Nagaoka Hikaru 長岡ひかる

Researcher Number	10757222
Other IDs
Affiliation (Current)	2026: 愛媛大学, プロテオサイエンスセンター, 准教授 2026: 東京科学大学, 大学院医歯学総合研究科, プロジェクト講師
Affiliation (based on the past Project Information) *help	2024 – 2025: 愛媛大学, プロテオサイエンスセンター, 特定講師 2021 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, プロジェクト講師 2017 – 2023: 愛媛大学, プロテオサイエンスセンター, 研究員 2020: 愛媛大学, 学内共同利用施設等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49040:Parasitology-related / Parasitology (including sanitary zoology) Except Principal Investigator Basic Section 49040:Parasitology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator ワクチン / マラリア / 新規ワクチン候補抗原 / Malaria / 小麦無細胞 / コムギ無細胞 / モノクローナル抗体 / 増殖阻害活性 / 赤血球期ステージ / GAMA … More / Blood stage / 構造解析 / 赤血球ステージ / Ripr / Mararia / vaccine / blood stage / 赤血球表面受容体 / 赤血球結合試験 / 増殖阻害試験 / タンパク質相互作用 … More Except Principal Investigator マラリア / 相互作用タンパク質探索 / 相互作用タンパク質 / 寄生胞膜 / スポロゾイト / 近位依存性ビオチン化酵素 / 赤血球感染 / 肝臓感染 / BioID / 宿主病原体相互作用 / マラリア原虫 / 抗体 / コムギ無細胞系 / ワクチン Less

Structural analysis of the candidate antigen Ripr for erythrocyte stage malaria vaccinePrincipal Investigator
- Principal Investigator
  
  長岡ひかる
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  Ehime University
  Tokyo Medical and Dental University
Elucidation of the molecular mechanisms of sporozoite infection of hepatocyte via host-parasite interaction
- Principal Investigator
  
  Tomoko Ishino
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  Institute of Science Tokyo
  Tokyo Medical and Dental University
Functional analysis of malaria vaccine candidate antigen GAMAPrincipal Investigator
- Principal Investigator
  
  NAGAOKA HIKARU
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  Tokyo Medical and Dental University
  Ehime University
Assessing the impact of Ripr genetic diversity on ex vivo malaria parasite growth inhibition assay.
- Principal Investigator
  
  Takashima Eizo
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Ehime University
Analysis of erythrocyte surface recognition mechanism by Plasmodium falciparum RiprPrincipal Investigator
- Principal Investigator
  
  NAGAOKA HIKARU
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  Ehime University
The interaction between GAMA and MSP10 plays an important role in P.falciparum erythrocyte invasionPrincipal Investigator
- Principal Investigator
  
  Nagaoka Hikaru
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  Ehime University

All 2025 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Antibody responses in Burkinabe children against P. falciparum proteins associated with reduced risk of clinical malaria2025
- Author(s)
  Yuguchi Takaaki、Dankyi Benedicta O.、Rojrung Rattanaporn、Nagaoka Hikaru、Kanoi Bernard N.、Tiono Alfred B.、Nebie Issa、Ouedraogo Alphonse、Miura Kazutoyo、Sattabongkot Jetsumon、Sirima Sodiomon B.、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 16 Pages: 1521082-1521082
- DOI
  10.3389/fimmu.2025.1521082
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138, KAKENHI-PROJECT-24K02273, KAKENHI-PROJECT-23KK0140
[Journal Article] Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria2024
- Author(s)
  Hagadorn Kelly A.、Peterson Mary E.、Kole Hemanta、Scott Bethany、Skinner Jeff、Diouf Ababacar、Takashima Eizo、Ongoiba Aissata、Doumbo Safiatou、Doumtabe Didier、Li Shanping、Sekar Padmapriya、Yan Mei、Zhu Chengsong、Nagaoka Hikaru、Kanoi Bernard N.、Li Quan-Zhen、Long Carole、Long Eric O.
- Journal Title
  
  Immunity
  
  Volume: 57 Issue: 8 Pages: 1769-1779
- DOI
  10.1016/j.immuni.2024.05.024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138, KAKENHI-PROJECT-24K02273, KAKENHI-PROJECT-23KK0140
[Journal Article] The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum2024
- Author(s)
  Takashima Eizo、Otsuki Hitoshi、Morita Masayuki、Ito Daisuke、Nagaoka Hikaru、Yuguchi Takaaki、Hassan Ifra、Tsuboi Takafumi
- Journal Title
  
