Fukushima Keijo 福島圭穣

… Alternative Names

FUKUSHIMA Keijo 福島圭穣

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Researcher Number	10805112
Other IDs
Affiliation (Current)	2023: 徳島大学, 大学院医歯薬学研究部(薬学域), 助教
Affiliation (based on the past Project Information) *help	2019 – 2022: 徳島大学, 大学院医歯薬学研究部(薬学域), 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator 大腸がん / 薬理学 / プロスタグランジン受容体 / 薬学 / EP受容体 / プロスタノイド / EP3受容体 / EP4受容体 / プロスタグランジンE2 / バイオインフォマティクス / プロスタノイド受容体

プロスタノイドEP4受容体高発現大腸がんの治療的探索を目指した機能解析Principal Investigator
- Principal Investigator
  
  福島圭穣
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  The University of Tokushima
Elucidation of prostanoid receptor subtype conversion and colorectal cancer development/malignancy mechanismPrincipal Investigator
- Principal Investigator
  
  FUKUSHIMA Keijo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  The University of Tokushima

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Phosphatidylcholine-Plasmalogen-Oleic Acid Has Protective Effects against Arachidonic Acid-Induced Cytotoxicity2022
- Author(s)
  Yamagiwa Natsuki、Kobayashi Haruka、Okabayashi Haruka、Yasuda Miki、Fukushima Keijo、Kawamura Jun、Kotoura Satoshi、Fujino Hiromichi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 5 Pages: 643-648
- DOI
  10.1248/bpb.b22-00035
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-05-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16374
[Journal Article] The Gαs‐protein‐mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors2022
- Author(s)
  Fukushima Keijo、Senoo Kanaho、Kurata Naoki、Regan John W.、Fujino Hiromichi
- Journal Title
  
  FEBS Open Bio
  
  Volume: 12 Issue: 4 Pages: 775-783
- DOI
  10.1002/2211-5463.13378
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16374, KAKENHI-PROJECT-20K07084
[Journal Article] Identification of prophylactic drugs for oxaliplatin-induced peripheral neuropathy using big data.2022
- Author(s)
  Zamami Y, Niimura T, Kawashiri T, Goda M, Naito Y, Fukushima K, Ushio S, Aizawa F, Hamano H, Okada N, Yagi K, Miyata K, Takechi K, Chuma M, Koyama T, Kobayashi D, Shimazoe T, Fujino H, Izawa-Ishizawa Y, Ishizawa K.
- Journal Title
  
  Biomed Pharmacother.
  
  Volume: 148 Pages: 112744-112744
- DOI
  10.1016/j.biopha.2022.112744
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-19K07321, KAKENHI-PROJECT-19K10533, KAKENHI-PROJECT-19K16374, KAKENHI-PROJECT-19K16448, KAKENHI-PROJECT-20K16007
[Journal Article] The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD2 or PGE22021
- Author(s)
  Okura Iori、Hasuoka Nanae、Senoo Kanaho、Suganami Akiko、Fukushima Keijo、Regan John W.、Mashimo Masato、Murayama Toshihiko、Tamura Yutaka、Fujino Hiromichi
- Journal Title
  
  Pharmacological Reports
  
  Volume: - Issue: 3 Pages: 946-953
- DOI
  10.1007/s43440-021-00247-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16374, KAKENHI-PROJECT-19K07315, KAKENHI-PROJECT-20K07084, KAKENHI-PROJECT-20K21825
[Journal Article] Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity2021
- Author(s)
  Hamano H, Ikeda Y, Goda M, Fukushima K, Kishi S, Chuma M, Yamashita M, Niimura T, Takechi K, Imanishi M, Zamami Y, Horinouchi Y, Izawa-Ishizawa Y, Miyamoto L, Ishizawa K, Fujino H, Tamaki T, Aihara KI,
- Journal Title
  
