TAKAYAMA Kazuo 高山和雄

… Alternative Names

Takayama Kazuo 高山和雄

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Researcher Number	10759509
Other IDs
Affiliation (Current)	2025: 京都大学, iPS細胞研究所, 研究員 2025: 東京科学大学, 総合研究院, 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 京都大学, iPS細胞研究所, 講師 2017 – 2019: 大阪大学, 薬学研究科, 助教 2016: 大阪大学, 薬学研究科, 特任助教(常勤) 2015: 大阪大学, 薬学研究科, 特任助教
Review Section/Research Field	Principal Investigator Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 90110:Biomedical engineering-related / General internal medicine and related fields / Medical pharmacy Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator ゲノム編集 / 薬物代謝 / ヒトES/iPS細胞 / 肝細胞 / iPS細胞 / 気管支 / SARS-CoV-2 / 呼吸器感染症 / 臓器チップ / 感染症 … More / 気道 / オルガノイド / 基底細胞 / 呼吸器 / ウイルス / 幹細胞 / 大腸がん / １細胞 / 光遺伝学 / 腸炎 / 慢性炎症 / 腸管上皮細胞 / 光操作 / 肝臓 / 分化誘導 / 異物代謝 / 創薬 / 胆管上皮細胞 / 肝障害 / ヒトES細胞 / ヒトiPS細胞 / zonation / 毒性 / 相同組換え / 薬物代謝酵素 / CYP3A4 / 創薬試験 / 肝毒性 / CYP … More Except Principal Investigator 炎症スパイラル / 炎症性腸疾患 / 腸運動 / 生体模倣デバイス / 治療薬 / 罹患後症状 / 血管バリア / 血管内皮細胞 / 重症感染症 Less

次世代の医療を開拓するヒト小腸組織チップの開発と応用Principal Investigator
- Principal Investigator
  
  高山和雄
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Kyoto University
血管バリアに着目する新しい視点での重症感染症の病態・後遺症発症機構の解明と制御
- Principal Investigator
  
  岡田欣晃
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Osaka University
Microphysiological system-based analysis of inflammatory sprials triggered by abnormal gut motility
- Principal Investigator
  
  山下富義
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kyoto University
Elucidation of the role of basal stem cells in respiratory diseasesPrincipal Investigator
- Principal Investigator
  
  Takayama Kazuo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kyoto University
Elucidation of mechanism of chronic intestinal inflammation at single-cell level using optogenetic techniquePrincipal Investigator
- Principal Investigator
  
  高山和雄
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Osaka University
Generation of zone-specific hepatocyte for study of liver injury and diseasesPrincipal Investigator
- Principal Investigator
  
  Takayama Kazuo
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  Osaka University
Generation of CYP3A4-expressing human ES/iPS cell-derived hepatocytes for drug screeningPrincipal Investigator
- Principal Investigator
  
  Takayama Kazuo
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Medical pharmacy
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2019 2018 2017 2016 2015