  Biomolecules
  
  Volume: 14 Issue: 1 Pages: 100-100
- DOI
  10.3390/biom14010100
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138, KAKENHI-PROJECT-23KK0140, KAKENHI-PROJECT-21K06989, KAKENHI-PROJECT-21H02724
[Journal Article] GATS tag system is compatible with biotin labelling methods for protein analysis2023
- Author(s)
  Yamada Kohdai、Soga Fumiya、Tokunaga Soh、Nagaoka Hikaru、Ozawa Tatsuhiko、Kishi Hiroyuki、Takashima Eizo、Sawasaki Tatsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 10243-10243
- DOI
  10.1038/s41598-023-36858-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138, KAKENHI-PROJECT-21K06990, KAKENHI-PROJECT-21H02724, KAKENHI-PROJECT-21H02962
[Journal Article] Pfs230 Domain 7 is targeted by a potent malaria transmission-blocking monoclonal antibody2023
- Author(s)
  Inklaar Maartje R.、de Jong Roos M.、Bekkering Ezra T.、Nagaoka Hikaru、Fennemann Felix L.、Teelen Karina、van de Vegte-Bolmer Marga、van Gemert Geert-Jan、Stoter Rianne、King C. Richter、Proellochs Nicholas I.、Bousema Teun、Takashima Eizo、Tsuboi Takafumi、Jore Matthijs M.
- Journal Title
  
  npj Vaccines
  
  Volume: 8 Issue: 1 Pages: 186-186
- DOI
  10.1038/s41541-023-00784-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138, KAKENHI-PROJECT-23KK0140, KAKENHI-PROJECT-21H02724
[Journal Article] Identification of novel Plasmodium vivax proteins associated with protection against clinical malaria2023
- Author(s)
  Mazhari Ramin、Takashima Eizo、Longley Rhea J.、Ruybal-Pesantez Shazia、White Michael T.、Kanoi Bernard N.、Nagaoka Hikaru、Kiniboro Benson、Siba Peter、Tsuboi Takafumi、Mueller Ivo
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 13
- DOI
  10.3389/fcimb.2023.1076150
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06990, KAKENHI-PROJECT-21KK0138, KAKENHI-PROJECT-21H02724
[Journal Article] High-Throughput Antibody Profiling Identifies Targets of Protective Immunity against P. falciparum Malaria in Thailand2023
- Author(s)
  Hassan Ifra、Kanoi Bernard N.、Nagaoka Hikaru、Sattabongkot Jetsumon、Udomsangpetch Rachanee、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 8 Pages: 1267-1267
- DOI
  10.3390/biom13081267
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138, KAKENHI-PROJECT-21H02724
[Journal Article] The Lipid-Binding Defective Dynamin 2 Mutant in Charcot-Marie-Tooth Disease Impairs Proper Actin Bundling and Actin Organization in Glomerular Podocytes2022
- Author(s)
  Hamasaki Eriko、Wakita Natsuki、Yasuoka Hiroki、Nagaoka Hikaru、Morita Masayuki、Takashima Eizo、Uchihashi Takayuki、Takeda Tetsuya、Abe Tadashi、Lee Ji-Won、Iimura Tadahiro、Saleem Moin A、Ogo Naohisa、Asai Akira、Narita Akihiro、Takei Kohji、Yamada Hiroshi
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 10 Pages: 884509-884509
- DOI
  10.3389/fcell.2022.884509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06990, KAKENHI-PROJECT-22K06580, KAKENHI-PROJECT-19K10044, KAKENHI-PROJECT-20K08591
[Journal Article] Recruitment of Irgb6 to the membrane is a direct trigger for membrane deformation2022
- Author(s)
  Yamada Hiroshi、Abe Tadashi、Nagaoka Hikaru、Takashima Eizo、Nitta Ryo、Yamamoto Masahiro、Takei Kohji
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 12 Pages: 2022-2022
- DOI
  10.3389/fcimb.2022.992198
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06990, KAKENHI-PROJECT-22K06580, KAKENHI-PROJECT-21K19484, KAKENHI-PROJECT-21KK0138, KAKENHI-PROJECT-21H02724, KAKENHI-PROJECT-20K08591, KAKENHI-PROJECT-21K19352, KAKENHI-PROJECT-23K24057, KAKENHI-PLANNED-21H05254
[Journal Article] Meta-Analysis of Human Antibodies Against Plasmodium falciparum Variable Surface and Merozoite Stage Antigens2022
- Author(s)
  Takashima Eizo、Kanoi Bernard N.、Nagaoka Hikaru、Morita Masayuki、Hassan Ifra、Palacpac Nirianne M. Q.、Egwang Thomas G.、Horii Toshihiro、Gitaka Jesse、Tsuboi Takafumi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 887219-887219
- DOI
  10.3389/fimmu.2022.887219
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06990, KAKENHI-PROJECT-21KK0138, KAKENHI-PROJECT-20H03481, KAKENHI-PROJECT-21H02724
[Journal Article] A novel asexual blood-stage malaria vaccine candidate: PfRipr5 formulated with human-use adjuvants induces potent growth inhibitory antibodies2022
- Author(s)
  Takashima Eizo、Nagaoka Hikaru、Correia Ricardo、Alves Paula M.、Rold?o Ant?nio、Christensen Dennis、Guderian Jeffrey A.、Fukushima Akihisa、Viebig Nicola K.、Depraetere Hilde、Tsuboi Takafumi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 1002430-1002430
- DOI
  10.3389/fimmu.2022.1002430
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138, KAKENHI-PROJECT-20H03481, KAKENHI-PROJECT-21H02724
[Journal Article] Asexual Blood-Stage Malaria Vaccine Candidate PfRipr5: Enhanced Production in Insect Cells2022
- Author(s)
  Correia Ricardo、Fernandes B、Castro Rute、Nagaoka Hikaru、Takashima Eizo、Tsuboi Takafumi、Fukushima Akihisa、Viebig Nicola K.、Depraetere Hilde、Alves Paula M.、Rold?o Ant?nio
- Journal Title
  