  Kidney International
  
  Volume: 99 Issue: 4 Pages: 885-899
- DOI
  10.1016/j.kint.2020.10.041
- NAID
  120007175668
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-19K07321, KAKENHI-PROJECT-20K07132, KAKENHI-PROJECT-19K16374, KAKENHI-PROJECT-20K17285, KAKENHI-PLANNED-20H05799, KAKENHI-PROJECT-19J11675, KAKENHI-PROJECT-19K16448, KAKENHI-PLANNED-20H05798, KAKENHI-PROJECT-21H02646, KAKENHI-PROJECT-21K06682, KAKENHI-PROJECT-21K07914, KAKENHI-PROJECT-19K17745
[Journal Article] 15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling2020
- Author(s)
  Endo Suzu、Suganami Akiko、Fukushima Keijo、Senoo Kanaho、Araki Yumi、Regan John W.、Mashimo Masato、Tamura Yutaka、Fujino Hiromichi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 38 Pages: 13338-13352
- DOI
  10.1074/jbc.ra120.013988
- NAID
  120007182108
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07315, KAKENHI-PROJECT-20K07084, KAKENHI-PROJECT-20K21825, KAKENHI-PROJECT-19K16374
[Journal Article] Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway2020
- Author(s)
  Hamano Hirofumi、Niimura Takahiro、Horinouchi Yuya、Zamami Yoshito、Takechi Kenshi、Goda Mitsuhiro、Imanishi Masaki、Chuma Masayuki、Izawa-Ishizawa Yuki、Miyamoto Licht、Fukushima Keijo、Fujino Hiromichi、Tsuchiya Koichiro、Ishizawa Keisuke、Tamaki Toshiaki、Ikeda Yasumasa
- Journal Title
  
  Toxicology Letters
  
  Volume: 318 Pages: 86-91
- DOI
  10.1016/j.toxlet.2019.10.016
- NAID
  120006894295
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-18K08480, KAKENHI-PROJECT-19K07321, KAKENHI-PROJECT-18K14983, KAKENHI-PROJECT-19H00341, KAKENHI-PROJECT-17K18262, KAKENHI-PROJECT-19K16374, KAKENHI-PROJECT-19K16448, KAKENHI-PROJECT-19J11675
[Journal Article] Fibroblast-specific ERK5 deficiency changes tumor vasculature and exacerbates tumor progression in a mouse model.2020
- Author(s)
  Masaki Imanishi, Yusuke Yamakawa, Keijo Fukushima, Raiki Ikuto, Akiko Maegawa, Yuki Izawa-Ishizawa, Yuya Horinouchi, Masateru Kondo, Masatoshi Kishuku, Mitsuhiro Goda, Yoshito Zamami, Kenshi Takechi, Masayuki Chuma, Yasumasa Ikeda, Koichiro Tsuchiya, Hiromichi Fujino, Koichi Tsuneyama, Keisuke Ishizawa
- Journal Title
  
  Naunyn-Schmiedeberg's Archives of Pharmacology
  
  Volume: - Issue: 7 Pages: 1239-1250
- DOI
  10.1007/s00210-020-01859-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07321, KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-19K16374, KAKENHI-PROJECT-18K06686, KAKENHI-PROJECT-18K08480, KAKENHI-PROJECT-18K14983
[Journal Article] Factors Associated With Immune Checkpoint Inhibitor?Related Myocarditis2019
- Author(s)
  Zamami Yoshito、Niimura Takahiro、Okada Naoto、Koyama Toshihiro、Fukushima Keijo、Izawa-Ishizawa Yuki、Ishizawa Keisuke
- Journal Title
  
