OTANI JYUNJI 大谷淳二

… Alternative Names

Otani Junji 大谷淳二

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Researcher Number	10770878
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2018 – 2023: 神戸大学, 医学研究科, 助教 2016 – 2017: 神戸大学, 医学研究科, 特命助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 49010:Pathological biochemistry-related / Molecular biology
Keywords	Principal Investigator Hippo経路 / YAP / Hippo / 翻訳 / 核小体ストレス / スプライソソーム / N末端則 / ヘテロクロマチン / スプライシング

YAP転写複合体制御機構の解明とその応用Principal Investigator
- Principal Investigator
  
  大谷淳二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kobe University
Posttranscriptional mechanism of Hippo pathway regulationPrincipal Investigator
- Principal Investigator
  
  Otani Junji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kobe University
Elucidation of molecular mechanisms of tumor initiation and progression by ribosomal stressesPrincipal Investigator
- Principal Investigator
  
  Otani Junji
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kobe University
Biochemical study of a splicing factor Sde2Principal Investigator
- Principal Investigator
  
  Otani Junji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kobe University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] The <i>TIGD5</i> gene located in 8q24 and frequently amplified in ovarian cancers is a tumor suppressor2022
- Author(s)
  Dai Yuntao、Kawaguchi Tetsuya、Nishio Miki、Otani Junji、Tashiro Hironori、Terai Yoshito、Sasaki Ryohei、Maehama Tomohiko、Suzuki Akira
- Journal Title
  
  Genes to Cells
  
  Volume: 27 Issue: 11 Pages: 633-642
- DOI
  10.1111/gtc.12980
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06430, KAKENHI-PROJECT-20K08108, KAKENHI-PROJECT-20K09621, KAKENHI-PROJECT-20K09643, KAKENHI-PROJECT-21K07594, KAKENHI-PROJECT-21K07642, KAKENHI-PROJECT-20K21576, KAKENHI-PROJECT-20KK0192, KAKENHI-PROJECT-21H04806, KAKENHI-PROJECT-20K07590, KAKENHI-PROJECT-23K24287
[Journal Article] N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ2022
- Author(s)
  Shiraishi Y, Maehama T, Nishio M, Otani J, Hikasa H, Mak TW, Sasaki T, Honma T, Kondoh Y, Osada H, Yoshida M, Fujisawa M, Suzuki A.
- Journal Title
  
  Genes Cells
  
  Volume: 27(10) Issue: 10 Pages: 602-612
- DOI
  10.1111/gtc.12979
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06830, KAKENHI-PROJECT-21H04806, KAKENHI-PROJECT-20K07590, KAKENHI-PROJECT-19H05640
[Journal Article] Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.2022
- Author(s)
  Soyama H, Nishio M, Otani J, Sakuma T, Takao S, Hara S, Masuda T, Mimori K, Toyokuni S, Lydon JP, Nakao K, Nishina H, Fukumoto T, Maehama T, Suzuki A.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 119 Issue: 29 Pages: 1-10
- DOI
  10.1073/pnas.2123134119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04806, KAKENHI-PROJECT-20H03381, KAKENHI-PROJECT-20K07590, KAKENHI-WRAPUP-22H04899
[Journal Article] Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation.2021
- Author(s)
  Nakatani K, Maehama T, Nishio M, Otani J, Yamaguchi K, Fukumoto M, Hikasa H, Hagiwara S, Nishina H, Mak TW, Honma T, Kondoh Y, Osada H, Yoshida M, Suzuki A
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 10 Pages: 4303-4316
- DOI
  10.1111/cas.15079
- NAID
  120007159906
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05503, KAKENHI-PUBLICLY-20H04905, KAKENHI-PROJECT-21H04806, KAKENHI-PROJECT-20H03381, KAKENHI-PROJECT-20K07572, KAKENHI-PROJECT-20K07590, KAKENHI-PROJECT-21K06830, KAKENHI-PROJECT-20K20661, KAKENHI-PLANNED-17H06412
[Journal Article] TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands.2021
- Author(s)
  Miyachi Y, Nishio M, Otani J, Matsumoto S, Kikuchi A, Mak TW, Maehama T, Suzuki A.
- Journal Title
  
  Genes Cells.
  
