• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

TAKAYAMA Kazuo  高山 和雄

ORCIDConnect your ORCID iD *help
… Alternative Names

高山 和雄  タカヤマ カズオ

Takayama Kazuo  高山 和雄

Less
Researcher Number 10759509
Other IDs
Affiliation (Current) 2022: 京都大学, iPS細胞研究所, 講師
Affiliation (based on the past Project Information) *help 2021 – 2022: 京都大学, iPS細胞研究所, 講師
2017 – 2019: 大阪大学, 薬学研究科, 助教
2016: 大阪大学, 薬学研究科, 特任助教(常勤)
2015: 大阪大学, 薬学研究科, 特任助教
Review Section/Research Field
Principal Investigator
Medical pharmacy / General internal medicine and related fields / Basic Section 90110:Biomedical engineering-related
Keywords
Principal Investigator
肝細胞 / ヒトES/iPS細胞 / 薬物代謝 / ゲノム編集 / CYP / 肝毒性 / 創薬試験 / CYP3A4 / 薬物代謝酵素 / 相同組換え … More / 毒性 / zonation / ヒトiPS細胞 / ヒトES細胞 / 肝障害 / 胆管上皮細胞 / 創薬 / 異物代謝 / 分化誘導 / 肝臓 / 光操作 / 腸管上皮細胞 / 慢性炎症 / 腸炎 / 光遺伝学 / 1細胞 / 大腸がん / 幹細胞 / 基底細胞 / 呼吸器感染症 / 気道 / 気管支 / iPS細胞 / SARS-CoV-2 Less
  • Research Projects

    (4 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (7 People)
  •  Elucidation of the role of basal stem cells in respiratory diseasesPrincipal Investigator

    • Principal Investigator
      高山 和雄
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Kyoto University
  •  Elucidation of mechanism of chronic intestinal inflammation at single-cell level using optogenetic techniquePrincipal Investigator

    • Principal Investigator
      高山 和雄
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      Osaka University
  •  Generation of zone-specific hepatocyte for study of liver injury and diseasesPrincipal Investigator

    • Principal Investigator
      Takayama Kazuo
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      General internal medicine and related fields
    • Research Institution
      Osaka University
  •  Generation of CYP3A4-expressing human ES/iPS cell-derived hepatocytes for drug screeningPrincipal Investigator

    • Principal Investigator
      Takayama Kazuo
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Medical pharmacy
    • Research Institution
      Osaka University

All 2019 2018 2017 2016 2015

All Journal Article Presentation Book Patent

  • [Book] ヒトiPS細胞由来肝細胞の創薬研究・非臨床試験への応用を目指して2015

    • Author(s)
      高山和雄、水口裕之
    • Total Pages
      5
    • Publisher
      薬剤学
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Book] ヒト多能性幹細胞由来肝細胞を用いた次世代型創薬の実現を目指した基盤技術創成2015

    • Author(s)
      高山和雄
    • Total Pages
      6
    • Publisher
      薬学雑誌
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Journal Article] Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies2019

    • Author(s)
      Yamashita T, Takayama K, Hori M, Harada-Shiba M, Mizuguchi H.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 42 Issue: 3 Pages: 312-318

    • DOI

      10.1248/bpb.b18-00544

    • NAID

      130007607360

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19657, KAKENHI-PROJECT-17K08681
  • [Journal Article] Generation of human iPS cell-derived intestinal epithelial cell monolayers by CDX2 transduction2019

    • Author(s)
      Takayama K., Negoro R., Yamashita T., Kawai K, Ichikawa M, Mori T, Nakatsu N, Harada K, Ito S, Yamada H, Yamaura Y, Hirata K, Ishida S, Mizuguchi H.
    • Journal Title

      Cell Mol Gastroenterol Hepatol.

      Volume: 8 Pages: 513-526

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-18H05033
  • [Journal Article] FGF signal is not required for hepatoblast differentiation of human iPS cells.2019

    • Author(s)
      Toba Y, Kiso A, Nakamae S, Sakurai F, Takayama K, Mizuguchi H.
    • Journal Title

      Sci Rep.

      Volume: 9 Pages: 3713-3713

    • DOI

      10.1038/s41598-019-40305-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19657
  • [Journal Article] Establishment of SLC15A1/PEPT1-knockout human induced pluripotent stem cell line for intestinal drug absorption studies2019

    • Author(s)
      Kawai K., Negoro R., Ichikawa M., Yamashita T., Deguchi S., Harada K., Hirata K., Takayama K., Mizuguchi H.
    • Journal Title

      Mol Ther Methods Clin Dev.

