Murase Hirotaka 村瀬裕貴

Researcher Number	10814486
Other IDs	https://orcid.org/0000-0001-5747-191X
Affiliation (Current)	2025: 崇城大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 崇城大学, 薬学部, 助教 2021 – 2022: 長崎国際大学, 薬学部, 特任助教 2020: 長崎国際大学, 薬学部, 博士研究員 2019: 名古屋大学, 理学研究科, 特任助教 2018: 名古屋大学, 理学研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator 低分子リガンド / RNA / 化学修飾 / 転移修飾核酸 / N4-acetylcytidine (ac4C) / 核酸化学 / 合成後修飾 / アセチル化剤 / 6-Thioguanine / 反応性オリゴ核酸 … More / 官能基転移 / RNA部位特異的化学修飾 / 生体機能分子 / RNAヘアピンループ / 疾患関連リピート配列 / G-clamp / 核酸アナログ / リピートRNA / RNA構造変化 / RNA構造変換 / ステム-ループ構造 / グアニン4重鎖 / repeat expansion disease / CGG repeat RNA / RNA構造変化誘起剤 / 機能性分子 / 脆弱X関連振戦/失調症候群(FXTAS) / G-quadruplex / リピート病 / RNA構造変化誘起 / 低分子G-clamp / G4重鎖 / ステム-ループ / G-Gミスマッチ / CGGリピートRNA / RNA高次構造 / RNA結合性低分子 / 蛍光ON型プローブ / 縮合反応 / 多機能化 / コンジュゲーション / 新規RNA結合分子 / 蛍光プローブ / pre-miRNA / RNA 高次構造 / 水素結合 / 分子認識 … More Except Principal Investigator ナンセンス変異 / 未熟停止コドン / リードスルー / 化学修飾mRNA / 核酸医薬 / FMR1 / 遺伝子発現促進 / 分子集積薬 / 低分子リガンド / CGGリピー / 翻訳活性化 / 転写活性化 / 低分子創薬 / CGGリピート / FMR1遺伝子 / リピート病 / 脆弱X症候群 Less

Basic research into nucleic acid drugs that induce readthrough by chemically modifying the adenosine at the premature termination codon
- Principal Investigator
  
  佐々木茂貴
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Nagasaki International University
シトシンN4位の部位特異的アシル基修飾法の開発Principal Investigator
- Principal Investigator
  
  村瀬裕貴
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Sojo University
Development of small molecule drugs for fragile X syndrome based on ligands that cooperatively accumulate on the CGG repeats.
- Principal Investigator
  
  佐々木茂貴
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Nagasaki International University
Development of small molecular ligands that bind to repeat RNA and induce a conformational change of RNA higher-order structurePrincipal Investigator
- Principal Investigator
  
  Murase Hirotaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Nagasaki International University
Development of the recognition molecules for pre-miRNA based on the hydrogen bondingPrincipal Investigator
- Principal Investigator
  
  Murase Hirotaka
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Nagoya University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA2023
- Author(s)
  Murase Hirotaka、Lee Jeongsu、Taniguchi Yosuke、Sasaki Shigeki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 1 Pages: 64-69
- DOI
  10.1248/cpb.c22-00738
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-01-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15398, KAKENHI-PROJECT-23K27301
[Journal Article] Development of a selective ligand for G-G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure2022
- Author(s)
  Murase Hirotaka, Nagatsugi Fumi, Sasaki Shigeki
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 20 Issue: 16 Pages: 3375-3381
- DOI
  10.1039/d2ob00279e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15398, KAKENHI-PROJECT-20H02855, KAKENHI-PROJECT-21K19038
[Journal Article] Application of the Functionality Transfer Oligodeoxynucleotide for the Site-Selective Modification of RNA with a Divers Molecule2022
- Author(s)
  Togo N., Murase H., Lee J., Taniguchi Y. and Sasaki S.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 70 Issue: 7 Pages: 498-504
- DOI
  10.1248/cpb.c22-00288
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2022-07-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03351, KAKENHI-PROJECT-20K15398
[Journal Article] Artificial Host Molecules to Covalently Capture 8-Nitro-cGMP in Neutral Aqueous Solutions and in Cells2021
- Author(s)
  Y. Fuchi, H. Murase, R. Kai, K. Kurata, S. Karasawa, and S. Sasaki*
- Journal Title
  
