Murase Hirotaka 村瀬裕貴

Researcher Number	10814486
Other IDs
Affiliation (Current)	2023: 崇城大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2023: 崇城大学, 薬学部, 助教 2021: 長崎国際大学, 薬学部, 特任助教 2020: 長崎国際大学, 薬学部, 博士研究員 2019: 名古屋大学, 理学研究科, 特任助教 2018: 名古屋大学, 理学研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator 低分子リガンド / 分子認識 / 水素結合 / RNA 高次構造 / pre-miRNA / 蛍光プローブ / 新規RNA結合分子 / コンジュゲーション / 多機能化 / 縮合反応 … More / 蛍光ON型プローブ / RNA結合性低分子 / RNA高次構造 / CGG repeat RNA / repeat expansion disease / グアニン4重鎖 / ステム-ループ構造 / RNA構造変換 / RNA構造変化 / リピートRNA / 核酸アナログ / G-clamp / 疾患関連リピート配列 / RNAヘアピンループ / 生体機能分子 / 核酸化学 / N4-acetylcytidine (ac4C) / 転移修飾核酸 / 化学修飾 / RNA … More Except Principal Investigator 脆弱X症候群 / リピート病 / FMR1遺伝子 / CGGリピー / 低分子創薬 / 低分子リガンド / 分子集積薬 / 遺伝子発現促進 / CGGリピート / 転写活性化 / 翻訳活性化 / FMR1 Less

シトシンN4位の部位特異的アシル基修飾法の開発Principal Investigator
- Principal Investigator
  
  村瀬裕貴
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Sojo University
Drug discovery for fragile X syndrome based on the small molecular ligands that form self-assembles on the CGG repeats
- Principal Investigator
  
  佐々木茂貴
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Nagasaki International University
リピートRNAに結合し高次構造変化を誘起する新規低分子リガンドの開発Principal Investigator
- Principal Investigator
  
  村瀬裕貴
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Nagasaki International University
Development of the recognition molecules for pre-miRNA based on the hydrogen bondingPrincipal Investigator
- Principal Investigator
  
  Murase Hirotaka
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Nagoya University

All 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Development of a selective ligand for G-G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure2022
- Author(s)
  Murase Hirotaka, Nagatsugi Fumi, Sasaki Shigeki
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 20 Issue: 16 Pages: 3375-3381
- DOI
  10.1039/d2ob00279e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15398
[Journal Article] Artificial Host Molecules to Covalently Capture 8-Nitro-cGMP in Neutral Aqueous Solutions and in Cells2021
- Author(s)
  Y. Fuchi, H. Murase, R. Kai, K. Kurata, S. Karasawa, and S. Sasaki*
- Journal Title
  
  Bioconjugate Chem
  
  Volume: 32 Issue: 2 Pages: 385-393
- DOI
  10.1021/acs.bioconjchem.1c00012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07016, KAKENHI-PROJECT-20K15398, KAKENHI-PROJECT-20K15963, KAKENHI-PROJECT-18H02558
[Journal Article] 核酸の高次構造・特殊配列に結合する低分子化合物-基盤分子の開発/評価法の構築-2020
- Author(s)
  村瀬裕貴
- Journal Title
  
