YAMASHITA Yasunori 山下恭徳

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Yamashita Yasunori 山下恭徳

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Researcher Number	10782568
Other IDs	https://orcid.org/0000-0002-5791-9005
Affiliation (Current)	2024: 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員
Affiliation (based on the past Project Information) *help	2018 – 2022: 長崎大学, 医歯薬学総合研究科(歯学系), 助教
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related Except Principal Investigator Basic Section 57030:Conservative dentistry-related
Keywords	Principal Investigator 慢性歯周炎 / LPS歯肉溝滴下歯周炎モデル / 補体 / 歯周炎モデル / 歯周炎 / 糖尿病 / 骨代謝 / TRAP染色 / 静止期破骨細胞前駆細胞 / RANKL … More / 破骨細胞前駆細胞 / 破骨細胞 / 咬合性外傷 / 歯周病 … More Except Principal Investigator 全身疾患 / インフラマソーム / 歯周病 Less

糖尿病ラットにおけるLPS歯肉溝滴下歯周炎モデルの作製と補体の発症・進行への関与Principal Investigator
- Principal Investigator
  
  山下恭徳
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Nagasaki University
Effects of NLRP3 inflammasome priming by periodontal diseases on systemic diseases
- Principal Investigator
  
  吉村篤利
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Nagasaki University
Involvement of vascular endothelial cell growth factor in mouse alveolar bone resorption by traumatic occlusionPrincipal Investigator
- Principal Investigator
  
  Yamashita Yasunori
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Nagasaki University

All 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 日本歯内療法学会が全ての歯科医師に贈る最新トレンド　知っておきたい!根管解剖と基礎コレステロール結晶はRAW-D細胞においてNLRP3インフラマソームを介して破骨細胞形成を促進する2021
- Author(s)
  ALAM Mohammad Ibtehaz, RAUDALES Jorge Luis Montenegro, 山下恭徳, 尾崎幸生, 吉村篤利
- Total Pages
  2
- Publisher
  Quintessence
- Data Source
  KAKENHI-PROJECT-20K09942
[Journal Article] NLRP3 inflammasome negatively regulates RANKL-induced osteoclastogenesis of mouse bone marrow macrophages but positively regulates it in the presence of lipopolysaccharides.2022
- Author(s)
  Mohammad Ibtehaz Alam, Megumi Mae, Fatima Farhana, Masayuki Oohira, Yasunori Yamashita, Yukio Ozaki, Eiko Sakai and Atsutoshi Yoshimura
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 23 Issue: 11 Pages: 6096-6096
- DOI
  10.3390/ijms23116096
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09474, KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-22K17043, KAKENHI-PROJECT-22K21019, KAKENHI-PROJECT-18K17072
[Journal Article] The efficacy of a novel zinc-containing desensitizer CAREDYNE Shield for cervical dentin hypersensitivity: a pilot randomized controlled trial2022
- Author(s)
  Matsuura Takashi、Mae Megumi、Ohira Masayuki、Mihara Yumiko、Yamashita Yasunori、Sugimoto Kouji、Yamada Shizuka、Yoshimura Atsutoshi
- Journal Title
  
  BMC Oral Health
  
  Volume: 22 Issue: 1 Pages: 294-294
- DOI
  10.1186/s12903-022-02324-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-22K17043, KAKENHI-PROJECT-18K17072
[Journal Article] Clinical Efficacy and Safety of Antimicrobial Photodynamic Therapy in Residual Periodontal Pockets during the Maintenance Phase2022
- Author(s)
  Yamashita Yasunori、Mae Megumi、Oohira Masayuki、Ozaki Yukio、Ohba Seigo、Asahina Izumi、Yoshimura Atsutoshi
- Journal Title
  
  Pharmaceuticals
  
  Volume: 15 Issue: 8 Pages: 924-924
- DOI
  10.3390/ph15080924
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-22K17043, KAKENHI-PROJECT-22K21019, KAKENHI-PROJECT-18K17072
[Journal Article] Cytotoxic effects of dental calculus particles and freeze‐dried Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum on HSC‐2 oral epithelial cells and THP‐1 macrophages2021
- Author(s)
  Ziauddin S.M.、Alam Mohammad Ibtehaz、Mae Megumi、Oohira Masayuki、Higuchi Kanako、Yamashita Yasunori、Ozaki Yukio、Yoshimura Atsutoshi
- Journal Title
  
