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Horioka Kohei  堀岡 宏平

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HORIOKA Kohei  堀岡 宏平

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Researcher Number 10783699
Affiliation (Current) 2025: 九州大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help 2023 – 2025: 九州大学, 大学病院, 助教
2016 – 2022: 九州大学, 医学研究院, 共同研究員
Review Section/Research Field
Principal Investigator
Digestive surgery / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 55020:Digestive surgery-related
Except Principal Investigator
Basic Section 55020:Digestive surgery-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 50010:Tumor biology-related
Keywords
Principal Investigator
癌関連線維芽細胞 / 腫瘍微小環境 / 膵癌肝転移 / 血管内皮細胞 / 好中球 / 膵癌 / 個別化治療 / 免疫治療 / MHCクラスII / CD4陽性T細胞 … More / scRNA-seq / 細胞障害性CD4陽性T細胞 / MHCクラスⅡ / 食道癌 / 癌微小環境 / 抗体医薬 / オートファジー / 膵星細胞 / 癌間質相互作用 / 腫瘍促進性好中球 / 腫瘍免疫 / 腫瘍免疫微小環境 / CCL5 / TAN / 薬剤抵抗性 / Spring-8 / SPring-8 / 蛍光X線分析 / 銅輸送体 / oxaliplatin / 治療抵抗性 / 白金製剤 / 大腸癌 / 癌細胞淘汰 / 肝内微小環境 / 循環癌細胞 / 肝星細胞 / 好中球細胞外トラップ / hepatic stellate cells / DNaseⅠ / NETs / CAFs / liver metastasis / pancreatic cancer / 癌セレクション機構 / 微小環境 / NETs / 肝微小転移 … More
Except Principal Investigator
膵癌 / 空間トランスクリプトーム解析 / メタボロミクス解析 / De novo searching / Direct identification / 膵癌HLAリガンドーム / HLA / リガンドーム / 膵臓癌 / Mass Spectrometry / 胃癌個別化免疫治療 / LMA / 免疫抑制細胞 / エピジェネティック / 乳酸 / 樹状細胞 / 腫瘍微小環境 / 食道癌 / 空間的transcriptome解析 / scRNAseq解析 / 領域リンパ節 (tdLN) / 腫瘍免疫微小環境 / 空間オミクス解析 / 膵癌間質内代謝異常 / レパトア解析 / シングルセルRNAシーケンス / 免疫チェックポイント阻害剤 / 三次リンパ組織(TLS) / Single Cell遺伝子発現解析 / エネルギー代謝 / 癌間質相互作用 / Single Cell解析 / 薬物送達システム / オートファジー / 薬剤送達 / 治療抵抗性 / 間質 / 膵星細胞 / ナノ粒子 Less
  • Research Projects

    (13 results)
  • Research Products

    (3 results)
  • Co-Researchers

    (17 People)
  •  scTCR・BCRレパトア解析と空間解析を用いた腫瘍局所TLS成熟機序の解明

    • Principal Investigator
      宮坂 義浩
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Kyushu University
  •  空間オミクス解析とメタボロミクス解析統合による膵癌間質内代謝異常の解明

    • Principal Investigator
      寅田 信博
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Kyushu University
  •  単一細胞レベルで解明する食道癌の進行が領域リンパ節微小環境に及ぼす影響

    • Principal Investigator
      森山 大樹
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kyushu University
  •  エピゲノム解析による樹状細胞のラクチル化が抗原提示機能に及ぼす影響の検討

    • Principal Investigator
      当間 宏樹
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kyushu University
  •  Xeniumを用いたLMAの機能的不均一性の解明と胃癌新規治療開発

    • Principal Investigator
      大内田 研宙
    • Project Period (FY)
      2025 – 2026
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Kyushu University
  •  Direct identificationによる膵癌HLAリガンドームの解明

    • Principal Investigator
      藤原 謙次
    • Project Period (FY)
      2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kyushu University
  •  MHCクラスⅡ陽性食道癌-細胞障害性CD4陽性T細胞を軸にした新規治療戦略Principal Investigator

    • Principal Investigator
      堀岡 宏平
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Kyushu University
  •  Elucidation of Metabolite Distribution in Pancreatic Cancer Stroma through Metabolomics and Single-Cell Analysis.

