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KANEKO SYUZO  金子 修三

ORCIDConnect your ORCID iD *help
Researcher Number 10777006
Affiliation (Current) 2022: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Affiliation (based on the past Project Information) *help 2016 – 2022: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Review Section/Research Field
Principal Investigator
Basic Section 62010:Life, health and medical informatics-related / Drug development chemistry
Except Principal Investigator
Basic Section 56010:Neurosurgery-related / Basic Section 56040:Obstetrics and gynecology-related
Keywords
Principal Investigator
エピジェネティクス / ロボティクス / エピジェネティックス / ChIP-seq / ヒストン修飾 / NGS解析 / エピゲノム / ヒストンメチル化 / ゲノム解析 / 癌 … More / バイオマーカー / 分子標的治療薬 / データマイニング / オミックス解析 / ATAC-seq / 機械学習・深層学習 / シングルセル解析 / Hi-C … More
Except Principal Investigator
脳腫瘍 / 上衣腫 / 融合遺伝子 / 転写因子 / 卵巣がん / マルチオミックス解析 / 人工知能 / ChIP-seq / ロボット / エピゲノム Less
  • Research Projects

    (5 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (16 People)
  •  Establishment of autonomous epigenetics analysis for clinical applicationPrincipal Investigator

    • Principal Investigator
      金子 修三
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 62010:Life, health and medical informatics-related
    • Research Institution
      National Cancer Center Japan
  •  RELA融合遺伝子陽性上衣腫に対する新規治療薬の同定

    • Principal Investigator
      小澤 達也
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      National Cancer Center Japan
  •  Next generation epigenomics using artificial intelligence and robotics in ovarian cancer

    • Principal Investigator
      小松 正明
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Construction of a multilayered integrated epigenetics database based on machine learning and deep learningPrincipal Investigator

    • Principal Investigator
      Kaneko Syuzo
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 62010:Life, health and medical informatics-related
    • Research Institution
      National Cancer Center Japan
  •  Development of new anti-cancer drugs targeted for protein demethylasePrincipal Investigator

    • Principal Investigator
      KANEKO SYUZO
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Drug development chemistry
    • Research Institution
      National Cancer Center Japan

All 2021 2020 2019 2018 2017

All Journal Article Presentation Book

  • [Book] AIが切り拓く未来の医療2020

    • Author(s)
      金子修三
    • Total Pages
      5
    • Publisher
      医歯薬出版株式会社
    • Data Source
      KAKENHI-PROJECT-18K11542
  • [Journal Article] C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation2021

    • Author(s)
      Ozawa T、Kaneko S、Szulzewsky F、Qiao Z、Takadera M、Narita Y、Kondo T、Holland EC、Hamamoto R、Ichimura K
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 9 Pages: 36-36

    • DOI

      10.1186/s40478-021-01135-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11542
  • [Journal Article] Genome-Wide Chromatin Analysis of FFPE Tissues Using a Dual-Arm Robot with Clinical Potential2021

    • Author(s)
      Kaneko S、Mitsuyama T、Shiraishi K、Ikawa N、Shozu K、Dozen A、Machino H、Asada K、Komatsu M、Kukita A、Sone K、Yoshida H、Motoi N、Hayami S、Yoneoka Y、Kato T、Kohno T、Natsume T、Keudell GV、Saloura V、Yamaue H、Hamamoto R
    • Journal Title

      Cancers

      Volume: 13 Pages: 2126-2126

    • DOI

      10.3390/cancers13092126

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11542
  • [Journal Article] Identification of the mutation signature of the cancer genome caused by irradiation2021

    • Author(s)
      Kageyama Shun-Ichiro、Du Junyan、Kaneko Syuzo、Hamamoto Ryuji、Yamaguchi Shigeo、Yamashita Riu、Okumura Masayuki、Motegi Atsushi、Hojo Hidehiro、Nakamura Masaki、Tsuchihara Katsuya、Akimoto Tetsuo
    • Journal Title

      Radiotherapy and Oncology

      Volume: 155 Pages: 10-16

    • DOI

      10.1016/j.radonc.2020.10.020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08190, KAKENHI-PROJECT-18K11542
  • [Journal Article] Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection2020

    • Author(s)
      Asada Ken、Bolatkan Amina、Takasawa Ken、Komatsu Masaaki、Kaneko Syuzo、Hamamoto Ryuji
    • Journal Title

      Biomolecules

      Volume: 10 Pages: 1071-1071

    • DOI

      10.3390/biom10071071

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09768, KAKENHI-PROJECT-18K05550
  • [Journal Article] Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer2020