      Volume: 17 Pages: 49-57

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-18H05033
  • [Journal Article] Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies.2018

    • Author(s)
      Negoro Ryosuke、Takayama Kazuo、Kawai Kanae、Harada Kazuo、Sakurai Fuminori、Hirata Kazumasa、Mizuguchi Hiroyuki
    • Journal Title

      Stem Cell Reports.

      Volume: 11 Pages: 1539-1550

    • DOI

      10.1016/j.stemcr.2018.10.019

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05033, KAKENHI-PROJECT-20K20381
  • [Journal Article] Optimal human iPS cell culture method for efficient hepatic differentiation.2018

    • Author(s)
      Matoba N, Yamashita T, Takayama K, Sakurai F, Mizuguchi H.
    • Journal Title

      Differentiation

      Volume: 104 Pages: 13-21

    • DOI

      10.1016/j.diff.2018.09.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19657
  • [Journal Article] Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells.2018

    • Author(s)
      Yamashita T, Takayama K, Sakurai F, Mizuguchi H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 496 Pages: 1269-1275

    • DOI

      10.1016/j.bbrc.2018.01.186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19657
  • [Journal Article] Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.2018

    • Author(s)
      Takayama K, Hagihara Y, Toba Y, Sekiguchi K, Sakurai F, Mizuguchi H.
    • Journal Title

      Biomaterials.

      Volume: 161 Pages: 24-32

    • DOI

      10.1016/j.biomaterials.2018.01.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19657
  • [Journal Article] Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells.2018

    • Author(s)
      Nakamae S, Toba Y, Takayama K, Sakurai F, Mizuguchi H.
    • Journal Title

      Stem Cells Dev.

      Volume: 未定

    • DOI

      10.1089/scd.2017.0251

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19657
  • [Journal Article] Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening2017

    • Author(s)
      Takayama K., Mizuguchi H.
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 32 Issue: 1 Pages: 12-20

    • DOI

      10.1016/j.dmpk.2016.10.408

    • ISSN
      1347-4367
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Journal Article] Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells2017

    • Author(s)
      Imagawa K. 1, Takayama K. 1, Isoyama S., Tanikawa K., Shinkai M., Harada K., Tachibana M., Sakurai F., Noguchi E., Hirata K., Kage M., Kawabata K., Sumazaki R., Mizuguchi H.
    • Journal Title

      Scientific reports

      Volume: 7 Pages: 41806-41806

    • DOI

      10.1038/srep41806

    • NAID

      120007135051

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H06365, KAKENHI-PROJECT-15K19600
  • [Journal Article] Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system2017

    • Author(s)
      Takayama K., Igai K., Hagihara Y., Hashimoto R., Hanawa M., Sakuma T., Tachibana M., Sakurai F., Yamamoto T., Mizuguchi H
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Pages: 5198-5207

    • DOI

      10.1093/nar/gkx130

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H06365, KAKENHI-PROJECT-16K18478
  • [Journal Article] Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation From Human Induced Pluripotent Stem Cells2017

    • Author(s)
      Hanawa M., Takayama K., Sakurai F., Tachibana M., Mizuguchi H.
    • Journal Title

      Stem Cells Reviews & Reports

      Volume: 13 Pages: 542-551

    • DOI

      10.1007/s12015-016-9709-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Journal Article] Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions.2017

    • Author(s)
      Fukuda T., Takayama K., Hirata M., Liu Y., Yanagihara K., Suga M., Mizuguchi H., Furue M.
    • Journal Title

      Exp Cell Res

      Volume: 352 Pages: 333-345

    • DOI

      10.1016/j.yexcr.2017.02.022

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H06365, KAKENHI-PROJECT-16H05535
  • [Journal Article] Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling.2017

    • Author(s)
      Mitani S, Takayama K, Nagamoto Y, Imagawa K, Sakurai F, Tachibana M, Sumazaki R, Mizuguchi H.
    • Journal Title

      Molecular Therapy

      Volume: 25 Pages: 1420-1433

    • DOI

      10.1016/j.ymthe.2017.04.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19657, KAKENHI-PROJECT-17J04585
  • [Journal Article] Human iPS Cell-Derived Hepatocyte-Like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling2017

    • Author(s)
      Mitani S., Takayama K., Nagamoto Y., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Mizuguchi H.
    • Journal Title

      Molecular Therapy

      Volume: 25 Pages: 1420-1433

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Journal Article] Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction2016

    • Author(s)
      Nakamori D., Takayama K., Nagamoto Y., Mitani S., Sakurai F., Tachibana M., Mizuguchi H.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 469 Pages: 424-429

    • DOI

      10.1016/j.bbrc.2015.12.007

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H06365, KAKENHI-PROJECT-13J02987
  • [Journal Article] Prediction of differentiation tendency toward hepatocytes from gene expression in undifferentiated human pluripotent stem cells.2016

