Hosokawa Kohei 細川晃平

Researcher Number	10786239
Other IDs	https://orcid.org/0000-0002-3423-1523
Affiliation (Current)	2025: 金沢大学, 附属病院, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 金沢大学, 附属病院, 講師 2018 – 2022: 金沢大学, 附属病院, 助教 2017: 金沢大学, 附属病院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 再生不良性貧血 / HLA-DR15 / 免疫学 / 造血不全 / 抗ネオ・セルフ抗体 / 自己免疫 / 造血障害 / 造血幹前駆細胞 / HLA-DRB1*15:01 / HLA-DR / iPS細胞 / HLA / トランスクリプトーム解析 … More Except Principal Investigator … More CD4陽性T細胞 / 発作性夜間ヘモグロビン尿症 / 免疫不全マウス / 骨髄移植 / 造血幹細胞 / 自己免疫疾患 / HLA / iPS細胞 / 免疫抑制剤 / 疾患モデル / 自己免疫性骨髄不全 / 自己抗原 / T細胞レセプター / HLA-DR15 / クロナリティ / PNH型血球 / PIGA遺伝子 / 再生不良性貧血 / 免疫学 Less

Identification of immunosuppressive agents that inhibit the expansion of PNH clones
- Principal Investigator
  
  中尾眞二
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
抗ネオ・セルフ抗体を利用した再生不良性貧血自己抗原の同定Principal Investigator
- Principal Investigator
  
  細川晃平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
Creation of a disease model using iPS cells from patients with autoimmune bone marrow failure and elucidation of selective hematopoietic regulation
- Principal Investigator
  
  片桐孝和
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
PNHクローンのエスケープメカニズムの解明
- Principal Investigator
  
  中尾眞二
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
Understanding the immune pathophysiology in acquired aplastic anemia with HLA-DR15 lacking cellsPrincipal Investigator
- Principal Investigator
  
  Hosokawa Kohei
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
Elucidation of the fundamental mechanism underlying hematopoietic control changes through a novel immune evasion mechanism in autoimmune bone marrow failure
- Principal Investigator
  
  Katagiri Takamasa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
Understanding the immune pathophysiology in bone marrow failure patients with HLA-B*54:01Principal Investigator
- Principal Investigator
  
  Hosokawa Kohei
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
Identification of T cell pathway causing the acquired aplastic anemiaPrincipal Investigator
- Principal Investigator
  
  Hosokawa Kohei
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book Patent

[Book] Congenital and Acquired Bone Marrow Failure2017
- Author(s)
  Hosokawa K, Scheinberg P, and Young, N.S.
- Total Pages
  274
- Publisher
  Elsevier
- ISBN
  9780128041529
- Data Source
  KAKENHI-PROJECT-17K16184
[Journal Article] A longitudinal analysis of paroxysmal nocturnal haemoglobinuria‐type cells in patients with bone marrow failure: Results of a prospective multi‐centre study in Japan2023
- Author(s)
  Ishiyama Ken、Yonemura Yuji、Kawaguchi Tatsuya、Hosokawa Kohei、Sugimori Chiharu、Ueda Yasutaka、Takamori Hiroyuki、Obara Naoshi、Noji Hideyoshi、Shirasugi Yukari、Ando Kiyoshi、Shichishima Tsutomu、Ninomiya Haruhiko、Chiba Shigeru、Nishimura Jun‐ichi、Kanakura Yuzuru、Nakao Shinji
- Journal Title
  
  British Journal of Haematology
  
  Volume: 203 Issue: 3 Pages: 468-476
- DOI
  10.1111/bjh.19048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07859, KAKENHI-PROJECT-21K08365, KAKENHI-PROJECT-21K08367
[Journal Article] Correction: Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR152023
- Author(s)
  Tsuji Noriaki、Hosokawa Kohei、Urushihara Ryota、Tanabe Mikoto、Zaimoku Yoshitaka、Katagiri Takamasa、Ozawa Tatsuhiko、Takamatsu Hiroyuki、Ishiyama Ken、Yamazaki Hirohito、Kishi Hiroyuki、Ogawa Seishi、Nakao Shinji
- Journal Title
  