    • Author(s)
      Wada Miku、Kukita Asako、Sone Kenbun、Hamamoto Ryuji、Kaneko Syuzo、Komatsu Masaaki、Takahashi Yu、Inoue Futaba、Kojima Machiko、Honjoh Harunori、Taguchi Ayumi、Kashiyama Tomoko、Miyamoto Yuichiro、Tanikawa Michihiro、Tsuruga Tetsushi、Mori-Uchino Mayuyo、Wada-Hiraike Osamu、Osuga Yutaka、Fujii Tomoyuki
    • Journal Title

      Biomolecules

      Volume: 10 Pages: 1686-1686

    • DOI

      10.3390/biom10121686

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09768, KAKENHI-PROJECT-19K09775, KAKENHI-PROJECT-20H03820, KAKENHI-PROJECT-18K09248, KAKENHI-PROJECT-18K11542
  • [Journal Article] Two Secreted Proteoglycans, Activators of Urothelial Cell-Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression2020

    • Author(s)
      Papadaki V, Asada K, Watson JK, Tamura T, Leung A, Hopkins J, Dellett M, Sasai N, Davaapil H, Nik-Zainal S, Longbottom R, Nakakido M, Torii R, Veerakumarasivam A, Kaneko S, Sagoo MS, Murphy G, Mitani A, Tsumoto K, Kelly JD, Hamamoto R, Ohnuma SI
    • Journal Title

      Cancers

      Volume: 12 Pages: 3362-3362

    • DOI

      10.3390/cancers12113362

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03429, KAKENHI-PROJECT-18K05550, KAKENHI-PROJECT-18K11542
  • [Journal Article] Application of Artificial Intelligence Technology in Oncology: Towards the Establishment of Precision Medicine2020

    • Author(s)
      Hamamoto Ryuji、Suvarna Kruthi、Yamada Masayoshi、Kobayashi Kazuma、Shinkai Norio、Miyake Mototaka、Takahashi Masamichi、Jinnai Shunichi、Shimoyama Ryo、Sakai Akira、Takasawa Ken、Bolatkan Amina、Shozu Kanto、Dozen Ai、Machino Hidenori、Takahashi Satoshi、Asada Ken、Komatsu Masaaki、Sese Jun、Kaneko Syuzo
    • Journal Title

      Cancers

      Volume: 12 Pages: 3532-3532

    • DOI

      10.3390/cancers12123532

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09768, KAKENHI-PROJECT-18K05550, KAKENHI-PROJECT-18K11542
  • [Journal Article] The histone methyltransferase SMYD2 is a novel therapeutic target for the induction of apoptosis in ovarian clear cell carcinoma cells2020

    • Author(s)
      Kojima Machiko、Sone Kenbun、Oda Katsutoshi、Hamamoto Ryuji、Kaneko Syuzo、Oki Shinya、Kukita Asako、Kawata Akira、Honjoh Harunori、Kawata Yoshiko、Kashiyama Tomoko、Sato Masakazu、Taguchi Ayumi、Miyamoto Yuichiro、Tanikawa Michihiro、Tsuruga Tetsushi、Nagasaka Kazunori、Wada?Hiraike Osamu、Osuga Yutaka、Fujii Tomoyuki
    • Journal Title

      Oncol Lett

      Volume: 20 Pages: 1-1

    • DOI

      10.3892/ol.2020.12014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09775, KAKENHI-PROJECT-20H03820, KAKENHI-PROJECT-18K09248, KAKENHI-PROJECT-18K09249, KAKENHI-PROJECT-18K11542
  • [Journal Article] Predicting Deep Learning Based Multi-Omics Parallel Integration Survival Subtypes in Lung Cancer Using Reverse Phase Protein Array Data2020

    • Author(s)
      Takahashi Satoshi、Asada Ken、Takasawa Ken、Shimoyama Ryo、Sakai Akira、Bolatkan Amina、Shinkai Norio、Kobayashi Kazuma、Komatsu Masaaki、Kaneko Syuzo、Sese Jun、Hamamoto Ryuji
    • Journal Title

      Biomolecules

      Volume: 10 Pages: 1460-1460

    • DOI

      10.3390/biom10101460

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17982, KAKENHI-PROJECT-18K05550, KAKENHI-PROJECT-18K11542
  • [Journal Article] The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation.2019

    • Author(s)
      Kojima Machiko、Sone Kenbun、Wada-Hiraike Osamu、Osuga Yutaka、Fujii Tomoyuki
    • Journal Title

      BMC Cancer.