  JAMA Oncology
  
  Volume: 5 Issue: 11 Pages: 1635-1635
- DOI
  10.1001/jamaoncol.2019.3113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-19K07321, KAKENHI-PROJECT-19K16374, KAKENHI-PROJECT-19K16414, KAKENHI-PROJECT-19J11675
[Journal Article] Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells2019
- Author(s)
  Kurata Naoki、Tokashiki Natsumi、Fukushima Keijo、Misao Takaya、Hasuoka Nanae、Kitagawa Kana、Mashimo Masato、Regan John W.、Murayama Toshihiko、Fujino Hiromichi
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 853 Pages: 308-315
- DOI
  10.1016/j.ejphar.2019.04.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16374, KAKENHI-PROJECT-17K08308
[Journal Article] A I131V Substitution in the Fusion Glycoprotein of Human Parainfluenza Virus Type 1 Enhances Syncytium Formation and Virus Growth2019
- Author(s)
  Keijo Fukushima*, Tadanobu Takahashi* (*They contributed equally as first authors), Masahiro Takaguchi, Seigo Ito, Chihiro Suzuki, Takashi Agarikuchi, Yuuki Kurebayashi, Akira Minami, Takashi Suzuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 5 Pages: 827-832
- DOI
  10.1248/bpb.b18-00714
- NAID
  130007641461
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05644, KAKENHI-PROJECT-16K08277, KAKENHI-PROJECT-18K14905, KAKENHI-PROJECT-19K16374
[Presentation] プロスタグランジンD2の代謝物はDPプロスタノイド受容体に対してバイアスアゴニストとして働く2022
- Author(s)
  妹尾香奈穂, 山本瞳, 遠藤すず, リーガンジョン, 福島圭穣, 藤野裕道
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] アラキドン酸による神経毒性を緩和するプラズマローゲン作用の解明2022
- Author(s)
  小林春花, 岡林春花, 安田美紀, 福島圭穣, 川村純, 琴浦聡, 藤野裕道
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] プロスタノイドEP4受容体の1アミノ酸変異によるシグナル伝達プロファイル変化2022
- Author(s)
  大西朗人, 東山晃子, 柳川瞬矢, 清良尚史, リーガンジョン, 大川内健人, 傳田将也, 福島圭穣, 大髙章, 藤野裕道
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] Resolvin E-seriesの炎症収束作用の検討2022
- Author(s)
  濵口綾花, 福島圭穣, 福田隼人, 藤原広一, 周東智, 藤野裕道
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] EP4プロスタノイド受容体を介したプロスタグランジンD2のバイアス性による抗癌作用2021
- Author(s)
  鷹野　晴美、妹尾　香奈穂、山下　真由、荒木　祐美、Regan John W、福島　圭穣、藤野　裕道
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] シスプラチン起因性腎障害の予防薬の同定2021
- Author(s)
  池田　康将、濱野　裕章、合田　光寛、福島　圭穣、岸　誠司、中馬　真幸、座間味　義人、宮本　理人、石澤　啓介、藤野　裕道、粟飯原　賢一、土屋　浩一郎、玉置　俊晃
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] 結腸癌転移に関与するヒスタミンH1受容体作用の解明2021
- Author(s)
  松本　礼、植木　花織、増田　雄大、間下　雅士、福島　圭穣、藤野　裕道
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] PGE2による結腸がん細胞内代謝変化の解析2021
- Author(s)
  松本　聖加、中野　佑基、高橋　弘喜、楠屋　陽子、村山　俊彦、福島　圭穣、藤野　裕道
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] 内因性カンナビノイドによる抗結腸がんメカニズムの解明2021
- Author(s)
  三竿　顕也、福島　圭穣、藤野　裕道
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] PGD2およびその代謝物によるCRTH2受容体へのバイアス作用の解明2021
- Author(s)
  蓮岡　奈苗、縣　美穂、間下　雅士、福島　圭穣、藤野　裕道
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] ヒト結腸がんHCA-7細胞においてインターロイキン4はEP4プロスタノイド受容体発現を抑制する2020
- Author(s)
  北川加奈, 濱口綾花, 間下雅士, Regan John W., 福島圭穣, 藤野裕道
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] アラキドン酸による神経毒性作用を緩和する有効な生理活性脂質としてのプラズマローゲン種の同定2020
- Author(s)
  山際菜月, 小林春花, 福島圭穣, 岡林春花, 川村純, 琴浦聡, 藤野裕道
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] inteinシステムを用いたプロスタノイドEP4受容体の局在解析を目指して2020
- Author(s)
  杉山学, 大西朗人, 森崎巧也, 重永章, 福島圭穣, 大高章, 藤野裕道
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] PGE2代謝物 15-keto-PGE2はバイアスアゴニストとしてEP2およびEP4プロスタノイド受容体に作用する2020
