Sasaguri Hiroki 笹栗弘貴

Researcher Number	10783053
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, ユニットリーダー
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人理化学研究所, 脳神経科学研究センター, ユニットリーダー 2019 – 2021: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 副チームリーダー 2018: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator マウスモデル / アルツハイマー病 / 健康長寿 / タウ病理 / PLCG2 / アミロイド病理 / PLCG2遺伝子 / 保護的変異 / βアミロイド / Base editor … More / 家族性アルツハイマー病 / ノックイン法 / 塩基編集 / ゲノム編集 / モデルマウス / 認知症 / アミロイドβ / プレセニリン / 塩基編集技術 / ゲノム編集技術 / γセクレターゼ / アミロイドβ（Aβ） / プレセニリン1遺伝子 … More Except Principal Investigator アルツハイマー病 / 神経変性疾患 / Aβ蓄積 / トランスクリプトーム / 病態モデル / タウ病理 / アミロイドβペプチド / APOE２ / 長寿 / APOE2 Less

How does Abeta amyloidosis promotes tau pathology in vivo?
- Principal Investigator
  
  西道隆臣
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Institute of Physical and Chemical Research
アルツハイマー病予防および健康長寿達成を目指したPLCG2遺伝子の機能解明Principal Investigator
- Principal Investigator
  
  笹栗弘貴
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Institute of Physical and Chemical Research
アルツハイマー病保護因子APOE２多型の作用機序の解明と治療薬開発への応用
- Principal Investigator
  
  篠原充
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center for Geriatrics and Gerontology
Systematic analysis of Alzheimer's disease pathomechanisms utilizing genome editing technologyPrincipal Investigator
- Principal Investigator
  
  Sasaguri Hiroki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s disease2023
- Author(s)
  Daniels Michael JD、Lefevre Lucas、Szymkowiak Stefan、Drake Alice、McCulloch Laura、Tzioras Makis、Barrington Jack、Dando Owen R、He Xin、Mohammad Mehreen、Sasaguri Hiroki、Saito Takashi、Saido Takaomi C、Spires-Jones Tara L、McColl Barry W
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.85279
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K26790
[Journal Article] A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury2023
- Author(s)
  Zhao Xinyi、Zeng Wen、Xu Hong、Sun Zihan、Hu Yingxin、Peng Beibei、McBride Jennifer D.、Duan Jiangtao、Deng Juan、Zhang Bin、Kim Soo-Jung、Zoll Bryan、Saito Takashi、Sasaguri Hiroki、Saido Takaomi C.、Ballatore Carlo、Yao Haishan、Wang Zhaoyin、Trojanowski John Q.、Brunden Kurt R.、Lee Virginia M.-Y.、He Zhuohao
- Journal Title
  
  Science Translational Medicine
  
  Volume: 15 Issue: 713
- DOI
  10.1126/scitranslmed.abo6889
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K26790
[Journal Article] A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior2023
- Author(s)
  Ho Hinze、Kejzar Nejc、Sasaguri Hiroki、Saito Takashi、Saido Takaomi C.、De Strooper Bart、Bauza Marius、Krupic Julija
- Journal Title
  
  Cell Reports Methods
  
  Volume: 3 Issue: 7 Pages: 100532-100532
- DOI
  10.1016/j.crmeth.2023.100532
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K26790
[Journal Article] A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide2021
- Author(s)
  Sato Kaori、Watamura Naoto、Fujioka Ryo、Mihira Naomi、Sekiguchi Misaki、Nagata Kenichi、Ohshima Toshio、Saito Takashi、Saido Takaomi C.、Sasaguri Hiroki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297 Issue: 3 Pages: 101004-101004
- DOI
  10.1016/j.jbc.2021.101004
- Data Source
  KAKENHI-PROJECT-18K07402
[Journal Article] Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID2018
- Author(s)
  Sasaguri Hiroki、Nagata Kenichi、Sekiguchi Misaki、Fujioka Ryo、Matsuba Yukio、Hashimoto Shoko、Sato Kaori、Kurup Deepika、Yokota Takanori、Saido Takaomi C.
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 2892-2892
- DOI
  10.1038/s41467-018-05262-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07402
[Presentation] ゲノム編集技術と認知症研究最前線2020
- Author(s)
  笹栗弘貴
- Organizer
  第20回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-18K07402
[Presentation] 塩基編集技術を利用した高効率な変異Psen1マウス作製2019
- Author(s)
  笹栗　弘貴
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07402
[Presentation] Generation of animal models using a novel RNA-guided base editing technology2019
- Author(s)
  Hiroki Sasaguri
- Organizer
  第4回日本ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-18K07402
[Presentation] Generation of AD animal models using a novel RNA-guided gene editing technology2019
- Author(s)
  Hiroki Sasaguri
- Organizer
  Alzheimer's Association International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07402
[Presentation] Generation of Alzheimer’s disease animal models using an RNA-guided base editing technology2019
- Author(s)
  Hiroki Sasaguri
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07402
[Presentation] 新規ゲノム編集技術を利用したアルツハイマー病動物モデル作製2018
- Author(s)
  笹栗弘貴、関口みさき、藤岡亮、永田健一、松葉由紀夫、西道隆臣
- Organizer
  第37回　日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07402
[Presentation] 新規ゲノム編集技術を利用したアルツハイマー病動物モデル作製2018
- Author(s)
  笹栗弘貴、関口みさき、藤岡亮、永田健一、松葉由紀夫、西道隆臣
- Organizer
  第3回　日本ゲノム編集学会大会
- Data Source
  KAKENHI-PROJECT-18K07402
[Presentation] Generation of mutant presenilin 1 mice using a novel RNA-guided base editing technology2018
- Author(s)
  Hiroki Sasaguri, Misaki Sekiguchi, Ryo Fujioka, Kenichi Nagata, Takaomi C Saido
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07402

1. 篠原充 (60800521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 大塚礼 (00532243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 齊藤祐子 (60344066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 西田裕紀子 (60393170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 佐藤亜希子 (80800979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 菊地正隆 (90722538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 小木曽昇 (40638350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 西道隆臣 (80205690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Sasaguri Hiroki 笹栗 弘貴

Research Projects

Research Products

Co-Researchers

How does Abeta amyloidosis promotes tau pathology in vivo?

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルツハイマー病予防および健康長寿達成を目指したPLCG2遺伝子の機能解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルツハイマー病保護因子APOE２多型の作用機序の解明と治療薬開発への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Systematic analysis of Alzheimer's disease pathomechanisms utilizing genome editing technologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] ゲノム編集技術と認知症研究最前線2020

Author(s)

Organizer

Data Source

[Presentation] 塩基編集技術を利用した高効率な変異Psen1マウス作製2019

Author(s)

Organizer

Data Source

[Presentation] Generation of animal models using a novel RNA-guided base editing technology2019

Author(s)

Organizer

Data Source

[Presentation] Generation of AD animal models using a novel RNA-guided gene editing technology2019

Author(s)

Organizer

Data Source

[Presentation] Generation of Alzheimer’s disease animal models using an RNA-guided base editing technology2019

Author(s)

Organizer

Data Source

[Presentation] 新規ゲノム編集技術を利用したアルツハイマー病動物モデル作製2018

Author(s)

Organizer

Data Source

[Presentation] 新規ゲノム編集技術を利用したアルツハイマー病動物モデル作製2018

Author(s)

Organizer

Sasaguri Hiroki 笹栗弘貴