Miyake Keisuke 三宅慧輔

Researcher Number	10814759
Affiliation (based on the past Project Information) *help	2020 – 2022: 熊本大学, 病院, リサーチ・スペシャリスト 2019: 熊本大学, 病院, リサーチスペシャリスト 2018: 熊本大学, 大学院生命科学研究部(医), リサーチスペシャリスト
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related
Keywords	Principal Investigator 炎症性発癌 / ストローマ細胞 / 腫瘍微小環境 / 繊維芽細胞 / 炎症 / 癌関連繊維芽細胞 / 胃がん / 腫瘍間質 / 癌関連線維芽細胞 / 胃癌 … More Except Principal Investigator … More 胃がん / CAFs / 胃癌 / 腫瘍微小環境 / JAK-STAT阻害剤 / 細胞老化 / 腹膜播種 / EZH2 / 浸潤 / 自律神経 / C AFs / 生体イメージング / 2光子顕微鏡 Less

Application of bioimaging technique for the investigation of mechanisms of metastasis depending on tumor stroma.
- Principal Investigator
  
  Fukuda Masahiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kumamoto University
Identification of molecular mechanism underlying peritoneal metastasis progression by tumor stromal cells.
- Principal Investigator
  
  Yasuda Tadahito
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kumamoto University
Identification of molecular mechanism underlying inflammatory-related carcinogenesis through activating the stroma in gastric cancerPrincipal Investigator
- Principal Investigator
  
  Miyake Keisuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kumamoto University

All 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination2021
- Author(s)
  Yasuda T, Koiwa M, Yonemura A, Miyake K, Kariya R, Kubota S, Yokomizo-Nakano T, Yasuda-Yoshihara N, Uchihara T, Itoyama R, Bu L, Fu L, Arima K, Izumi D, Iwagami S, Eto K, Iwatsuki M, Baba Y, Yoshida N, Ohguchi H, Okada S, Matsusaki K, Sashida G, Takahashi A, Tan P, Baba H, Ishimoto T.
- Journal Title
  
  Cell Reports
  
  Volume: 34 Issue: 8 Pages: 108779-108779
- DOI
  10.1016/j.celrep.2021.108779
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08543, KAKENHI-PROJECT-19K16749, KAKENHI-PROJECT-19H03507, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-20K08985, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-21K16384, KAKENHI-PROJECT-21KK0153
[Journal Article] Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance2020
- Author(s)
  Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani Jaffer A, Tan Patrick, Baba H, Ishimoto T
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 16 Pages: 3222-3235
- DOI
  10.1158/0008-5472.can-19-3803
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09177, KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-20K08985, KAKENHI-PROJECT-18H02694, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-18K08543, KAKENHI-PROJECT-19K16720, KAKENHI-PROJECT-19K16749, KAKENHI-PROJECT-18H02883
[Journal Article] Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment.2019
- Author(s)
  Bu L, Baba H, Yoshida N, Miyake K, Yasuda T, Uchihara T, Tan P, Ishimoto T
- Journal Title
  
  Oncogene
  
  Volume: 38 Pages: 4887-4901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08543
[Journal Article] Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas2018
- Author(s)
  Arima Kota、Ohmuraya Masaki、Miyake Keisuke、Koiwa Mayu、Uchihara Tomoyuki、Izumi Daisuke、Gao Feng、Yonemura Atsuko、Bu Luke、Okabe Hirohisa、Imai Katsunori、Hashimoto Daisuke、Baba Yoshifumi、Chikamoto Akira、Yamashita Yo-ichi、Furukawa Toru、Araki Kimi、Baba Hideo、Ishimoto Takatsugu
- Journal Title
  
  Oncogene
  
  Volume: 38 Issue: 8 Pages: 1211-1224
- DOI
  10.1038/s41388-018-0510-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08543, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-16H06257, KAKENHI-PROJECT-16K07093, KAKENHI-PROJECT-16K09398, KAKENHI-PROJECT-17K16570, KAKENHI-PROJECT-17K16571
[Presentation] 胃癌由来CAFsの老化と腹膜播種進展機序の解明2020
- Author(s)
  安田忠仁、石本崇胤、小岩麻由、米村敦子、三宅慧輔、内原智幸、江藤弘二郎、岩上志朗、馬場祥史、岩槻政晃、吉田直矢、馬場秀夫
- Organizer
  第120回日本外科学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08985
[Presentation] Gastric cancer CAFs maintain SASP through epigenetic histone modification and enhance peritoneal dissemination2020
- Author(s)
  Tadahito Yasuda, Mayu Koiwa, Atsuko Yonemura, Keisuke Miyake, Luke Bu, Hideo Baba, and Takatsugu Ishimoto
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08985
[Presentation] 腫瘍微小環境に依存する胃がん浸潤性増殖機構の解明2019
- Author(s)
  石本崇胤、三宅慧輔、米村敦子、安田忠仁、伊東山瑠美、内原智幸、吉田直矢、馬場秀夫
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08543
[Presentation] Activated-stroma by cancer-related inflammation enhances gastric cancer progression through activation of STAT1/3 signaling2018
- Author(s)
  三宅慧輔、内原智幸、江藤二男、有馬浩太、安田忠仁、付凌峰、米村敦子、岩槻政晃、馬場祥史、宮本裕士、吉田直矢、馬場秀夫、石本崇胤
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K08543

1. 石本崇胤 (00594889)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. Fukuda Masahiro (60802113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Yasuda Tadahito (00867947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 有馬浩太 (10792616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 泉大輔 (60594877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 今村裕 (70583045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 日比泰造 (10338072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 林洋光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyake Keisuke 三宅 慧輔

Research Projects

Research Products

Co-Researchers

Application of bioimaging technique for the investigation of mechanisms of metastasis depending on tumor stroma.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of molecular mechanism underlying peritoneal metastasis progression by tumor stromal cells.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of molecular mechanism underlying inflammatory-related carcinogenesis through activating the stroma in gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment.2019

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] 胃癌由来CAFsの老化と腹膜播種進展機序の解明2020

Author(s)

Organizer

Data Source

[Presentation] Gastric cancer CAFs maintain SASP through epigenetic histone modification and enhance peritoneal dissemination2020

Author(s)

Organizer

Data Source

[Presentation] 腫瘍微小環境に依存する胃がん浸潤性増殖機構の解明2019

Author(s)

Organizer

Data Source

[Presentation] Activated-stroma by cancer-related inflammation enhances gastric cancer progression through activation of STAT1/3 signaling2018

Author(s)

Organizer

Data Source

Miyake Keisuke 三宅慧輔