  Frontiers in Bioengineering and Biotechnology
  
  Volume: 10 Pages: 908509-908509
- DOI
  10.3389/fbioe.2022.908509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06990, KAKENHI-PROJECT-21KK0138, KAKENHI-PROJECT-20H03481, KAKENHI-PROJECT-21H02724
[Journal Article] Characterization of a Plasmodium falciparum PHISTc protein, PF3D7_0801000, in blood- stage malaria parasites2021
- Author(s)
  Nagaoka Hikaru、Kanoi Bernard N.、Morita Masayuki、Nakata Takahiro、Palacpac Nirianne M.Q.、Egwang Thomas G.、Horii Toshihiro、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Parasitology International
  
  Volume: 80 Pages: 102240-102240
- DOI
  10.1016/j.parint.2020.102240
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-19K16629, KAKENHI-PROJECT-19K16630
[Journal Article] Plasmodium yoelii Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein2021
- Author(s)
  Yuguchi Takaaki、Kanoi Bernard N.、Nagaoka Hikaru、Miura Toyokazu、Ito Daisuke、Takeda Hiroyuki、Tsuboi Takafumi、Takashima Eizo、Otsuki Hitoshi
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 11 Pages: 656620-656620
- DOI
  10.3389/fcimb.2021.656620
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06989, KAKENHI-PROJECT-21K06990
[Journal Article] Leveraging the wheat germ cell-free protein synthesis system to accelerate malaria vaccine development2021
- Author(s)
  Kanoi Bernard N.、Nagaoka Hikaru、Morita Masayuki、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Parasitology International
  
  Volume: 80 Pages: 102224-102224
- DOI
  10.1016/j.parint.2020.102224
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-19K16629, KAKENHI-PROJECT-19K16630
[Journal Article] Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressed in Mature P. falciparum Gametocytes2021
- Author(s)
  Muthui Michelle K.、Takashima Eizo、Omondi Brian R.、Kinya Christine、Muasya William I.、Nagaoka Hikaru、Mwai Kennedy W.、Orindi Benedict、Wambua Juliana、Bousema Teun、Drakeley Chris、Blagborough Andrew M.、Marsh Kevin、Bejon Philip、Kapulu Melissa C.
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 11 Pages: 774537-774537
- DOI
  10.3389/fcimb.2021.774537
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06990
[Journal Article] Identification of Novel Malaria Transmission-Blocking Vaccine Candidates2021
- Author(s)
  Takashima Eizo、Tachibana Mayumi、Morita Masayuki、Nagaoka Hikaru、Kanoi Bernard N.、Tsuboi Takafumi
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 11 Pages: 1-8
- DOI
  10.3389/fcimb.2021.805482
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02724, KAKENHI-PROJECT-21K06990
[Journal Article] Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A2020
- Author(s)
  Nagaoka Hikaru、Kanoi Bernard N.、Ntege Edward H.、Aoki Masamitsu、Fukushima Akihisa、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-14
- DOI
  10.1038/s41598-020-63611-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19455, KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-19K22535, KAKENHI-PROJECT-19K16629
[Journal Article] Global repertoire of human antibodies against Plasmodium falciparum RIFINs, SURFINs, and STEVORs in a malaria exposed population2020
- Author(s)
  Kanoi Bernard N.、Nagaoka Hikaru、Morita Masayuki、White Michael T.、Palacpac Nirianne M.Q.、Ntege Edward H.、Balikagala Betty、Yeka Adoke、Egwang Thomas G.、Horii Toshihiro、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Frontiers in Immunology
  
