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obata atsushi  小畑 淳史

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OBATA ATSUSHI  小畑 淳史

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Researcher Number 10771298
Other IDs
Affiliation (Current) 2023: 川崎医科大学, 医学部, 特任研究員
Affiliation (based on the past Project Information) *help 2020 – 2021: 川崎医科大学, 医学部, 特任研究員
2016 – 2020: 川崎医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 54040:Metabolism and endocrinology-related / Metabolomics
Except Principal Investigator
Basic Section 54040:Metabolism and endocrinology-related / Metabolomics
Keywords
Principal Investigator
PDK1 / 血管内皮 / 膵β細胞 / 虚血 / インスリン抵抗性 / 骨格筋 / 糖代謝 / Vascularity / vascularity / 血流 … More / 小胞体ストレス / β細胞 / SGLT2阻害薬 / 健康寿命 / 寿命延長 / 間接的カロリー制限 / 加齢現象 … More
Except Principal Investigator
膵β細胞 / ブドウ糖毒性 / インスリン転写因子 / インスリン遺伝子 / 転写因子 / 膵β細胞糖毒性 / 新規糖尿病治療薬 / インクレチン受容体 / SGLT2阻害薬 / 糖尿病 / 膵β細胞ブドウ糖毒性 / 血管石灰化 / IL-17A / 動脈硬化 / 大動脈 / 血管平滑筋細胞 / 炎症性サイトカイン / IL-17 / IL-1 / 骨芽細胞 / 骨細胞様細胞 / アンジオテンシンII Less
  • Research Projects

    (6 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (10 People)
  •  The effect of indirect energy restriction due to glucose excretion by SGLT2 inhibitor on life longevity and agingPrincipal Investigator

    • Principal Investigator
      小畑 淳史
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Kawasaki Medical School
  •  血管石灰化病変の退縮を目指した、骨細胞様細胞に着目した血管石灰化の病態解析

    • Principal Investigator
      藤田 俊一
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Kawasaki Medical School
  •  Comprehensive searching for compounds which can directly enhance MafA and/or PDX-1 expression

    • Principal Investigator
      Kaneto Hideaki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Kawasaki Medical School
  •  The role of vascular endothelial PDK1 on glucose metabolism and beta-cell functionPrincipal Investigator

    • Principal Investigator
      Obata Atsushi
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Kawasaki Medical School
  •  Elucidation of pathophysiological roles of endothelial PDK1 on glucose metabolism and pancreatic beta cellsPrincipal Investigator

    • Principal Investigator
      OBATA ATSUSHI
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      Kawasaki Medical School
  •  Investigation of novel diabetic medicine based on glucose toxicity

    • Principal Investigator
      Hideaki Kaneto
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Kawasaki Medical School

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Switching From Daily DPP-4 Inhibitor to Once-Weekly GLP-1 Receptor Activator Dulaglutide Significantly Ameliorates Glycemic Control in Subjects With Poorly Controlled Type 2 Diabetes Mellitus: A Retrospective Observational Study.2022

    • Author(s)
      Sanada J, Kimura T, Shimoda M, Tomita A, Fushimi Y, Kinoshita T, Obata A, Okauchi S, Hirukawa H, Kohara K, Tatsumi F, Nakanishi S, Mune T, Kaku K, Kaneto H.
    • Journal Title

      Front Endocrinol (Lausanne)

      Volume: 6

    • DOI

      10.3389/fendo.2021.714447

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08540
  • [Journal Article] Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus. Biomedicines.2022

    • Author(s)
      Kaneto H, Kimura T, Shimoda M, Obata A, Sanada J, Fushimi Y, Matsuoka TA, Kaku K.
    • Journal Title

      Biomedicines.

      Volume: 31 Issue: 4 Pages: 818-831

    • DOI

      10.3390/biomedicines10040818

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08540
  • [Journal Article] Favorable effects of GLP-1 receptor activator against pancreatic beta-cell glucose toxicity and the development of arteriosclerosis: “The earlier, the better” in therapy with incretin-based medicine.2021

    • Author(s)
      Kaneto H, Kimura T, Shimoda M, Obata A, Sanada J, Fushimi Y, Nakanishi S, Mune T, and Kaku K.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 22 Issue: 15 Pages: 7917-7917

    • DOI

      10.3390/ijms22157917

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
  • [Journal Article] Dulaglutide exerts beneficial anti atherosclerotic effects in ApoE knockout mice with diabetes: the earlier, the better2021

    • Author(s)
      Sanada J, Obata A, Obata Y, Fushimi Y, Shimoda M, Kohara K, Nakanishi S, Mune T, Kaku K, Kaneto H.
    • Journal Title

      Sci Rep .

