Kobayashi Norio 小林記緒

Researcher Number	10803885
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2022: 東北大学, 医学系研究科, 助教 2017: 東北大学, 医学系研究科, 産学官連携研究員
Review Section/Research Field	Principal Investigator Basic Section 44020:Developmental biology-related / Obstetrics and gynecology Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 58020:Hygiene and public health-related: including laboratory approach
Keywords	Principal Investigator DNAメチル化 / エピゲノム / ヒト精子 / 精子 / ヒト胎盤発生 / 栄養膜幹細胞 / 胚性幹細胞 / ゲノムインプリンティング / 転写因子 / 栄養膜幹細胞（TS細胞） … More / 胚体外細胞系譜 / 細胞運命決定 / 分化転換 / C19MC … More Except Principal Investigator 胎盤幹細胞 / オルガノイド / ヒト胎盤 / 妊娠高血圧症候群 / 母体ー胎児間相互作用 / 凍結胚移植 / 不妊治療 / 胎盤 / 低分子RNA（miRNA） / 生殖補助医療（ART） / 胚着床不全 Less

ヒト胎盤特異的なインプリント遺伝子C19MCの発現制御因子の解明Principal Investigator
- Principal Investigator
  
  小林記緒
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Tohoku University
ヒト胎盤形成のエピゲノム制御と母体－胎盤間分子シグナルコミュニケーションの理解
- Principal Investigator
  
  有馬隆博
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Tohoku University
凍結胚移植法によるART出生児の神経行動学的発達に及ぼす影響についての実証的研究
- Principal Investigator
  
  宮内尚子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Tohoku University
ヒト胎盤幹細胞を用いた胚着床オルガノイドの創出と着床不全細胞治療への挑戦
- Principal Investigator
  
  有馬隆博
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Tohoku University
ヒトES細胞から胚体外細胞系譜への分化転換に伴う分子機構の解明Principal Investigator
- Principal Investigator
  
  小林記緒
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Tohoku University
Epigenetics of Next-Generation Inheritance in Sperm AgingPrincipal Investigator
- Principal Investigator
  
  Kobayashi Norio
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Tohoku University

All 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] 加齢によるエピジェネティクス変異2019
- Author(s)
  服部裕充、小林記緒、岡江寛明、有馬隆博
- Total Pages
  6
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19K16135
[Book] ART治療における遺伝的安全性とリスク2019
- Author(s)
  宮内尚子、服部裕充、小林記緒、樋浦仁、有馬隆博
- Total Pages
  4
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-19K16135
[Book] Epigenetics in Human Disease, Second Edition2018
- Author(s)
  Hiura H, Hattori H, Kobayashi N, Takahashi S, Okae H, Arima T
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-17H06529
[Book] Therapeutic approaches to imprinting diseases. Epigenetics in Human Disease2018
- Author(s)
  Hattori H, Hiura H, Kobayashi N, Takahashi S, Okae H, Arima T.
- Total Pages
  6
- Publisher
  Academic Press.
- Data Source
  KAKENHI-PROJECT-17H06529
[Book] Handbook of Nutrition, Diet, and Epigenetics2017
- Author(s)
  Miyauchi N, Kitamura A, Hiura H, Okae H, Kobayashi N, Hattori H, Takahashi S, Arima T
- Publisher
  Springer International Publishing
- Data Source
  KAKENHI-PROJECT-17H06529
[Journal Article] Unique features and emerging in vitro models of human placental development2020
- Author(s)
  Shun Shibata, Eri H Kobayashi, Norio Kobayashi, Akira Oike, Hiroaki Okae, Takahiro Arima.
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 12 Pages: 301-313
- DOI
  10.1002/rmb2.12347
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16135, KAKENHI-PROJECT-20K22615, KAKENHI-PROJECT-20K22943, KAKENHI-PLANNED-19H05757, KAKENHI-PROJECT-18K09216
[Journal Article] Loss of p57KIP2expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells2019
- Author(s)
  Takahashi Sota、Okae Hiroaki、Kobayashi Norio、Kitamura Akane、Kumada Kanako、Yaegashi Nobuo、Arima Takahiro
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Pages: 26606-26613
- DOI
  10.1073/pnas.1916019116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09216, KAKENHI-PROJECT-19K16135, KAKENHI-PROJECT-19K18660, KAKENHI-PLANNED-19H05757, KAKENHI-PROJECT-17H04335
[Journal Article] Association of four imprinting disorders and ART.2019
- Author(s)
  Hattori H, Hiura H, Kitamura A, Miyauchi N, Kobayashi N, Takahashi S, Okae H, Kyono K, Kagami M, Ogata T, Arima T.
- Journal Title
  