    • Principal Investigator
      TORATA Nobuhiro
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kyushu University
  •  Elucidation of the tumor-associated neutrophil creating the immunosuppressive microenvironment in pancreatic cancerPrincipal Investigator

    • Principal Investigator
      HORIOKA Kohei
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kyushu University
  •  Development of novel treatment for pancreatic cancer to break through the fibrotic barrier by combining pancreatic stellate cell inhibitors with nanoparticles

    • Principal Investigator
      EGAMI Takuya
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kyushu University
  •  Analysis of copper distribution by X-ray fluorescence analysis and platinum preparation resistance mechanism by copper transportersPrincipal Investigator

    • Principal Investigator
      HORIOKA Kohei
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kyushu University
  •  Elucidation of mechanisms that hepatic microenvironment sort out pancreatic cancer cells, and management the stress in microenvironment.Principal Investigator

    • Principal Investigator
      HORIOKA Kohei
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  肝内微小環境による膵癌細胞のセレクション機構解明と微小環境ストレスの制御Principal Investigator

    • Principal Investigator
      堀岡 宏平
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University

All 2025 2024

All Journal Article Presentation

  • [Journal Article] TIM3 on natural killer cells regulates antibody-dependent cellular cytotoxicity in HER2-positive gastric cancer2025

    • Author(s)
      Tsutsumi C、Ohuchida K、Tsutsumi H、Shimada Y、Yamada Y、Son K、Hayashida S、Katayama N、Mochida Y、Iwamoto C、Torata N、Horioka K、Shindo K、Mizuuchi Y、Ikenaga N、Nakata K、Ota K、Iwama E、Yamamoto M、Tsukamoto T、Nomura S、Morisaki T、Oda Y、Okamoto I、Nakamura M
    • Journal Title

      Cancer Letters

      Volume: 611 Pages: 217412-217412

    • DOI

      10.1016/j.canlet.2024.217412

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07171
  • [Journal Article] Tumor-infiltrating monocytic myeloid-derived suppressor cells contribute to the development of an immunosuppressive tumor microenvironment in gastric cancer2024

    • Author(s)
      Tsutsumi Chikanori、Ohuchida Kenoki、Katayama Naoki、Yamada Yutaka、Nakamura Shoichi、Okuda Sho、Otsubo Yoshiki、Iwamoto Chika、Torata Nobuhiro、Horioka Kohei、Shindo Koji、Mizuuchi Yusuke、Ikenaga Naoki、Nakata Kohei、Nagai Eishi、Morisaki Takashi、Oda Yoshinao、Nakamura Masafumi
    • Journal Title

      Gastric Cancer

      Volume: 27 Issue: 2 Pages: 248-262

    • DOI

      10.1007/s10120-023-01456-4

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K15570, KAKENHI-PROJECT-21K07244, KAKENHI-PROJECT-22K15584, KAKENHI-PROJECT-22K20943, KAKENHI-PROJECT-22K07171, KAKENHI-PROJECT-23KJ1698
  • [Presentation] 胃癌シングルセル遺伝子発現解析による腫瘍免疫抑制環境の解明と個別化治療戦略2024

    • Author(s)
      堤親範、大内田研宙、 片山直樹、寅田信博、 堀岡宏平、進藤幸治、永吉絹子、水内 祐介、 仲田興平、 中村雅史
    • Organizer
      第79回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-22K07171
  • 1.  水内 祐介 (20849088)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  TORATA Nobuhiro (00398075)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  中村 祥一 (60994035)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  進藤 幸治 (00788432)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  EGAMI Takuya (40507787)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  仲田 興平 (30419569)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  池永 直樹 (90759755)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  三好 圭 (70755272)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  阿部 俊也 (20722028)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  宮坂 義浩 (40507795)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  森山 大樹 (70586859)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  当間 宏樹 (80437780)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  新川 智彦 (40982319)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  安井 隆晴 (60611283)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  大内田 研宙 (20452708)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  岩本 千佳 (10752842)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  藤原 謙次 (10727184)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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