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TAKASHIMA HIROKI  高島 大輝

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高島 大輝  タカシマ ヒロキ

Takashima Hiroki  高島 大輝

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Researcher Number 10785588
Other IDs
Affiliation (Current) 2022: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
Affiliation (based on the past Project Information) *help 2022: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
2018 – 2020: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords
Principal Investigator
Drug Delivery System / 抗体 / 抗体-薬物複合体 / 抗体付加抗がん剤内包ミセル / Drug delivery system / エピルビシン / 腫瘍内分布 / 組織因子 / HER2 / Drug Delivery System … More / 武装抗体 / ナノパーティクル / 放射免疫療法 / アスタチン-211 / リンカー技術 / 抗体工学 Less
  • Research Projects

    (2 results)
  • Research Products

    (6 results)
  • Co-Researchers

    (5 People)
  •  リンカー技術と抗体工学を駆使したアスタチン-211の腫瘍特異的送達方法の開発Principal Investigator

    • Principal Investigator
      高島 大輝
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      National Cancer Center Japan
  •  Development of drug delivery systems using antibodyPrincipal Investigator

    • Principal Investigator
      Takashima Hiroki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      National Cancer Center Japan

All 2020 2019

All Journal Article Presentation

  • [Journal Article] Reinforcement of antitumor effect of micelles containing anticancer drugs by binding of an anti-tissue factor antibody without direct cytocidal effects2020

    • Author(s)
      Takashima Hiroki、Koga Yoshikatsu、Tsumura Ryo、Yasunaga Masahiro、Tsuchiya Masami、Inoue Tadashi、Negishi Eriko、Harada Mitsunori、Yoshida Sei、Matsumura Yasuhiro
    • Journal Title

      Journal of Controlled Release

      Volume: 323 Pages: 138-150

    • DOI

      10.1016/j.jconrel.2020.03.048

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15297
  • [Journal Article] Evaluation of the Antitumor Mechanism of Antibody-Drug Conjugates Against Tissue Factor in Stroma-Rich Allograft Models2019

    • Author(s)
      Tsumura Ryo、Manabe Shino、Takashima Hiroki、Koga Yoshikatsu、Yasunaga Masahiro、Matsumura Yasuhiro
    • Journal Title

      Cancer Science

      Volume: 110 Pages: 3296-3305

    • DOI

      10.1111/cas.14146

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15297, KAKENHI-PROJECT-18K14931
  • [Journal Article] Preclinical studies of immunomicelles incorporating anticancer drugs2019

    • Author(s)
      Takashima Hiroki、Tsumura Ryo、Koga Yoshikatsu、Yasunaga Masahiro、Harada Mitsunori、Matsumura Yasuhiro
    • Journal Title

      DDS

      Volume: 34 Issue: 1 Pages: 29-37

    • DOI

      10.2745/dds.34.29

    • NAID

      130007636842

    • ISSN
      0913-5006, 1881-2732
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-18K15297
  • [Journal Article] Anti-tissue factor antibody-mediated immuno-SPECT imaging of tissue factor expression in mouse models of pancreatic cancer2019

    • Author(s)
      Sugyo Aya、Aung Winn、Tsuji Atsushi、Sudo Hitomi、Takashima Hiroki、Yasunaga Masahiro、Matsumura Yasuhiro、Saga Tsuneo、Higashi Tatsuya
    • Journal Title

      Oncology Reports

      Volume: 41 (4) Pages: 23712378-23712378

    • DOI

      10.3892/or.2019.7017

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10460, KAKENHI-PROJECT-18K15297, KAKENHI-PROJECT-18H02774, KAKENHI-PROJECT-17K10497
  • [Presentation] Development of micelles containing anticancer drugs conjugated with an anti-tissue factor antibody without direct cytocidal effects2020

    • Author(s)
      Hiroki Takashima, Yoshikatsu Koga, Ryo Tsumura, Masahiro Yasunaga, Masami Tsuchiya, Tadashi Inoue, Eriko Negish, Chihiro Tanabe, Mitsunori Harada, Sei Yoshida, Yasuhiro Matsumura
    • Organizer
      2020 Controlled Release Society Virtual Annual Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15297
  • [Presentation] Antitumor effect of nanomicelles conjugated to an anti-tissue factor antibody without a direct cytocidal effect2020

    • Author(s)
      Hiroki Takashima, Yoshikatsu Koga, Ryo Tsumura, Masami Tsuchiya, Tadashi Inoue, Eriko Negishi, Mitsunori Harada, Sei Yoshida, Yasuhiro Matsumura, Masahiro Yasunaga
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K15297
  • 1.  YASUNAGA Masahiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  SUGYO Aya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  津村 遼
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  U・WINN Aung
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  辻 厚至
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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