Sasaya Takashi 笹谷聖

Researcher Number	10815715
Affiliation (Current)	2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2023 – 2025: 札幌医科大学, 医学部, 助教 2021 – 2022: 札幌医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related Except Principal Investigator Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator ストレス応答 / 口腔癌 / PD-L1 / シスプラチン Except Principal Investigator がん免疫環境 / 遺伝子変異 / 免疫チェックポイント阻害剤 / 再発口腔がん / 腫瘍微小環境 / バイオマーカー … More / がん特異抗原 / 免疫逃避機構 / 口腔がん / がん免疫療法 / 3Dスフェロイド / 口腔癌 / がん抗原 / HLA / HLA class I / がん幹細胞 / 個別化・複合免疫療法 / がんペプチドワクチン療法 / がん幹細胞特異抗原 / シスプラチン / 免疫チェックポイント阻害薬 Less

口腔癌における免疫チェックポイント阻害薬の治療効果因子としてのNotch1変異の意義
- Principal Investigator
  
  荻和弘
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Sapporo Medical University
Elucidation of the mechanisms relating to immunoregulation in oral tumor microenvironment and development of novel treatments
- Principal Investigator
  
  宮崎晃亘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Sapporo Medical University
ストレス応答を介した化学療法による口腔癌細胞上のPD-L1誘導機構の解明Principal Investigator
- Principal Investigator
  
  笹谷聖
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Sapporo Medical University
遺伝子変異とがん免疫環境は口腔癌の免疫チェックポイント阻害薬の奏効率の指標となる
- Principal Investigator
  
  荻和弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Sapporo Medical University
Personalized combination immunotherapy targeting cancer stem cells in oral cancer
- Principal Investigator
  
  Miyazaki Akihiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Sapporo Medical University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Notch signaling genes and <scp>CD8</scp><sup>+</sup> T‐cell dynamics: Their contribution to immune‐checkpoint inhibitor therapy in oral squamous cell carcinoma: A retrospective study2024
- Author(s)
  Ogi Kazuhiro、Iwamoto Takahiro、Sasaya Takashi、Nishiyama Koyo、Tokura Takaaki、Sasaki Takanori、Dehari Hironari、Arihara Yohei、Murase Kazuyuki、Saito Masato、Someya Masanori、Takada Kohichi、Miyazaki Akihiro
- Journal Title
  
  Cancer Medicine
  
  Volume: 13 Issue: 5
- DOI
  10.1002/cam4.6985
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K16160, KAKENHI-PROJECT-22K10197, KAKENHI-PROJECT-21K07680, KAKENHI-PROJECT-23K27794
[Journal Article] Cisplatin-induced HSF1-HSP90 axis enhances the expression of functional PD-L1 in oral squamous cell carcinoma2023
- Author(s)
  Sasaya T, Kubo T, Murata K, Mizue Y, Sasaki K, Yanagawa J, Imagawa M, Kato H, Tsukahara T, Kanaseki T, Tamura Y, Miyazaki A, Hirohashi Y, Torigoe T.
- Journal Title
  
  Cancer Med
  
  Volume: 12 Issue: 4 Pages: 4605-4615
- DOI
  10.1002/cam4.5310
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-19K10292, KAKENHI-PROJECT-21K18257
[Journal Article] Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy2023
- Author(s)
  Miyamoto Sho、Hirohashi Yoshihiko、Morita Rena、Miyazaki Akihiro、Ogi Kazuhiro、Kanaseki Takayuki、Ide Kentaro、Shirakawa Jumpei、Tsukahara Tomohide、Murai Aiko、Sasaya Takashi、Koike Kazushige、Kina Shinichiro、Kawano Toshihiro、Goto Takahiro、Ntege Edward Hosea、Shimizu Yusuke、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 9 Pages: 3496-3508
- DOI
  10.1111/cas.15873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10084, KAKENHI-PROJECT-23K27794
[Journal Article] Three-dimensional spheroid configurations and cellular metabolic properties of oral squamous carcinomas are possible pharmacological and pathological indicators.2023
- Author(s)
  Miyamoto S, Nishikiori N, Sato T, Watanabe M, Umetsu A, Tsugeno Y, Hikage F, Sasaya T, Kato H, Ogi K, Furuhashi M, Ohguro H, Miyazaki A.
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 10 Pages: 2793-2793
- DOI
  10.3390/cancers15102793
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27794
[Journal Article] Prognostic value of CD45Ro+ T-cell expression in patients with oral squamous cell carcinoma.2021
- Author(s)
  Koike K, Nishiyama K, Dehari H, Ogi K, Sasaki T, Shimizu S, Sasaya T, Tsuchihashi K, Sonoda T, Hasegawa T, Hiratsuka H, Miyazaki A.
- Journal Title
  
  Anticancer Res
  
  Volume: 41 Pages: 4415-4522
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10292
[Journal Article] Prognostic value of HLA class Ⅰ expression in patients with oral squamous cell carcinoma2020
- Author(s)
  Koike K, Dehari H, Shimizu S, Nishiyama K, Sonoda T, Ogi K, Kobayashi J, Sasaki T, Sasaya T, Tsuchihashi K, Tsukahara T, Hasegawa T, Torigoe T, Hiratsuka H, Miyazaki A
- Journal Title
  