All Journal Article Presentation Book Patent

[Book] iPS細胞とオルガノイドが切り拓く生命科学の未来2024
- Author(s)
  高山和雄、山中伸弥
- Total Pages
  4
- Publisher
  実験医学「増刊」オルガノイド生命医科学研究の衝撃
- ISBN
  9784758104173
- Data Source
  KAKENHI-PROJECT-21H03795
[Book] オルガノイドを用いた呼吸器疾患研究の最前線2023
- Author(s)
  出口清香、高山和雄
- Total Pages
  5
- Publisher
  日本薬理学雑誌
- Data Source
  KAKENHI-PROJECT-21H03795
[Book] いま知りたい!!「真の生理学性に挑む organ-on-a-chip」実験医学2021年10月号2021
- Author(s)
  出口清香、高山和雄
- Total Pages
  141
- Publisher
  羊土社
- ISBN
  9784758125482
- Data Source
  KAKENHI-PROJECT-21H03795
[Book] ヒトiPS細胞やオルガノイドを用いたSARS-CoV-2研究2021
- Author(s)
  出口清香、高山和雄
- Total Pages
  3
- Publisher
  和光純薬時報　Vol.89 No. 4
- Data Source
  KAKENHI-PROJECT-21H03795
[Book] ヒトiPS細胞由来肝細胞の創薬研究・非臨床試験への応用を目指して2015
- Author(s)
  高山和雄、水口裕之
- Total Pages
  5
- Publisher
  薬剤学
- Data Source
  KAKENHI-PROJECT-15H06365
[Book] ヒト多能性幹細胞由来肝細胞を用いた次世代型創薬の実現を目指した基盤技術創成2015
- Author(s)
  高山和雄
- Total Pages
  6
- Publisher
  薬学雑誌
- Data Source
  KAKENHI-PROJECT-15H06365
[Journal Article] Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids2023
- Author(s)
  Hashimoto Rina、Tamura Tomokazu、Watanabe Yukio、Sakamoto Ayaka、Yasuhara Naoko、Ito Hayato、Nakano Masahiro、Fuse Hiromitsu、Ohta Akira、Noda Takeshi、Matsumura Yasufumi、Nagao Miki、Yamamoto Takuya、Fukuhara Takasuke、Takayama Kazuo
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 4 Pages: 2276-2287
- DOI
  10.1021/acs.molpharmaceut.3c00114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ1155, KAKENHI-PROJECT-22K07099, KAKENHI-PROJECT-21H03795
[Journal Article] Cell response analysis in SARS-CoV-2 infected bronchial organoids2022
- Author(s)
  Sano Emi、Suzuki Tatsuya、Hashimoto Rina、Itoh Yumi、Sakamoto Ayaka、Sakai Yusuke、Saito Akatsuki、Okuzaki Daisuke、Motooka Daisuke、Muramoto Yukiko、Noda Takeshi、Takasaki Tomohiko、Sakuragi Jun-Ichi、Minami Shohei、Kobayashi Takeshi、Yamamoto Takuya、Matsumura Yasufumi、Nagao Miki、Okamoto Toru、Takayama Kazuo
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 516-516
- DOI
  10.1038/s42003-022-03499-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K10429, KAKENHI-PROJECT-22K07086, KAKENHI-PROJECT-21K18298, KAKENHI-PROJECT-21H03795
[Journal Article] Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells.2021
- Author(s)
  Hashimoto, R., Sakamoto, A., Deguchi, S., Yi, R., Sano, E., Hotta, A., Takahashi, K., Yamanaka, S., Takayama, K.
- Journal Title
  
  Molecular Therapy Nucleic Acids
  
  Volume: 26 Pages: 1107-1114
- DOI
  10.1016/j.omtn.2021.10.016
- NAID
  120007167315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02155, KAKENHI-PROJECT-21H03795, KAKENHI-PROJECT-20K20585
[Journal Article] Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells2021
- Author(s)
  Sano Emi、Deguchi Sayaka、Sakamoto Ayaka、Mimura Natsumi、Hirabayashi Ai、Muramoto Yukiko、Noda Takeshi、Yamamoto Takuya、Takayama Kazuo
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 5 Pages: 102428-102428
- DOI
  10.1016/j.isci.2021.102428
- NAID
  120007032353
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06401, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PUBLICLY-19H04831, KAKENHI-PROJECT-20H03494, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-21H03795
[Journal Article] Generation of human iPS cell-derived intestinal epithelial cell monolayers by CDX2 transduction2019
- Author(s)
  Takayama K., Negoro R., Yamashita T., Kawai K, Ichikawa M, Mori T, Nakatsu N, Harada K, Ito S, Yamada H, Yamaura Y, Hirata K, Ishida S, Mizuguchi H.
- Journal Title
  
  Cell Mol Gastroenterol Hepatol.
  
  Volume: 8 Pages: 513-526
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H05033
[Journal Article] Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies2019
- Author(s)
  Yamashita T, Takayama K, Hori M, Harada-Shiba M, Mizuguchi H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 3 Pages: 312-318
- DOI
  10.1248/bpb.b18-00544
- NAID
  130007607360
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19657, KAKENHI-PROJECT-17K08681
[Journal Article] FGF signal is not required for hepatoblast differentiation of human iPS cells.2019
- Author(s)
  Toba Y, Kiso A, Nakamae S, Sakurai F, Takayama K, Mizuguchi H.
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Issue: 1 Pages: 3713-3713
- DOI
  10.1038/s41598-019-40305-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19657
[Journal Article] Establishment of SLC15A1/PEPT1-knockout human induced pluripotent stem cell line for intestinal drug absorption studies2019
- Author(s)
  Kawai K., Negoro R., Ichikawa M., Yamashita T., Deguchi S., Harada K., Hirata K., Takayama K., Mizuguchi H.
- Journal Title
  
  Mol Ther Methods Clin Dev.
  
