Kobayashi Hiroshi 小林央

Researcher Number	10749542
Other IDs	https://orcid.org/0000-0002-0924-1252
Affiliation (Current)	2025: 東北大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2024: 東北大学, 医学系研究科, 准教授 2017 – 2023: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords	Principal Investigator 造血幹細胞 / 静止期維持培養 / ステムセルエイジング / 幹細胞ニッチ / 間葉系幹細胞 / CRISPR/Cas9 / 遺伝子編集 / 成熟 / 胎生期 / 再生医療 … More / 遺伝子・細胞治療 / 幹細胞成熟 / 加齢 / 単一細胞RNAシークエンス Less

Identification of mesenchyme-derived factors essential for maintenance of hematopoietic stem cellPrincipal Investigator
- Principal Investigator
  
  小林央
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
Development of a method to induce maturation of fetal hematopoietic stem cellsPrincipal Investigator
- Principal Investigator
  
  Kobayashi Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Center for Global Health and Medicine
Study on the mechanism of HSC aging through quiescence maintaining culturePrincipal Investigator
- Principal Investigator
  
  Kobayashi Hiroshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Center for Global Health and Medicine
Study of aged hematopoietic stem cells through single-cell RNA-sequencingPrincipal Investigator
- Principal Investigator
  
  Kobayashi Hiroshi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  National Center for Global Health and Medicine

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis2024
- Author(s)
  Watanuki S et al
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.87674
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18137, KAKENHI-PROJECT-23K06416, KAKENHI-PROJECT-21K06072, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-23K23797
[Journal Article] Mesenchymal loss of p53 alters stem cell capacity and models human soft tissue sarcoma traits.2023
- Author(s)
  Sorimachi Y, Kobayashi H, Shiozawa Y, Koide S, Nakato R, Shimizu Y, Okamura T, Shirahige K, Iwama A, Goda N, Takubo K, Takubo K.
- Journal Title
  
  Stem Cell Reports
  
  Volume: S2213-6711(23) Issue: 5 Pages: 00097-8
- DOI
  10.1016/j.stemcr.2023.03.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05940, KAKENHI-PROJECT-23K06416, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22KJ2948, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H05686, KAKENHI-PROJECT-21H02957
[Journal Article] Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis2023
- Author(s)
  Watanuki Shintaro、Kobayashi Hiroshi、、Takubo Keiyo
- Journal Title
  
  BioRxiv
  
  Volume: On line Pages: 1-30
- DOI
  10.1101/2023.03.16.532898
- Data Source
  KAKENHI-PROJECT-21K08431
[Journal Article] Distinct roles of the preparatory and payoff phases of glycolysis in hematopoietic stem cells2023
- Author(s)
  Shiroshita Kohei、Kobayashi Hiroshi、Takubo Keiyo
- Journal Title
  
  Experimental Hematology
  
  Volume: 124 Pages: 56-67
- DOI
  10.1016/j.exphem.2023.06.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22KJ2948, KAKENHI-PROJECT-21H02957
[Journal Article] The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent2023
- Author(s)
  Suchacki Karla J、Thomas Benjamin J、Ikushima Yoshiko Matsumoto、、Kobayashi Hiroshi、、Cawthorn William P
- Journal Title
  
  eLife
  
  Volume: 12 Pages: 88080-88080
- DOI
  10.7554/elife.88080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08431
[Journal Article] MBTD1 preserves adult hematopoietic stem cell pool size and function2023
- Author(s)
  Takubo Keiyo、Htun Phyo Wai、Ueda Takeshi、Sera Yasuyuki、Iwasaki Masayuki、Koizumi Miho、Shiroshita Kohei、Kobayashi Hiroshi、Haraguchi Miho、Watanuki Shintaro、Honda Zen-ichiro、Yamasaki Norimasa、Nakamura-Ishizu Ayako、Arai Fumio、Motoyama Noboru、Hatta Tomohisa、Natsume Tohru、Suda Toshio、Honda Hiroaki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 32
- DOI
  10.1073/pnas.2206860120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16333, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-23K07134, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-23K27442
[Journal Article] Evaluating the function of murine quiescent hematopoietic stem cells following non-homologous end joining-based genome editing2023
- Author(s)
  Shiroshita Kohei、Kobayashi Hiroshi、Takubo Keiyo
- Journal Title
  
  STAR Protocols
  
  Volume: 4 Issue: 2 Pages: 102347-102347
- DOI
  10.1016/j.xpro.2023.102347
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-21H02957
[Journal Article] Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis2023
- Author(s)
  Iga Takahito、Kobayashi Hiroshi、Kusumoto Dai、Sanosaka Tsukasa、Fujita Nobuyuki、Tai-Nagara Ikue、Ando Tomofumi、Takahashi Tomoko et.al
- Journal Title
  
