obata atsushi 小畑淳史

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OBATA ATSUSHI 小畑淳史

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Researcher Number	10771298
Other IDs
Affiliation (Current)	2023: 川崎医科大学, 医学部, 特任研究員
Affiliation (based on the past Project Information) *help	2020 – 2021: 川崎医科大学, 医学部, 特任研究員 2016 – 2020: 川崎医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics
Keywords	Principal Investigator PDK1 / 血管内皮 / 膵β細胞 / 虚血 / インスリン抵抗性 / 骨格筋 / 糖代謝 / Vascularity / vascularity / 血流 … More / 小胞体ストレス / β細胞 / SGLT2阻害薬 / 健康寿命 / 寿命延長 / 間接的カロリー制限 / 加齢現象 … More Except Principal Investigator 膵β細胞 / ブドウ糖毒性 / インスリン転写因子 / インスリン遺伝子 / 転写因子 / 膵β細胞糖毒性 / 新規糖尿病治療薬 / インクレチン受容体 / SGLT2阻害薬 / 糖尿病 / 膵β細胞ブドウ糖毒性 / 血管石灰化 / IL-17A / 動脈硬化 / 大動脈 / 血管平滑筋細胞 / 炎症性サイトカイン / IL-17 / IL-1 / 骨芽細胞 / 骨細胞様細胞 / アンジオテンシンII Less

The effect of indirect energy restriction due to glucose excretion by SGLT2 inhibitor on life longevity and agingPrincipal Investigator
- Principal Investigator
  
  小畑淳史
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
血管石灰化病変の退縮を目指した、骨細胞様細胞に着目した血管石灰化の病態解析
- Principal Investigator
  
  藤田俊一
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
Comprehensive searching for compounds which can directly enhance MafA and/or PDX-1 expression
- Principal Investigator
  
  Kaneto Hideaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
The role of vascular endothelial PDK1 on glucose metabolism and beta-cell functionPrincipal Investigator
- Principal Investigator
  
  Obata Atsushi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
Elucidation of pathophysiological roles of endothelial PDK1 on glucose metabolism and pancreatic beta cellsPrincipal Investigator
- Principal Investigator
  
  OBATA ATSUSHI
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
Investigation of novel diabetic medicine based on glucose toxicity
- Principal Investigator
  
  Hideaki Kaneto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Switching From Daily DPP-4 Inhibitor to Once-Weekly GLP-1 Receptor Activator Dulaglutide Significantly Ameliorates Glycemic Control in Subjects With Poorly Controlled Type 2 Diabetes Mellitus: A Retrospective Observational Study.2022
- Author(s)
  Sanada J, Kimura T, Shimoda M, Tomita A, Fushimi Y, Kinoshita T, Obata A, Okauchi S, Hirukawa H, Kohara K, Tatsumi F, Nakanishi S, Mune T, Kaku K, Kaneto H.
- Journal Title
  
  Front Endocrinol (Lausanne)
  
  Volume: 6
- DOI
  10.3389/fendo.2021.714447
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08540
[Journal Article] Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus. Biomedicines.2022
- Author(s)
  Kaneto H, Kimura T, Shimoda M, Obata A, Sanada J, Fushimi Y, Matsuoka TA, Kaku K.
- Journal Title
  
  Biomedicines.
  
  Volume: 31 Issue: 4 Pages: 818-831
- DOI
  10.3390/biomedicines10040818
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08540
[Journal Article] Favorable effects of GLP-1 receptor activator against pancreatic beta-cell glucose toxicity and the development of arteriosclerosis: “The earlier, the better” in therapy with incretin-based medicine.2021
- Author(s)
  Kaneto H, Kimura T, Shimoda M, Obata A, Sanada J, Fushimi Y, Nakanishi S, Mune T, and Kaku K.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 22 Issue: 15 Pages: 7917-7917
- DOI
  10.3390/ijms22157917
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
[Journal Article] Dulaglutide exerts beneficial anti atherosclerotic effects in ApoE knockout mice with diabetes: the earlier, the better2021
- Author(s)
  Sanada J, Obata A, Obata Y, Fushimi Y, Shimoda M, Kohara K, Nakanishi S, Mune T, Kaku K, Kaneto H.
- Journal Title
  
  Sci Rep .
  
