KANEKO SYUZO 金子修三

… Alternative Names

Researcher Number	10777006
Affiliation (Current)	2021: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Affiliation (based on the past Project Information) *help	2021: 国立研究開発法人国立がん研究センター, その他部局等, その他 2016 – 2019: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Review Section/Research Field	Principal Investigator Basic Section 62010:Life, health and medical informatics-related / Drug development chemistry Except Principal Investigator Basic Section 56010:Neurosurgery-related / Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator エピジェネティクス / ヒストン修飾 / NGS解析 / エピゲノム / ヒストンメチル化 / ゲノム解析 / 癌 / バイオマーカー / 分子標的治療薬 / エピジェネティックス … More Except Principal Investigator 脳腫瘍 / 上衣腫 / 融合遺伝子 / 転写因子 / ChIP-seq / ロボット / エピゲノム / 卵巣がん / 人工知能 Less

臨床応用を志向した自律型エピジェネティクス解析の確立Principal InvestigatorOngoing
- Principal Investigator
  
  金子修三
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  National Cancer Center Japan
RELA融合遺伝子陽性上衣腫に対する新規治療薬の同定Ongoing
- Principal Investigator
  
  小澤達也
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  National Cancer Center Japan
Next generation epigenomics using artificial intelligence and robotics in ovarian cancerOngoing
- Principal Investigator
  
  小松正明
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Institute of Physical and Chemical Research
機械学習・深層学習に基づいた多層化統合エピジェネティクスデータベースの構築Principal InvestigatorOngoing
- Principal Investigator
  
  金子修三
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  National Cancer Center Japan
Development of new anti-cancer drugs targeted for protein demethylasePrincipal Investigator
- Principal Investigator
  
  KANEKO SYUZO
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  National Cancer Center Japan

All 2019 2018 2017

All Journal Article Presentation

[Journal Article] Epigenetics Analysis and Integrated Analysis of Multiomics Data, Including Epigenetic Data, Using Artificial Intelligence in the Era of Precision Medicine2019
- Author(s)
  Hamamoto Ryuji、Komatsu Masaaki、Takasawa Ken、Asada Ken、Kaneko Syuzo
- Journal Title
  
  Biomolecules
  
  Volume: 10 Pages: 62-62
- DOI
  10.3390/biom10010062
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11542, KAKENHI-PROJECT-19K09768, KAKENHI-PUBLICLY-18H04908, KAKENHI-PROJECT-19H03429
[Journal Article] Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma.2019
- Author(s)
  Kim Sangchul、Bolatkan Amina、Kaneko Syuzo、Ikawa Noriko、Asada Ken、Komatsu Masaaki、Hayami Shinya、Ojima Hidenori、Abe Nobutsugu、Yamaue Hiroki、Hamamoto Ryuji
- Journal Title
  
  Biomolecules.
  
  Volume: 9 Pages: 810-810
- DOI
  10.3390/biom9120810
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11542, KAKENHI-PUBLICLY-18H04908, KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-19H03429
[Journal Article] The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation.2019
- Author(s)
  Kojima Machiko、Sone Kenbun、Wada-Hiraike Osamu、Osuga Yutaka、Fujii Tomoyuki
- Journal Title
  
  BMC Cancer.
  
  Volume: 19 Pages: 455-455
- DOI
  10.1186/s12885-019-5638-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09248, KAKENHI-PROJECT-18K11542, KAKENHI-PROJECT-19K09775, KAKENHI-PROJECT-18K15304, KAKENHI-PUBLICLY-18H04908, KAKENHI-PROJECT-19H03429, KAKENHI-PROJECT-17K11268, KAKENHI-PROJECT-18K16759
[Journal Article] Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro.2019
- Author(s)
  Matsuno Yusuke、Atsumi Yuko、Shimizu Atsuhiro、Katayama Kotoe、Fujimori Haruka、Hyodo Mai、Minakawa Yusuke、Nakatsu Yoshimichi、Kaneko Syuzo、Hamamoto Ryuji、Shimamura Teppei、Miyano Satoru、Tsuzuki Teruhisa、Hanaoka Fumio、Yoshioka Ken-ichi
- Journal Title
  
  Nat Commun
  
  Volume: 10 Pages: 1-13
- DOI
  10.1038/s41467-019-11760-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11542, KAKENHI-PROJECT-19K12215, KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-18H04798, KAKENHI-PUBLICLY-18H04908, KAKENHI-PUBLICLY-19H05210, KAKENHI-PROJECT-19H03429
[Journal Article] Histone methyltransferase SMYD2 selective inhibitor LLY-507 in combination with poly ADP ribose polymerase inhibitor has therapeutic potential against high-grade serous ovarian carcinomas2019
- Author(s)
  Kukita A, Sone K, Oda K, Hamamoto R, Kaneko S, Komatsu M, Wada M, Honjoh H, Kawata Y, Kojima M, Oki S, Sato M, Asada K, Taguchi A, Miyasaka A, Tanikawa M, Nagasaka K, Matsumoto Y, Wada-Hiraike O, Osuga Y, Fujii T
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: in press Pages: 340-346
- DOI
  10.1016/j.bbrc.2019.03.155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09249, KAKENHI-PROJECT-16K21330, KAKENHI-PROJECT-18K09248, KAKENHI-PROJECT-18K11542, KAKENHI-PROJECT-18K15304, KAKENHI-PUBLICLY-18H04908, KAKENHI-PROJECT-19H03429, KAKENHI-PROJECT-17K11268, KAKENHI-PROJECT-18K16757, KAKENHI-PROJECT-18K16759
[Journal Article] Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin2018
- Author(s)
  Lee Chul-Hwan、Yu Jia-Ray、Kumar Sunil、Jin Ying、LeRoy Gary、Bhanu Natarajan、Kaneko Syuzo、Garcia Benjamin A.、Hamilton Andrew D.、Reinberg Danny
- Journal Title
  