  Bioconjugate Chem
  
  Volume: 32 Issue: 2 Pages: 385-393
- DOI
  10.1021/acs.bioconjchem.1c00012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07016, KAKENHI-PROJECT-20K15398, KAKENHI-PROJECT-20K15963, KAKENHI-PROJECT-18H02558
[Journal Article] Protection of all cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme, indicative of simultaneous binding of small ligands2020
- Author(s)
  Murase Hirotaka、Wakisaka Gentaro、Noguchi Tomoharu、Sasaki Shigeki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 20 Pages: 115730-115730
- DOI
  10.1016/j.bmc.2020.115730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15398, KAKENHI-PROJECT-18H02558
[Journal Article] 核酸の高次構造・特殊配列に結合する低分子化合物-基盤分子の開発/評価法の構築-2020
- Author(s)
  村瀬裕貴
- Journal Title
  
  日本核酸化学会誌
  
  Volume: 4 Pages: 15-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15398
[Journal Article] Development of the binding molecules for the RNA higher-order structures based on the guanine-recognition by the G-clamp2019
- Author(s)
  Murase Hirotaka、Nagatsugi Fumi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Issue: 11 Pages: 1320-1324
- DOI
  10.1016/j.bmcl.2019.03.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14330, KAKENHI-PLANNED-15H05838
[Patent] 核酸の部位特異的アシル修飾剤2023
- Inventor(s)
  村瀬裕貴
- Industrial Property Rights Holder
  学校法人君が淵学園
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-112639
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K06064
[Presentation] CGGリピート配列への低分子集積によるFMR1遺伝子の転写活性化2024
- Author(s)
  村瀬裕貴、川久保厚佑、塩田倫史、佐々木茂貴
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-23K21354
[Presentation] CGGリピート関連疾患に対する低分子創薬2024
- Author(s)
  村瀬裕貴、塩田倫史、佐々木茂貴
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06064
[Presentation] CGGリピート関連疾患に対する低分子創薬2024
- Author(s)
  村瀬裕貴、塩田倫史、佐々木茂貴
- Organizer
  日本薬学会第143回年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21354
[Presentation] Study on read-through of premature termination codon by site-specific chemical modification2023
- Author(s)
  Jeongsu Lee, Hirotaka Murase, Norihiro Togo, Yosuke Taniguchi, Shigeki Sasaki
- Organizer
  The 50th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21354
[Presentation] 部位特異的化学修飾法を基盤としたRNAの分子修飾とラベル化2023
- Author(s)
  村瀬裕貴、都甲典弘、李政洙、谷口陽祐、佐々木茂貴
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] Development of new oligonucleotide agents for site specific RNA acetylation2023
- Author(s)
  Hirotaka Murase, Jeongsu Lee, Yosuke Taniguchi, Shuhei Imoto, Shigeki Sasaki
- Organizer
  The 50th international Symposium on Nucleic Acids Chemistry (ISNAC)
- Data Source
  KAKENHI-PROJECT-23K06064
[Presentation] Read-through of the premature-termination codon (PTC) based on the site-specific chemical modifications of mRNA2023
- Author(s)
  Hirotaka Murase, Jeongsu Lee, Yosuke Taniguchi, Shigeki Sasaki
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23K06064
[Presentation] mRNAの部位特異的分子修飾による未熟終止コドン(PTC)のリードスルー2023
- Author(s)
  村瀬裕貴、李政洙、谷口陽祐、佐々木茂貴
- Organizer
  核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23K21354
[Presentation] Development of a new oligonucleotide agent for site-specific RNA acetylation2023
- Author(s)
  Hirotaka Murase, Jeongsu Lee, Yosuke Taniguchi, Shuhei Imoto, Shigeki Sasaki
- Organizer
  The 50th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21354
[Presentation] Development of a small-molecule inducer that converts the G-quadruplex structure of CGG repetitive RNA to a hairpin form2022
- Author(s)
  Hirotaka Murase, Fumi Nagatsugi, Shigeki Sasaki
- Organizer
  The 49th international Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] CGGリピートRNAの構造変換を誘起する1,3-diazaphenoxazine誘導体の開発2022
- Author(s)
  村瀬裕貴、永次史、佐々木茂貴
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] 天然及び人工核酸の部位特異的化学修飾とその応用2022
- Author(s)
  村瀬裕貴、都甲典弘、李政洙、谷口陽祐、佐々木茂貴
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] CGGリピートRNAの構造変換を誘起する1,3-diazaphenoxazine誘導体の開発2022
- Author(s)
  村瀬裕貴、永次史、佐々木茂貴
- Organizer
  日本薬学会　第１４２年会
- Data Source
  KAKENHI-PROJECT-23K21354
[Presentation] RNAの高次構造変化を誘起する新規低分子リガンドの開発2021
- Author(s)
  村瀬裕貴、永次史、佐々木茂貴
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] CGG-リピートRNA に結合する低分子型G-clamp 誘導体の開発2021
- Author(s)
  村瀬裕貴、永次史、佐々木茂貴
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] CGG-リピートRNA に結合する低分子型G-clamp 誘導体の開発2021
- Author(s)
  村瀬裕貴、永次史、佐々木茂貴
- Organizer
  日本ケミカルバイオロジー学会　第15回年会
- Data Source
  KAKENHI-PROJECT-23K21354
[Presentation] Development of the small molecular binder for the r(CGG) repeat2021
- Author(s)
  Hirotaka Murase, Fumi Nagatsugi, Shigeki Sasaki
- Organizer
  IS3NA-IRT Virtual Symposium 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] リピートDNA配列中の複数連続する結合サイトに協奏的に全サイト結合する低分子リガンドの開発2020
- Author(s)
  村瀬裕貴、脇坂元太郎、野口幹晴、 Ting Wu、佐々木茂貴
- Organizer
  反応と合成の進歩2020特別企画シンポジウム
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] G-clampによるグアニン認識を基本としたRNA高次構造結合性低分子リガンドの開発2019
- Author(s)
  村瀬裕貴、永次史
- Organizer
  日本薬学会第１３９年会
- Data Source
  KAKENHI-PROJECT-18K14330
[Presentation] 1,3-ジアザフェノキサジン環によるグアニン認識を利用したRNA高次構造検出プローブの開発2018
- Author(s)
  村瀬裕貴、永次史
- Organizer
  日本ケミカルバイオロジー学会第１３回年会
- Data Source
  KAKENHI-PROJECT-18K14330
[Presentation] Development of small molecular G-clamp derivatives binding to RNA higher-order structure2018
- Author(s)
  Hirotaka Murase, Fumi Nagatsugi
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14330
[Presentation] 制限酵素阻害アッセイによるChromomycin A3の繰り返しDNAに対する同時結合性の評価2018
- Author(s)
  村瀬裕貴、野口幹晴、脇坂元太郎、Ting Wu、佐々木茂貴
- Organizer
  第６０回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-18K14330
[Presentation] Development of fluorescent probe for RNA higher-order structure2018
- Author(s)
  Hirotaka Murase, Fumi Nagatsugi
- Organizer
  The 23rd International Roundtable on Nucleosides, Nucleotides and Nucleic acids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14330

