Koga Junichiro 古賀純一郎

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Junchiro Koga 古賀純一郎

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Researcher Number	10746142
Other IDs
Affiliation (Current)	2023: 産業医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2022: 産業医科大学, 医学部, 助教 2019 – 2021: 九州大学, 大学病院, 学術研究員 2016 – 2018: 九州大学, 循環器病未来医療研究センター, 学術研究員 2015: 九州大学, 学内共同利用施設等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator マクロファージ / 動脈硬化 / ミトコンドリアダイナミクス / 分子血管学 / ドラッグデリバリーシステム / Notch / 急性心筋梗塞 / 心筋虚血再灌流障害 / 循環器内科学 / 線維化 … More / 左室リモデリング / 心筋梗塞 / マイトファジー / 心筋梗塞後リモデリング / 活性酸素 / 炎症 / 分子血管額学 / ナノメディスン … More Except Principal Investigator 再灌流傷害 / 酸化ストレス / コレステロール / 急性心筋梗塞 / 動脈硬化 / 心筋梗塞 / マクロファージ / 炎症 / 酸化ステロール / 冠動脈疾患 Less

NotchリガンドDll1による動脈硬化プラーク不安定化機構の解明と新規治療開発Principal Investigator
- Principal Investigator
  
  古賀純一郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Role of oxysterol in cardiovascular inflammation
- Principal Investigator
  
  的場哲哉
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyushu University
Mitochondrial dynamics in myocardial ischemia-reperfusion injury and post-infarct remodelingPrincipal Investigator
- Principal Investigator
  
  Koga Jun-ichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyushu University
Monocyte/macrophage Drp1 in the pathobiology of atherosclerotic vascular diseasesPrincipal Investigator
- Principal Investigator
  
  KOGA Junichiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kyushu University
PPARgamma-targeting Nanomedicine for the Treatment of Atherosclerotic Plaque RupturePrincipal Investigator
- Principal Investigator
  
  Junchiro Koga
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kyushu University

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Nanoparticle-mediated Endothelial Cell-selective Drug Delivery System.2017
- Author(s)
  Nakano K, Koga J, Egashira K
- Publisher
  Therapeutic Angiogenesis.
- Data Source
  KAKENHI-PROJECT-15K19384
[Book] Mouse Models of Atherosclerosis.2016
- Author(s)
  Iwata H, Koga J, Decano J, Choi J, Mlynarchik AK, Mattson PC, Aikawa E, Aikawa M.
- Total Pages
  35
- Publisher
  Mouse Models of Vascular Diseases.
- Data Source
  KAKENHI-PROJECT-15K19384
[Journal Article] Macrophage Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury2020
- Author(s)
  Umezu Ryuta、Koga Jun-ichiro、Matoba Tetsuya、Katsuki Shunsuke、Wang Lixiang、Hasuzawa Nao、Nomura Masatoshi、Tsutsui Hiroyuki、Egashira Kensuke
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 40 Issue: 7
- DOI
  10.1161/atvbaha.120.314383
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08518, KAKENHI-PROJECT-20K08921
[Journal Article] Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.2019
- Author(s)
  Fujiwara Masaki、Matoba Tetsuya、Koga Jun-Ichiro、Okahara Arihide、Funamoto Daiki、Nakano Kaku、Tsutsui Hiroyuki、Egashira Kensuke
- Journal Title
  
  Cardiovascular Research
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16011
[Journal Article] Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models2018
- Author(s)
  Tokutome Masaki、Matoba Tetsuya、Nakano Yasuhiro、Okahara Arihide、Fujiwara Masaki、Koga Jun-Ichiro、Nakano Kaku、Tsutsui Hiroyuki、Egashira Kensuke
- Journal Title
  
