Nagaoka Hikaru 長岡ひかる

Researcher Number	10757222
Other IDs
Affiliation (Current)	2023: 東京医科歯科大学, 大学院医歯学総合研究科, プロジェクト講師
Affiliation (based on the past Project Information) *help	2021 – 2022: 東京医科歯科大学, 大学院医歯学総合研究科, プロジェクト講師 2017 – 2021: 愛媛大学, プロテオサイエンスセンター, 研究員 2020: 愛媛大学, 学内共同利用施設等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49040:Parasitology-related / Parasitology (including sanitary zoology) Except Principal Investigator Basic Section 49040:Parasitology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator マラリア / ワクチン / モノクローナル抗体 / コムギ無細胞 / 小麦無細胞 / タンパク質相互作用 / 増殖阻害活性 / 増殖阻害試験 / 赤血球結合試験 / 赤血球表面受容体 / Malaria / blood stage / vaccine … More Except Principal Investigator … More マラリア / スポロゾイト / 相互作用タンパク質 / ワクチン Less

スポロゾイトと肝細胞の相互作用に着目したマラリア原虫感染成立の分子基盤の解明
- Principal Investigator
  
  石野智子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  Tokyo Medical and Dental University
Functional analysis of malaria vaccine candidate antigen GAMAPrincipal Investigator
- Principal Investigator
  
  長岡ひかる
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  Ehime University
流行地変異株原虫に対するRipr5マラリア赤血球期ワクチン効果の検証
- Principal Investigator
  
  高島英造
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Ehime University
赤血球期マラリアワクチン候補抗原Riprの構造解析Principal Investigator
- Principal Investigator
  
  長岡ひかる
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  Tokyo Medical and Dental University
  Ehime University
Analysis of erythrocyte surface recognition mechanism by Plasmodium falciparum RiprPrincipal Investigator
- Principal Investigator
  
  NAGAOKA HIKARU
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  Ehime University
The interaction between GAMA and MSP10 plays an important role in P.falciparum erythrocyte invasionPrincipal Investigator
- Principal Investigator
  
  Nagaoka Hikaru
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  Ehime University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Characterization of a Plasmodium falciparum PHISTc protein, PF3D7_0801000, in blood- stage malaria parasites.2021
- Author(s)
  Nagaoka Hikaru、Kanoi Bernard N.、Morita Masayuki、Nakata Takahiro、Palacpac Nirianne M.Q.、Egwang Thomas G.、Horii Toshihiro、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Parasitology International
  
  Volume: 80 Pages: 102240-102240
- DOI
  10.1016/j.parint.2020.102240
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-19K16629, KAKENHI-PROJECT-19K16630
[Journal Article] Plasmodium yoelii Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein2021
- Author(s)
  Yuguchi Takaaki、Kanoi Bernard N.、Nagaoka Hikaru、Miura Toyokazu、Ito Daisuke、Takeda Hiroyuki、Tsuboi Takafumi、Takashima Eizo、Otsuki Hitoshi
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 11 Pages: 656620-656620
- DOI
  10.3389/fcimb.2021.656620
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06989, KAKENHI-PROJECT-21K06990
[Journal Article] Leveraging the wheat germ cell-free protein synthesis system to accelerate malaria vaccine development.2021
- Author(s)
  Kanoi Bernard N.、Nagaoka Hikaru、Morita Masayuki、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Parasitology International
  
  Volume: 80 Pages: 102224-102224
- DOI
  10.1016/j.parint.2020.102224
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-19K16629, KAKENHI-PROJECT-19K16630
[Journal Article] Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressed in Mature P. falciparum Gametocytes2021
- Author(s)
  Muthui Michelle K.、Takashima Eizo、Omondi Brian R.、Kinya Christine、Muasya William I.、Nagaoka Hikaru、Mwai Kennedy W.、Orindi Benedict、Wambua Juliana、Bousema Teun、Drakeley Chris、Blagborough Andrew M.、Marsh Kevin、Bejon Philip、Kapulu Melissa C.
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 11 Pages: 774537-774537
- DOI
  10.3389/fcimb.2021.774537
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06990
[Journal Article] Identification of Novel Malaria Transmission-Blocking Vaccine Candidates2021
- Author(s)
  Takashima Eizo、Tachibana Mayumi、Morita Masayuki、Nagaoka Hikaru、Kanoi Bernard N.、Tsuboi Takafumi
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 11 Pages: 1-8
- DOI
  10.3389/fcimb.2021.805482
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02724, KAKENHI-PROJECT-21K06990
[Journal Article] Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A2020
- Author(s)
  Nagaoka Hikaru、Kanoi Bernard N.、Ntege Edward H.、Aoki Masamitsu、Fukushima Akihisa、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 1-14
- DOI
  10.1038/s41598-020-63611-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19455, KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-19K22535, KAKENHI-PROJECT-19K16629
[Journal Article] Global Repertoire of Human Antibodies Against Plasmodium falciparum RIFINs, SURFINs, and STEVORs in a Malaria Exposed Population2020
- Author(s)
  Kanoi Bernard N.、Nagaoka Hikaru、Morita Masayuki、White Michael T.、Palacpac Nirianne M.Q.、Ntege Edward H.、Balikagala Betty、Yeka Adoke、Egwang Thomas G.、Horii Toshihiro、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Frontiers in Immunology
  
