Kobayashi Hiroshi 小林央

… Alternative Names

Researcher Number	10749542
Affiliation (Current)	2021: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2021: 国立研究開発法人国立国際医療研究センター, その他部局等, その他 2017 – 2019: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords	Principal Investigator 造血幹細胞 / ステムセルエイジング / 単一細胞RNAシークエンス / 加齢 / 静止期維持培養

胎児型造血幹細胞の成熟過程の解明と体外成熟化誘導法開発Principal InvestigatorOngoing
- Principal Investigator
  
  小林央
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Center for Global Health and Medicine
静止期維持培養法による造血幹細胞加齢メカニズムの解明Principal InvestigatorOngoing
- Principal Investigator
  
  小林央
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Center for Global Health and Medicine
Study of aged hematopoietic stem cells through single-cell RNA-sequencingPrincipal Investigator
- Principal Investigator
  
  Kobayashi Hiroshi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  National Center for Global Health and Medicine

All 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation2019
- Author(s)
  Watanuki Shintaro、Kobayashi Hiroshi、Sorimachi Yuriko、Yamamoto Masamichi、Okamoto Shinichiro、Takubo Keiyo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 印刷中 Pages: 287-294
- DOI
  10.1016/j.bbrc.2019.04.123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16200, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-18K19570
[Journal Article] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo2019
- Author(s)
  Kobayashi H, Morikawa T, Okinaga A, Hamano F, Hashidate-Yoshida T, Watanuki S, Hishikawa D, Shindou H, Arai F, Kabe Y, Suematsu M, Shimizu T, Takubo K.
- Journal Title
  
  Cell Reports
  
  Volume: 28 Pages: 145-158
- DOI
  10.1016/j.celrep.2019.06.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-19K22638, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-18K19570
[Journal Article] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo2018
- Author(s)
  Kobayashi Hiroshi、Morikawa Takayuki、Okinaga Ayumi、Hamano Fumie、Hashidate-Yoshida Tomomi、Watanuki Shintaro、Hishikawa Daisuke、Shindou Hideo、Arai Fumio、Kabe Yasuaki、Suematsu Makoto、Shimizu Takao、Takubo Keiyo
- Journal Title
  
  BioRxive
  
  Volume: -
- DOI
  10.1101/475905
- Open Access
- Data Source
  KAKENHI-PROJECT-17K16200
[Journal Article] Abnormal hematopoiesis and hematopoietic stem cell niche2017
- Author(s)
  田久保圭誉、森川隆之、小林央
- Journal Title
  
  Jpn. J. Clin. Hematol.
  
  Volume: 58 Issue: 10 Pages: 1844-1850
- DOI
  10.11406/rinketsu.58.1844
- NAID
  130006132651
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16200, KAKENHI-PLANNED-26115005, KAKENHI-PROJECT-15H04861, KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-16K15507
[Patent] 造血幹細胞を維持培養するための培地、及びそれを用いた培養方法2018
- Inventor(s)
  小林央、田久保圭誉
- Industrial Property Rights Holder
  小林央、田久保圭誉
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-100036
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K16200
[Presentation] 造血幹細胞の休眠状態を体外で誘導する2019
- Author(s)
  小林　央、田久保　圭誉
- Organizer
  第92回日本生化学会
- Data Source
  KAKENHI-PROJECT-19K17847
[Presentation] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo2019
- Author(s)
  Hiroshi Kobayashi, Keiyo Takubo
- Organizer
  48th Annual Scientific Meeting, International Society of Experimental Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17847
[Presentation] 造血幹細胞の静止期維持培養法2019
- Author(s)
  小林　央、田久保　圭誉
- Organizer
  第81回日本血液学会
- Data Source
  KAKENHI-PROJECT-19K17847
[Presentation] Maintenance of quiescent hematopoietic stem cells ex vivo2019
- Author(s)
  小林　央
- Organizer
  第17回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-19K17847
[Presentation] Age-Dependent Decrease in Requirement for Glycolysis in Hematopoietic Stem Cells.2018
- Author(s)
  Shintaro Watanuki, Hiroshi Kobayashi, Daiki Karigane, Yukako Ootomo, Ayumi Okinaga, Shinichiro Okamoto, Keiyo Takubo
- Organizer
  61st ASH Annual Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16200
[Presentation] Glycolytic addiction of hematopoietic stem cells is modulated by age and cell cycle status.2018
- Author(s)
  Shintaro Watanuki, Hiroshi Kobayashi, Daiki Karigane, Yukako Ootomo, Ayumi Okinaga, Shinichiro Okamoto, Keiyo Takubo
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16200
[Presentation] The acceleration pattern of RhoA-dependent motility is a parameter to distinguish HSCs from MPPs.2017
- Author(s)
  Okinaga A, Kobayashi H, Takubo K.
- Organizer
  第79回日本血液学会
- Data Source
  KAKENHI-PROJECT-17K16200

1. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. MORIKAWA Takayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
3. ARAI Fumio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 加部泰明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Hiroshi 小林 央

小林 央 コバヤシ ヒロシ

Research Projects

Research Products

Co-Researchers

胎児型造血幹細胞の成熟過程の解明と体外成熟化誘導法開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

静止期維持培養法による造血幹細胞加齢メカニズムの解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of aged hematopoietic stem cells through single-cell RNA-sequencingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abnormal hematopoiesis and hematopoietic stem cell niche2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Patent] 造血幹細胞を維持培養するための培地、及びそれを用いた培養方法2018

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] 造血幹細胞の休眠状態を体外で誘導する2019

Author(s)

Organizer

Data Source

[Presentation] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo2019

Author(s)

Organizer

Data Source

[Presentation] 造血幹細胞の静止期維持培養法2019

Author(s)

Organizer

Data Source

[Presentation] Maintenance of quiescent hematopoietic stem cells ex vivo2019

Author(s)

Organizer

Data Source

[Presentation] Age-Dependent Decrease in Requirement for Glycolysis in Hematopoietic Stem Cells.2018

Author(s)

Organizer

Data Source

[Presentation] Glycolytic addiction of hematopoietic stem cells is modulated by age and cell cycle status.2018

Author(s)

Organizer

Data Source

[Presentation] The acceleration pattern of RhoA-dependent motility is a parameter to distinguish HSCs from MPPs.2017

Author(s)

Organizer

Kobayashi Hiroshi 小林央

小林央コバヤシヒロシ