  Cardiovascular Research
  
  Volume: 115 Issue: 2 Pages: 419-431
- DOI
  10.1093/cvr/cvy200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09590, KAKENHI-PROJECT-17K16011
[Journal Article] Lipid-Lowering Therapy With Ezetimibe Decreases Spontaneous Atherothrombotic Occlusions in a Rabbit Model of Plaque Erosion: A Role of Serum Oxysterols2018
- Author(s)
  K. Honda, T. Matoba, Y. Antoku, J.I. Koga, I. Ichi, K. Nakano, H. Tsutsui, K. Egashira
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 38 Issue: 4 Pages: 757-771
- DOI
  10.1161/atvbaha.117.310244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K00848, KAKENHI-PROJECT-17K16011
[Journal Article] A Multicenter, Randomized, Placebo-Controlled Phase I Investigator-Initiated Trial for Intravenous Administration of Pitavastatin-Loaded PLGA Nanoparticles (NK-104-NP) in Healthy Japanese Male Subjects2018
- Author(s)
  Nakano Kaku、Matoba Tetsuya、Koga Jun-ichiro、Kashihara Yushi、Fukae Masato、Ieiri Ichiro、Shiramoto Masanari、Irie Shin、Kishimoto Junji、Todaka Koji、Egashira Kensuke
- Journal Title
  
  Int. Heart J.
  
  Volume: 59 Issue: 5 Pages: 1015-1025
- DOI
  10.1536/ihj.17-555
- NAID
  130007490519
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2018-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16011
[Journal Article] Nanoparticle-Mediated Targeting of Pitavastatin to Small Pulmonary Arteries and Leukocytes by Intravenous Administration Attenuates the Progression of Monocrotaline-Induced Established Pulmonary Arterial Hypertension in Rats2018
- Author(s)
  Ichimura Kenzo、Matoba Tetsuya、Koga Jun-ichiro、Nakano Kaku、Funamoto Daiki、Tsutsui Hiroyuki、Egashira Kensuke
- Journal Title
  
  Int. Heart J.
  
  Volume: 59 Issue: 6 Pages: 1432-1444
- DOI
  10.1536/ihj.17-683
- NAID
  130007522561
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2018-11-30
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16011
[Journal Article] Anti-inflammatory Nanomedicine for Cardiovascular Disease2017
- Author(s)
  Katsuki Shunsuke、Matoba Tetsuya、Koga Jun-ichiro、Nakano Kaku、Egashira Kensuke
- Journal Title
  
  Frontiers in Cardiovascular Medicine
  
  Volume: 4 Pages: 1383-1395
- DOI
  10.3389/fcvm.2017.00087
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09590, KAKENHI-PROJECT-17K16011
[Journal Article] Nanoparticle-Mediated Delivery of Pitavastatin to Monocytes/Macrophages Inhibits Left Ventricular Remodeling After Acute Myocardial Infarction by Inhibiting Monocyte-Mediated Inflammation2017
- Author(s)
  Mao Y, Koga JI, Tokutome M, Matoba T, Ikeda G, Nakano K, Egashira K
- Journal Title
  
  Int. Heart J.
  
  Volume: 58 Issue: 4 Pages: 615-623
- DOI
  10.1536/ihj.16-457
- NAID
  130005901270
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16011
[Journal Article] Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.2016
- Author(s)
  Nakano T, Fukuda D, Koga J, Aikawa M
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 36(10) Issue: 10 Pages: 2038-2047
- DOI
  10.1161/atvbaha.116.306926
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19384, KAKENHI-PROJECT-16K09517
[Journal Article] BubR1 Insufficiency Results in Decreased Macrophage Proliferation and Attenuated Atherogenesis in Apolipoprotein E-Deficient Mice.2016
- Author(s)
  Tanaka S, Matsumoto T, Matsubara Y, Harada Y, Kyuragi R, Koga JI, Egashira K, Nakashima Y, Yonemitsu Y, Maehara Y
- Journal Title
  
  J Am Heart Assoc.
  
  Volume: 5(9)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19384
[Journal Article] Anti-inflammatory Nanoparticle for Prevention of Atherosclerotic Vascular Diseases.2016
- Author(s)
  Koga J, Matoba T, Egashira K.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis.
  
  Volume: 印刷中
- NAID
  130005160389
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19384
[Journal Article] Nanoparticle-mediated delivery of pitavastatin to monocytes/macrophages inhibits left ventricular remodeling after acute myocardial infarction by inhibiting monocyte-mediated inflammation.2016
- Author(s)
  Mao Y, Koga J, Tokutome M, Matoba T, Ikeda G, Nakano K, Egashira K
- Journal Title
  
  Int Heart J.
  