- Author(s)
  遠藤すず, 妹尾香奈穂, 鷹野晴美, 荒木祐美, Regan John W., 福島圭穣, 藤野裕道
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] 抗ヒスタミン薬による大腸がん誘発への有害事象の検討2019
- Author(s)
  増田雄大, 松本聖加, 松本礼, 福島圭穣, 藤野裕道
- Organizer
  第26回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] 大規模医療情報を用いたニコランジルの心肺停止後予後改善効果の検討2019
- Author(s)
  新村貴博, 座間味義人, 石澤有紀, 合田光寛, 武智研志, 中馬真幸, 福島圭穣, 堀ノ内裕也, 池田康将, 藤野裕道, 土屋浩一郎, 石澤啓介
- Organizer
  医療薬学フォーラム2019／第27回クリニカルファーマシーシンポジウム
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] 医療ビッグデータを活用したシスプラチン誘発腎障害に対する新規予防薬の探索とその有効性の検証2019
- Author(s)
  合田光寛, 斉家和仁, 前川晃子, 神田将哉, 吉田愛美, 村井陽一, 新村貴博, 石澤有紀, 座間味義人, 中馬真幸, 武智研志, 濱野裕章, 岡田直人, 福島圭穣, 藤野裕道, 土屋浩一郎, 堀ノ内裕也, 池田康将, 楊河宏章, 石澤啓介
- Organizer
  第４回中四国臨床薬理学会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] 医療ビッグデータ解析と基礎研究を融合した薬剤性副作用の機序解明および治療薬の開発2019
- Author(s)
  新村貴博, 座間味義人, 石澤有紀, 合田光寛, 武智研志, 中馬真幸, 福島圭穣, 堀ノ内裕也, 池田康将, 藤野裕道, 土屋浩一郎, 石澤啓介
- Organizer
  第29回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] ドラッグリポジショニング手法を用いたシスプラチン誘発腎障害に対する新規予防薬探索2019
- Author(s)
  合田光寛, 神田将哉, 前川晃子, 吉田愛美, 新村貴博, 石澤有紀, 座間味義人, 中馬真幸, 武智研志, 福島圭穣, 藤野裕道, 土屋浩一郎, 堀ノ内　裕也, 池田康将, 石澤啓介
- Organizer
  第29回日本循環薬理学会・第55回高血圧関連疾患モデル学会
- Data Source
  KAKENHI-PROJECT-19K16374
[Presentation] 大規模医療情報データベースを活用したシスプラチン誘発腎障害に対する新規予防薬の探索とその有効性の検証2019
- Author(s)
  合田光寛, 神田将哉, 前川晃子, 新村貴博, 石澤有紀, 座間味義人, 中馬真幸, 武智研志, 濱野裕章, 岡田直人, 福島圭穰, 藤野裕道, 土屋浩一郎, 堀ノ内裕也, 池田康将, 楊河宏章, 石澤啓介
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16374

1. GODA Mitsuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
2. TAMURA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. SUGANAMI Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 座間味義人

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
5. 今西正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 武智研志

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. 中馬真幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
8. 石澤有紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 堀ノ内裕也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fukushima Keijo 福島 圭穣

FUKUSHIMA Keijo 福島 圭穣

Research Projects

Research Products

Co-Researchers

プロスタノイドEP4受容体高発現大腸がんの治療的探索を目指した機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of prostanoid receptor subtype conversion and colorectal cancer development/malignancy mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Phosphatidylcholine-Plasmalogen-Oleic Acid Has Protective Effects against Arachidonic Acid-Induced Cytotoxicity2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] The Gαs‐protein‐mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of prophylactic drugs for oxaliplatin-induced peripheral neuropathy using big data.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD2 or PGE22021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Fibroblast-specific ERK5 deficiency changes tumor vasculature and exacerbates tumor progression in a mouse model.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Factors Associated With Immune Checkpoint Inhibitor?Related Myocarditis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A I131V Substitution in the Fusion Glycoprotein of Human Parainfluenza Virus Type 1 Enhances Syncytium Formation and Virus Growth2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Fukushima Keijo 福島圭穣

FUKUSHIMA Keijo 福島圭穣