  Volume: "" Pages: 1-12
- DOI
  10.3389/fimmu.2020.00893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16630, KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-18K19455, KAKENHI-PROJECT-20K16238, KAKENHI-PROJECT-19K22535, KAKENHI-PROJECT-19K16629
[Journal Article] PfMSA180 is a novel Plasmodium falciparum vaccine antigen that interacts with human erythrocyte integrin associated protein (CD47)2019
- Author(s)
  Nagaoka Hikaru、Sasaoka Chisa、Yuguchi Takaaki、Kanoi Bernard N.、Ito Daisuke、Morita Masayuki、Udomsangpetch Rachanee、Sattabongkot Jetsumon、Ishino Tomoko、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 5923-5923
- DOI
  10.1038/s41598-019-42366-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06873, KAKENHI-PROJECT-17K15678, KAKENHI-PROJECT-19K22535, KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-18K19455
[Journal Article] Anti-MSP11 IgG inhibits Plasmodium falciparum merozoite invasion into erythrocytes in vitro2019
- Author(s)
  Tohmoto Tatsuhiro、Takashima Eizo、Takeo Satoru、Morita Masayuki、Nagaoka Hikaru、Udomsangpetch Rachanee、Sattabongkot Jetsumon、Ishino Tomoko、Torii Motomi、Tsuboi Takafumi
- Journal Title
  
  Parasitology International
  
  Volume: 69 Pages: 25-29
- DOI
  10.1016/j.parint.2018.10.012
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19455, KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-17K15678
[Journal Article] Identification of domains within Pfs230 that elicit transmission blocking antibody responses2019
- Author(s)
  Tachibana Mayumi、Miura Kazutoyo、Takashima Eizo、Morita Masayuki、Nagaoka Hikaru、Zhou Luwen、Long Carole A.、Richter King C.、Torii Motomi、Tsuboi Takafumi、Ishino Tomoko
- Journal Title
  
  Vaccine
  
  Volume: 37 Issue: 13 Pages: 1799-1806
- DOI
  10.1016/j.vaccine.2019.02.021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15678
[Journal Article] Comprehensive analysis of antibody responses to Plasmodium falciparum erythrocyte membrane protein 1 domains2018
- Author(s)
  Kanoi Bernard N.、Nagaoka Hikaru、Morita Masayuki、White Michael T.、Palacpac Nirianne M.Q.、Ntege Edward H.、Balikagala Betty、Yeka Adoke、Egwang Thomas G.、Horii Toshihiro、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Vaccine
  