  Volume: 17 Pages: 49-57
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H05033
[Journal Article] Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies2018
- Author(s)
  Negoro Ryosuke、Takayama Kazuo、Kawai Kanae、Harada Kazuo、Sakurai Fuminori、Hirata Kazumasa、Mizuguchi Hiroyuki
- Journal Title
  
  Stem Cell Reports
  
  Volume: 11 Issue: 6 Pages: 1539-1550
- DOI
  10.1016/j.stemcr.2018.10.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05033, KAKENHI-PROJECT-20K20381
[Journal Article] Optimal human iPS cell culture method for efficient hepatic differentiation.2018
- Author(s)
  Matoba N, Yamashita T, Takayama K, Sakurai F, Mizuguchi H.
- Journal Title
  
  Differentiation
  
  Volume: 104 Pages: 13-21
- DOI
  10.1016/j.diff.2018.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19657
[Journal Article] Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells.2018
- Author(s)
  Yamashita T, Takayama K, Sakurai F, Mizuguchi H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 496 Issue: 4 Pages: 1269-1275
- DOI
  10.1016/j.bbrc.2018.01.186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19657
[Journal Article] Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.2018
- Author(s)
  Takayama K, Hagihara Y, Toba Y, Sekiguchi K, Sakurai F, Mizuguchi H.
- Journal Title
  
  Biomaterials.
  
  Volume: 161 Pages: 24-32
- DOI
  10.1016/j.biomaterials.2018.01.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19657
[Journal Article] Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells.2018
- Author(s)
  Nakamae S, Toba Y, Takayama K, Sakurai F, Mizuguchi H.
- Journal Title
  
  Stem Cells Dev.
  
  Volume: 未定 Issue: 6 Pages: 405-414
- DOI
  10.1089/scd.2017.0251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19657
[Journal Article] Prediction of drug-induced liver injury by using human pluripotent stem cell-derived hepatocyte-like cells.2017
- Author(s)
  Takayama K., Mizuguchi H.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 32 Issue: 1 Pages: 12-20
- DOI
  10.1016/j.dmpk.2016.10.408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06365
[Journal Article] Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells2017
- Author(s)
  Imagawa K. 1, Takayama K. 1, Isoyama S., Tanikawa K., Shinkai M., Harada K., Tachibana M., Sakurai F., Noguchi E., Hirata K., Kage M., Kawabata K., Sumazaki R., Mizuguchi H.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 41806-41806
- DOI
  10.1038/srep41806
- NAID
  120007135051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06365, KAKENHI-PROJECT-15K19600
[Journal Article] Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN systems2017
- Author(s)
  Takayama K., Igai K., Hagihara Y., Hashimoto R., Hanawa M., Sakuma T., Tachibana M., Sakurai F., Yamamoto T., Mizuguchi H
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 45 Issue: 9 Pages: 5198-5207
- DOI
  10.1093/nar/gkx130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06365, KAKENHI-PROJECT-16K18478
[Journal Article] Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation From Human Induced Pluripotent Stem Cells2017
- Author(s)
  Hanawa M., Takayama K., Sakurai F., Tachibana M., Mizuguchi H.
- Journal Title
  
  Stem Cells Reviews & Reports
  
  Volume: 13 Issue: 4 Pages: 542-551
- DOI
  10.1007/s12015-016-9709-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06365
[Journal Article] Isolation and Expansion of Human Pluripotent Stem Cell-derived Hepatic Progenitor Cells by Growth Factor Defined Serum-free Culture Conditions2017
- Author(s)
  Fukuda T., Takayama K., Hirata M., Liu Y., Yanagihara K., Suga M., Mizuguchi H., Furue M.
- Journal Title
  
  Experimental Cell Research
  
  Volume: 352 Issue: 2 Pages: 333-345
- DOI
  10.1016/j.yexcr.2017.02.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06365, KAKENHI-PROJECT-16H05535, KAKENHI-PROJECT-15K11035
[Journal Article] Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling.2017
- Author(s)
  Mitani S, Takayama K, Nagamoto Y, Imagawa K, Sakurai F, Tachibana M, Sumazaki R, Mizuguchi H.
- Journal Title
  
  Mol Ther.
  
  Volume: 25 Issue: 6 Pages: 1420-1433
- DOI
  10.1016/j.ymthe.2017.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19657, KAKENHI-PROJECT-17J04585
[Journal Article] Human iPS Cell-Derived Hepatocyte-Like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling2017
- Author(s)
  Mitani S., Takayama K., Nagamoto Y., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Mizuguchi H.
- Journal Title
  