  Leukemia
  
  Volume: 37 Issue: 10 Pages: 2143-2143
- DOI
  10.1038/s41375-023-02011-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08367
[Journal Article] Immune pathophysiology of bone marrow failure2023
- Author(s)
  細川晃平
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 64 Issue: 9 Pages: 908-915
- DOI
  10.11406/rinketsu.64.908
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08367
[Journal Article] GPI(-) granulocyte populations in aplastic anemia and healthy individuals derived from a few PIGA-mutated hematopoietic stem progenitor cells2023
- Author(s)
  Mizumaki Hiroki、Tran Dung Cao、Hosokawa Kohei、Hosomichi Kazuyoshi、Zaimoku Yoshitaka、 Takamatsu Hiroyuki、Yamazaki Hirohito、Ishiyama Ken、Yamazaki Rena、Fujiwara Hiroshi、Tajima Atsushi、Nakao Shinji
- Journal Title
  
  Blood Cancer Journal
  
  Volume: 13 Issue: 1 Pages: 165-165
- DOI
  10.1038/s41408-023-00932-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08473, KAKENHI-PROJECT-23K07808, KAKENHI-PROJECT-21K08367
[Journal Article] Hematopoietic stem progenitor cells with malignancy‐related gene mutations in patients with acquired aplastic anemia are characterized by the increased expression of CXCR42022
- Author(s)
  Katagiri Takamasa,Espinoza Luis,Uemori Mizuho,Ikeda Honoka,Hosokawa Kohei,Ishiyama Ken,Yoroidaka Takeshi,Imi Tatsuya,Takamatsu Hiroyuki,Ozawa Tatsuhiko,Kishi Hiroyuki,Yamamoto Yasuhiko,Elbadry Mahmoud,Yoshida Yoshinori,Chonabayashi Kazuhisa,Takenaka Katsuto,Akashi Koichi,Nannya Yasuhito,Ogawa Seishi,Nakao Shinji
- Journal Title
  
  eJHaem
  
  Volume: 3 Issue: 3 Pages: 669-680
- DOI
  10.1002/jha2.515
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08367, KAKENHI-PROJECT-21H02695, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-20K08707
[Journal Article] Somatic mutations and clonal expansions in paroxysmal nocturnal hemoglobinuria2022
- Author(s)
  Hosokawa Kohei、Nakao Shinji
- Journal Title
  
  Seminars in Hematology
  
  Volume: 59 Issue: 3 Pages: 143-149
- DOI
  10.1053/j.seminhematol.2022.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08367
[Journal Article] Clinical significance of the increased expression of the WT1 gene in peripheral blood of patients with acquired aplastic anemia2022
- Author(s)
  Ishiyama Ken、Dung Tran Cao、Imi Tatsuya、Hosokawa Kohei、Nannya Yasuhito、Yamazaki Hirohito、Ogawa Seishi、Nakao Shinji
- Journal Title
  
  eJHaem
  
  Volume: 3 Issue: 4 Pages: 1116-1125
- DOI
  10.1002/jha2.563
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08367, KAKENHI-PROJECT-20K08708
[Journal Article] Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR152022
- Author(s)
  Tsuji Noriaki、Hosokawa Kohei、Urushihara Ryota、Tanabe Mikoto、Katagiri Takamasa、Ozawa Tatsuhiko、Takamatsu Hiroyuki、Ishiyama Ken、Yamazaki Hirohito、Kishi Hiroyuki、Ogawa Seishi、Nakao Shinji
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 6 Pages: 1666-1675
- DOI
  10.1038/s41375-022-01549-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08367, KAKENHI-PROJECT-22K08473, KAKENHI-PROJECT-21H02962, KAKENHI-PROJECT-20K08707, KAKENHI-PROJECT-20K08708
[Journal Article] Hematopoietic stem progenitor cells lacking HLA differ from those lacking GPI-anchored proteins in the hierarchical stage and sensitivity to immune attack in patients with acquired aplastic anemia2021
- Author(s)
  Yoroidaka T, Hosokawa K, Imi T, Mizumaki H, Katagiri T, Ishiyama K, Yamazaki H, Azuma F, Nanya Y, Ogawa S, Nakao S
- Journal Title
  