    • Author(s)
      Yanagihara K., Liu Y., Kanie K., Takayama K., Okamura M., Hirata M., Fukuda T., Suga M., Nikawa H., Mizuguchi H., Kato R., Furue M.
    • Journal Title

      Stem Cells and Development

      Volume: 25 Pages: 1884-1897

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Journal Article] Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells2016

    • Author(s)
      Takayama K., Mitani S., Nagamoto Y., Sakurai F., Tachibana M., Taniguchi Y., Sekiguchi K., Mizuguchi H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 474 Pages: 91-96

    • DOI

      10.1016/j.bbrc.2016.04.075

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Journal Article] Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells2016

    • Author(s)
      Negoro R., Takayama K., Nagamoto Y, Sakurai F., Tachibana M, Mizuguchi H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 472 Pages: 631-636

    • DOI

      10.1016/j.bbrc.2016.03.012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Journal Article] Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine2015

    • Author(s)
      Ozawa T., Takayama K., Okamoto R., Negoro R., Sakurai F., Tachibana M., Kawabata K., Mizuguchi H.
    • Journal Title

      Scientific Reports

      Volume: 12 Pages: 16479-16479

    • DOI

      10.1038/srep16479

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Patent] 小腸上皮様細胞の製造方法2019

    • Inventor(s)
      水口裕之、高山和雄、根来亮介、初山麻子、戸坂泰弘、榎竜嗣
    • Industrial Property Rights Holder
      阪大、基盤研、タカラバイオ
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-117536
    • Filing Date
      2019
    • Data Source
      KAKENHI-PUBLICLY-18H05033
  • [Presentation] ヒトiPS細胞由来肝細胞および小腸細胞の作製とMPSシステムへの応用2019

    • Author(s)
      高山和雄
    • Organizer
      日本動物実験代替法学会 第32回大会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-18H05033
  • [Presentation] Generation of photoactivatable adenovirus vector for spatiotemporally controllable gene therapy2019

    • Author(s)
      Kazuo Takayama
    • Organizer
      第57回日本生物物理学会年会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-18H05033
  • [Presentation] Generation of hepatocytes from human ES/iPS cells for medicinal sciences2018

    • Author(s)
      Takayama K., Mizuguchi H.
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19657
  • [Presentation] ヒトES/iPS細胞のゲノム編集と創薬研究への応用2018

    • Author(s)
      高山和雄、水口裕之
    • Organizer
      第17回日本再生医療学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19657
  • [Presentation] WNTシグナル制御による門脈域及び中心静脈域肝細胞の性質を有するヒトiPS細胞由来肝細胞作製法の開発2017

    • Author(s)
      三谷成二、高山和雄、櫻井文教、水口裕之
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-17K19657
  • [Presentation] ヒトES/iPS細胞における高効率相同組換え技術の開発2017

    • Author(s)
      高山和雄、井貝圭佑、櫻井文教、水口裕之
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Presentation] ヒトES/iPS細胞由来肝臓細胞の作製とその創薬研究への利用2017

    • Author(s)
      高山和雄
    • Organizer
      第6回超異分野学会
    • Place of Presentation
      東京
    • Year and Date
      2017-03-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Presentation] ヒトiPS細胞由来肝細胞の創薬・再生医療への応用2016

    • Author(s)
      高山和雄
    • Organizer
      K-CONNEXスタートアップシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2016-01-29
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Presentation] ヒトES/iPS細胞由来肝細胞の三次元培養による機能向上2016

    • Author(s)
      高山和雄
    • Organizer
      細胞凝集研究会2016
    • Place of Presentation
      札幌
    • Year and Date
      2016-09-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Presentation] Generation of enterocyte-like cells from human iPS cells for drug absorption and metabolism studies in small intestine2015

    • Author(s)
      Takayama K., Ozawa T., Sakurai F., Tachibana M., Mizuguchi H.
    • Organizer
      日本薬物動態学会第30回年会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-15H06365
  • [Presentation] ヒト多能性幹細胞から肝細胞様細胞への高効率分化誘導技術の開発―創薬応用を目指して―2015

    • Author(s)
      高山和雄、三村菜摘、萩原康子、立花雅史、櫻井文教、神田勝弘、川端健二、水口裕之
    • Organizer
      第65回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-17
    • Data Source
      KAKENHI-PROJECT-15H06365
  • 1.  Mizuguchi Hiroyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 2.  Imagawa Kazuo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  Mitani Seiji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  佐久間 哲史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  古江 美保
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  菅 三佳(岸本三佳)
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  堀 美香
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to connect your ORCID iD to this researcher?
* This action can be performed only by the researcher themselves.

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi