TAKASHIMA HIROKI 高島大輝

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Takashima Hiroki 高島大輝

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Researcher Number	10785588
Other IDs
Affiliation (Current)	2023: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
Affiliation (based on the past Project Information) *help	2022: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員 2018 – 2020: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 抗体工学 / リンカー技術 / アスタチン-211 / 放射免疫療法 / ナノパーティクル / 武装抗体 / Drug Delivery Sｙｓtem / HER2 / 組織因子 / 腫瘍内分布 … More / エピルビシン / Drug delivery system / 抗体付加抗がん剤内包ミセル / 抗体-薬物複合体 / 抗体 / Drug Delivery System Less

リンカー技術と抗体工学を駆使したアスタチン-211の腫瘍特異的送達方法の開発Principal Investigator
- Principal Investigator
  
  高島大輝
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Development of drug delivery systems using antibodyPrincipal Investigator
- Principal Investigator
  
  Takashima Hiroki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan

All 2020 2019

All Journal Article Presentation

[Journal Article] Reinforcement of antitumor effect of micelles containing anticancer drugs by binding of an anti-tissue factor antibody without direct cytocidal effects2020
- Author(s)
  Takashima Hiroki、Koga Yoshikatsu、Tsumura Ryo、Yasunaga Masahiro、Tsuchiya Masami、Inoue Tadashi、Negishi Eriko、Harada Mitsunori、Yoshida Sei、Matsumura Yasuhiro
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 323 Pages: 138-150
- DOI
  10.1016/j.jconrel.2020.03.048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15297
[Journal Article] Evaluation of the antitumor mechanism of antibody‐drug conjugates against tissue factor in stroma‐rich allograft models2019
- Author(s)
  Tsumura Ryo、Manabe Shino、Takashima Hiroki、Koga Yoshikatsu、Yasunaga Masahiro、Matsumura Yasuhiro
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 10 Pages: 3296-3305
- DOI
  10.1111/cas.14146
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15297, KAKENHI-PROJECT-18K14931
[Journal Article] Preclinical studies of immunomicelles incorporating anticancer drugs2019
- Author(s)
  Takashima Hiroki、Tsumura Ryo、Koga Yoshikatsu、Yasunaga Masahiro、Harada Mitsunori、Matsumura Yasuhiro
- Journal Title
  
  Drug Delivery System
  
  Volume: 34 Issue: 1 Pages: 29-37
- DOI
  10.2745/dds.34.29
- NAID
  130007636842
- ISSN
  0913-5006, 1881-2732
- Year and Date
  2019-01-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K15297
[Journal Article] Anti-tissue factor antibody?mediated immuno?SPECT imaging of tissue factor expression in mouse models of pancreatic cancer2019
- Author(s)
  Sugyo Aya、Aung Winn、Tsuji Atsushi、Sudo Hitomi、Takashima Hiroki、Yasunaga Masahiro、Matsumura Yasuhiro、Saga Tsuneo、Higashi Tatsuya
- Journal Title
  
  Oncology Reports
  
  Volume: 41 (4) Pages: 2371-2378
- DOI
  10.3892/or.2019.7017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10460, KAKENHI-PROJECT-18K15297, KAKENHI-PROJECT-18H02774, KAKENHI-PROJECT-17K10497
[Presentation] Development of micelles containing anticancer drugs conjugated with an anti-tissue factor antibody without direct cytocidal effects2020
- Author(s)
  Hiroki Takashima, Yoshikatsu Koga, Ryo Tsumura, Masahiro Yasunaga, Masami Tsuchiya, Tadashi Inoue, Eriko Negish, Chihiro Tanabe, Mitsunori Harada, Sei Yoshida, Yasuhiro Matsumura
- Organizer
  2020 Controlled Release Society Virtual Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15297
[Presentation] Antitumor effect of nanomicelles conjugated to an anti-tissue factor antibody without a direct cytocidal effect2020
- Author(s)
  Hiroki Takashima, Yoshikatsu Koga, Ryo Tsumura, Masami Tsuchiya, Tadashi Inoue, Eriko Negishi, Mitsunori Harada, Sei Yoshida, Yasuhiro Matsumura, Masahiro Yasunaga
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15297

1. U・WINN Aung

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKASHIMA HIROKI 高島 大輝

Takashima Hiroki 高島 大輝

Research Projects

Research Products

Co-Researchers

リンカー技術と抗体工学を駆使したアスタチン-211の腫瘍特異的送達方法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of drug delivery systems using antibodyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Reinforcement of antitumor effect of micelles containing anticancer drugs by binding of an anti-tissue factor antibody without direct cytocidal effects2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of the antitumor mechanism of antibody‐drug conjugates against tissue factor in stroma‐rich allograft models2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preclinical studies of immunomicelles incorporating anticancer drugs2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Anti-tissue factor antibody?mediated immuno?SPECT imaging of tissue factor expression in mouse models of pancreatic cancer2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Development of micelles containing anticancer drugs conjugated with an anti-tissue factor antibody without direct cytocidal effects2020

Author(s)

Organizer

Data Source

[Presentation] Antitumor effect of nanomicelles conjugated to an anti-tissue factor antibody without a direct cytocidal effect2020

Author(s)

Organizer

Data Source

TAKASHIMA HIROKI 高島大輝

Takashima Hiroki 高島大輝