0 0 小関宏和

… Alternative Names

小関宏和コセキヒロカズ

KOSEKI Hirokazu 小関宏和

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Researcher Number	10766546
Other IDs	https://orcid.org/0000-0002-2939-7182
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2023: 東京慈恵会医科大学, 医学部, 助教 2019 – 2021: 東京慈恵会医科大学, 医学部, 助教 2017 – 2018: 東京女子医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related Except Principal Investigator Basic Section 59010:Rehabilitation science-related / Neurosurgery
Keywords	Principal Investigator 脳動脈瘤 / 炎症 / メタゲノム解析 / 口腔内細菌 / 脳血管疾患 / 精神的ストレス / CFD / SITH-1 / 脳血管障害 / 慢性ストレス … More / くも膜下出血 / 血流ストレス / 慢性炎症 / 慢性的精神ストレス / ストレス … More Except Principal Investigator 近赤外線分光法 / 反復性経頭蓋磁気刺激法 / 高頻度磁気刺激 / 社会復帰 / 脳波 / てんかん / 機能的脳画像 / 反復性経頭蓋磁気刺激 / 失語症 / 脳卒中後遺症 / レアバリアント / 次世代シーケンサー / 感受性遺伝子 / 多発性のう胞腎 / 家族性 / 遺伝子 / 脳動脈瘤 / familial / gene / aneurysm / subarachnoid hemorrhge Less

Elucidation of pathophysiology of intracranial aneurysms based on metagenome analyses of oral bacteriaPrincipal Investigator
- Principal Investigator
  
  小関宏和
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Jikei University School of Medicine
Establishment of repetitive transcranial magnetic stimulation as a further treatment for aphasia and intractable epilepsy
- Principal Investigator
  
  安保雅博
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Jikei University School of Medicine
Evaluation of the relationship between chronic psychological stress and intracranial aneurysm formation / rupturePrincipal Investigator
- Principal Investigator
  
  Koseki Hirokazu
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Jikei University School of Medicine
  Tokyo Women's Medical University
Identification of susceptible genes by genome-wide genetic analysis in patients with familial aneurysms
- Principal Investigator
  
  Kasuya Hidetoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Tokyo Women's Medical University

All 2024 2023 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Hemodynamics in Intracranial Aneurysm Formation2024
- Author(s)
  Hirokazu Koseki
- Journal Title
  
  Hemodynamics of Human Body
  
  Volume: -
- DOI
  10.5772/intechopen.114925
- ISBN
  9780850142648, 9780850142655
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08509
[Journal Article] 総説実験的脳動脈瘤モデルを用いた基礎研究の歴史と最新知見2021
- Author(s)
  小関宏和、村山雄一
- Journal Title
  
  Neurological Surgery 脳神経外科
  
  Volume: 49 Issue: 4 Pages: 888-897
- DOI
  10.11477/mf.1436204467
- ISSN
  0301-2603, 1882-1251
- Year and Date
  2021-07-10
- Data Source
  KAKENHI-PROJECT-18K16599
[Journal Article] Computational fluid dynamic analysis of the initiation of cerebral aneurysms2021
- Author(s)
  Fujimura Soichiro、Tanaka Kazutoshi、Takao Hiroyuki、Okudaira Takuma、Koseki Hirokazu、Hasebe Akiko、Suzuki Takashi、Uchiyama Yuya、Ishibashi Toshihiro、Otani Katharina、Karagiozov Kostadin、Fukudome Koji、Hayakawa Motoharu、Yamamoto Makoto、Murayama Yuichi
- Journal Title
  