  Volume: 11 Issue: 1 Pages: 1425-1425
- DOI
  10.1038/s41598-020-80894-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18016, KAKENHI-PROJECT-21K08540
[Journal Article] Early combination therapy of empagliflozin and linagliptin exerts beneficial effects on pancreatic β cells in diabetic db/db mice.2021
- Author(s)
  Fushimi Y, Obata A, Sanada J, Nogami Y, Ikeda T, Yamasaki Y, Obata Y, Shimoda M, Nakanishi S, Mune T, Kaku K, Kaneto H.
- Journal Title
  
  Sci Rep.
  
  Volume: 11 Issue: 1
- DOI
  10.1038/s41598-021-94896-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08540
[Journal Article] Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class2021
- Author(s)
  Kaneto H, Obata A, Kimura T, Shimoda M, Kinoshita T, Matsuoka TA, Kaku K.
- Journal Title
  
  Int J Mol Sci .
  
  Volume: 22 Issue: 6 Pages: 3062-3062
- DOI
  10.3390/ijms22063062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18016, KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
[Journal Article] Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History2021
- Author(s)
  Kaneto H, Kimura T, Obata A, Shimoda M, Kaku K.
- Journal Title
  
  Int J Mol Sci .
  
  Volume: 22 Issue: 5 Pages: 2596-2596
- DOI
  10.3390/ijms22052596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18016, KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
[Journal Article] Notable underlying mechanism for pancreatic beta-cell dysfunction and atherosclerosis: Pleiotropic role of incretin and insulin signaling in various situation.2020
- Author(s)
  Kaneto H, Obata A, Kimura T, Shimoda M, Sanada J, Fushimi Y, Katakami N, Matsuoka T, and Kaku K.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 24 Pages: 1-13
- DOI
  10.3390/ijms21249444
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-19K18016
[Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019
- Author(s)
  Obata A, Kimura T, Obata Y, Shimoda M, Kinoshita T, Kohara K, Okauchi S, Hirukawa H, Kamei S, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetologia
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice2019
- Author(s)
  Obata A, Kimura T, Obata Y, Shimoda M, Kinoshita T, Kohara K, Okauchi S, Hirukawa H, Kamei S, Nakanishi S, Mune T, Kaku K, Kaneto H
- Journal Title
  
  Diabetologia
  
  Volume: 62 Issue: 7 Pages: 1225-1236
- DOI
  10.1007/s00125-019-4878-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18016
[Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019
- Author(s)
  Obata A, Kimura T, Obata Y, Shimoda M, Kinoshita T, Kohara K, Okauchi S, Hirukawa H, Kamei S, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetologia
  
  Volume: 62 Issue: 12 Pages: 1225-1236
- DOI
  10.1007/s00125-019-04982-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08990
[Journal Article] Durability of protective effect of dulaglutide on pancreatic beta-cells in diabetic mice: GLP-1 receptor expression is not reduced at all even after long-term exposure to dulaglutide.2018
- Author(s)
  Kimura T, Obata A, Shimoda M, Hirukawa H, Kanda-Kimura Y, Nogami Y, Kohara K, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetes Metab.
  
  Volume: 44 Pages: 250-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic beta-cells in obese diabetic db/db mice: The earlier and longer, the better.2018
- Author(s)
  Kimura T, Obata A, Shimoda M, Okauchi S, Kanda-Kimura Y, Nogami Y, Hirukawa H, Kohara K, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetes Obes. Metab.
  
  Volume: 20 Pages: 2442-2457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Increase of cortisol / ACTH ratio after chronic treatment with liraglutide in subjects with type 2 diabetes mellitus.2017
- Author(s)
  Kamei S, Kaneto H, Tanabe A, Kinoshita T, Obata A, Kimura T, Hirukawa H, Tatsumi F, Shimoda M, Kohara K, Anno T, Nakanishi S, Mune T, and Kaku K.
- Journal Title
  
  Diabetes Metab
  
  Volume: 43 Issue: 4 Pages: 398-399
- DOI
  10.1016/j.diabet.2017.01.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Beneficial effects of SGLT2 inhibitors for preservation of pancreatic beta-cell function and reduction of insulin resistance.2017
- Author(s)
  Kaneto H, Obata A, Kimura T, Shimoda M, Okauchi S, Shimo N, Matsuoka T, and Kaku K.
- Journal Title
  