  Molecular Therapy
  
  Volume: 25 Pages: 1420-1433
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H06365
[Journal Article] Hepatic Maturation of Human iPS Cell-Derived Hepatocyte-Like Cells by ATF5, c/EBPα, and PROX1 Transduction2016
- Author(s)
  Nakamori D., Takayama K., Nagamoto Y., Mitani S., Sakurai F., Tachibana M., Mizuguchi H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 469 Issue: 3 Pages: 424-429
- DOI
  10.1016/j.bbrc.2015.12.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06365, KAKENHI-PROJECT-13J02987
[Journal Article] Prediction of differentiation tendency toward hepatocytes from gene expression in undifferentiated human pluripotent stem cells.2016
- Author(s)
  Yanagihara K., Liu Y., Kanie K., Takayama K., Okamura M., Hirata M., Fukuda T., Suga M., Nikawa H., Mizuguchi H., Kato R., Furue M.
- Journal Title
  
  Stem Cells and Development
  
  Volume: 25 Pages: 1884-1897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06365
[Journal Article] Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells2016
- Author(s)
  Takayama K., Mitani S., Nagamoto Y., Sakurai F., Tachibana M., Taniguchi Y., Sekiguchi K., Mizuguchi H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 474 Issue: 1 Pages: 91-96
- DOI
  10.1016/j.bbrc.2016.04.075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06365
[Journal Article] Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells2016
- Author(s)
  Negoro R., Takayama K., Nagamoto Y, Sakurai F., Tachibana M, Mizuguchi H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 472 Issue: 4 Pages: 631-636
- DOI
  10.1016/j.bbrc.2016.03.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06365
[Journal Article] Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine2015
- Author(s)
  Ozawa T., Takayama K., Okamoto R., Negoro R., Sakurai F., Tachibana M., Kawabata K., Mizuguchi H.
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 16479-16479
- DOI
  10.1038/srep16479
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06365
[Patent] 呼吸器オルガノイドの製造方法2022
- Inventor(s)
  高山和雄、岡本徹
- Industrial Property Rights Holder
  国立大学法人京都大学、国立大学法人大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-21H03795
[Patent] 呼吸器オルガノイドの製造方法2021
- Inventor(s)
  高山和雄、岡本徹
- Industrial Property Rights Holder
  高山和雄、岡本徹
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-21H03795
[Patent] 小腸上皮様細胞の製造方法2019
- Inventor(s)
  水口裕之、高山和雄、根来亮介、初山麻子、戸坂泰弘、榎竜嗣
- Industrial Property Rights Holder
  阪大、基盤研、タカラバイオ
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-117536
- Filing Date
  2019
- Data Source
  KAKENHI-PUBLICLY-18H05033
[Presentation] 呼吸器オルガノイドを用いたCOVID-19の病態解明と創薬2023
- Author(s)
  高山和雄
- Organizer
  第22回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] オルガノイドと臓器チップを用いた感染症研究のためのモデル開発2023
- Author(s)
  高山和雄
- Organizer
  第22回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] オルガノイドと臓器チップを用いた新型コロナウイルス研究2023
- Author(s)
  高山和雄
- Organizer
  日本遺伝学会第95回大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] オルガノイドや臓器チップを用いた高次in vitro評価系の構築と感染症創薬への応用2023
- Author(s)
  高山和雄
- Organizer
  第97回日本感染症学会総会・学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] 肺オルガノイドと肺チップを用いた感染症研究2023
- Author(s)
  高山和雄
- Organizer
  京都大学第三回医薬系研究交流サロン
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] 臓器チップ技術を用いた機能性細胞の開発と感染症創薬研究への応用2022
- Author(s)
  高山和雄
- Organizer
  日本組織培養学会第94回大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] 感染症創薬のための仮想人体モデルの開発2022
- Author(s)
  高山和雄
- Organizer
  大阪大学微生物病研究所アドバンストセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] オルガノイドおよび臓器チップを用いた感染症研究の最前線2022
- Author(s)
  高山和雄
- Organizer
  第58回日本肝臓学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] オルガノイド技術や臓器チップ技術を用いた感染症創薬研究2022
- Author(s)
  高山和雄
- Organizer
  iSeminar
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] 呼吸器感染症研究への応用を目指した気道オルガノイドやiPS細胞を用いたin vitro評価系の構築2021
- Author(s)
  高山和雄
- Organizer
  日本動物細胞工学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] 感染症創薬のための呼吸器オルガノイドの開発研究の現状と課題2021
- Author(s)
  高山和雄
- Organizer
  第59回日本人工臓器学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] 呼吸器オルガノイドの開発とCOVID-19創薬への応用2021
- Author(s)
  高山和雄
- Organizer
  第40回サイトプロテクション研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] 気道オルガノイドを用いたCOVID-19における炎症と組織再生の理解と制御2021
- Author(s)
  高山和雄
- Organizer
  第42回日本炎症・再生医学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] 幹細胞と臓器チップを用いた新型コロナウイルス研究2021
- Author(s)
  高山和雄
- Organizer
  日本薬理学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03795
[Presentation] ヒトiPS細胞由来肝細胞および小腸細胞の作製とMPSシステムへの応用2019
- Author(s)
  高山和雄
- Organizer
  日本動物実験代替法学会　第32回大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H05033
[Presentation] Generation of photoactivatable adenovirus vector for spatiotemporally controllable gene therapy2019
- Author(s)
  Kazuo Takayama
- Organizer
  第57回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H05033
[Presentation] Generation of hepatocytes from human ES/iPS cells for medicinal sciences2018
- Author(s)
  Takayama K., Mizuguchi H.
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19657
[Presentation] ヒトES/iPS細胞のゲノム編集と創薬研究への応用2018
- Author(s)
  高山和雄、水口裕之
- Organizer
  第17回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19657
[Presentation] WNTシグナル制御による門脈域及び中心静脈域肝細胞の性質を有するヒトiPS細胞由来肝細胞作製法の開発2017
- Author(s)
  三谷成二、高山和雄、櫻井文教、水口裕之
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K19657
[Presentation] ヒトES/iPS細胞における高効率相同組換え技術の開発2017
- Author(s)
  高山和雄、井貝圭佑、櫻井文教、水口裕之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15H06365
[Presentation] ヒトES/iPS細胞由来肝臓細胞の作製とその創薬研究への利用2017
- Author(s)
  高山和雄
- Organizer
  第6回超異分野学会
- Place of Presentation
  東京
- Year and Date
  2017-03-02
- Invited
- Data Source
  KAKENHI-PROJECT-15H06365
[Presentation] ヒトiPS細胞由来肝細胞の創薬・再生医療への応用2016
- Author(s)
  高山和雄
- Organizer
  K-CONNEXスタートアップシンポジウム
- Place of Presentation
  大阪
- Year and Date
  2016-01-29
- Data Source
  KAKENHI-PROJECT-15H06365
[Presentation] ヒトES/iPS細胞由来肝細胞の三次元培養による機能向上2016
- Author(s)
  高山和雄
- Organizer
  細胞凝集研究会2016
- Place of Presentation
  札幌
- Year and Date
  2016-09-09
- Invited
- Data Source
  KAKENHI-PROJECT-15H06365
[Presentation] Generation of enterocyte-like cells from human iPS cells for drug absorption and metabolism studies in small intestine2015
- Author(s)
  Takayama K., Ozawa T., Sakurai F., Tachibana M., Mizuguchi H.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15H06365
[Presentation] ヒト多能性幹細胞から肝細胞様細胞への高効率分化誘導技術の開発―創薬応用を目指して―2015
- Author(s)
  高山和雄、三村菜摘、萩原康子、立花雅史、櫻井文教、神田勝弘、川端健二、水口裕之
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15H06365