  Journal of Neurosurgery
  
  Volume: Dec 21. Issue: 2 Pages: 1-9
- DOI
  10.3171/2021.8.jns211452
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16599, KAKENHI-PROJECT-20J30001
[Journal Article] Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats2020
- Author(s)
  Abekura Yu、Ono Isao、Kawashima Akitsugu、Takizawa Katsumi、Koseki Hirokazu、Miyata Haruka、Shimizu Kampei、Oka Mieko、Kushamae Mika、Miyamoto Susumu、Kataoka Hiroharu、Ishii Akira、Aoki Tomohiro
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 17 Issue: 1 Pages: 129-129
- DOI
  10.1186/s12974-020-01802-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09367, KAKENHI-PROJECT-18K16599
[Journal Article] Hemodynamic Force as a Potential Regulator of Inflammation-Mediated Focal Growth of Saccular Aneurysms in a Rat Model2020
- Author(s)
  Shimizu Kampei、Kataoka Hiroharu、Imai Hirohiko、Yamamoto Yuto、Yamada Tomohiro、Miyata Haruka、Koseki Hirokazu、Abekura Yu、Oka Mieko、Kushamae Mika、Ono Isao、Miyamoto Susumu、Nakamura Masanori、Aoki Tomohiro
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 80 Issue: 1 Pages: 79-88
- DOI
  10.1093/jnen/nlaa131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09367, KAKENHI-PROJECT-18K16599, KAKENHI-PROJECT-20K09381
[Journal Article] Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis2020
- Author(s)
  Oka M, Shimo S, Ohno N, Imai H, Abekura Y, Koseki H, Miyata H, Shimizu K, Kushamae M, Ono I, Nozaki K, Kawashima A, Kawamata T, Aoki T
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 8330-8330
- DOI
  10.1038/s41598-020-65361-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09479, KAKENHI-PROJECT-18K16599
[Journal Article] Involvement of neutrophils in machineries underlying the rupture of intracranial aneurysms2020
- Author(s)
  Kushamae M, Miyata H, Shirai M, Shimizu K, Oka M, Koseki H, Abekura Y, Ono I, Nozaki K, Mizutani T, Aoki T
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 20004-20004
- DOI
  10.1038/s41598-020-74594-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09479, KAKENHI-PROJECT-18K16599, KAKENHI-PROJECT-20K17929
[Journal Article] Rat Model of Intracranial Aneurysm: Variations, Usefulness, and Limitations of the?Hashimoto Model2019
- Author(s)
  Aoki Tomohiro、Miyata Haruka、Abekura Yu、Koseki Hirokazu、Shimizu Kampei
- Journal Title
  
  Acta Neurochirurgica Supplement
  
  Volume: 127 Pages: 35-41
- DOI
  10.1007/978-3-030-04615-6_6
- ISBN
  9783030046149, 9783030046156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16599
[Journal Article] Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation.2019
- Author(s)
  Koseki H, Miyata H, Shimo S, Ohno N, Mifune K, Shimano K, Yamamoto K, Nozaki K, Kasuya H, Narumiya S, Aoki T.
- Journal Title
  
  Transl Stroke Res.
  
  Volume: Epub ahead of print Issue: 1 Pages: 1-13
- DOI
  10.1007/s12975-019-0690-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17945, KAKENHI-PROJECT-19K09479, KAKENHI-PROJECT-19K22952, KAKENHI-PROJECT-18K16599, KAKENHI-PROJECT-18H03510
[Journal Article] Vasa vasorum formation is associated with rupture of intracranial aneurysms2019
- Author(s)
  Miyata Haruka、Imai Hirohiko、Koseki Hirokazu、Shimizu Kampei、Abekura Yu、Oka Mieko、Kawamata Takakazu、Matsuda Tetsuya、Nozaki Kazuhiko、Narumiya Shuh、Aoki Tomohiro
- Journal Title
  
  Journal of Neurosurgery
  
  Volume: ePub Issue: 3 Pages: 1-11
- DOI
  10.3171/2019.5.jns19405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19914, KAKENHI-PROJECT-18K16599, KAKENHI-PROJECT-16H03167
[Journal Article] Real-time Imaging of an Experimental Intracranial Aneurysm in Rats2019
- Author(s)
  MIYATA Haruka、SHIMIZU Kampei、KOSEKI Hirokazu、ABEKURA Yu、KATAOKA Hiroharu、MIYAMOTO Susumu、NOZAKI Kazuhiko、NARUMIYA Shuh、AOKI Tomohiro
- Journal Title
  
  Neurol. Med. Chir.(Tokyo)
  
