Yamamori Morita Tomoko 山盛智子

… Alternative Names

森田智子

Morita Tomoko 森田智子

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Researcher Number	10767750
Other IDs
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 特任研究員 2019 – 2023: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 特任研究員 2017: 北海道大学, 遺伝子病制御研究所, 客員研究員 2016: 北海道大学, 遺伝子病制御研究所, 学術研究員
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Basic Section 50010:Tumor biology-related / 0901:Oncology and related fields / Drug development chemistry
Keywords	Principal Investigator 細胞競合 / 染色体不安定性 / がん / 癌 / 化合物スクリーニング / 環境適応 / スクリーニング / 細胞・組織 / 創薬 / 抗がん物質探索

CTNNB1/PIK3CA二重変異を有する子宮体がんに対するb-catenin阻害剤の検討Principal Investigator
- Principal Investigator
  
  山盛智子 (森田智子)
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  National Cancer Center Japan
染色体不安定性を有する細胞の細胞死回避メカニズムの解明Principal Investigator
- Principal Investigator
  
  山盛智子 (森田智子)
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
Elucidation of the mechanism for determining the winner of cell competition among cancer cells with genetic diversityPrincipal Investigator
- Principal Investigator
  
  Yamamori Morita Tomoko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  National Cancer Center Japan
The development of novel cancer therapeutic/diagnostic drugs targeting cell competition.Principal Investigator
- Principal Investigator
  
  Morita Tomoko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University

All 2023 2022 2021 2020 2017

All Journal Article Presentation

[Journal Article] CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade2023
- Author(s)
  Morita Tomoko Yamamori、Yu Jie、Kashima Yukie、Kamata Ryo、Yamamoto Gaku、Minamide Tatsunori、Mashima Chiaki、Yoshiya Miyuki、Sakae Yuta、Yamauchi Toyohiro、Hakozaki Yumi、Kageyama Shun-ichiro、Nakamura Akito、Lightcap Eric、Tanaka Kosuke、Niu Huifeng、Kannan Karuppiah、Ohashi Akihiro
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1
- DOI
  10.1038/s41467-023-43274-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15520
[Journal Article] Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells2020
- Author(s)
  Fujimoto Yumi、Morita Tomoko Yamamori、Ohashi Akihiro、Haeno Hiroshi、Hakozaki Yumi、Fujii Masanori、Kashima Yukie、Kobayashi Susumu S.、Mukohara Toru
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 21762-21762
- DOI
  10.1038/s41598-020-78646-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07342, KAKENHI-PROJECT-19K23930, KAKENHI-PROJECT-19K23929, KAKENHI-PROJECT-16K21746
[Journal Article] ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition2020
- Author(s)
  Maruyama Takeshi、Sasaki Ayana、Iijima Sayuri、Ayukawa Shiyu、Goda Nobuhito、Tazuru Keisuke、Hashimoto Norikazu、Hayashi Takashi、Kozawa Kei、Sato Nanami、Ishikawa Susumu、Morita Tomoko、Fujita Yasuyuki
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 7 Pages: 101327-101327
- DOI
  10.1016/j.isci.2020.101327
- NAID
  120006979756
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21411, KAKENHI-PROJECT-18H03994, KAKENHI-PROJECT-18H02675, KAKENHI-PROJECT-19K23929
[Presentation] BRCA2非翻訳領域上に存在する新規生殖細胞系列突然変異のメカニズム解析2023
- Author(s)
  山盛(森田)智子, 箱崎優美, 藤本祐未, 齋藤仁志, 鹿島幸恵, 鎌田諒, 眞島千晶, 清野透, 堀居拓郎, 牛尼美年子, 平岡弓枝, 榮雄大, 仲尾岳大, 原野謙一, 古川孝広, 藤井誠志, 桑田健, 吉田輝彦, 向原徹, 大橋紹宏
- Organizer
  第46回日本分子生物学会年会 2023年12月8日
- Data Source
  KAKENHI-PROJECT-21K15520
[Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2022
- Author(s)
  Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Tatsunori Minamide, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, and Akihiro Ohashi
- Organizer
  AACR annual meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15520
[Presentation] Property analysis of chromosomal instability-adapted cells using multi-omics approaches2021
- Author(s)
  Tomoko Yamamori Morita, Hiroshi Haeno, Hideki Makinoshima, Ayako Suzuki, Susumu S. Kobayashi, Akihiro Ohashi.
- Organizer
  AACR Annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15520
[Presentation] The CDC7 inhibitor-induced replication stress inflames the aneuploid cells to sensitize immune checkpoint inhibitors2021
- Author(s)
  Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Tatsunori Minamide, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, and Akihiro Ohashi.
- Organizer
  The 44th Annual Meeting of the Molecular Biology Society of Japan.
- Data Source
  KAKENHI-PROJECT-21K15520
[Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2021
- Author(s)
  Tomoko Y Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, and Akihiro Ohashi.
- Organizer
  2021 AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15520
[Presentation] CENP-E inhibition generates micronucleus formation activating the cGAS-STING pathway in cancer cells2021
- Author(s)
  Yumi Hakozaki, Yukie Kashima, Tomoko Y. Morita, Kosuke Tanaka, Susumu S. Kobayashi, Akihiro Ohashi.
- Organizer
  AACR Annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15520
[Presentation] Multi-omics approaches to clarify adaptive mechanisms of cancer cells to antiproliferative effects by chromosomal instability2020
- Author(s)
  T. Y. Morita, H. Haeno, H. Makinoshima, A. Suzuki, S. S. Kobayashi, A. Ohashi
- Organizer
  32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, virtual meeting, Oct., (2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23929
[Presentation] 正常細胞の抗腫瘍能を促進する低分子化合物の探索2017
- Author(s)
  森田　智子
- Organizer
  第6回　細胞競合コロキウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-16K20879
[Presentation] 正常細胞の抗腫瘍能を促進する低分子化合物の探索2017
- Author(s)
  森田智子
- Organizer
  第6回　細胞競合コロキウム
- Data Source
  KAKENHI-PROJECT-16K20879