  Volume: "" Pages: 1-12
- DOI
  10.3389/fimmu.2020.00893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16630, KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-18K19455, KAKENHI-PROJECT-20K16238, KAKENHI-PROJECT-19K22535, KAKENHI-PROJECT-19K16629
[Journal Article] PfMSA180 is a novel Plasmodium falciparum vaccine antigen that interacts with human erythrocyte integrin associated protein (CD47)2019
- Author(s)
  Nagaoka Hikaru、Sasaoka Chisa、Yuguchi Takaaki、Kanoi Bernard N.、Ito Daisuke、Morita Masayuki、Udomsangpetch Rachanee、Sattabongkot Jetsumon、Ishino Tomoko、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 1-11
- DOI
  10.1038/s41598-019-42366-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06873, KAKENHI-PROJECT-17K15678, KAKENHI-PROJECT-19K22535, KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-18K19455
[Journal Article] Anti-MSP11 IgG inhibits Plasmodium falciparum merozoite invasion into erythrocytes in vitro2019
- Author(s)
  Tohmoto Tatsuhiro、Takashima Eizo、Takeo Satoru、Morita Masayuki、Nagaoka Hikaru、Udomsangpetch Rachanee、Sattabongkot Jetsumon、Ishino Tomoko、Torii Motomi、Tsuboi Takafumi
- Journal Title
  
  Parasitology International
  
  Volume: 69 Pages: 25-29
- DOI
  10.1016/j.parint.2018.10.012
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19455, KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-17K15678
[Journal Article] Identification of domains within Pfs230 that elicit transmission blocking antibody responses2019
- Author(s)
  Tachibana Mayumi、Miura Kazutoyo、Takashima Eizo、Morita Masayuki、Nagaoka Hikaru、Zhou Luwen、Long Carole A.、Richter King C.、Torii Motomi、Tsuboi Takafumi、Ishino Tomoko
- Journal Title
  
  Vaccine
  
  Volume: 37 Pages: 1799-1806
- DOI
  10.1016/j.vaccine.2019.02.021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15678
[Journal Article] Comprehensive analysis of antibody responses to Plasmodium falciparum erythrocyte membrane protein 1 domains2018
- Author(s)
  Kanoi Bernard N.、Nagaoka Hikaru、Morita Masayuki、White Michael T.、Palacpac Nirianne M.Q.、Ntege Edward H.、Balikagala Betty、Yeka Adoke、Egwang Thomas G.、Horii Toshihiro、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Vaccine
  