  Journal of Periodontology
  
  Volume: － Issue: 6
- DOI
  10.1002/jper.21-0196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-20K18540, KAKENHI-PROJECT-22K17063, KAKENHI-PROJECT-22K20996, KAKENHI-PROJECT-22K21019
[Journal Article] High-mobility group box 1 released by traumatic occlusion accelerates bone resorption in the root furcation area in mice2021
- Author(s)
  Oyama M, Ukai T, Yamashita Y, Yoshimura A.
- Journal Title
  
  J Periodontal Res
  
  Volume: 56 Issue: 1 Pages: 186-194
- DOI
  10.1111/jre.12813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10154, KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-18K17072
[Journal Article] Expression of osteoclastogenic and anti-osteoclastogenic cytokines differs in mouse gingiva injected with lipopolysaccharide, peptidoglycan, or both2021
- Author(s)
  Ozaki Yukio、Kishimoto Takaaki、Yamashita Yasunori、Kaneko Takashi、Higuchi Kanako、Mae Megumi、Oohira Masayuki、Mohammad Alam Ibtehaz、Yanagiguchi Kajiro、Yoshimura Atsutoshi
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 122 Pages: 104990-104990
- DOI
  10.1016/j.archoralbio.2020.104990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09615, KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-18K17072
[Journal Article] The Role of Cytokines Produced via the NLRP3 Inflammasome in Mouse Macrophages Stimulated with Dental Calculus in Osteoclastogenesis2021
- Author(s)
  Mae Megumi、Alam Mohammad Ibtehaz、Yamashita Yasunori、Ozaki Yukio、Higuchi Kanako、Ziauddin S. M.、Montenegro Raudales Jorge Luis、Sakai Eiko、Tsukuba Takayuki、Yoshimura Atsutoshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 22 Pages: 12434-12434
- DOI
  10.3390/ijms222212434
- NAID
  120007186852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10092, KAKENHI-PROJECT-19K10112, KAKENHI-PROJECT-20H03860, KAKENHI-PROJECT-20K09474, KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-21K10047, KAKENHI-PROJECT-18K17072, KAKENHI-PROJECT-20K18540
[Journal Article] The efficacy of the novel zinc-containing desensitizer CAREDYNE Shield on dentin hypersensitivity: a study protocol for a pilot randomized controlled trial2020
- Author(s)
  Matsuura Takashi、Mae Megumi、Ohira Masayuki、Yamashita Yasunori、Nakazono Ayako、Sugimoto Kouji、Yanagiguchi Kajiro、Yamada Shizuka
- Journal Title
  