  Clinical Epigenetics
  
  Volume: 11 Pages: 21-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06529
[Journal Article] The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study2019
- Author(s)
  Hattori Hiromitsu、Kitamura Akane、Takahashi Fumiaki、Kobayashi Norio、Sato Akiko、Miyauchi Naoko、Nishigori Hidekazu、Mizuno Satoshi、Sakurai Kasumi、Ishikuro Mami、Obara Taku、Tatsuta Nozomi、Nishijima Ichiko、Fujiwara Ikuma、Kuriyama Shinichi、Metoki Hirohito、Yaegashi Nobuo、Nakai Kunihiko、Arima Takahiro
- Journal Title
  
  Reproductive Biology and Endocrinology
  
  Volume: 17 Pages: 27-27
- DOI
  10.1186/s12958-019-0471-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08564, KAKENHI-PROJECT-17K09188, KAKENHI-PROJECT-19K16135, KAKENHI-PROJECT-19K18660
[Journal Article] The risk of secondary sex ratio imbalance and increased monozygotic twinning 1 after blastocyst transfer: data from The Japan Environment and Children’s Study.2019
- Author(s)
  Hattori H, Kitamura A, Takahashi F, Kobayashi N, Sato A, Miyauchi N, Nishigori H, Mizuno S, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Fujiwara I, Kuriyama S, Metoki H, Yaegashi N, Nakai K, Arima T, Japan Environment Children;s Study Group.
- Journal Title
  
  Reproductive Biology and Endocrinology
  
  Volume: 17 Pages: 27-27
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06529
[Journal Article] Association of four imprinting disorders and ART.2019
- Author(s)
  Hattori H, Hiura H, Kitamura A, Miyauchi N, Kobayashi N, Takahashi S, Okae H, Kyono K, Kagami M, Ogata T, Arima T.
- Journal Title
  
  Clinical Epigenetics
  
  Volume: 11 Pages: 21-21
- DOI
  10.1186/s13148-019-0623-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02355, KAKENHI-PROJECT-17K09188, KAKENHI-PROJECT-18K09216, KAKENHI-PROJECT-19K16135, KAKENHI-PROJECT-19K18660, KAKENHI-PROJECT-17H04204
[Journal Article] Genome-wide microRNA expression profiling in placentae from frozen-thawed blastocyst transfer2017
- Author(s)
  Hiura Hitoshi、Hattori Hiromitsu、Kobayashi Norio、Okae Hiroaki、Chiba Hatsune、Miyauchi Naoko、Kitamura Akane、Kikuchi Hiroyuki、Yoshida Hiroaki、Arima Takahiro
- Journal Title
  