  Volume: 印刷中
- NAID
  130005901270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19384
[Journal Article] Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation in ApoE-/- Mice.2016
- Author(s)
  Nakashiro S, Matoba T, Umezu R, Koga J, Tokutome M, Katsuki S, Nakano K, Sunagawa K, Egashira K.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 36(3) Issue: 3 Pages: 491-500
- DOI
  10.1161/atvbaha.115.307057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19384, KAKENHI-PROJECT-25461135
[Journal Article] Nanoparticle-Mediated Delivery of Irbesartan Induces Cardioprotection from Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-Mediated Inflammation.2016
- Author(s)
  Nakano Y, Matoba T, Tokutome M, Funamoto D, Katsuki S, Ikeda G, Nagaoka K, Ishikita A, Nakano K, Koga J, Sunagawa K, Egashira K
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 29601-29601
- DOI
  10.1038/srep29601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461131, KAKENHI-PROJECT-15K19384
[Journal Article] A Translational Study of a New Therapeutic Approach for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduces Ischemia-Reperfusion Injury in a Preclinical Porcine Model.2016
- Author(s)
  Ichimura K, Matoba T, Nakano K, Tokutome M, Honda K, Koga J, Egashira K
- Journal Title
  
  PLoS One.
  
  Volume: 11(9) Issue: 9 Pages: e0162425-e0162425
- DOI
  10.1371/journal.pone.0162425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461131, KAKENHI-PROJECT-15K19384
[Journal Article] Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction.2016
- Author(s)
  Ishikita A, Matoba T, Ikeda G, Koga J, Mao Y, Nakano K, Takeuchi O, Sadoshima J, Egashira K
- Journal Title
  
  J Am Heart Assoc.
  
  Volume: 5(7) Issue: 7
- DOI
  10.1161/jaha.116.003872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461131, KAKENHI-PROJECT-15K19384
[Journal Article] 冠動脈疾患に対するナノ粒子・ドラッグデリバリーシステムの開発2015
- Author(s)
  的場哲哉、古賀純一郎、中野覚、江頭健輔
- Journal Title
  
  Drug Delivery System.
  