  Volume: 36 Issue: 45 Pages: 6826-6833
- DOI
  10.1016/j.vaccine.2018.08.058
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19455, KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-17K15678
[Journal Article] PV1, a novel Plasmodium falciparum merozoite dense granule protein, interacts with exported protein in infected erythrocytes2018
- Author(s)
  Morita Masayuki、Nagaoka Hikaru、Ntege Edward H.、Kanoi Bernard N.、Ito Daisuke、Nakata Takahiro、Lee Ji-Won、Tokunaga Kazuaki、Iimura Tadahiro、Torii Motomi、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 3696-3696
- DOI
  10.1038/s41598-018-22026-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06873, KAKENHI-PROJECT-17K15678, KAKENHI-PROJECT-16K20412
[Presentation] Immunoprofiling of naturally acquired transmission-blocking immunity against plasmodium vivax2024
- Author(s)
  Rojrung R, Thongpoon S, Takaaki Y, Roobsoong W, Nagaoka H, Nguitragool W, Kanoi BN, Chotirat S, Tachibana M, Cui L, Ishino T, Miura K, Tsuboi T, Sattabongkot J, Takashima E
- Organizer
  Joint International Tropical Medicine Meeting (JITMM) 2024 Bangkok, Thailand
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138
[Presentation] Immunoscreening of P. falciparum Antigens to Identify Gametocyte Carriers2024
- Author(s)
  Hikaru Nagaoka, Shuya Ninose, Gyamah Bredu, Linda Eva Amoah, Eizo Takashima.
- Organizer
  American Society of Tropical Medicine and Hygiene (ASTMH) 2024 Annual Meeting New Orleans, United States
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138
[Presentation] Comparison of a flCSP/SA-1 malaria vaccine candidate with RTS,S/AS01 in two pre-clinical models2024
- Author(s)
  Takashima E, Tachibana M, Culleton R, Morita M, Nagaoka H, Fukushima A, Aoki M, Hayashi H, Nemoto D, Tomita Y, Torii M, Miura K, Locke E, King RC, Wu Y, Tsuboi T.
- Organizer
  Joint International Tropical Medicine Meeting (JITMM) 2024 Bangkok, Thailand
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138
[Presentation] 熱帯熱マラリア原虫ガメトサイト感染者を検出する抗体バイオマーカーの探索2024
- Author(s)
  長岡ひかる1, 二瀬周哉2, Dorcas Gyamah Bredu3, Linda Eva Amoah3, 高島英造2.
- Organizer
  第93回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-21K06990
[Presentation] Evaluation of a novel malaria vaccine candidate flCSP/SA-1 in comparison to RTS,S/AS01 in two pre-clinical models2024
- Author(s)
  Takashima E, Tachibana M, Culleton R, Morita M, Nagaoka H, Fukushima A, Aoki M, Hayashi H, Nemoto D, Tomita Y, Torii M, Miura K, Locke E, King RC, Wu Y, Tsuboi T.
- Organizer
  American Society of Tropical Medicine and Hygiene (ASTMH) 2024 Annual Meeting New Orleans, United States
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138
[Presentation] PfRipr5, a novel blood-stage malaria vaccine candidate, formulated with adjuvants for human use, induced potent growth inhibitory antibodies2022
- Author(s)
  Eizo Takashima, Hikaru Nagaoka, Ricardo Correia, Antonio Roldao, Akihisa Fukushima, Nicola Viebig, Takafumi Tsuboi
- Organizer
  American Society of Tropical Medicine and Hygiene Meeting (ASTMH) 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138
[Presentation] Plasmodium falciparum PF3D7_0715200 is a merozoite surface protein that induces antibodies with mild growth inhibitory activity.2022
- Author(s)
  長岡ひかる
- Organizer
  ASTMH 2022 Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06990
[Presentation] A NOVEL BLOOD-STAGE MALARIA VACCINE CANDIDATE, PFRIPR5 FORMULATED WITH ADJUVANTS FOR HUMAN USE, INDUCED POTENT GROWTH INHIBITORY ANTIBODIES2022
- Author(s)
  Eizo Takashima, Hikaru Nagaoka, Ricardo Correia, Antonio Roldao, Akihisa Fukushima, Nicola Viebig, Takafumi Tsuboi
- Organizer
  15th International Congress of Parasitology (ICOPA)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0138
[Presentation] 熱帯熱マラリア原虫メロゾイト侵入機構解明に向けた原虫増殖活性を有する抗 Ripr モノクローナル抗体の作出2022
- Author(s)
  長岡ひかる，福島晃久，坪井敬文，高島英造
- Organizer
  第91回日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-21K06990
[Presentation] 三日熱マラリア原虫タンパク質MSP7の生化学的解析2021
- Author(s)
  長岡ひかる, 小川晃輝, カノイ・バーナード, 坪井敬文, 高島英造
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-21K06990
[Presentation] 赤血球期熱帯熱マラリア原虫PHISTcタンパク質Pf3D7_0801000の性状解析2021
- Author(s)
  長岡ひかる, カノイ・バーナード, 森田将之, 中田貴敬, ニリアン・パラクパック, 堀井俊宏, 坪井敬文, 高島英造
- Organizer
  第90回日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-21K06990
[Presentation] Reverse vaccinology approach for discovery of novel malaria blood-stage vaccine candidates: The case of Ripr5.2021
- Author(s)
  Hikaru Nagaoka
- Organizer
  9th Academic symposium, The Genetics, Biology, and Epidemiology of Diseases of Poverty.
- Invited
- Data Source
  KAKENHI-PROJECT-21K06990
[Presentation] 熱帯熱マラリア原虫MSP10の赤血球侵入におけるメカニズムの解明2020
- Author(s)
  長岡ひかる, カノイ・バーナード, 神岡花奈, 森田将之, 二リアン・パラクパック, 堀井俊宏, 坪井敬文, 高島英造
- Organizer
  第89回　日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-19K16629
[Presentation] The N-terminal region of Plasmodium falciparum MSP10 is important for PfGAMA/MSP10 interaction and is a target of protective antibodies.2019
- Author(s)
  Hikaru Nagaoka, Bernard N. Kanoi, Kana Jinoka, Masayuki Morita, Thangavelu U Arumugam, Nirianne M. Q. Palacpac, Thomas G. Egwang, Toshihiro Horii, Takafumi Tsuboi, Eizo Takashima
- Organizer
  ASTMH 68th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16629
[Presentation] 熱帯熱マラリアワクチン候補分子Riprにおける増殖阻害活性エピトープの同定2019
- Author(s)
  長岡ひかる
- Organizer
  日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] PfRipr_5: a potent blood-stage malaria vaccine candidate antigen2018
- Author(s)
  Nagaoka Hikaru
- Organizer
  American Society of Tropical Medicine and Hygiene 67th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] Identification of PfRipr_5 as a potent blood-stage malaria vaccine candidate2018
- Author(s)
  Nagaoka Hikaru
- Organizer
  ICOPA 2018 14th International congress of parasitology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] マラリアワクチン候補RIPRの赤血球侵入における分子機能の解明2018
- Author(s)
  長岡ひかる
- Organizer
  日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] Truncation of PfRipr reveals region that induces antibody with the most potent growth inhibitory activity against Plasmodium falciparum2017
- Author(s)
  長岡ひかる
- Organizer
  American society of tropical medicine and hygiene
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] 熱帯熱マラリアワクチン候補分子RiprのCyRPAとの相互作用領域の同定2017
- Author(s)
  長岡ひかる
- Organizer
  日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] Riprを中心としたタンパク質相互作用解析2017
- Author(s)
  長岡ひかる
- Organizer
  分子寄生虫ワークショップ&分子寄生虫・マラリア研究フォーラム
- Data Source
  KAKENHI-PROJECT-17K15678

