Hosokawa Kohei 細川晃平

Researcher Number	10786239
Other IDs	https://orcid.org/0000-0002-3423-1523
Affiliation (Current)	2021: 金沢大学, 附属病院, 助教
Affiliation (based on the past Project Information) *help	2021: 金沢大学, 大学病院, 助教 2018 – 2020: 金沢大学, 附属病院, 助教 2017: 金沢大学, 附属病院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 再生不良性貧血 / 造血不全 / 免疫学 / トランスクリプトーム解析 / HLA / iPS細胞 Except Principal Investigator 免疫学 / 自己免疫疾患 / iPS細胞 / HLA / 免疫不全マウス

HLA-DR15欠失血球陽性再生不良性貧血における免疫病態の解明Principal InvestigatorOngoing
- Principal Investigator
  
  細川晃平
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
自己免疫性造血不全における新たな免疫回避機構による造血制御変容の基盤的解明Ongoing
- Principal Investigator
  
  片桐孝和
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
HLA-B*54:01陽性造血不全患者における免疫病態の解明Principal InvestigatorOngoing
- Principal Investigator
  
  細川晃平
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
Identification of T cell pathway causing the acquired aplastic anemiaPrincipal Investigator
- Principal Investigator
  
  Hosokawa Kohei
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University

All 2019 2018 2017

All Journal Article Presentation Book Patent

[Book] Congenital and Acquired Bone Marrow Failure2017
- Author(s)
  Hosokawa K, Scheinberg P, and Young, N.S.
- Total Pages
  274
- Publisher
  Elsevier
- ISBN
  9780128041529
- Data Source
  KAKENHI-PROJECT-17K16184
[Journal Article] Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia2019
- Author(s)
  Elbadry MI, Ogawa S.et al.,
- Journal Title
  
  Haematologica
  
  Volume: - Pages: 210856-210856
- DOI
  10.3324/haematol.2018.210856
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-16H05335, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-16K09847, KAKENHI-PROJECT-17K19804, KAKENHI-PROJECT-17K16184, KAKENHI-PLANNED-15H05909, KAKENHI-PLANNED-16H06502, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-17K09007
[Journal Article] Acquired aplastic anemia2019
- Author(s)
  Hosokawa K, Nakao S
- Journal Title
  
  Jpn. J. Clin. Hematol.
  
  Volume: 60(5) Issue: 5 Pages: 417-422
- DOI
  10.11406/rinketsu.60.417
- NAID
  130007659585
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17823
[Journal Article] Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia.2019
- Author(s)
  Hosokawa K, Mizumaki H, Elbadry M, Saito C, Espinoza JL, An DTT, Katagiri T, Harashima A, Kikuchi A, Kanai A, Matsui H, Inaba T, Taniwaki M, Yamamoto Y, Nakao S
- Journal Title
  
  Leukemia
  
  Volume: 33 Pages: 2732-2737
- DOI
  10.1038/s41375-019-0510-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17823, KAKENHI-PROJECT-19H03686, KAKENHI-PROJECT-17K09007, KAKENHI-PROJECT-17K09822
[Journal Article] Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing2018
- Author(s)
  Banaszak LG, Giudice V, Zhao X, Wu Z, Gao S, Hosokawa K, Keyvanfar K, Townsley DM, Gutierrez-Rodrigues F, Fernandez Ibanez MDP, Kajigaya S, Young NS
- Journal Title
  
  Blood cells, molecules & diseases
  
  Volume: 69 Pages: 10-22
- DOI
  10.1016/j.bcmd.2017.12.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184
[Journal Article] Establishment of a flow cytometry assay for detecting paroxysmal nocturnal hemoglobinuria-type cells specific to patients with bone marrow failure.2018
- Author(s)
  Hosokawa Kohei、Sugimori Chiharu、Ishiyama Ken、Takamatsu Hiroyuki、Noji Hideyoshi、Shichishima Tsutomu、Obara Naoshi、Chiba Shigeru、Ninomiya Haruhiko、Shirasugi Yukari、Nakamura Yoshihiko、Ando Kiyoshi、Ueda Yasutaka、Yonemura Yuji、Kawaguchi Tatsuya、Nishimura Jun-ichi、Kanakura Yuzuru、Nakao Shinji
- Journal Title
  