  Volume: 36 Pages: 6826-6833
- DOI
  10.1016/j.vaccine.2018.08.058
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19455, KAKENHI-PROJECT-18H02651, KAKENHI-PROJECT-17K15678
[Journal Article] PV1, a novel Plasmodium falciparum merozoite dense granule protein, interacts with exported protein in infected erythrocytes.2018
- Author(s)
  Morita Masayuki、Nagaoka Hikaru、Ntege Edward H.、Kanoi Bernard N.、Ito Daisuke、Nakata Takahiro、Lee Ji-Won、Tokunaga Kazuaki、Iimura Tadahiro、Torii Motomi、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 3696-3696
- DOI
  10.1038/s41598-018-22026-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06873, KAKENHI-PROJECT-17K15678, KAKENHI-PROJECT-16K20412
[Presentation] 熱帯熱マラリア原虫メロゾイト侵入機構解明に向けた原虫増殖活性を有する抗 Ripr モノクローナル抗体の作出2022
- Author(s)
  長岡ひかる，福島晃久，坪井敬文，高島英造
- Organizer
  第91回日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-21K06990
[Presentation] 三日熱マラリア原虫タンパク質MSP7の生化学的解析2021
- Author(s)
  長岡ひかる, 小川晃輝, カノイ・バーナード, 坪井敬文, 高島英造
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-21K06990
[Presentation] 赤血球期熱帯熱マラリア原虫PHISTcタンパク質Pf3D7_0801000の性状解析2021
- Author(s)
  長岡ひかる, カノイ・バーナード, 森田将之, 中田貴敬, ニリアン・パラクパック, 堀井俊宏, 坪井敬文, 高島英造
- Organizer
  第90回日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-21K06990
[Presentation] Reverse vaccinology approach for discovery of novel malaria blood-stage vaccine candidates: The case of Ripr5.2021
- Author(s)
  Hikaru Nagaoka
- Organizer
  9th Academic symposium, The Genetics, Biology, and Epidemiology of Diseases of Poverty.
- Invited
- Data Source
  KAKENHI-PROJECT-21K06990
[Presentation] 熱帯熱マラリア原虫MSP10の赤血球侵入におけるメカニズムの解明2020
- Author(s)
  長岡ひかる, カノイ・バーナード, 神岡花奈, 森田将之, 二リアン・パラクパック, 堀井俊宏, 坪井敬文, 高島英造
- Organizer
  第89回　日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-19K16629
[Presentation] The N-terminal region of Plasmodium falciparum MSP10 is important for PfGAMA/MSP10 interaction and is a target of protective antibodies.2019
- Author(s)
  Hikaru Nagaoka, Bernard N. Kanoi, Kana Jinoka, Masayuki Morita, Thangavelu U Arumugam, Nirianne M. Q. Palacpac, Thomas G. Egwang, Toshihiro Horii, Takafumi Tsuboi, Eizo Takashima
- Organizer
  ASTMH 68th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16629
[Presentation] 熱帯熱マラリアワクチン候補分子Riprにおける増殖阻害活性エピトープの同定2019
- Author(s)
  長岡ひかる
- Organizer
  日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] PfRipr_5: a potent blood-stage malaria vaccine candidate antigen2018
- Author(s)
  Nagaoka Hikaru
- Organizer
  American Society of Tropical Medicine and Hygiene 67th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] Identification of PfRipr_5 as a potent blood-stage malaria vaccine candidate2018
- Author(s)
  Nagaoka Hikaru
- Organizer
  ICOPA 2018 14th International congress of parasitology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] マラリアワクチン候補RIPRの赤血球侵入における分子機能の解明2018
- Author(s)
  長岡ひかる
- Organizer
  日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] Truncation of PfRipr reveals region that induces antibody with the most potent growth inhibitory activity against Plasmodium falciparum2017
- Author(s)
  長岡ひかる
- Organizer
  American society of tropical medicine and hygiene
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] 熱帯熱マラリアワクチン候補分子RiprのCyRPAとの相互作用領域の同定2017
- Author(s)
  長岡ひかる
- Organizer
  日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-17K15678
[Presentation] Riprを中心としたタンパク質相互作用解析2017
- Author(s)
  長岡ひかる
- Organizer
  分子寄生虫ワークショップ&分子寄生虫・マラリア研究フォーラム
- Data Source
  KAKENHI-PROJECT-17K15678

1. 石野智子 (40402680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 橘真由美 (00301325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 新澤直明 (10583015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 高島英造 (50366762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 森田将之 (60709632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Nganga KanoiBernard

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 伊藤大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 坪井敬文

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 李智媛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagaoka Hikaru 長岡 ひかる

Research Projects

Research Products

Co-Researchers

スポロゾイトと肝細胞の相互作用に着目したマラリア原虫感染成立の分子基盤の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of malaria vaccine candidate antigen GAMAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

流行地変異株原虫に対するRipr5マラリア赤血球期ワクチン効果の検証

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

赤血球期マラリアワクチン候補抗原Riprの構造解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of erythrocyte surface recognition mechanism by Plasmodium falciparum RiprPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The interaction between GAMA and MSP10 plays an important role in P.falciparum erythrocyte invasionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Characterization of a Plasmodium falciparum PHISTc protein, PF3D7_0801000, in blood- stage malaria parasites.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasmodium yoelii Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Leveraging the wheat germ cell-free protein synthesis system to accelerate malaria vaccine development.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressed in Mature P. falciparum Gametocytes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Novel Malaria Transmission-Blocking Vaccine Candidates2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Global Repertoire of Human Antibodies Against Plasmodium falciparum RIFINs, SURFINs, and STEVORs in a Malaria Exposed Population2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PfMSA180 is a novel Plasmodium falciparum vaccine antigen that interacts with human erythrocyte integrin associated protein (CD47)2019

Author(s)

Journal Title

DOI

Data Source

Nagaoka Hikaru 長岡ひかる