1. Takashima Eizo (50366762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
2. Tomoko Ishino (40402680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 森田将之 (60709632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 橘真由美 (00301325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 新澤直明 (10583015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 伊藤大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. Nganga KanoiBernard

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagaoka Hikaru 長岡 ひかる

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Structural analysis of the candidate antigen Ripr for erythrocyte stage malaria vaccinePrincipal Investigator

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Elucidation of the molecular mechanisms of sporozoite infection of hepatocyte via host-parasite interaction

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Functional analysis of malaria vaccine candidate antigen GAMAPrincipal Investigator

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Assessing the impact of Ripr genetic diversity on ex vivo malaria parasite growth inhibition assay.

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Analysis of erythrocyte surface recognition mechanism by Plasmodium falciparum RiprPrincipal Investigator

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The interaction between GAMA and MSP10 plays an important role in P.falciparum erythrocyte invasionPrincipal Investigator

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[Journal Article] Antibody responses in Burkinabe children against P. falciparum proteins associated with reduced risk of clinical malaria2025

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[Journal Article] Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria2024

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[Journal Article] The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum2024

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[Journal Article] GATS tag system is compatible with biotin labelling methods for protein analysis2023

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[Journal Article] Pfs230 Domain 7 is targeted by a potent malaria transmission-blocking monoclonal antibody2023

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[Journal Article] Identification of novel Plasmodium vivax proteins associated with protection against clinical malaria2023

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[Journal Article] High-Throughput Antibody Profiling Identifies Targets of Protective Immunity against P. falciparum Malaria in Thailand2023

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[Journal Article] The Lipid-Binding Defective Dynamin 2 Mutant in Charcot-Marie-Tooth Disease Impairs Proper Actin Bundling and Actin Organization in Glomerular Podocytes2022

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Nagaoka Hikaru 長岡ひかる