  Volume: 59 Issue: 1 Pages: 19-26
- DOI
  10.2176/nmc.oa.2018-0197
- NAID
  130007579712
- ISSN
  0470-8105, 1349-8029
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16599
[Journal Article] RNA sequencing analysis revealed the induction of CCL3 expression in human intracranial aneurysms2019
- Author(s)
  Aoki Tomohiro、Koseki Hirokazu、Miyata Haruka、Itoh Masayoshi、Kawaji Hideya、Takizawa Katsumi、Kawashima Akitsugu、Ujiie Hiroshi、Higa Takashi、Minamimura Kenzo、Kimura Toshikazu、Kasuya Hidetoshi、Nozaki Kazuhiko、Morita Akio、Sano Hirotoshi、Narumiya Shuh
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10387-10387
- DOI
  10.1038/s41598-019-46886-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16599
[Journal Article] 総説炎症を通し脳動脈瘤を理解する2018
- Author(s)
  青木友浩、小関宏和、宮田悠、安部倉友、清水寛平
- Journal Title
  
  Neurological Surgery 脳神経外科
  
  Volume: 46 Issue: 4 Pages: 275-294
- DOI
  10.11477/mf.1436203718
- ISSN
  0301-2603, 1882-1251
- Year and Date
  2018-04-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16599, KAKENHI-PROJECT-16K10719
[Journal Article] Macrophage Imaging of Cerebral Aneurysms with Ferumoxytol: an Exploratory Study in an Animal Model and in Patients2017
- Author(s)
  Aoki Tomohiro、Saito Makoto、Koseki Hirokazu、Tsuji Keiichi、Tsuji Atsushi、Murata Kiyoshi、Kasuya Hidetoshi、Morita Akio、Narumiya Shuh、Nozaki Kazuhiko
- Journal Title
  
  Journal of Stroke and Cerebrovascular Diseases
  
  Volume: 26 Issue: 10 Pages: 2055-2064
- DOI
  10.1016/j.jstrokecerebrovasdis.2016.10.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-15H04949, KAKENHI-PROJECT-15K10316
[Journal Article] T cell function is dispensable for intracranial aneurysm formation and progression.2017
- Author(s)
  Miyata H., Koseki H., Takizawa K., Kasuya H., Nozaki K., Narumiya S., Aoki T.
- Journal Title
  