  Leukemia
  
  Volume: in press Issue: 11 Pages: 3257-3267
- DOI
  10.1038/s41375-021-01202-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03686, KAKENHI-PROJECT-18K08318, KAKENHI-PROJECT-19K17823, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-21K08367
[Journal Article] The GPI-anchored protein CD109 protects hematopoietic progenitor cells from undergoing erythroid differentiation induced by TGF-β2021
- Author(s)
  Tanabe Mikoto、Hosokawa Kohei、Nguyen Mai Anh Thi、Nakagawa Noriharu、Maruyama Kana、Tsuji Noriaki、Urushihara Ryota、Espinoza Luis、Elbadry Mahmoud I.、Mohiuddin Md、Katagiri Takamasa、Ono Masanori、Fujiwara Hiroshi、Chonabayashi Kazuhisa、Yoshida Yoshinori、Yamazaki Hirohito、Hirao Atsushi、Nakao Shinji
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 3 Pages: 847-855
- DOI
  10.1038/s41375-021-01463-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01033, KAKENHI-PROJECT-19H03686, KAKENHI-PROJECT-20K08707, KAKENHI-PROJECT-21K08367, KAKENHI-PROJECT-21K19502
[Journal Article] High-dose romiplostim accelerates hematologic recovery in patients with aplastic anemia refractory to eltrombopag2021
- Author(s)
  Hosokawa Kohei, Yamazaki Hirohito, Tanabe Mikoto, Imi Tatsuya, Sugimori Naomi, Nakao Shinji
- Journal Title
  
  Leukemia
  
  Volume: 35 Issue: 3 Pages: 906-909
- DOI
  10.1038/s41375-020-0950-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08318, KAKENHI-PROJECT-19K17823
[Journal Article] Detection of Antibodies Against Human Leukocyte Antigen Class II in the Sera of Patients Receiving Intravenous Immunoglobulin2021
- Author(s)
  Takamatsu Hiroyuki、Yamada Shinya、Tsuji Noriaki、Nakagawa Noriharu、Matsuura Erika、Kasada Atsuo、Sato Keijiro、Hosokawa Kohei、Iwaki Noriko、Arahata Masahisa、Tanaka Hidenori、Nakao Shinji
- Journal Title
  
  Transplantation Direct
  
  Volume: 7 Issue: 6 Pages: e697-e697
- DOI
  10.1097/txd.0000000000001146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08367
[Journal Article] HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic　anemia.2021
- Author(s)
  Hosokawa K, Mizumaki H, Yoroidaka T, Maruyama H, Imi T, Tsuji N, Urushihara R, Tanabe M, Zaimoku Y, Nguyen MAT, Tran DC, Ishiyama K, Yamazaki H, Katagiri T, Takamatsu H, Hosomichi K, Tajima A, Azuma F, Ogawa S, Nakao S.
- Journal Title
  
  Blood
  
  Volume: － Issue: 25 Pages: 3576-3580
- DOI
  10.1182/blood.2020010586
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08707, KAKENHI-PROJECT-20K21705, KAKENHI-PLANNED-16H06502, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-18K07293, KAKENHI-PROJECT-18K08318, KAKENHI-PROJECT-19K17823, KAKENHI-PUBLICLY-21H00342
[Journal Article] The effectiveness of immunosuppressive therapy in patients with aplastic anaemia secondary to chemoradiotherapy for cancers2021
- Author(s)
  Nakagawa Noriharu、Ishiyama Ken、Tanabe Mikoto、Yoroidaka Takeshi、Mizumaki Hiroki、Imi Tatsuya、Zaimoku Yoshitaka、Maruyama Hiroyuki、Hosokawa Kohei、Yamazaki Hirohito、Nakao Shinji
- Journal Title
  
  British Journal of Haematology
  
  Volume: 195 Issue: 5 Pages: 770-780
- DOI
  10.1111/bjh.17802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08367
[Journal Article] Resistance of KIR Ligand-Missing Leukocytes to NK Cells In Vivo in Patients with Acquired Aplastic Anemia.2020
- Author(s)
  Nguyen MAT, Hosokawa K, Yoroidaka T, Maruyama H, Espinoza JL, Elbadry MI, Mohiuddin M, Tanabe M, Katagiri T, Nakagawa N, Chonabayashi K, Yoshida Y, Arima N, Kashiwase K, Saji H, Ogawa S, Nakao S.
- Journal Title
  
  Immunohorizons
  
  Volume: 4 Issue: 7 Pages: 430-441
- DOI
  10.4049/immunohorizons.2000046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08707, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19K17823
[Journal Article] A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia.2020
- Author(s)
  Mizumaki H, Hosomichi K, Hosokawa K, Yoroidaka T, Imi T, Zaimoku Y, Katagiri T, Nguyen MAT, Tran DC, Elbadry MIY, Chonabayashi K, Yoshida Y, Takamatsu H, Ozawa T, Azuma F, Kishi H, Fujii Y, Ogawa S, Tajima A, Nakao S.
- Journal Title
  
  Haematologica
  
  Volume: － Issue: 6 Pages: 247809-247809
- DOI
  10.3324/haematol.2020.247809
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08707, KAKENHI-PROJECT-20K21705, KAKENHI-PLANNED-16H06502, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-18H02689, KAKENHI-PROJECT-19H03686, KAKENHI-PROJECT-18K07293, KAKENHI-PROJECT-19K17823
[Journal Article] Acquired aplastic anemia2019
- Author(s)
  Hosokawa K, Nakao S
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 60 Issue: 5 Pages: 417-422
- DOI
  10.11406/rinketsu.60.417
- NAID
  130007659585
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17823
[Journal Article] Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia.2019
- Author(s)
  Mahmoud I. Elbadry、Mizumaki Hiroki、Hosokawa Kohei、J. Luis Espinoza、Nakagawa Noriharu、Chonabayashi Kazuhisa、Yoshida Yoshinori、Katagiri Takamasa、Hosomichi Kazuyoshi、Zaimoku Yoshitaka、Imi Tatsuya、Mai Anh Thi Nguyen、Fujii Youichi、Tajima Atsushi、Ogawa Seishi、Takenaka Katsuto、Akashi Koichi、Nakao Shinji
- Journal Title
  
  Haematologica
  
  Volume: 印刷中 Issue: 10 Pages: 210856-210856
- DOI
  10.3324/haematol.2018.210856
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06502, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-16H05335, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-16K09847, KAKENHI-PROJECT-17K19804, KAKENHI-PROJECT-17K16184, KAKENHI-PLANNED-15H05909, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-17K09007
[Journal Article] Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia2019
- Author(s)
  Hosokawa K, Mizumaki H, Elbadry M, Saito C, Espinoza JL, An DTT, Katagiri T, Harashima A, Kikuchi A, Kanai A, Matsui H, Inaba T, Taniwaki M, Yamamoto Y, Nakao S
- Journal Title
  
  Leukemia
  
  Volume: 33 Issue: 11 Pages: 2732-2766
- DOI
  10.1038/s41375-019-0510-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17823, KAKENHI-PROJECT-19H03686, KAKENHI-PROJECT-17K09007, KAKENHI-PROJECT-17K09822
[Journal Article] Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing2018
- Author(s)
  Banaszak LG, Giudice V, Zhao X, Wu Z, Gao S, Hosokawa K, Keyvanfar K, Townsley DM, Gutierrez-Rodrigues F, Fernandez Ibanez MDP, Kajigaya S, Young NS
- Journal Title
  
  Blood cells, molecules & diseases
  
  Volume: 69 Pages: 10-22
- DOI
  10.1016/j.bcmd.2017.12.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184
[Journal Article] Establishment of a flow cytometry assay for detecting paroxysmal nocturnal hemoglobinuria-type cells specific to patients with bone marrow failure2018
- Author(s)
  Hosokawa Kohei、Sugimori Chiharu、Ishiyama Ken、Takamatsu Hiroyuki、Noji Hideyoshi、Shichishima Tsutomu、Obara Naoshi、Chiba Shigeru、Ninomiya Haruhiko、Shirasugi Yukari、Nakamura Yoshihiko、Ando Kiyoshi、Ueda Yasutaka、Yonemura Yuji、Kawaguchi Tatsuya、Nishimura Jun-ichi、Kanakura Yuzuru、Nakao Shinji
- Journal Title
  