  Nature Cell Biology
  
  Volume: 25 Issue: 10 Pages: 1415-1425
- DOI
  10.1038/s41556-023-01240-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KJ1885, KAKENHI-PROJECT-22K06915, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-19H03623, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-21H03057, KAKENHI-PROJECT-23K21467, KAKENHI-PROJECT-23K27352
[Journal Article] A culture platform to study quiescent hematopoietic stem cells following genome editing2022
- Author(s)
  Shiroshita Kohei、Kobayashi Hiroshi、Watanuki Shintaro、Karigane Daiki、Sorimachi Yuriko、Fujita Shinya、Tamaki Shinpei、Haraguchi Miho、Itokawa Naoki、Aoyama Kazumasa、Koide Shuhei、Masamoto Yosuke、Kobayashi Kenta、Nakamura-Ishizu Ayako、Kurokawa Mineo、Iwama Atsushi、Okamoto Shinichiro、Kataoka Keisuke、Takubo Keiyo
- Journal Title
  
  Cell Reports Methods
  
  Volume: 2 Issue: 12 Pages: 100354-100354
- DOI
  10.1016/j.crmeth.2022.100354
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-21J11016, KAKENHI-PROJECT-22KJ2948, KAKENHI-PROJECT-23K24366
[Journal Article] Approaches towards Elucidating the Metabolic Program of Hematopoietic Stem/Progenitor Cells2022
- Author(s)
  Kobayashi Hiroshi、Watanuki Shintaro、Takubo Keiyo
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 20 Pages: 3189-3189
- DOI
  10.3390/cells11203189
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-21H02957
[Journal Article] OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy2021
- Author(s)
  Murakami Koichi、 ... 、Takubo Keiyo、Okamoto Shinichiro、Tamura Tomohiko、Nakajima Hideaki
- Journal Title
  
  Cell Reports
  
  Volume: 34 Issue: 1 Pages: 108579-108579
- DOI
  10.1016/j.celrep.2020.108579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19K17864
[Journal Article] A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells2021
- Author(s)
  Kobayashi H,?Takubo K.
- Journal Title
  
  J Vis Exp
  
  Volume: 17 Issue: 171 Pages: 171-171
- DOI
  10.3791/61938
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21621, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-21K08431
[Journal Article] p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts2021
- Author(s)
  Sorimachi Yuriko、Karigane Daiki、Ootomo Yukako、Kobayashi Hiroshi、Morikawa Takayuki、Otsu Kinya、Kubota Yoshiaki、Okamoto Shinichiro、Goda Nobuhito、Takubo Keiyo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100563-100563
- DOI
  10.1016/j.jbc.2021.100563
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21621, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19K17877, KAKENHI-PROJECT-21K08383, KAKENHI-PROJECT-20K07345
[Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021
- Author(s)
  Sera Y; Nakata Y; Ueda T; Yamasaki N; Koide S; Kobayashi H; Ikeda KI; Kobatake K; Iwasaki M; Oda H; Wolff L; Kanai A; Nagamachi A; Inaba T; Sotomaru Y; Ichinohe T; Koizumi M; Miyakawa Y; Honda ZI; Iwama A; Suda T; Takubo K; Honda H
- Journal Title
  
  Blood.
  
  Volume: 137 Issue: 7 Pages: 908-922
- DOI
  10.1182/blood.2019001044
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19K17918, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19H01056, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-21K08395
[Journal Article] Detection of residual disease in chronic myeloid leukemia utilizing genomic next generation sequencing reveals persistence of differentiated Ph+ B cells but not bone marrow stem/progenitors2020
- Author(s)
  Daiki Karigane, Hidenori Kasahara, ... , Keiyo Takubo.
- Journal Title
  
  Leukemia & Lymphoma
  
  Volume: 62 Issue: 3 Pages: 679-687
- DOI
  10.1080/10428194.2020.1837366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21621, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-19J00502, KAKENHI-PROJECT-19K17847
[Journal Article] Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells2020
- Author(s)
  Kobayashi Hiroshi、Takubo Keiyo
- Journal Title
  
  STAR Protocols
  
  Volume: 1 Issue: 2 Pages: 100078-100078
- DOI
  10.1016/j.xpro.2020.100078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19K17847
[Journal Article] ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation2019
- Author(s)
  Watanuki Shintaro、Kobayashi Hiroshi、Sorimachi Yuriko、Yamamoto Masamichi、Okamoto Shinichiro、Takubo Keiyo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 印刷中 Issue: 1 Pages: 287-294
- DOI
  10.1016/j.bbrc.2019.04.123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16200, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-18K19570
[Journal Article] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo.2019
- Author(s)
  Kobayashi H, Morikawa T, Okinaga A, Hamano F, Hashidate-Yoshida T, Watanuki S, Hishikawa D, Shindou H, Arai F, Kabe Y, Suematsu M, Shimizu T, Takubo K.
- Journal Title
  
  Cell Reports
  
  Volume: 28 Issue: 1 Pages: 145-158
- DOI
  10.1016/j.celrep.2019.06.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-19K22638, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-18K19570
[Journal Article] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo2018
- Author(s)
  Kobayashi Hiroshi、Morikawa Takayuki、Okinaga Ayumi、Hamano Fumie、Hashidate-Yoshida Tomomi、Watanuki Shintaro、Hishikawa Daisuke、Shindou Hideo、Arai Fumio、Kabe Yasuaki、Suematsu Makoto、Shimizu Takao、Takubo Keiyo
- Journal Title
  
  BioRxive
  
  Volume: -
- DOI
  10.1101/475905
- Open Access
- Data Source
  KAKENHI-PROJECT-17K16200
[Journal Article] Abnormal hematopoiesis and hematopoietic stem cell niche2017
- Author(s)
  田久保圭誉、森川隆之、小林央
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 58 Issue: 10 Pages: 1844-1850
- DOI
  10.11406/rinketsu.58.1844
- NAID
  130006132651
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16200, KAKENHI-PLANNED-26115005, KAKENHI-PROJECT-15H04861, KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-16K15507
[Patent] 造血幹細胞を維持培養するための培地、及びそれを用いた培養方法2018
- Inventor(s)
  小林央、田久保圭誉
- Industrial Property Rights Holder
  小林央、田久保圭誉
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-100036
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K16200
[Presentation] Maintenance of HSC quiescence in vitro and its application to genome editing.2023
- Author(s)
  Hiroshi Kobayashi, Keiyo Takubo
- Organizer
  JPAN-UK joint meeting in Tokyo
- Data Source
  KAKENHI-PROJECT-21K08431
[Presentation] The Pbx1-G9a axis dysregulates lineage output of old hematopoietic stem cells.2023
- Author(s)
  Hiroshi Kobayashi, Shintaro Watanuki, Keiyo Takubo
- Organizer
  第20回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-21K08431
[Presentation] 統合的代謝解析による加齢造血幹細胞特異的なエネルギー代謝制御とその意義の解明2020
- Author(s)
  綿貫慎太郎, 小林央, 杉浦悠毅, 反町優理子, 山本正道, 末松誠, 岡本真一郎, 田久保圭誉
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17847
[Presentation] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo2019
- Author(s)
  Hiroshi Kobayashi, Keiyo Takubo
- Organizer
  48th Annual Scientific Meeting, International Society of Experimental Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17847
[Presentation] 造血幹細胞の休眠状態を体外で誘導する2019
- Author(s)
  小林　央、田久保　圭誉
- Organizer
  第92回日本生化学会
- Data Source
  KAKENHI-PROJECT-19K17847
[Presentation] 造血幹細胞の静止期維持培養法2019
- Author(s)
  小林　央、田久保　圭誉
- Organizer
  第81回日本血液学会
- Data Source
  KAKENHI-PROJECT-19K17847
[Presentation] Maintenance of quiescent hematopoietic stem cells ex vivo2019
- Author(s)
  小林　央
- Organizer
  第17回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-19K17847
[Presentation] Age-Dependent Decrease in Requirement for Glycolysis in Hematopoietic Stem Cells.2018
- Author(s)
  Shintaro Watanuki, Hiroshi Kobayashi, Daiki Karigane, Yukako Ootomo, Ayumi Okinaga, Shinichiro Okamoto, Keiyo Takubo
- Organizer
  61st ASH Annual Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16200
[Presentation] Glycolytic addiction of hematopoietic stem cells is modulated by age and cell cycle status.2018
- Author(s)
  Shintaro Watanuki, Hiroshi Kobayashi, Daiki Karigane, Yukako Ootomo, Ayumi Okinaga, Shinichiro Okamoto, Keiyo Takubo
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16200
[Presentation] The acceleration pattern of RhoA-dependent motility is a parameter to distinguish HSCs from MPPs.2017
- Author(s)
  Okinaga A, Kobayashi H, Takubo K.
- Organizer
  第79回日本血液学会
- Data Source
  KAKENHI-PROJECT-17K16200

1. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
2. UEDA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 白髭克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 加部泰明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 金井昭教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 世良康如

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Hiroshi 小林 央

Research Projects

Research Products

Co-Researchers

Identification of mesenchyme-derived factors essential for maintenance of hematopoietic stem cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a method to induce maturation of fetal hematopoietic stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the mechanism of HSC aging through quiescence maintaining culturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of aged hematopoietic stem cells through single-cell RNA-sequencingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mesenchymal loss of p53 alters stem cell capacity and models human soft tissue sarcoma traits.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct roles of the preparatory and payoff phases of glycolysis in hematopoietic stem cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MBTD1 preserves adult hematopoietic stem cell pool size and function2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluating the function of murine quiescent hematopoietic stem cells following non-homologous end joining-based genome editing2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A culture platform to study quiescent hematopoietic stem cells following genome editing2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Approaches towards Elucidating the Metabolic Program of Hematopoietic Stem/Progenitor Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy2021

Author(s)

Kobayashi Hiroshi 小林央