  Volume: 26(9) Issue: 9 Pages: 714-726
- DOI
  10.1111/gtc.12879
- NAID
  120007148944
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06956, KAKENHI-PUBLICLY-20H04905, KAKENHI-PROJECT-21H04806, KAKENHI-PROJECT-20K07572, KAKENHI-PROJECT-20K07590, KAKENHI-PROJECT-20K20661, KAKENHI-PROJECT-21K19407, KAKENHI-PROJECT-21H04797, KAKENHI-PROJECT-21K07121
[Journal Article] The role of Hippo-YAP signaling in squamous cell carcinomas.2020
- Author(s)
  Tomohiko Maehama , Miki Nishio , Junji Otani , Tak Wah Mak , Akira Suzuki
- Journal Title
  
  Cancer science
  
  Volume: 112 Issue: 1 Pages: 51-60
- DOI
  10.1111/cas.14725
- NAID
  120006950333
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07572, KAKENHI-PROJECT-20K07590, KAKENHI-PROJECT-20K20661, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-18K06132
[Journal Article] Enhanced processivity of Dnmt1 by monoubiquitinated histone H32020
- Author(s)
  Y. Mishima, L. Brueckner, S. Takahashi, T. Kawakami, J. Otani, A. Shinohara, K. Takeshita, R. G. Garvilles, M. Watanabe, N. Sakai, H. Takeshima, C. Nachtegael, A. Nishiyama, M. Nakanishi, K. Arita, K. Nakashima, H. Hojo, I. Suetake
- Journal Title
  
  Genes Cells
  
  Volume: 25 Issue: 1 Pages: 22-32
- DOI
  10.1111/gtc.12732
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05316, KAKENHI-PROJECT-18K06095, KAKENHI-PROJECT-18K14681, KAKENHI-PROJECT-19K17878, KAKENHI-PLANNED-15H05973, KAKENHI-PROJECT-18H02392, KAKENHI-PROJECT-19H04048, KAKENHI-PROJECT-18K15211, KAKENHI-PLANNED-19H05740, KAKENHI-PLANNED-19H05741, KAKENHI-PROJECT-17H01398, KAKENHI-PROJECT-19H00981, KAKENHI-ORGANIZER-19H05739
[Journal Article] Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.2020
- Author(s)
  Miki Nishio , Yoko To , Tomohiko Maehama , Yukari Aono , Junji Otani , Hiroki Hikasa , Akihiro Kitagawa , Koshi Mimori , Takehiko Sasaki , Hiroshi Nishina , Shinya Toyokuni , John P Lydon , Kazuwa Nakao , Tak Wah Mak , Tohru Kiyono , Hidetaka Katabuchi , Hironori Tashiro , Akira Suzuki
- Journal Title
  
  Cancer science
  
  Volume: 111 Issue: 10 Pages: 3576-3578
- DOI
  10.1111/cas.14581
- NAID
  120006892076
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07572, KAKENHI-PROJECT-20K07590, KAKENHI-PROJECT-20K09621, KAKENHI-PROJECT-20K20661, KAKENHI-PUBLICLY-20H05039, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-19H03715, KAKENHI-PROJECT-20H03381, KAKENHI-PROJECT-18K06132, KAKENHI-PROJECT-18K06232, KAKENHI-PROJECT-16H06276
[Journal Article] Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency2019
- Author(s)
  Nishio Miki、Miyachi Yousuke、Otani Junji、Tane Shoji、Omori Hirofumi、Ueda Fumihito、Togashi Hideru、Sasaki Takehiko、Mak Tak Wah、Nakao Kazuwa、Fujita Yasuyuki、Nishina Hiroshi、Maehama Tomohiko、Suzuki Akira
- Journal Title
  
  The FASEB Journal
  
  Volume: 33 Issue: 4 Pages: 5548-5560
- DOI
  10.1096/fj.201802005r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15211, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-16K08626, KAKENHI-PROJECT-18K06132, KAKENHI-PROJECT-18K06219, KAKENHI-ORGANIZER-15H05897, KAKENHI-PUBLICLY-18H04764, KAKENHI-PUBLICLY-19H04965, KAKENHI-PROJECT-17H01566, KAKENHI-PROJECT-18H03994, KAKENHI-PROJECT-17H03980, KAKENHI-PROJECT-19K22508, KAKENHI-PLANNED-15H05899
[Journal Article] RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails.2017
- Author(s)
  Mishima Y, Brueckner L, Takahashi S, Kawakami T, Arita K, Oka S, Otani J, Hojo H, Shirakawa M, Shinohara A, Watanabe M, Suetake I
- Journal Title
  
  FEBS J.
  