  Annals of Hematology
  
  Volume: 97 Issue: 12 Pages: 2289-2297
- DOI
  10.1007/s00277-018-3443-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-17K16184
[Journal Article] T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways.2017
- Author(s)
  Hosokawa K, Kajigaya S, Keyvanfar K, Qiao W, Xie Y, Townsley DM, Feng X, Young NS.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 199(2) Issue: 2 Pages: 477-488
- DOI
  10.4049/jimmunol.1601299
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184
[Patent] ＨＬＡクラスＩアレル欠失血球の検出方法2020
- Inventor(s)
  水牧裕希, 中尾眞二, 細川　晃平
- Industrial Property Rights Holder
  水牧裕希, 中尾眞二, 細川　晃平
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19K17823
[Patent] HLAクラスIアレルにおける機能喪失型共通変異の検出方法2019
- Inventor(s)
  水牧裕希、中尾眞二、細川晃平
- Industrial Property Rights Holder
  水牧裕希、中尾眞二、細川晃平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-090219
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] Single-Cell Dissection Reveals a Distinct Origin of Small Paroxysmal Nocturnal Hemoglobinuria Clones in Immune Aplastic Anemia and Healthy Individuals2023
- Author(s)
  Dung Cao Cao Tran, Yoshitaka Zaimoku, Kazuyoshi Hosomichi, Hiroki Mizumaki, Kohei Hosokawa, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao
- Organizer
  2023 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08367
[Presentation] Recent advances in the pathogenesis and treatment of aplastic anemia2023
- Author(s)
  Kohei Hosokawa
- Organizer
  2023 Korean Society of Hematology International Conference ＆ 64rd annual meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08367
[Presentation] Frequent HLA allelic loss in leukocytes of patients with hepatitis-associated aplastic anemia.2023
- Author(s)
  岩崎寛香、上森瑞穂、材木義隆、細川晃平、中尾眞二、片桐孝和.
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07829
[Presentation] 再生不良性貧血における新たな免疫逃避機構の同定2023
- Author(s)
  辻紀章, 細川晃平, 漆原涼太, 田辺命, 材木義隆, 高松博幸, 石山謙, 山崎宏人, 中尾眞二, 宮本敏浩
- Organizer
  第120回日本内科学会講演会
- Data Source
  KAKENHI-PROJECT-21K08367
[Presentation] Cyclosporine-free remission of aplastic anemia requires evolution of hematopoietic stem cells.2023
- Author(s)
  細川晃平、Dung Cao Tran、水牧裕希、鎧高健志、井美達也、丸山裕之、辻紀章、漆原涼太、田辺命、材木義隆、片桐孝和、高松博幸、石山謙、山崎宏人、宮本敏浩、中尾眞二.
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07829
[Presentation] 再生不良性貧血におけるシクロスポリン非依存性の寛解には造血幹細胞の進化が必要である2023
- Author(s)
  細川晃平, Tran Dung Cao, 水牧裕希, 鎧高健志, 井美達也, 丸山裕之, 辻紀章, 漆原涼太, 田辺命, 材木義隆, 片桐孝和, 高松博幸, 石山謙, 山崎宏人, 宮本敏浩, 中尾眞二
- Organizer
  85回　日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08367
[Presentation] Single-Cell Dissection Reveals a Distinct Origin of Small Paroxysmal Nocturnal Hemoglobinuria Clones in Immune Aplastic Anemia and Healthy Individuals2023
- Author(s)
  Dung Cao Tran, Yoshitaka Zaimoku, Kazuyoshi Hosomichi, Hiroki Mizumaki, Kohei Hosokawa, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao
- Organizer
  Annual meeting of the American Society Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08473
[Presentation] HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia.2022
- Author(s)
  Yoshitaka Zaimoku, Hiroki Mizumaki, Takeshi Yoroidaka, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Kohei Hosokawa, Takamasa Katagiri, Hiroyuki Takamatsu, Ken Ishiyama, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao.
- Organizer
  64th American Society of Hematology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08707
[Presentation] HLA class I allele-lacking leukocytes prevent the development of secondary PNH in aplastic anemia.2022
- Author(s)
  細川晃平、水牧裕希、鎧高健志、丸山裕之、井美達也、辻紀章、漆原涼太、田辺命、材木義隆、Maianh Thinguyen、Dung Cao Tran Thi、石山謙、山崎宏人、片桐孝和、高松博幸、細道一善、田嶋敦、東史啓、小川誠司、宮本敏浩、中尾眞二.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08707
[Presentation] PNH clone expansion: our understanding in 20222022
- Author(s)
  Kohei Hosokawa
- Organizer
  Eighth International Bone Marrow Failure Scientific Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08367
[Presentation] HSPCs with MDS-related mutations in aplastic anemia are characterized by increased CXCR4 expression.2022
- Author(s)
  片桐孝和、Juis Espinoza、上森瑞穂、池田ほのか、細川晃平、石山謙、鎧高健志、井美達也、高松博幸、小澤龍彦、岸裕幸、山本靖彦、Mahmoud Elbadry、吉田善紀、蝶名林和久、竹中克斗、赤司浩一、南谷泰仁、小川誠司、中尾眞二.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08707
[Presentation] The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia2021
- Author(s)
  Yoshitaka Zaimoku, Hiroki Mizumaki, Tatsuya Imi, Kohei Hosokawa, Hiroyuki Maruyama, Takamasa Katagiri, Takeshi Yoroidaka, Noriharu Nakagawa, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Shinji Nakao
- Organizer
  63th American Society of Hematology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08707
[Presentation] Minor GPI(-) Granulocyte Populations in Patients with Acquired Aplastic Anemia and Healthy Individuals Are Derived from a Few Piga-Mutated Hematopoietic Stem Progenitor Cells2021
- Author(s)
  Hiroki Mizumaki, Dung Cao Tran, Kohei Hosokawa, Kazuyoshi Hosomichi, Hiroyuki Takamatsu, Hirohito Yamazaki, Atsushi Tajima, Ken Ishiyama and Shinji Nakao
- Organizer
  2021 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08367
[Presentation] The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia2021
- Author(s)
  Yoshitaka Zaimoku, Hiroki Mizumaki, Tatsuya Imi, Kohei Hosokawa, Hiroyuki Maruyama, Takamasa Katagiri, Takeshi Yoroidaka, Noriharu Nakagawa, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama and Shinji Nakao
- Organizer
  2021 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08367
[Presentation] Frequencies and clinical significance of HLA alleles in acquired aplastic anemia2021
- Author(s)
  Yoshitaka Zaimoku, Kohei Hosokawa, Takamasa Katagiri, Hiroyuki Maruyama, Tatsuya Imi, Hiroki Mizumaki, Takeshi Yoroidaka, Mikoto Tanabe, Ryota Urushihara, Noriaki Tsuji, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Shinji Nakao
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08707
[Presentation] 再生不良性貧血におけるHLAクラスIアレル欠失血球検出の臨床的意義2021
- Author(s)
  細川晃平、中尾眞二
- Organizer
  第83回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K08367
[Presentation] Anti-COX-2 Autoantibody Is a Novel Diagnostic Marker of Aplastic Anemia2021
- Author(s)
  Yasutaka Ueda, Kohei Hosokawa, Ken Ishiyama, Hiroyuki Takamori, Yuji Yonemura, Naoshi Obara, Hideyoshi Noji, Kiyoshi Ando, Tsutomu Shichishima, Takayuki Ikezoe, Shigeru Chiba, Haruhiko Ninomiya, Tatsuya Kawaguchi, Jun-ichi Nishimura, Yuzuru Kanakura and Shinji Nakao
- Organizer
  2021 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08367
[Presentation] Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia2020
- Author(s)
  Kohei Hosokawa, Hiroki Mizumaki, Takeshi Yoroidaka, Hiroyuki Maruyama, Tatsuya Imi, Noriaki Tsuji, Ryota Urushihara, Mikoto Tanabe, Yoshitaka Zaimoku, Mai Anh Nguyen, Dung Tran, Ken Ishiyama, Hirohito Yamazaki, Takamasa Katagiri, Kazuyoshi Hosomichi, Atsushi Tajima, Fumihiro Azuma, Seishi Ogawa, Shinji Nakao
- Organizer
  2020 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia.2020
- Author(s)
  Kohei Hosokawa, Eiji Kobayashi, Yoshiki Akatsuka, Luis Espinoza, Noriharu Nakagawa, Tanabe Mikoto, Noriaki Tsuji, Takeshi Yoroidaka, Hiroki Mizumaki, Thi Mai Anh Nguyen, Takamasa Katagiri, Kiyomi Shitaoka, Hiroshi Hamana, Hiroyuki Kishi, Shinji Nakao,
- Organizer
  62th American Society of Hematology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08707
[Presentation] High-dose romiplostim accelerates hematologic recovery in patients with aplastic anemia refractory to eltrombopag.2020
- Author(s)
  Kohei Hosokawa, Hirohito Yamazaki, Mikoto Tanabe, Tatsuya Imi, Keiji Aoshima, Naomi Sugimori, Shinji Nakao
- Organizer