  J. Diabetes
  
  Volume: 9 Issue: 3 Pages: 219-225
- DOI
  10.1111/1753-0407.12494
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice.2016
- Author(s)
  Okauchi S, Shimoda M, Obata A, Kimura T, Hirukawa H, Kohara K, Mune T, Kaku K, Kaneto H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 470 Issue: 3 Pages: 772-782
- DOI
  10.1016/j.bbrc.2015.10.109
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461350, KAKENHI-PROJECT-16K09770
[Journal Article] Clinical effects of liraglutide are possibly influenced by hypertriglyceridemia and remaining pancreatic beta-cell function in subjects with type 2 diabetes mellitus.2016
- Author(s)
  Tanabe A, Kaneto H, Kamei S, Hirukawa H, Shimoda M, Kimura T, Obata A, Okauchi S, Tatsumi F, Kohara K, Mune T, and Kaku K.
- Journal Title
  
  J. Diabetes Complications
  
  Volume: 30 Pages: 1201-1203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Promising diabetes therapy based on the molecular mechanism for glucose toxicity: Usefulness of SGLT2 inhibitors as well as incretin-related drugs.2016
- Author(s)
  Kaneto H, Obata A, Shimoda M, Kimura T, Hirukawa H, Okauchi S, Matsuoka T, and Kaku K.
- Journal Title
  
  Curr. Med. Chem.
  
  Volume: 23 Pages: 3044-3051
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Presentation] 血管内皮PDK1は膵β細胞機能維持に重要な役割を果たす2018
- Author(s)
  小畑　淳史、木村友彦、蛭川英典、小原健司、木下智恵、田邊昭仁、下田将司、亀井信二、中西修平、宗友厚、加来浩平、金藤秀明
- Organizer
  第61回日本糖尿病学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16157
[Presentation] 血管内皮PDK1は膵β細胞機能維持に重要な役割を果たす2017
- Author(s)
  小畑　淳史
- Organizer
  日本糖尿病学会中国四国地方会第55回総会
- Data Source
  KAKENHI-PROJECT-17K16157
[Presentation] 血管内皮PDK1は膵β細胞機能維持に重要な役割を果たす2017
- Author(s)
  小畑　淳史
- Organizer
  第60回日本糖尿病学会学年次術集会
- Data Source
  KAKENHI-PROJECT-17K16157
[Presentation] 血管内皮PDK1は膵β細胞の機能および量の維持に極めて重要な役割を果たす2017
- Author(s)
  小畑　淳史
- Organizer
  第29回分子糖尿病シンポジウム
- Data Source
  KAKENHI-PROJECT-17K16157
[Presentation] Vascular Endothelial PDK1 Plays Pivotal Roles for Maintenance of Pancreatic β Cell Function2017
- Author(s)
  Atsushi Obata
- Organizer
  American Diabetes Association, 77th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16157

1. Hideaki Kaneto (80448034)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. 下田将司 (60388957)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. 木村友彦 (50454830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. 藤田俊一 (30722607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 向井知之 (00454421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 内田治仁 (00550857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 守田吉孝 (50346441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HIRUKAWA Hidenori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. OKAUCHI Seizo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 加来浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

obata atsushi 小畑 淳史

OBATA ATSUSHI 小畑 淳史

Research Projects

Research Products

Co-Researchers

The effect of indirect energy restriction due to glucose excretion by SGLT2 inhibitor on life longevity and agingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血管石灰化病変の退縮を目指した、骨細胞様細胞に着目した血管石灰化の病態解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive searching for compounds which can directly enhance MafA and/or PDX-1 expression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of vascular endothelial PDK1 on glucose metabolism and beta-cell functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathophysiological roles of endothelial PDK1 on glucose metabolism and pancreatic beta cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of novel diabetic medicine based on glucose toxicity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Switching From Daily DPP-4 Inhibitor to Once-Weekly GLP-1 Receptor Activator Dulaglutide Significantly Ameliorates Glycemic Control in Subjects With Poorly Controlled Type 2 Diabetes Mellitus: A Retrospective Observational Study.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus. Biomedicines.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Favorable effects of GLP-1 receptor activator against pancreatic beta-cell glucose toxicity and the development of arteriosclerosis: “The earlier, the better” in therapy with incretin-based medicine.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dulaglutide exerts beneficial anti atherosclerotic effects in ApoE knockout mice with diabetes: the earlier, the better2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Early combination therapy of empagliflozin and linagliptin exerts beneficial effects on pancreatic β cells in diabetic db/db mice.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Notable underlying mechanism for pancreatic beta-cell dysfunction and atherosclerosis: Pleiotropic role of incretin and insulin signaling in various situation.2020

Author(s)

Journal Title

DOI

obata atsushi 小畑淳史

OBATA ATSUSHI 小畑淳史