  Annals of hematology
  
  Volume: 97 Pages: 2289-2297
- DOI
  10.1007/s00277-018-3443-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-17K16184
[Journal Article] T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways.2017
- Author(s)
  Hosokawa K, Kajigaya S, Keyvanfar K, Qiao W, Xie Y, Townsley DM, Feng X, Young NS.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 199(2) Pages: 477-488
- DOI
  10.4049/jimmunol.1601299
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184
[Patent] HLAクラスIアレルにおける機能喪失型共通変異の検出方法2019
- Inventor(s)
  水牧裕希、中尾眞二、細川晃平
- Industrial Property Rights Holder
  水牧裕希、中尾眞二、細川晃平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-090219
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β2019
- Author(s)
  Tanabe Mikoto, Mai Anh Thi Nguyen, Kohei Hosokawa, Noriharu Nakagawa, Luis Espinoza, Hirohito Yamazaki, Shinji Nakao
- Organizer
  2019 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] Distinct Escape Mechanisms of HLA Class I Allele-Lacking Hematopoietic Stem Progenitor Cells (HSPCs) from GPI-Deficient HSPCs in Acquired Aplastic Anemia2019
- Author(s)
  Noriaki Tsuji, Kohei Hosokawa, Takeshi Yoroidaka, Tanabe Mikoto, Hiroki Mizumaki, Shinji Nakao
- Organizer
  2019 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] Olfactomedin 4 Inhibits Erythroid Differentiation of Leukemic Cell Lines Induced By TGF-β: A Model of Preferential Commitment of Del(13q) Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure2019
- Author(s)
  Mai Anh Thi Nguyen, Kohei Hosokawa, Tanabe Mikoto, Md Mohiuddin, Takeshi Yoroidaka, Hiroki Mizumaki, Tatsuya Imi, Masaya Ueno, Atsushi Hirao, Shinji Nakao
- Organizer
  2019 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia2019
- Author(s)
  Hiroki Mizumaki, Kazuyoshi Hosomichi, Tatsuya Imi, Noriaki Tsuji, Tanabe Mikoto, Dung Cao Tran, Mai Anh Thi Nguyen, Yoshitaka Zaimoku, Kohei Hosokawa, Takamasa Katagiri, Fumihiro Azuma, Atsushi Tajima, Shinji Nakao
- Organizer
  2019 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia2019
- Author(s)
  Kohei Hosokawa, Eiji Kobayashi, Yoshiki Akatsuka, Luis Espinoza, Noriharu Nakagawa, Tanabe Mikoto, Noriaki Tsuji, Takeshi Yoroidaka, Hiroki Mizumaki, Thi Mai Anh Nguyen, Takamasa Katagiri, Kiyomi Shitaoka, Hiroshi Hamana, Hiroyuki Kishi, Shinji Nakao
- Organizer
  2019 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17823
[Presentation] Bystander Proliferation of Piga-Mutated Hematopoietic Progenitor Cells in Acquired Aplastic Anemia Patients Possessing HLA Class I Allele-Lacking Leukocytes2018
- Author(s)
  Takeshi Yoroidaka, Kohei Hosokawa, Tatsuya Imi, Takamasa Katagiri, Fumihiro Azuma and Shinji Nakao
- Organizer
  2018 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184
[Presentation] The Depletion of TGF-β Co-Receptor CD109 Induces Erythroid Differentiation of TF-1 Cells: A Model of Preferential Commitment of PIGA-Mutated Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure2018
- Author(s)
  Tanabe Mikoto, Noriharu Nakagawa, Kohei Hosokawa, Luis Espinoza, Kana Maruyama, Takamasa Katagiri, Hirohito Yamazaki and Shinji Nakao
- Organizer
  2018 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184
[Presentation] Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia2018
- Author(s)
  Kohei Hosokawa, Mahmoud Ibrahim Elbadry, Hiroki Mizumaki, Luis Espinoza, Noriharu Nakagawa, Kazuhisa Chonabayashi, Yoshinori Yoshida, Takamasa Katagiri, Yoshitaka Zaimoku, Tatsuya Imi, Nguyen Thi Mai Anh, Yoichi Fujii, Seishi Ogawa, Katsuto Takenaka, Koichi Akashi and Shinji Nakao
- Organizer
  2018 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184
[Presentation] Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia2018
- Author(s)
  Hiroki Mizumaki, Kazuyoshi Hosomichi, Tanabe Mikoto, Takeshi Yoroidaka, Tatsuya Imi, Yoshitaka Zaimoku, Kohei Hosokawa, Takamasa Katagiri, Hiroyuki Takamatsu, Tatsuhiko Ozawa, Fumihiro Azuma, Hiroyuki Kishi, Atsushi Tajima and Shinji Nakao
- Organizer
  2018 ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16184
[Presentation] 免疫性造血不全における変異造血幹細胞によるエスケープ造血2018
- Author(s)
  細川晃平、中尾眞二
- Organizer
  第80回　日本血液学会学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K16184

1. 片桐孝和 (60621159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. Hosomichi Kazuyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. Young Neal. S.

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. YOSHIDA Yoshinori

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. Tajima Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. HARASHIMA Ai

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中尾真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 竹中克斗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 蝶名林和久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 中川正宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 小原直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山本靖彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 金井昭教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 菊地晶裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosokawa Kohei 細川 晃平

Research Projects

Research Products

Co-Researchers

HLA-DR15欠失血球陽性再生不良性貧血における免疫病態の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自己免疫性造血不全における新たな免疫回避機構による造血制御変容の基盤的解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

HLA-B*54:01陽性造血不全患者における免疫病態の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of T cell pathway causing the acquired aplastic anemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Congenital and Acquired Bone Marrow Failure2017

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acquired aplastic anemia2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of a flow cytometry assay for detecting paroxysmal nocturnal hemoglobinuria-type cells specific to patients with bone marrow failure.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways.2017

Author(s)

Journal Title

DOI

Data Source

[Patent] HLAクラスIアレルにおける機能喪失型共通変異の検出方法2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β2019

Author(s)

Organizer

Data Source

[Presentation] Distinct Escape Mechanisms of HLA Class I Allele-Lacking Hematopoietic Stem Progenitor Cells (HSPCs) from GPI-Deficient HSPCs in Acquired Aplastic Anemia2019

Author(s)

Hosokawa Kohei 細川晃平