  25th Congress of European Hematology Association.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] Epigenetic Loss of the HLA-DR15 Expression on Hematopoietic Stem Progenitor Cells in Patients with Acquired Aplastic Anemia Characterized By Cyclosporine Dependency: A Novel Mechanism Underlying the Immune Escape of Hematopoietic Stem Progenitor Cells2020
- Author(s)
  Noriaki Tsuji, Kohei Hosokawa, Ryota Urushihara, Mikoto Tanabe, Hiroyuki Takamatsu, Ken Ishiyama, Hirohito Yamazaki, Shinji Nakao
- Organizer
  2020 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] Olfactomedin 4 Inhibits Erythroid Differentiation of Leukemic Cell Lines Induced By TGF-β: A Model of Preferential Commitment of Del(13q) Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure2019
- Author(s)
  Mai Anh Thi Nguyen, Kohei Hosokawa, Tanabe Mikoto, Md Mohiuddin, Takeshi Yoroidaka, Hiroki Mizumaki, Tatsuya Imi, Masaya Ueno, Atsushi Hirao, Shinji Nakao
- Organizer
  2019 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia2019
- Author(s)
  Kohei Hosokawa, Eiji Kobayashi, Yoshiki Akatsuka, Luis Espinoza, Noriharu Nakagawa, Tanabe Mikoto, Noriaki Tsuji, Takeshi Yoroidaka, Hiroki Mizumaki, Thi Mai Anh Nguyen, Takamasa Katagiri, Kiyomi Shitaoka, Hiroshi Hamana, Hiroyuki Kishi, Shinji Nakao
- Organizer
  2019 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] Distinct Escape Mechanisms of HLA Class I Allele-Lacking Hematopoietic Stem Progenitor Cells (HSPCs) from GPI-Deficient HSPCs in Acquired Aplastic Anemia2019
- Author(s)
  Noriaki Tsuji, Kohei Hosokawa, Takeshi Yoroidaka, Tanabe Mikoto, Hiroki Mizumaki, Shinji Nakao
- Organizer
  2019 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β2019
- Author(s)
  Tanabe Mikoto, Mai Anh Thi Nguyen, Kohei Hosokawa, Noriharu Nakagawa, Luis Espinoza, Hirohito Yamazaki, Shinji Nakao
- Organizer
  2019 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia2019
- Author(s)
  Hiroki Mizumaki, Kazuyoshi Hosomichi, Tatsuya Imi, Noriaki Tsuji, Tanabe Mikoto, Dung Cao Tran, Mai Anh Thi Nguyen, Yoshitaka Zaimoku, Kohei Hosokawa, Takamasa Katagiri, Fumihiro Azuma, Atsushi Tajima, Shinji Nakao
- Organizer
  2019 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia2018
- Author(s)
  Hiroki Mizumaki, Kazuyoshi Hosomichi, Tanabe Mikoto, Takeshi Yoroidaka, Tatsuya Imi, Yoshitaka Zaimoku, Kohei Hosokawa, Takamasa Katagiri, Hiroyuki Takamatsu, Tatsuhiko Ozawa, Fumihiro Azuma, Hiroyuki Kishi, Atsushi Tajima and Shinji Nakao
- Organizer
  2018 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184
[Presentation] Bystander Proliferation of Piga-Mutated Hematopoietic Progenitor Cells in Acquired Aplastic Anemia Patients Possessing HLA Class I Allele-Lacking Leukocytes2018
- Author(s)
  Takeshi Yoroidaka, Kohei Hosokawa, Tatsuya Imi, Takamasa Katagiri, Fumihiro Azuma and Shinji Nakao
- Organizer
  2018 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184
[Presentation] Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia2018
- Author(s)
  Kohei Hosokawa, Mahmoud Ibrahim Elbadry, Hiroki Mizumaki, Luis Espinoza, Noriharu Nakagawa, Kazuhisa Chonabayashi, Yoshinori Yoshida, Takamasa Katagiri, Yoshitaka Zaimoku, Tatsuya Imi, Nguyen Thi Mai Anh, Yoichi Fujii, Seishi Ogawa, Katsuto Takenaka, Koichi Akashi and Shinji Nakao
- Organizer
  2018 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184
[Presentation] 免疫性造血不全における変異造血幹細胞によるエスケープ造血2018
- Author(s)
  細川晃平、中尾眞二
- Organizer
  第80回　日本血液学会学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K16184
[Presentation] The Depletion of TGF-β Co-Receptor CD109 Induces Erythroid Differentiation of TF-1 Cells: A Model of Preferential Commitment of PIGA-Mutated Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure2018
- Author(s)
  Tanabe Mikoto, Noriharu Nakagawa, Kohei Hosokawa, Luis Espinoza, Kana Maruyama, Takamasa Katagiri, Hirohito Yamazaki and Shinji Nakao
- Organizer
  2018 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184