  PLoS ONE
  
  Volume: １２ Issue: 4 Pages: e0175421-e0175421
- DOI
  10.1371/journal.pone.0175421
- NAID
  120006309300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10719, KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-15H04949, KAKENHI-PROJECT-15K10316
[Presentation] Computational Fluid Dynamics解析を駆使した動脈瘤発生機序に関する研究2024
- Author(s)
  小関宏和，藤村宗一郎，星野耕平，増田和範, 金林春希，石橋敏寛，高尾洋之，山本誠，村山雄一
- Organizer
  第7回東京慈恵会医科大学・東京理科大学合同シンポジウム
- Data Source
  KAKENHI-PROJECT-23K08509
[Presentation] 脳動脈瘤患者における新規ストレス耐性マーカー"SITH-1"の測定意義2023
- Author(s)
  小関宏和, 府賀道康, 佐野透, 園田章太, 郭樟吾, 小菊実, 小林伸行, 近藤一博, 長山剛太, 加藤直樹, 石橋敏寛, 村山雄一
- Organizer
  第39回日本脳血管内治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K08509
[Presentation] 実験動物モデルに対するCFD解析を用いた脳動脈瘤発生に寄与する血行力学的因子に関する研究2023
- Author(s)
  星野耕平，小関宏和，藤村宗一郎，増田和範, 金林春希，石橋敏寛，高尾洋之，山本誠，村山雄一
- Organizer
  第39回日本脳血管内治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K08509
[Presentation] ストレス耐性マーカー"SITH-1"を用いた脳動脈瘤とストレスの関連性の検証2023
- Author(s)
  小関宏和, 府賀道康, 佐野透, 園田章太, 郭樟吾, 小菊実, 長谷川譲, 小林伸行, 近藤一博, 長山剛太, 菅一成, 加藤直樹, 石橋敏寛, 村山雄一
- Organizer
  日本脳神経外科学会第82回学術総会
- Data Source
  KAKENHI-PROJECT-23K08509
[Presentation] Computational Fluid Dynamics Simulation of Aneurysm Initiation in Experimental Animal Models2021
- Author(s)
  Kasai Tomoki, Koseki Hirokazu, Takao Hiroyuki, Fujimura Soichiro, Kato Naoki, Kan Issei, Uchiyama Yuya, Yamanaka Yuma, Ishibashi Toshihiro, Fukudome Kouji, Murayama Yuichi, Yamamoto Makoto
- Organizer
  The 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16599
[Presentation] 実験的動物モデルにおける動脈瘤発生に対するCFD解析の研究2021
- Author(s)
  葛西智基、小関宏和、高尾洋之、加藤直樹、菅一成、藤村宗一郎、内山祐也、山中悠真、石橋敏寛、福留功二、山本誠、村山雄一
- Organizer
  第37回日本脳血管内治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16599
[Presentation] A high wall shear stress and a mechanical stretch cooperatively regulate intracranial aneurysm formation.2019
- Author(s)
  Koseki H, Kasuya H, Aoki T
- Organizer
  International Subarachnoid Hemorrhage Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16599
[Presentation] Usefulness of animal model for translational research of intracranial aneurysm.2019
- Author(s)
  Koseki Hirokazu and Kasuya Hidetoshi
- Organizer
  6th Tokyo-Shanghai Friendship Neurosurgical Forum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16599
[Presentation] 脳動脈瘤初期形成過程を規定するwall shear stress以外の血行力学的因子ー伸展張力の重要性ー2019
- Author(s)
  小関宏和、宮田悠、野崎和彦、糟谷英俊、村山雄一、青木友浩
- Organizer
  第78回日本脳神経外科学会学術総会
- Data Source
  KAKENHI-PROJECT-18K16599
[Presentation] Utility of animal model and translational research for intracranial aneurysms2018
- Author(s)
  Koseki Hirokazu, Aoki Tomohiro and Kasuya Hidetoshi
- Organizer
  2nd China-Japan Cerebrovascular Disease Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16599
[Presentation] Two distinct mechanical force, high wall shear stress and mechanical stretch, regulate intracranial aneurysm formation2018
- Author(s)
  Koseki Hirokazu, Miyata Haruka and Aoki Tomohiro
- Organizer
  Intracranial Aneurysm Workshop 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16599
[Presentation] S1P1アゴニストによるマクロファージの経内皮的浸潤経路の遮断を介した脳動脈瘤抑制効果2018
- Author(s)
  小関宏和、山本梨絵、宮田悠、糟谷英俊、野崎和彦、青木友浩、成宮周
- Organizer
  第43回日本脳卒中学会学術集会
- Data Source
  KAKENHI-PROJECT-15K10316

1. Kasuya Hidetoshi (50169455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. SASAHARA atsushi (40287371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 広田健吾 (10532690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 藤田俊之 (40718095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 恩田英明 (60185692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 赤川浩之 (60398807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 安保雅博 (00266587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 海渡信義 (30224330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKAHASHI yuichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKAMURA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. AOKI TOMOHIRO

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. IMAI Hirohiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 片岡大治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 志茂聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 野崎和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 成宮周

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 松田哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

0 0 小関 宏和

小関 宏和 コセキ ヒロカズ

KOSEKI Hirokazu 小関 宏和

Research Projects

Research Products

Co-Researchers

Elucidation of pathophysiology of intracranial aneurysms based on metagenome analyses of oral bacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of repetitive transcranial magnetic stimulation as a further treatment for aphasia and intractable epilepsy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of the relationship between chronic psychological stress and intracranial aneurysm formation / rupturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of susceptible genes by genome-wide genetic analysis in patients with familial aneurysms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hemodynamics in Intracranial Aneurysm Formation2024

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] 総説 実験的脳動脈瘤モデルを用いた基礎研究の歴史と最新知見2021

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] Computational fluid dynamic analysis of the initiation of cerebral aneurysms2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hemodynamic Force as a Potential Regulator of Inflammation-Mediated Focal Growth of Saccular Aneurysms in a Rat Model2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of neutrophils in machineries underlying the rupture of intracranial aneurysms2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rat Model of Intracranial Aneurysm: Variations, Usefulness, and Limitations of the?Hashimoto Model2019

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vasa vasorum formation is associated with rupture of intracranial aneurysms2019

0 0 小関宏和

小関宏和コセキヒロカズ

KOSEKI Hirokazu 小関宏和

[Journal Article] 総説実験的脳動脈瘤モデルを用いた基礎研究の歴史と最新知見2021

[Journal Article] 総説炎症を通し脳動脈瘤を理解する2018