  Clinical Epigenetics
  
  Volume: 9
- DOI
  10.1186/s13148-017-0379-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19709, KAKENHI-PROJECT-15K20121, KAKENHI-PROJECT-17H04335, KAKENHI-PROJECT-17H06529, KAKENHI-PROJECT-15K10657
[Journal Article] Transcriptomic signature of the follicular somatic compartment surrounding an oocyte with high developmental competence.2017
- Author(s)
  Sugimura Satoshi、Kobayashi Norio、Okae Hiroaki、Yamanouchi Tadayuki、Matsuda Hideo、Kojima Takumi、Yajima Akira、Hashiyada Yutaka、Kaneda Masahiro、Sato Kan、Imai Kei、Tanemura Kentaro、Arima Takahiro、Gilchrist Robert B.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 6815-6815
- DOI
  10.1038/s41598-017-07039-5
- NAID
  120006711707
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19709, KAKENHI-PROJECT-17H04335, KAKENHI-PROJECT-17H06529, KAKENHI-PROJECT-15K18768
[Presentation] ヒト胎盤幹細胞のエピジェネティクス2020
- Author(s)
  有馬隆博、岡江寛明、小林記緒
- Organizer
  第93回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16135
[Presentation] Epigenetic restriction of human pluripotency by silencing of the chromosome 19 miRNA cluster2020
- Author(s)
  岡江寛明、小林記緒、有馬隆博
- Organizer
  第43回日本分子生物学会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16135
[Presentation] 分化全能性の消失に関わるインプリント遺伝子の同定2020
- Author(s)
  岡江寛明、小林記緒、有馬隆博
- Organizer
  日本繁殖生物学会第113回大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16135
[Presentation] ヒト胎盤幹（TS）細胞の樹立とその細胞特性2019
- Author(s)
  小林記緒、樋浦仁、岡江寛明、有馬隆博
- Organizer
  第14回日本生殖発生医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06529
[Presentation] ヒト胚性幹細胞の栄養膜幹細胞への分化転換2019
- Author(s)
  小林記緒
- Organizer
  第42回日本分子生物学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16135
[Presentation] ARTによるエピジェネティクスの変調2018
- Author(s)
  小林記緒、樋浦仁、岡江寛明、有馬隆博
- Organizer
  第63回日本生殖医学会学術講演会・総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06529
[Presentation] ヒト胎盤のトロフォブラスト幹細胞の樹立と臨床への応用2018
- Author(s)
  小林記緒、樋浦仁、岡江寛明、有馬隆博
- Organizer
  第70回日本産科婦人科学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06529

1. 小林枝里 (70634971)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 有馬隆博 (80253532)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 柴田峻 (40885670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 宮内尚子 (60596162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. OGATA Tsutomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 北村茜

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. 岡江寛明

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
8. 大歳維知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 杉村智史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. Gilchrist Robert B

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 樋浦仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Norio 小林 記緒

Research Projects

Research Products

Co-Researchers

ヒト胎盤特異的なインプリント遺伝子C19MCの発現制御因子の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト胎盤形成のエピゲノム制御と母体－胎盤間分子シグナルコミュニケーションの理解

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

凍結胚移植法によるART出生児の神経行動学的発達に及ぼす影響についての実証的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト胎盤幹細胞を用いた胚着床オルガノイドの創出と着床不全細胞治療への挑戦

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトES細胞から胚体外細胞系譜への分化転換に伴う分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetics of Next-Generation Inheritance in Sperm AgingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 加齢によるエピジェネティクス変異2019

Author(s)

Total Pages

Publisher

Data Source

[Book] ART治療における遺伝的安全性とリスク2019

Author(s)

Total Pages

Publisher

Data Source

[Book] Epigenetics in Human Disease, Second Edition2018

Author(s)

Publisher

Data Source

[Book] Therapeutic approaches to imprinting diseases. Epigenetics in Human Disease2018

Author(s)

Total Pages

Publisher

Data Source

[Book] Handbook of Nutrition, Diet, and Epigenetics2017

Author(s)

Publisher

Data Source

[Journal Article] Unique features and emerging in vitro models of human placental development2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of p57KIP2expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of four imprinting disorders and ART.2019

Author(s)

Journal Title

Data Source

[Journal Article] The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study2019

Author(s)

Journal Title

Kobayashi Norio 小林記緒