      Volume: 11 Issue: 1 Pages: 1425-1425

    • DOI

      10.1038/s41598-020-80894-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18016, KAKENHI-PROJECT-21K08540
  • [Journal Article] Early combination therapy of empagliflozin and linagliptin exerts beneficial effects on pancreatic β cells in diabetic db/db mice.2021

    • Author(s)
      Fushimi Y, Obata A, Sanada J, Nogami Y, Ikeda T, Yamasaki Y, Obata Y, Shimoda M, Nakanishi S, Mune T, Kaku K, Kaneto H.
    • Journal Title

      Sci Rep.

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-94896-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08540
  • [Journal Article] Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class2021

    • Author(s)
      Kaneto H, Obata A, Kimura T, Shimoda M, Kinoshita T, Matsuoka TA, Kaku K.
    • Journal Title

      Int J Mol Sci .

      Volume: 22 Issue: 6 Pages: 3062-3062

    • DOI

      10.3390/ijms22063062

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18016, KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
  • [Journal Article] Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History2021

    • Author(s)
      Kaneto H, Kimura T, Obata A, Shimoda M, Kaku K.
    • Journal Title

      Int J Mol Sci .

      Volume: 22 Issue: 5 Pages: 2596-2596

    • DOI

      10.3390/ijms22052596

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18016, KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
  • [Journal Article] Notable underlying mechanism for pancreatic beta-cell dysfunction and atherosclerosis: Pleiotropic role of incretin and insulin signaling in various situation.2020

    • Author(s)
      Kaneto H, Obata A, Kimura T, Shimoda M, Sanada J, Fushimi Y, Katakami N, Matsuoka T, and Kaku K.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 21 Issue: 24 Pages: 1-13

    • DOI

      10.3390/ijms21249444

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-19K18016
  • [Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019

    • Author(s)
      Obata A, Kimura T, Obata Y, Shimoda M, Kinoshita T, Kohara K, Okauchi S, Hirukawa H, Kamei S, Nakanishi S, Mune T, Kaku K, and Kaneto H.
    • Journal Title

      Diabetologia

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09770
  • [Journal Article] Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice2019

    • Author(s)
      Obata A, Kimura T, Obata Y, Shimoda M, Kinoshita T, Kohara K, Okauchi S, Hirukawa H, Kamei S, Nakanishi S, Mune T, Kaku K, Kaneto H
    • Journal Title

      Diabetologia

      Volume: 62 Issue: 7 Pages: 1225-1236

    • DOI

      10.1007/s00125-019-4878-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18016
  • [Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019

    • Author(s)
      Obata A, Kimura T, Obata Y, Shimoda M, Kinoshita T, Kohara K, Okauchi S, Hirukawa H, Kamei S, Nakanishi S, Mune T, Kaku K, and Kaneto H.
    • Journal Title

      Diabetologia

      Volume: 62 Issue: 12 Pages: 1225-1236

    • DOI

      10.1007/s00125-019-04982-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08990
  • [Journal Article] Durability of protective effect of dulaglutide on pancreatic beta-cells in diabetic mice: GLP-1 receptor expression is not reduced at all even after long-term exposure to dulaglutide.2018

    • Author(s)
      Kimura T, Obata A, Shimoda M, Hirukawa H, Kanda-Kimura Y, Nogami Y, Kohara K, Nakanishi S, Mune T, Kaku K, and Kaneto H.
    • Journal Title

      Diabetes Metab.

      Volume: 44 Pages: 250-260

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09770
  • [Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic beta-cells in obese diabetic db/db mice: The earlier and longer, the better.2018

    • Author(s)
      Kimura T, Obata A, Shimoda M, Okauchi S, Kanda-Kimura Y, Nogami Y, Hirukawa H, Kohara K, Nakanishi S, Mune T, Kaku K, and Kaneto H.
    • Journal Title

      Diabetes Obes. Metab.