  Volume: 30(4) Pages: 299-308
- NAID
  130005116532
- Data Source
  KAKENHI-PROJECT-15K19384
[Presentation] Abstract 10573: Dietary 7-Ketocholesterol Exacerbates Myocardial Ischemia-Reperfusion Injury Through Macrophage-Mediated Inflammation in Mice2021
- Author(s)
  Tomoki Uchikawa , Tetsuya Matoba , Shunsuke Katsuki , Jun-ichiro Koga and Hiroyuki Tsutsui
- Organizer
  American Heart Association Scientific Sessions 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02916
[Presentation] Mitochondrial dynamics in macrophage-mediated inflammation and cardiovascular diseases2021
- Author(s)
  Jun-ichiro Koga
- Organizer
  第85回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08518
[Presentation] Dynamin-related protein 1 induces macrophage activation and intimal hyperplasia after mechanical injury in mouse femoral arteries2020
- Author(s)
  Jun-ichiro Koga, Ryuta Umezu, Shunsuke Katsuki, Tetsuya Matoba, Hiroyuki Tsutsui
- Organizer
  VASCULAR BIOLOGY 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08518
[Presentation] Macrophage dynamin-related protein 1, a mitochondrial fission protein, promotes inflammation and vascular remodeling after mechanical injury in mice.2019
- Author(s)
  Jun-ichiro Koga, Ryuta Umezu, Tetsuya Matoba, Hiroyuki Tsutsui, Kensuke Egashira.
- Organizer
  The 3rd JCS Council Forum on Basic CardioVascular Research
- Data Source
  KAKENHI-PROJECT-19K08518
[Presentation] ミトコンドリアダイナミクスによるマクロファージ機能制御と血管病.2019
- Author(s)
  古賀　純一郎，的場　哲哉，蓮澤　奈央，野村　政壽，江頭　健輔，筒井　裕之.
- Organizer
  Cardiovascular and Metabolic Week 2019
- Invited
- Data Source
  KAKENHI-PROJECT-19K08518
[Presentation] Macrophage dynamin-related protein 1, a mitochondrial fission protein, accelerates inflammation and neointimal thickening after vascular injury2018
- Author(s)
  Jun-ichiro Koga, Ryuta Umezu, Tetsuya Matoba, Hiroyuki Tsutsui, Kensuke Egashira
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16011
[Presentation] Macrophage Dynamin-related Protein1 Promotes Neointima Formation after Mechanical Injury in Mouse Femoral Arteries.2017
- Author(s)
  Koga J, Umezu R, Egashira K
- Organizer
  第5回 IRG (Inflammation and ReGeneration) Meeting
- Place of Presentation
  品川プリンスホテル（東京都・港区）
- Year and Date
  2017-01-06
- Data Source
  KAKENHI-PROJECT-15K19384
[Presentation] マクロファージに発現するミトコンドリア形態制御分子Drp1はマウス大腿動脈において血管傷害後の内膜肥厚を促進する2017
- Author(s)
  古賀純一郎、梅津隆太、的場哲哉、王麗香、野村政壽、江頭健輔
- Organizer
  第49回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K16011
[Presentation] Macrophage Dynamin-related Protein1 Promotes Neointima Formation after Mechanical Injury in Mouse Femoral Arteries2016
- Author(s)
  Umezu R, Koga J, Wang L, Nomura M, Egashira K
- Organizer
  19th International Vascular Biology Meeting 2016
- Place of Presentation
  ボストン（アメリカ）
- Year and Date
  2016-10-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19384
[Presentation] Macrophage Dynamin-related Protein1 Promotes Neointima Formation after Mechanical Injury in Mouse Femoral Arteries2016
- Author(s)
  Koga J, Umezu R, Wang L, Nomura M, Egashira K
- Organizer
  第24回日本血管生物医学会学術集会
- Place of Presentation
  長崎ブリックホール（長崎県・長崎市）
- Year and Date
  2016-12-08
- Data Source
  KAKENHI-PROJECT-15K19384
[Presentation] Nanotechnology-based anti-atherosclerotic therapy targeting monocytes-mediated inflammation.2015
- Author(s)
  Koga J
- Organizer
  The 13th. Japan-Korea Joint Symposium on Vascular Biology.
- Place of Presentation
  釜山(韓国)
- Year and Date
  2015-10-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19384

1. 的場哲哉 (20448426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 香月俊輔 (60641016)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 仲野泰啓 (30752133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ICHI Ikuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 中野覚

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Koga Junichiro 古賀 純一郎

Junchiro Koga 古賀 純一郎

Research Projects

Research Products

Co-Researchers

NotchリガンドDll1による動脈硬化プラーク不安定化機構の解明と新規治療開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of oxysterol in cardiovascular inflammation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mitochondrial dynamics in myocardial ischemia-reperfusion injury and post-infarct remodelingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Monocyte/macrophage Drp1 in the pathobiology of atherosclerotic vascular diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PPARgamma-targeting Nanomedicine for the Treatment of Atherosclerotic Plaque RupturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Nanoparticle-mediated Endothelial Cell-selective Drug Delivery System.2017

Author(s)

Publisher

Data Source

[Book] Mouse Models of Atherosclerosis.2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Macrophage Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.2019

Author(s)

Journal Title

Data Source

[Journal Article] Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipid-Lowering Therapy With Ezetimibe Decreases Spontaneous Atherothrombotic Occlusions in a Rabbit Model of Plaque Erosion: A Role of Serum Oxysterols2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Multicenter, Randomized, Placebo-Controlled Phase I Investigator-Initiated Trial for Intravenous Administration of Pitavastatin-Loaded PLGA Nanoparticles (NK-104-NP) in Healthy Japanese Male Subjects2018

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Nanoparticle-Mediated Targeting of Pitavastatin to Small Pulmonary Arteries and Leukocytes by Intravenous Administration Attenuates the Progression of Monocrotaline-Induced Established Pulmonary Arterial Hypertension in Rats2018

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Koga Junichiro 古賀純一郎

Junchiro Koga 古賀純一郎