  Volume: 284 Issue: 20 Pages: 3455-3469
- DOI
  10.1111/febs.14205
- NAID
  120006537075
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14418, KAKENHI-PLANNED-15H05973, KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-16H04742, KAKENHI-PROJECT-15K05565, KAKENHI-PROJECT-16K18490
[Presentation] Role of MOB1 in murine mature adipocytes in vivo2024
- Author(s)
  Keiko Yamaguchi, Miki Nishio, Katsuya Yuguchi, Junji Otani, Hidekazu Furuzawa, Riko Tokita, Tomohiko Maehama, Akira Suzuki
- Organizer
  The 6th UW-KU International Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06400
[Presentation] PICT1による核小体ストレス制御機構とその破綻病態2023
- Author(s)
  前濱朝彦,西尾美希,湯口勝也,山口慶子,大谷淳二,鈴木聡
- Organizer
  第20回生命科学研究会
- Data Source
  KAKENHI-PROJECT-23K06400
[Presentation] 脂肪細胞におけるMOB1の機能解析2023
- Author(s)
  山口慶子、西尾美希、湯口勝也、大谷淳二、古澤秀和、鴇田瑠香、前濱朝彦、鈴木聡
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K06400
[Presentation] PICT1安定化因子による核小体ストレスと個体応答2023
- Author(s)
  湯口勝也,西尾美希,大谷淳二,山口慶子,前濱朝彦,鈴木聡
- Organizer
  第69回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-23K06400
[Presentation] 転写後調節によるHippo-YAP経路の制御2023
- Author(s)
  大谷淳二,西尾美希,前濱朝彦,鴇田瑠香,古澤秀和,鈴木聡
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06400
[Presentation] PICT1安定化因子による核小体ストレスと個体応答2023
- Author(s)
  湯口勝也,西尾美希,大谷淳二,山口慶子,鈴木聡,前濱朝彦
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K06400
[Presentation] 脂肪細胞におけるMOB1の機能解析2023
- Author(s)
  山口慶子、西尾美希、湯口勝也、大谷淳二、前濱朝彦、鈴木聡
- Organizer
  第69回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-23K06400
[Presentation] PICT1による核小体ストレス制御機構とその破綻病態2023
- Author(s)
  前濱朝彦,西尾美希,湯口勝也,山口慶子,大谷淳二,鈴木聡
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06400
[Presentation] がん抑制因子PTENの制御に関わる新たな因子の同定2022
- Author(s)
  前濱朝彦、池末信太郎、西尾美希、大谷淳二、鈴木聡
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07590
[Presentation] がん抑制因子PTENの制御に関わる新たな因子の同定2022
- Author(s)
  池末信太郎、前濱朝彦、西尾美希、大谷淳二、鈴木聡
- Organizer
  第19回生命科学研究会
- Data Source
  KAKENHI-PROJECT-20K07590
[Presentation] Hippo-TAZ signaling is the master regulator for the onset of triple-negative basal-like breast cancers2022
- Author(s)
  Junji Otani, Hirotoshi Soyama, Miki Nishio, Tomohiko Maehama, Akira Suzuki
- Organizer
  FASEB 2023 The Protein Phosphatases Conference
- Data Source
  KAKENHI-PROJECT-20K07590
[Presentation] A natural product Alantolactone is a potent YAP1/TAZ inhibitor via ROS production2020
- Author(s)
  Junji Otani, Keisuke Nakatani, Tomohiko Maehama, Miki Nishio, Akira Suzuki
- Organizer
  The 14th International Conference on Protein Phosphatase
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07590
[Presentation] 核小体オルガネラゾーンにおけるストレス制御と癌の発症進展機構2020
- Author(s)
  前濱朝彦、大谷淳二、鈴木聡
- Organizer
  オルガネラゾーン領域会議
- Data Source
  KAKENHI-PROJECT-20K07590
[Presentation] YAP1/TAZ阻害による抗腫瘍作用を示す天然物の同定2020
- Author(s)
  西尾美希、中谷圭佑、大谷淳二、日笠弘基、前濱朝彦、鈴木聡
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07590
[Presentation] Hippo-YAP/TAZ経路による肥満の制御2020
- Author(s)
  山口慶子、西尾美希、大谷淳二、前濱朝彦、鈴木聡
- Organizer
  オルガネラゾーン若手の会
- Data Source
  KAKENHI-PROJECT-20K07590
[Presentation] Hippoシグナル経路による細胞増殖変化と細胞間コミュニケーション2018
- Author(s)
  西尾美希、宮地洋佑、大森裕文、上田史仁、大谷淳二、前濱朝彦、藤田恭之、仁科博史、鈴木聡
- Organizer
  第6回新学術領域「細胞競合」班会議　2018年6月14-15日　神戸
- Data Source
  KAKENHI-PROJECT-18K15211
[Presentation] Sde2のユビキチン様蛋白質ドメインの切断は機能に必要である2016
- Author(s)
  大谷淳二　石川冬木
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K18490

1. 西尾美希 (10467897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. 末武勲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 川上徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 近藤恭光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 吉田稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 佐々木良平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 松本真司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 日笠弘基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 鈴木聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OTANI JYUNJI 大谷 淳二

Otani Junji 大谷 淳二

Research Projects

Research Products

Co-Researchers

YAP転写複合体制御機構の解明とその応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Posttranscriptional mechanism of Hippo pathway regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanisms of tumor initiation and progression by ribosomal stressesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biochemical study of a splicing factor Sde2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The <i>TIGD5</i> gene located in 8q24 and frequently amplified in ovarian cancers is a tumor suppressor2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation.2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands.2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] The role of Hippo-YAP signaling in squamous cell carcinomas.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Enhanced processivity of Dnmt1 by monoubiquitinated histone H32020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails.2017

Author(s)

OTANI JYUNJI 大谷淳二

Otani Junji 大谷淳二