  日本核酸化学会誌
  
  Volume: 4 Pages: 15-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15398
[Journal Article] Protection of all cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme, indicative of simultaneous binding of small ligands2020
- Author(s)
  Murase Hirotaka、Wakisaka Gentaro、Noguchi Tomoharu、Sasaki Shigeki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 20 Pages: 115730-115730
- DOI
  10.1016/j.bmc.2020.115730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15398, KAKENHI-PROJECT-18H02558
[Journal Article] Development of the binding molecules for the RNA higher-order structures based on the guanine-recognition by the G-clamp2019
- Author(s)
  Murase Hirotaka、Nagatsugi Fumi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Issue: 11 Pages: 1320-1324
- DOI
  10.1016/j.bmcl.2019.03.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14330, KAKENHI-PLANNED-15H05838
[Presentation] CGGリピートRNAの構造変換を誘起する1,3-diazaphenoxazine誘導体の開発2022
- Author(s)
  村瀬裕貴、永次史、佐々木茂貴
- Organizer
  日本薬学会　第１４２年会
- Data Source
  KAKENHI-PROJECT-21H02612
[Presentation] CGGリピートRNAの構造変換を誘起する1,3-diazaphenoxazine誘導体の開発2022
- Author(s)
  村瀬裕貴、永次史、佐々木茂貴
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] RNAの高次構造変化を誘起する新規低分子リガンドの開発2021
- Author(s)
  村瀬裕貴、永次史、佐々木茂貴
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] CGG-リピートRNA に結合する低分子型G-clamp 誘導体の開発2021
- Author(s)
  村瀬裕貴、永次史、佐々木茂貴
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] Development of the small molecular binder for the r(CGG) repeat2021
- Author(s)
  Hirotaka Murase, Fumi Nagatsugi, Shigeki Sasaki
- Organizer
  IS3NA-IRT Virtual Symposium 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] CGG-リピートRNA に結合する低分子型G-clamp 誘導体の開発2021
- Author(s)
  村瀬裕貴、永次史、佐々木茂貴
- Organizer
  日本ケミカルバイオロジー学会　第15回年会
- Data Source
  KAKENHI-PROJECT-21H02612
[Presentation] リピートDNA配列中の複数連続する結合サイトに協奏的に全サイト結合する低分子リガンドの開発2020
- Author(s)
  村瀬裕貴、脇坂元太郎、野口幹晴、 Ting Wu、佐々木茂貴
- Organizer
  反応と合成の進歩2020特別企画シンポジウム
- Data Source
  KAKENHI-PROJECT-20K15398
[Presentation] G-clampによるグアニン認識を基本としたRNA高次構造結合性低分子リガンドの開発2019
- Author(s)
  村瀬裕貴、永次史
- Organizer
  日本薬学会第１３９年会
- Data Source
  KAKENHI-PROJECT-18K14330
[Presentation] 1,3-ジアザフェノキサジン環によるグアニン認識を利用したRNA高次構造検出プローブの開発2018
- Author(s)
  村瀬裕貴、永次史
- Organizer
  日本ケミカルバイオロジー学会第１３回年会
- Data Source
  KAKENHI-PROJECT-18K14330
[Presentation] 制限酵素阻害アッセイによるChromomycin A3の繰り返しDNAに対する同時結合性の評価2018
- Author(s)
  村瀬裕貴、野口幹晴、脇坂元太郎、Ting Wu、佐々木茂貴
- Organizer
  第６０回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-18K14330
[Presentation] Development of fluorescent probe for RNA higher-order structure2018
- Author(s)
  Hirotaka Murase, Fumi Nagatsugi
- Organizer
  The 23rd International Roundtable on Nucleosides, Nucleotides and Nucleic acids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14330
[Presentation] Development of small molecular G-clamp derivatives binding to RNA higher-order structure2018
- Author(s)
  Hirotaka Murase, Fumi Nagatsugi
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14330

1. 佐々木茂貴 (10170672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 塩田倫史 (00374950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 唐沢悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 渕靖史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Murase Hirotaka 村瀬 裕貴

Research Projects

Research Products

Co-Researchers

シトシンN4位の部位特異的アシル基修飾法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery for fragile X syndrome based on the small molecular ligands that form self-assembles on the CGG repeats

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

リピートRNAに結合し高次構造変化を誘起する新規低分子リガンドの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the recognition molecules for pre-miRNA based on the hydrogen bondingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Development of a selective ligand for G-G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Artificial Host Molecules to Covalently Capture 8-Nitro-cGMP in Neutral Aqueous Solutions and in Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 核酸の高次構造・特殊配列に結合する低分子化合物-基盤分子の開発/評価法の構築-2020

Author(s)

Journal Title

Data Source

[Journal Article] Protection of all cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme, indicative of simultaneous binding of small ligands2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of the binding molecules for the RNA higher-order structures based on the guanine-recognition by the G-clamp2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] CGGリピートRNAの構造変換を誘起する1,3-diazaphenoxazine誘導体の開発2022

Author(s)

Organizer

Data Source

[Presentation] CGGリピートRNAの構造変換を誘起する1,3-diazaphenoxazine誘導体の開発2022

Author(s)

Organizer

Data Source

[Presentation] RNAの高次構造変化を誘起する新規低分子リガンドの開発2021

Author(s)

Organizer

Data Source

[Presentation] CGG-リピートRNA に結合する低分子型G-clamp 誘導体の開発2021

Author(s)

Organizer

Data Source

[Presentation] Development of the small molecular binder for the r(CGG) repeat2021

Author(s)

Organizer

Data Source

[Presentation] CGG-リピートRNA に結合する低分子型G-clamp 誘導体の開発2021

Author(s)

Organizer

Data Source

[Presentation] リピートDNA配列中の複数連続する結合サイトに協奏的に全サイト結合する低分子リガンドの開発2020

Author(s)

Organizer

Data Source

Murase Hirotaka 村瀬裕貴