[Presentation] STUDY FOR DEVELOPMENT OF THE ONE-POT LIGATION BY USING TWO ORTHOGONAL THIOESTERIFICATION DEVICES2016
- Author(s)
  Yuya Asahina, Toru Kawakami, Hironobu Hojo
- Organizer
  第５３回ペプチド討論会
- Place of Presentation
  京都テルサ（京都府、京都市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K21124
[Presentation] Total Synthesis of Human Interleukin-2 Having Core 1 Disaccharide by the Reverse Polarity Protection Strategy2016
- Author(s)
  Yuya Asahina, Shinobu Komiya, Ami Ohagi, Rina Fujimoto, Hiroko Tamagaki, Katsuhiro Nakagawa, Takashi Sato, Shizuo Akira, Toshifumi Takao, Akira Ishii, Yoshiaki Nakahara, Hironobu Hojo
- Organizer
  8th International Peptide Symposium
- Place of Presentation
  ライプツィヒ大学（ライプツィヒ、ドイツ）
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21124
[Presentation] STUDY ON A PREPARATION OF PROLYL THIOESTER BY THE N- ALKYLCYSTEINE METHOD2015
- Author(s)
  Ami Ohagi, Yuya Asahina, Hironobu Hojo
- Organizer
  第52回日本ペプチド討論会
- Place of Presentation
  平塚公民館（神奈川県平塚市）
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K21124
[Presentation] TOTAL SYNTHESIS OF INTERLEUKIN-2 HAVING CORE 1 TYPE DISACCHARIDE BY THE REVERSE POLARITY PROTECTION STRATEGY2015
- Author(s)
  Rina Fujimoto, Yuya Asahina, Shinobu Komiya, Ami Ohagi, Hiroko Tamagaki, Katsuhiro Nakagawa, Takashi Sato, Shizuo Akira, Toshifumi Takao, Akira Ishii, Yoshiaki Nakahara, Hironobu Hojo
- Organizer
  第52回日本ペプチド討論会
- Place of Presentation
  平塚公民館（神奈川県平塚市）
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K21124
[Presentation] O-結合型糖鎖を有するインターロイキン－２の化学合成2015
- Author(s)
  朝比奈雄也、小宮忍、大萩亜美、藤本梨菜、玉垣裕子、中川勝博、佐藤荘、審良静男、石井彰、高尾敏文、中原義昭、北條裕信
- Organizer
  第３４回日本糖質学会年会
- Place of Presentation
  東京大学安田講堂（東京都文京区）
- Year and Date
  2015-07-31
- Data Source
  KAKENHI-PROJECT-15K21124
[Presentation] SYNTHESIS OF O-LINKED GLYCOPEPTIDE THIOESTER BY THE 4- METHYLBENZYL PROTECTION STRATEGY2015
- Author(s)
  Naoki Takeda, Yuya Asahina, Rina Fujimoto, Akemi Suzuki, Hironobu Hojo
- Organizer
  第52回日本ペプチド討論会
- Place of Presentation
  平塚公民館（神奈川県平塚市）
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K21124
[]

1. 川上徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 北條裕信

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Asahina Yuya 朝比奈 雄也

Research Projects

Research Products

Co-Researchers

Novel protecting strategy for the synthesis of fucosylated glycoproteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of a novel peptide solubilizing tag based on picoline derivativePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthetic study of the O-glycoprotein using the solubilizing methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glycopeptide synthesis based on a TFA-labile protection strategy and one-pot four-segment ligation for the synthesis of O-glycosylated histone H2A2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] One Step Synthesis of Fmoc-Aminoacyl-N-alkylcysteine via the Ugi Four-Component Condensation Reaction2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of electrostatic interaction between ganglioside GM3 and transmembrane peptide2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sialyl Tn Unit with TFA-Labile Protection Realizes Efficient Synthesis of Sialyl Glycoprotein2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] One-pot native chemical ligation by combination of two orthogonal thioester precursors2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of the One-pot Ligation by Using Two Orthogonal Thioesterification Devices2017

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of O-Linked Glycopeptide Thioester by the 4-Methylbenzyl Protection Strategy2016

Author(s)

Journal Title

Data Source

[Journal Article] Study on a Preparation of Prolyl Thioester by the N-Alkylcysteine Method2016

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of Interleukin-2 Having Core 1 Type Disaccharide by the Reverse Polarity Protection Strategy2016

Author(s)

Journal Title

Data Source

[Journal Article] Chemoenzymatic Synthesis of Glycoprotein Using the Peptide Ligation Chemistry2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Chemical Synthesis of O-Glycosylated Human Interleukin-2 by the Reverse Polarity Protection Strategy2015

Author(s)

Journal Title

DOI

Asahina Yuya 朝比奈雄也

[Presentation] 直交型チオエステル化素子を利用したヒトヒストンH4の化学合成2017