  Trials
  
  Volume: 21 Issue: 1 Pages: 464-470
- DOI
  10.1186/s13063-020-04426-8
- NAID
  120006988160
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17072
[Journal Article] Initial periodontal treatment affects nucleotide-binding domain leucine-rich repeat-containing protein 3 inflammasome priming in peripheral blood mononuclear cells2020
- Author(s)
  Higuchi Kanako、SM Ziauddin、Yamashita Yasunori、Ozaki Yukio、Yoshimura Atsutoshi
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 110 Pages: 104625-104625
- DOI
  10.1016/j.archoralbio.2019.104625
- NAID
  120006988348
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17072
[Presentation] Osteoclastogenic and anti-osteoclastogenic cytokines induced by dental calculus2022
- Author(s)
  Megumi Mae, Mohammad Ibtehaz Alam, Yasunori Yamashita, Yukio Ozaki, Masayuki Oohira, Atsutoshi Yoshimura
- Organizer
  第108回アメリカ歯周病学会共催日本臨床歯周病学会・日本歯周病学会2022年大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] Effectiveness of antimicrobial photodynamic therapy in the periodontal maintenance phase2022
- Author(s)
  Yasunori Yamashita, Atsutoshi Yoshimura
- Organizer
  第108回アメリカ歯周病学会共催日本臨床歯周病学会・日本歯周病学会2022年大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K17043
[Presentation] Effectiveness of antimicrobial photodynamic therapy in the periodontal maintenance phase2022
- Author(s)
  yasunori yamashita
- Organizer
  第108回アメリカ歯周病学会共催日本臨床歯周病学会・日本歯周病学会2022年大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17072
[Presentation] Effectiveness of antimicrobial photodynamic therapy in the periodontal maintenance phase2022
- Author(s)
  Yasunori Yamashita, Megumi Mae, Masayuki Oohira, Yukio Ozaki, Atsutoshi Yoshimura
- Organizer
  第108回アメリカ歯周病学会共催日本臨床歯周病学会・日本歯周病学会2022年大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] 全身性疾患への影響を考慮した新たな歯周病重症度検査項目の策定学会主導型多施設臨床研究2022
- Author(s)
  松田真司, 菅谷勉, 加藤幸紀, 根本英二, 竹内康雄, 喜田大智, 沼部幸博, 西田哲也, 小方頼昌, 申基哲, 長野孝俊, 両角俊哉, 小松康高, 出分菜々衣, 神谷洋介, 北村正博, 田口洋一郎, 高柴正悟, 湯本浩通, 山下明子, 吉永泰周, 吉村篤利, 河口浩之
- Organizer
  日本歯周病学会秋季学術大会
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] 歯石刺激後のマウスマクロファージにより産生されたサイトカインが破骨細胞分化に与える影響2021
- Author(s)
  前めぐみ, Alam Mohammad, 山下恭徳, 吉村篤利
- Organizer
  第64回日本歯周病学会春季学術大会
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] 新規亜鉛含有知覚過敏抑制剤ケアダインシールドの知覚過敏抑制効果に関する2群間並行ランダム化比較試験2021
- Author(s)
  松裏貴史, 前めぐみ, 大平真之, 三原有美子, 山下恭徳, 杉本浩司, 山田志津香, 吉村篤利
- Organizer
  第155回日本歯科保存学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] 音波振動歯ブラシの臨床的有用性の評価2020
- Author(s)
  山下恭徳，前めぐみ，大平真之，樋口賀奈子，Ziauddin S.M.，尾崎幸生，吉村篤利
- Organizer
  第63回日本歯周病学会春季学術大会
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] コレステロール結晶はRAW-D細胞においてNLRP3インフラマソームを介して破骨細胞形成を促進する2020
- Author(s)
  ALAM Ibtehaz Mohammad、山下恭徳、尾崎幸生、吉村篤利
- Organizer
  第41回日本歯内療法学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] 歯周基本治療後に残存した歯周ポケットへの光殺菌治療の安全性および有効性の検討2020
- Author(s)
  吉村篤利, 山下恭徳
- Organizer
  第63回日本歯周病学会秋季学術大会
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] Role of quiescent osteoclast precursors in occlusal trauma in mice2020
- Author(s)
  yasunori yamashita
- Organizer
  アメリカ歯周病学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17072
[Presentation] Role of quiescent osteoclast precursors in occlusal trauma in mice2020
- Author(s)
  Yasunori Yamashita*, Yukio Ozaki, Kanako Higuchi, Masayuki Oohira, Megumi Mae, Ziauddin S.M., Atsutoshi Yoshimura
- Organizer
  he 106th Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology, the Japanese Academy of Clinical Periodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] Effect of Initial Periodontal Therapy on Inflammasome Priming in PBMCs2019
- Author(s)
  山下　恭德
- Organizer
  国際歯科研究学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17072
[Presentation] ペプチドグリカン投与マウス歯槽骨面上の破骨細胞形成におけるIL-17の役割2019
- Author(s)
  山下　恭德
- Organizer
  2019年度日本歯科保存学会秋季学術大会（第151回）
- Data Source
  KAKENHI-PROJECT-18K17072
[Presentation] 歯周基本治療が末梢血単核球におけるインフラマソームプライミング状態に及ぼす影響2019
- Author(s)
  山下　恭德
- Organizer
  日本歯周病学会
- Data Source
  KAKENHI-PROJECT-18K17072
[Presentation] 歯石粒子と凍結乾燥歯周病原細菌のHSC-2口腔上皮細胞に対する細胞障害性の比較2019
- Author(s)
  山下　恭德
- Organizer
  第62回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-18K17072
[Presentation] 咬合性外傷を伴う重度慢性歯周炎患者に対して包括的治療を行った一症例2019
- Author(s)
  山下　恭德
- Organizer
  令和元年度日本歯周病学会九州五大学日本臨床歯周病学会九州支部合同研修会
- Data Source
  KAKENHI-PROJECT-18K17072
[Presentation] コレステロール結晶はRAW-D細胞においてNLRP3インフラマソーム活性化とIL-1β産生を介して破骨細胞形成を促進する2018
- Author(s)
  樋口賀奈子,山下恭德,尾崎幸生,吉村篤利
- Organizer
  第149回日本歯科保存学会2018年度秋季学術大会
- Data Source
  KAKENHI-PROJECT-18K17072
[Presentation] リポ多糖およびペプチドグリカン局所投与マウス歯槽骨面上の破骨細胞形成への炎症性および抗炎症性サイトカインの関与2018
- Author(s)
  尾崎幸生, 岸本隆明, 山下恭德, ZIAUDDIN Sm, 樋口賀奈子, 金子高士, 吉村篤利
- Organizer
  第61回日本歯周病学会秋季学術大会
- Data Source
  KAKENHI-PROJECT-18K17072
[Presentation] マウス臼歯への外傷性咬合による骨吸収における HMGB-1の関与2018
- Author(s)
  鵜飼孝,小山美香,山下恭德
- Organizer
  第149回日本歯科保存学会2018年度秋季学術大会
- Data Source
  KAKENHI-PROJECT-18K17072
[Presentation] リポ多糖およひペプチドグリカン局所投与マウスにおける歯槽骨吸収に異なるサイトカインが関与する2018
- Author(s)
  尾崎幸生,山下恭德,岸本隆明, Ziauddin SM,樋口賀奈子,金子高士,吉村篤利
- Organizer
  平成30年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会
- Data Source
  KAKENHI-PROJECT-18K17072