  Molecular Cell
  
  Volume: 70
- DOI
  10.1016/j.molcel.2018.03.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11542
[Presentation] ChIP-seq解析に基づいた“がん”創薬ターゲット探索を加速させるバイオ実験自動化システムの構築2019
- Author(s)
  金子修三
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K11542
[Presentation] Tumor suppressive roles of MARK3 in high-grade serous ovarian carcinomas2019
- Author(s)
  Hidenori Machino, Syuzo Kaneko, Masaaki Komatsu, Ai Dozen, Kanto Shozu, Ryuji Hamamoto
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09768
[Presentation] Toward the application of precision medicine: Multi-omics analysis including clinical ChIP-seq datasets may reveal pivotal regulation of gene expression in cancer2019
- Author(s)
  金子修三
- Organizer
  第2回日本メディカルAI学会学術集会
- Data Source
  KAKENHI-PROJECT-18K11542
[Presentation] Clinical epigenetics using artificial intelligence and robotics in ovarian cancer2019
- Author(s)
  Masaaki Komatsu, Syuzo Kaneko, Ken Asada, Tomoyasu Kato, Ryuji Hamamoto
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09768
[Presentation] Epigenetic regulation of epithelial cell integrity through extracellular matrix in ovarian cancer2019
- Author(s)
  Ai Dozen, Masaaki Komatsu, Syuzo Kaneko, Kanto Shozu, Hidenori Machino, Tatsuyuki Chiyoda, Daisuke Aoki, Ryuji Hamamoto
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09768
[Presentation] Epigenetic regulation of the WNT7A gene in ovarian clear cell carcinoma2019
- Author(s)
  Kanto Shozu, Masaaki Komatsu, Syuzo Kaneko, Ai Dozen, Hidenori Machino, Akitoshi Nakashima, Shigeru Saito, Ryuji Hamamoto
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09768
[Presentation] 臨床応用を志向したChIP-seq技術に基づいたがんエピゲノム解析の開発2018
- Author(s)
  Syuzo Kaneko and Ryuji Hamamoto
- Organizer
  The 1st Annual Meeting of the Japanese Association for Medical Artificial Intelligence
- Data Source
  KAKENHI-PROJECT-18K11542
[Presentation] Toward precision medicine: developing new toolbox to study the epigenetics applied for cancer treatment2018
- Author(s)
  Syuzo Kaneko and Ryuji Hamamoto
- Organizer
  The 77th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-18K11542
[Presentation] Precision Medicineを志向した次世代型のChIP-seq法の開発と今後の展開2017
- Author(s)
  金子修三、浜本隆二
- Organizer
  がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-16H07461
[Presentation] Toward precision medicine: developing new ChIP-seq techniques applied for cancer treatment2017
- Author(s)
  Syuzo Kaneko and Ryuji Hamamoto
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-16H07461

1. 浜本隆二 (80321800)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. 小澤達也 (80296483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 小松正明 (70750842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 浅田健 (70773414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OJIMA Toshiyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. HIRAIKE Osamu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. SONE Kembun

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. ODA Katsutoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 山上裕機

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 谷川道洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 島村徹平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 宮野悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 宮坂亞希

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 田口歩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KANEKO SYUZO 金子 修三

金子 修三 カネコ シユウゾウ

Research Projects

Research Products

Co-Researchers

臨床応用を志向した自律型エピジェネティクス解析の確立Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RELA融合遺伝子陽性上衣腫に対する新規治療薬の同定Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Next generation epigenomics using artificial intelligence and robotics in ovarian cancerOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

機械学習・深層学習に基づいた多層化統合エピジェネティクスデータベースの構築Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new anti-cancer drugs targeted for protein demethylasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Epigenetics Analysis and Integrated Analysis of Multiomics Data, Including Epigenetic Data, Using Artificial Intelligence in the Era of Precision Medicine2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histone methyltransferase SMYD2 selective inhibitor LLY-507 in combination with poly ADP ribose polymerase inhibitor has therapeutic potential against high-grade serous ovarian carcinomas2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] ChIP-seq解析に基づいた“がん”創薬ターゲット探索を加速させるバイオ実験自動化システムの構築2019

Author(s)

Organizer

Data Source

[Presentation] Tumor suppressive roles of MARK3 in high-grade serous ovarian carcinomas2019

Author(s)

Organizer

Data Source

[Presentation] Toward the application of precision medicine: Multi-omics analysis including clinical ChIP-seq datasets may reveal pivotal regulation of gene expression in cancer2019

Author(s)

Organizer

Data Source

[Presentation] Clinical epigenetics using artificial intelligence and robotics in ovarian cancer2019

Author(s)

Organizer

KANEKO SYUZO 金子修三

金子修三カネコシユウゾウ