      Volume: 19 Pages: 455-455

    • DOI

      10.1186/s12885-019-5638-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09248, KAKENHI-PROJECT-18K11542, KAKENHI-PROJECT-19K09775, KAKENHI-PROJECT-18K15304, KAKENHI-PUBLICLY-18H04908, KAKENHI-PROJECT-19H03429, KAKENHI-PROJECT-17K11268, KAKENHI-PROJECT-18K16759
  • [Journal Article] Epigenetics Analysis and Integrated Analysis of Multiomics Data, Including Epigenetic Data, Using Artificial Intelligence in the Era of Precision Medicine2019

    • Author(s)
      Hamamoto Ryuji、Komatsu Masaaki、Takasawa Ken、Asada Ken、Kaneko Syuzo
    • Journal Title

      Biomolecules

      Volume: 10 Pages: 62-62

    • DOI

      10.3390/biom10010062

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11542, KAKENHI-PROJECT-19K09768, KAKENHI-PUBLICLY-18H04908, KAKENHI-PROJECT-19H03429
  • [Journal Article] Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma.2019

    • Author(s)
      Kim Sangchul、Bolatkan Amina、Kaneko Syuzo、Ikawa Noriko、Asada Ken、Komatsu Masaaki、Hayami Shinya、Ojima Hidenori、Abe Nobutsugu、Yamaue Hiroki、Hamamoto Ryuji
    • Journal Title

      Biomolecules.

      Volume: 9 Pages: 810-810

    • DOI

      10.3390/biom9120810

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11542, KAKENHI-PUBLICLY-18H04908, KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-19H03429
  • [Journal Article] Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro.2019

    • Author(s)
      Matsuno Yusuke、Atsumi Yuko、Shimizu Atsuhiro、Katayama Kotoe、Fujimori Haruka、Hyodo Mai、Minakawa Yusuke、Nakatsu Yoshimichi、Kaneko Syuzo、Hamamoto Ryuji、Shimamura Teppei、Miyano Satoru、Tsuzuki Teruhisa、Hanaoka Fumio、Yoshioka Ken-ichi
    • Journal Title

      Nat Commun

      Volume: 10 Pages: 1-13

    • DOI

      10.1038/s41467-019-11760-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11542, KAKENHI-PROJECT-19K12215, KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-18H04798, KAKENHI-PUBLICLY-18H04908, KAKENHI-PUBLICLY-19H05210, KAKENHI-PROJECT-19H03429
  • [Journal Article] Histone methyltransferase SMYD2 selective inhibitor LLY-507 in combination with poly ADP ribose polymerase inhibitor has therapeutic potential against high-grade serous ovarian carcinomas2019

    • Author(s)
      Kukita A, Sone K, Oda K, Hamamoto R, Kaneko S, Komatsu M, Wada M, Honjoh H, Kawata Y, Kojima M, Oki S, Sato M, Asada K, Taguchi A, Miyasaka A, Tanikawa M, Nagasaka K, Matsumoto Y, Wada-Hiraike O, Osuga Y, Fujii T
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: in press Pages: 340-346

    • DOI

      10.1016/j.bbrc.2019.03.155

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K09249, KAKENHI-PROJECT-16K21330, KAKENHI-PROJECT-18K09248, KAKENHI-PROJECT-18K11542, KAKENHI-PROJECT-18K15304, KAKENHI-PUBLICLY-18H04908, KAKENHI-PROJECT-19H03429, KAKENHI-PROJECT-17K11268, KAKENHI-PROJECT-18K16757, KAKENHI-PROJECT-18K16759
  • [Journal Article] Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin2018

    • Author(s)
      Lee Chul-Hwan、Yu Jia-Ray、Kumar Sunil、Jin Ying、LeRoy Gary、Bhanu Natarajan、Kaneko Syuzo、Garcia Benjamin A.、Hamilton Andrew D.、Reinberg Danny
    • Journal Title

      Molecular Cell

      Volume: 70

    • DOI

      10.1016/j.molcel.2018.03.020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11542
  • [Presentation] ロボティクス技術を駆使した大規模クリニカルChIP-seq解析の確立2020

    • Author(s)
      金子修三
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K11542
  • [Presentation] Clinical epigenetic analysis with robotics in ovarian cancer.2020

    • Author(s)
      Masaaki Komatsu, Syuzo Kaneko, Ken Asada, Hiroshi Yoshida, Tomoyasu Kato, Ryuji Hamamoto.
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K09768
  • [Presentation] Biological mechanisms of PRELP in ovarian cancer.2020

    • Author(s)
      Kanto Shozu, Masaaki Komatsu, Syuzo Kaneko, Ai Dozen, Hidenori Machino, Akitoshi Nakashima, Shigeru Saito, Ken Asada, Ryuji Hamamoto.
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K09768
  • [Presentation] WNT7A gene was regulated by epigenetic changes and associated with tumorigenesis in ovarian clear cell carcinoma.2020