1. 吉村篤利 (70253680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
2. 尾崎幸生 (60204187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. 坂井詠子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 鵜飼孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 金子高士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 筑波隆幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMASHITA Yasunori 山下 恭徳

Yamashita Yasunori 山下 恭徳

Research Projects

Research Products

Co-Researchers

糖尿病ラットにおけるLPS歯肉溝滴下歯周炎モデルの作製と補体の発症・進行への関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of NLRP3 inflammasome priming by periodontal diseases on systemic diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Involvement of vascular endothelial cell growth factor in mouse alveolar bone resorption by traumatic occlusionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 日本歯内療法学会が全ての歯科医師に贈る最新トレンド 知っておきたい!根管解剖と基礎 コレステロール結晶はRAW-D細胞においてNLRP3インフラマソームを介して破骨細胞形成を促進する2021

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] NLRP3 inflammasome negatively regulates RANKL-induced osteoclastogenesis of mouse bone marrow macrophages but positively regulates it in the presence of lipopolysaccharides.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The efficacy of a novel zinc-containing desensitizer CAREDYNE Shield for cervical dentin hypersensitivity: a pilot randomized controlled trial2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Efficacy and Safety of Antimicrobial Photodynamic Therapy in Residual Periodontal Pockets during the Maintenance Phase2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytotoxic effects of dental calculus particles and freeze‐dried Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum on HSC‐2 oral epithelial cells and THP‐1 macrophages2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-mobility group box 1 released by traumatic occlusion accelerates bone resorption in the root furcation area in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of osteoclastogenic and anti-osteoclastogenic cytokines differs in mouse gingiva injected with lipopolysaccharide, peptidoglycan, or both2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Role of Cytokines Produced via the NLRP3 Inflammasome in Mouse Macrophages Stimulated with Dental Calculus in Osteoclastogenesis2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] The efficacy of the novel zinc-containing desensitizer CAREDYNE Shield on dentin hypersensitivity: a study protocol for a pilot randomized controlled trial2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Initial periodontal treatment affects nucleotide-binding domain leucine-rich repeat-containing protein 3 inflammasome priming in peripheral blood mononuclear cells2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Osteoclastogenic and anti-osteoclastogenic cytokines induced by dental calculus2022

Author(s)

Organizer

Data Source

YAMASHITA Yasunori 山下恭徳

Yamashita Yasunori 山下恭徳

[Book] 日本歯内療法学会が全ての歯科医師に贈る最新トレンド　知っておきたい!根管解剖と基礎コレステロール結晶はRAW-D細胞においてNLRP3インフラマソームを介して破骨細胞形成を促進する2021

[Presentation] 全身性疾患への影響を考慮した新たな歯周病重症度検査項目の策定学会主導型多施設臨床研究2022

[Presentation] ペプチドグリカン投与マウス歯槽骨面上の破骨細胞形成におけるIL-17の役割2019