1. 仲尾岳大 (20817358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 鎌田諒 (60801420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 向原徹 (80435718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 藤田恭之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamamori Morita Tomoko 山盛 智子

森田智子

Morita Tomoko 森田 智子

Research Projects

Research Products

Co-Researchers

CTNNB1/PIK3CA二重変異を有する子宮体がんに対するb-catenin阻害剤の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

染色体不安定性を有する細胞の細胞死回避メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism for determining the winner of cell competition among cancer cells with genetic diversityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of novel cancer therapeutic/diagnostic drugs targeting cell competition.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] BRCA2非翻訳領域上に存在する新規生殖細胞系列突然変異のメカニズム解析2023

Author(s)

Organizer

Data Source

[Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2022

Author(s)

Organizer

Data Source

[Presentation] Property analysis of chromosomal instability-adapted cells using multi-omics approaches2021

Author(s)

Organizer

Data Source

[Presentation] The CDC7 inhibitor-induced replication stress inflames the aneuploid cells to sensitize immune checkpoint inhibitors2021

Author(s)

Organizer

Data Source

[Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2021

Author(s)

Organizer

Data Source

[Presentation] CENP-E inhibition generates micronucleus formation activating the cGAS-STING pathway in cancer cells2021

Author(s)

Organizer

Data Source

[Presentation] Multi-omics approaches to clarify adaptive mechanisms of cancer cells to antiproliferative effects by chromosomal instability2020

Author(s)

Organizer

Data Source

[Presentation] 正常細胞の抗腫瘍能を促進する低分子化合物の探索2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Yamamori Morita Tomoko 山盛智子

Morita Tomoko 森田智子