1. 岡田欣晃 (50444500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 山下富義 (30243041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Mizuguchi Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. Imagawa Kazuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Mitani Seiji

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 高橋和利

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 櫻木淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 村本裕紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAYAMA Kazuo 高山 和雄

Takayama Kazuo 高山 和雄

Research Projects

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Co-Researchers

次世代の医療を開拓するヒト小腸組織チップの開発と応用Principal Investigator

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血管バリアに着目する新しい視点での重症感染症の病態・後遺症発症機構の解明と制御

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Microphysiological system-based analysis of inflammatory sprials triggered by abnormal gut motility

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Elucidation of the role of basal stem cells in respiratory diseasesPrincipal Investigator

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Elucidation of mechanism of chronic intestinal inflammation at single-cell level using optogenetic techniquePrincipal Investigator

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Generation of zone-specific hepatocyte for study of liver injury and diseasesPrincipal Investigator

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Generation of CYP3A4-expressing human ES/iPS cell-derived hepatocytes for drug screeningPrincipal Investigator

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[Book] iPS細胞とオルガノイドが切り拓く生命科学の未来2024

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[Book] オルガノイドを用いた呼吸器疾患研究の最前線2023

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[Book] いま知りたい!!「真の生理学性に挑む organ-on-a-chip」実験医学2021年10月号2021

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[Book] ヒトiPS細胞やオルガノイドを用いたSARS-CoV-2研究2021

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[Book] ヒトiPS細胞由来肝細胞の創薬研究・非臨床試験への応用を目指して2015

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[Book] ヒト多能性幹細胞由来肝細胞を用いた次世代型創薬の実現を目指した基盤技術創成2015

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[Journal Article] Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids2023

Author(s)

TAKAYAMA Kazuo 高山和雄

Takayama Kazuo 高山和雄