    • Author(s)
      Kanto Shozu, Masaaki Komatsu, Syuzo Kaneko, Ai Dozen, Hidenori Machino, Akitoshi Nakashima, Shigeru Saito, Tomoyasu Kato, Ryuji Hamamoto.
    • Organizer
      第72回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-19K09768
  • [Presentation] LKB1-MARK3 axis is a novel stress-activated cell cycle checkpoint and dysregulated in high-grade serous ovarian cancer.2020

    • Author(s)
      Hidenori Machino, Syuzo Kaneko, Masaaki Komatsu, Ken Asada, Ai Dozen, Kanto Shozu, Ryuji Hamamoto.
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K09768
  • [Presentation] Integrative multi-omics analysis of multistage carcinogenesis in high-grade serous ovarian cancer.2020

    • Author(s)
      Ai Dozen, Masaaki Komatsu, Hidenori Machino, Kohei Nakamura, Syuzo Kaneko, Kanto Shozu, Ken Asada, Tatsuaki Chiyoda, Kentaro Nakayama, Daisuke Aoki, Satoru Kyo, Ryuji Hamamoto.
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K09768
  • [Presentation] Epigenetic regulation of epithelial cell integrity through extracellular matrix in ovarian cancer2019

    • Author(s)
      Ai Dozen, Masaaki Komatsu, Syuzo Kaneko, Kanto Shozu, Hidenori Machino, Tatsuyuki Chiyoda, Daisuke Aoki, Ryuji Hamamoto
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K09768
  • [Presentation] Epigenetic regulation of the WNT7A gene in ovarian clear cell carcinoma2019

    • Author(s)
      Kanto Shozu, Masaaki Komatsu, Syuzo Kaneko, Ai Dozen, Hidenori Machino, Akitoshi Nakashima, Shigeru Saito, Ryuji Hamamoto
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K09768
  • [Presentation] ChIP-seq解析に基づいた“がん”創薬ターゲット探索を加速させるバイオ実験自動化システムの構築2019

    • Author(s)
      金子 修三
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K11542
  • [Presentation] Tumor suppressive roles of MARK3 in high-grade serous ovarian carcinomas2019

    • Author(s)
      Hidenori Machino, Syuzo Kaneko, Masaaki Komatsu, Ai Dozen, Kanto Shozu, Ryuji Hamamoto
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K09768
  • [Presentation] Toward the application of precision medicine: Multi-omics analysis including clinical ChIP-seq datasets may reveal pivotal regulation of gene expression in cancer2019

    • Author(s)
      金子 修三
    • Organizer
      第2回日本メディカルAI学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K11542
  • [Presentation] Clinical epigenetics using artificial intelligence and robotics in ovarian cancer2019

    • Author(s)
      Masaaki Komatsu, Syuzo Kaneko, Ken Asada, Tomoyasu Kato, Ryuji Hamamoto
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K09768
  • [Presentation] 臨床応用を志向したChIP-seq技術に基づいたがんエピゲノム解析の開発2018

    • Author(s)
      Syuzo Kaneko and Ryuji Hamamoto
    • Organizer
      The 1st Annual Meeting of the Japanese Association for Medical Artificial Intelligence
    • Data Source
      KAKENHI-PROJECT-18K11542
  • [Presentation] Toward precision medicine: developing new toolbox to study the epigenetics applied for cancer treatment2018

    • Author(s)
      Syuzo Kaneko and Ryuji Hamamoto
    • Organizer
      The 77th Annual Meeting of the Japanese Cancer Association
    • Data Source
      KAKENHI-PROJECT-18K11542
  • [Presentation] Precision Medicineを志向した次世代型のChIP-seq法の開発と今後の展開2017

    • Author(s)
      金子 修三、浜本 隆二
    • Organizer
      がん分子標的治療学会
    • Data Source
      KAKENHI-PROJECT-16H07461
  • [Presentation] Toward precision medicine: developing new ChIP-seq techniques applied for cancer treatment2017

    • Author(s)
      Syuzo Kaneko and Ryuji Hamamoto
    • Organizer
      日本癌学会
    • Data Source
      KAKENHI-PROJECT-16H07461
  • 1.  浜本 隆二 (80321800)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 25 results
  • 2.  小澤 達也 (80296483)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  小松 正明 (70750842)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  浅田 健 (70773414)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 5.  HIRAIKE Osamu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 6.  SONE Kembun
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 7.  OJIMA Toshiyasu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  ODA Katsutoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 9.  谷川 道洋
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 10.  山上 裕機
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  田口 歩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 12.  島村 徹平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  宮野 悟
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  宮坂 亞希
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  北條 秀博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  秋元 哲夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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