1. Katagiri Takamasa (60621159)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. 中尾眞二 (70217660)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. エスピノザホルヘルイス (30621213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Hosomichi Kazuyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. Young Neal. S.

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. NISHIMURA Jun-Ichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. YAMAZAKI Hirohito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. HARASHIMA Ai

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 植田康敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 中尾真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 平尾敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 小原直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山本靖彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosokawa Kohei 細川 晃平

Research Projects

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Co-Researchers

Identification of immunosuppressive agents that inhibit the expansion of PNH clones

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抗ネオ・セルフ抗体を利用した再生不良性貧血自己抗原の同定Principal Investigator

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Creation of a disease model using iPS cells from patients with autoimmune bone marrow failure and elucidation of selective hematopoietic regulation

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PNHクローンのエスケープメカニズムの解明

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Understanding the immune pathophysiology in acquired aplastic anemia with HLA-DR15 lacking cellsPrincipal Investigator

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Elucidation of the fundamental mechanism underlying hematopoietic control changes through a novel immune evasion mechanism in autoimmune bone marrow failure

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Understanding the immune pathophysiology in bone marrow failure patients with HLA-B*54:01Principal Investigator

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Identification of T cell pathway causing the acquired aplastic anemiaPrincipal Investigator

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[Book] Congenital and Acquired Bone Marrow Failure2017

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[Journal Article] A longitudinal analysis of paroxysmal nocturnal haemoglobinuria‐type cells in patients with bone marrow failure: Results of a prospective multi‐centre study in Japan2023

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[Journal Article] Correction: Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR152023

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[Journal Article] Immune pathophysiology of bone marrow failure2023

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[Journal Article] GPI(-) granulocyte populations in aplastic anemia and healthy individuals derived from a few PIGA-mutated hematopoietic stem progenitor cells2023

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Hosokawa Kohei 細川晃平

[Journal Article] HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic　anemia.2021