      Volume: 20 Pages: 2442-2457

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09770
  • [Journal Article] Increase of cortisol / ACTH ratio after chronic treatment with liraglutide in subjects with type 2 diabetes mellitus.2017

    • Author(s)
      Kamei S, Kaneto H, Tanabe A, Kinoshita T, Obata A, Kimura T, Hirukawa H, Tatsumi F, Shimoda M, Kohara K, Anno T, Nakanishi S, Mune T, and Kaku K.
    • Journal Title

      Diabetes Metab

      Volume: 43 Issue: 4 Pages: 398-399

    • DOI

      10.1016/j.diabet.2017.01.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09770
  • [Journal Article] Beneficial effects of SGLT2 inhibitors for preservation of pancreatic beta-cell function and reduction of insulin resistance.2017

    • Author(s)
      Kaneto H, Obata A, Kimura T, Shimoda M, Okauchi S, Shimo N, Matsuoka T, and Kaku K.
    • Journal Title

      J. Diabetes

      Volume: 9 Issue: 3 Pages: 219-225

    • DOI

      10.1111/1753-0407.12494

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09770
  • [Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice.2016

    • Author(s)
      Okauchi S, Shimoda M, Obata A, Kimura T, Hirukawa H, Kohara K, Mune T, Kaku K, Kaneto H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 470 Issue: 3 Pages: 772-782

    • DOI

      10.1016/j.bbrc.2015.10.109

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461350, KAKENHI-PROJECT-16K09770
  • [Journal Article] Clinical effects of liraglutide are possibly influenced by hypertriglyceridemia and remaining pancreatic beta-cell function in subjects with type 2 diabetes mellitus.2016

    • Author(s)
      Tanabe A, Kaneto H, Kamei S, Hirukawa H, Shimoda M, Kimura T, Obata A, Okauchi S, Tatsumi F, Kohara K, Mune T, and Kaku K.
    • Journal Title

      J. Diabetes Complications

      Volume: 30 Pages: 1201-1203

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09770
  • [Journal Article] Promising diabetes therapy based on the molecular mechanism for glucose toxicity: Usefulness of SGLT2 inhibitors as well as incretin-related drugs.2016

    • Author(s)
      Kaneto H, Obata A, Shimoda M, Kimura T, Hirukawa H, Okauchi S, Matsuoka T, and Kaku K.
    • Journal Title

      Curr. Med. Chem.

      Volume: 23 Pages: 3044-3051

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09770
  • [Presentation] 血管内皮PDK1は膵β細胞機能維持に重要な役割を果たす2018

    • Author(s)
      小畑 淳史、木村 友彦、蛭川 英典、小原 健司、木下 智恵、田邊 昭仁、下田 将司、亀井 信二、中西 修平、宗 友厚、加来 浩平、金藤 秀明
    • Organizer
      第61回日本糖尿病学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K16157
  • [Presentation] 血管内皮PDK1は膵β細胞機能維持に重要な役割を果たす2017

    • Author(s)
      小畑 淳史
    • Organizer
      日本糖尿病学会中国四国地方会第55回総会
    • Data Source
      KAKENHI-PROJECT-17K16157
  • [Presentation] 血管内皮PDK1は膵β細胞機能維持に重要な役割を果たす2017

    • Author(s)
      小畑 淳史
    • Organizer
      第60回日本糖尿病学会学年次術集会
    • Data Source
      KAKENHI-PROJECT-17K16157
  • [Presentation] 血管内皮PDK1は膵β細胞の機能および量の維持に極めて重要な役割を果たす2017

    • Author(s)
      小畑 淳史
    • Organizer
      第29回分子糖尿病シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K16157
  • [Presentation] Vascular Endothelial PDK1 Plays Pivotal Roles for Maintenance of Pancreatic β Cell Function2017

    • Author(s)
      Atsushi Obata
    • Organizer
      American Diabetes Association, 77th Scientific Sessions
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16157
  • 1.  Hideaki Kaneto (80448034)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 11 results
  • 2.  下田 将司 (60388957)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 3.  木村 友彦 (50454830)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 4.  藤田 俊一 (30722607)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  向井 知之 (00454421)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  内田 治仁 (00550857)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  守田 吉孝 (50346441)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  HIRUKAWA Hidenori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  OKAUCHI Seizo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  加来 浩平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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