1. 佐々木茂貴 (10170672)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. 塩田倫史 (00374950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 山田耕平 (40583232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 吉田達貞 (80527557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 西奥剛 (90435115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 唐沢悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 渕靖史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Murase Hirotaka 村瀬 裕貴

Research Projects

Research Products

Co-Researchers

Basic research into nucleic acid drugs that induce readthrough by chemically modifying the adenosine at the premature termination codon

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

シトシンN4位の部位特異的アシル基修飾法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of small molecule drugs for fragile X syndrome based on ligands that cooperatively accumulate on the CGG repeats.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of small molecular ligands that bind to repeat RNA and induce a conformational change of RNA higher-order structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the recognition molecules for pre-miRNA based on the hydrogen bondingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Development of a selective ligand for G-G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Application of the Functionality Transfer Oligodeoxynucleotide for the Site-Selective Modification of RNA with a Divers Molecule2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Artificial Host Molecules to Covalently Capture 8-Nitro-cGMP in Neutral Aqueous Solutions and in Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protection of all cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme, indicative of simultaneous binding of small ligands2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 核酸の高次構造・特殊配列に結合する低分子化合物-基盤分子の開発/評価法の構築-2020

Author(s)

Journal Title

Data Source

[Journal Article] Development of the binding molecules for the RNA higher-order structures based on the guanine-recognition by the G-clamp2019

Author(s)

Journal Title

DOI

Data Source

[Patent] 核酸の部位特異的アシル修飾剤2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Murase Hirotaka 村瀬裕貴