  Cancer Sci
  
  Volume: in press Issue: 5 Pages: 1491-1499
- DOI
  10.1111/cas.14388
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10292, KAKENHI-PROJECT-19K10337, KAKENHI-PROJECT-20K18675, KAKENHI-PROJECT-20K18732
[Journal Article] Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma2020
- Author(s)
  Koike Kazushige、Dehari Hironari、Ogi Kazuhiro、Shimizu Shota、Nishiyama Koyo、Sonoda Tomoko、Sasaki Takanori、Sasaya Takashi、Tsuchihashi Kei、Hasegawa Tadashi、Torigoe Toshihiko、Hiratsuka Hiroyoshi、Miyazaki Akihiro
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 8 Pages: e0237465-e0237465
- DOI
  10.1371/journal.pone.0237465
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10292, KAKENHI-PROJECT-19K10337, KAKENHI-PROJECT-20K18675
[Journal Article] Borderline Microenvironment Fibrosis Is a Novel Poor Prognostic Marker of Oral Squamous Cell Carcinoma2020
- Author(s)
  Tsuchihashi Kei、Nakatsugawa Munehide、Kobayashi Jun-ichi、Sasaya Takashi、Morita Rena、Kubo Terufumi、Kanaseki Takayuki、Tsukahara Tomohide、Asanuma Hiroko、Hasegawa Tadashi、Hirano Hiroshi、Miyazaki Akihiro、Hirohashi Yoshihiko、Torigoe Toshihiko
- Journal Title
  
  Anticancer Research
  
  Volume: 40 Issue: 8 Pages: 4319-4326
- DOI
  10.21873/anticanres.14434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10292, KAKENHI-PROJECT-18K19458
[Presentation] PVT1を標的とした人工抗体の開発2024
- Author(s)
  加藤大貴, 笹谷聖, 宮﨑晃亘
- Organizer
  第42回日本口腔腫瘍学会　総会・学術大会
- Data Source
  KAKENHI-PROJECT-23K27794
[Presentation] 新規口腔がん幹細胞特異的抗原とペプチドワクチンへの応用2023
- Author(s)
  宮本昇, 笹谷聖, 荻和弘, 宮﨑晃亘, 廣橋良彦, 金関貴幸, 塚原智英, 鳥越俊彦
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27794
[Presentation] NOTCHシグナル伝達系の遺伝子変異は再発口腔癌における免疫チェックポイント阻害剤の治療効果に影響する.2023
- Author(s)
  荻　和弘，岩本空大，笹谷　聖，都倉尭明，佐々木敬則，出張裕也，平塚博義，宮﨑晃亘.
- Organizer
  第47回日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-22K10197
[Presentation] 口腔がん細胞の3Dスフェロイド培養と細胞代謝特性の解析2023
- Author(s)
  宮本昇, 笹谷聖, 加藤大貴, 平川結, 荻和弘, 宮﨑晃亘
- Organizer
  第68回(公社)日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-23K27794
[Presentation] シスプラチンによるHSF1およびHSP90を介した口腔扁平上皮癌細胞上のPD-L1誘導機構の解明2022
- Author(s)
  笹谷聖, 廣橋良彦, 久保輝文, 宮﨑晃亘, 鳥越俊彦
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K10292
[Presentation] 再発口腔癌におけるPD-L1, CD8の発現の意義とNOTCHシグナルを介したがん免疫機構の解析2022
- Author(s)
  荻　和弘，岩本空大，笹谷　聖，小池和茂，岡本準也，金子　剛，佐々木敬則，出張裕也，中井裕美，宮﨑晃亘
- Organizer
  第46回日本頭頸部癌学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-22K10197
[Presentation] シスプラチンはHSF1の活性化とHSP90の誘導を介して口腔扁平上皮癌細胞上のPD-L1発現を亢進させCTL機能を抑制する2022
- Author(s)
  笹谷聖, 廣橋良彦, 久保輝文, 佐々木敬則, 土橋恵, 加藤大貴, 鳥越俊彦, 宮﨑晃亘
- Organizer
  第43回日本癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-19K10292
[Presentation] シスプラチンは HSF1 および HSP90 を介して口腔扁平上皮癌細胞上の PD-L1 発現を誘導する2022
- Author(s)
  笹谷聖, 久保輝文, 廣橋良彦, 加藤大貴, 鳥越俊彦, 宮﨑晃亘
- Organizer
  第58回日本口腔組織培養学会学術大会・総会
- Data Source
  KAKENHI-PROJECT-19K10292
[Presentation] 口腔癌患者における免疫担当細胞の発現と予後との関連性についての検討2021
- Author(s)
  小池和茂、西山廣陽、出張裕也、荻和弘、笹谷聖、土橋恵、畠中柚衣、関口翔平、宮﨑晃亘
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K10292
[Presentation] シスプラチンは口腔扁平上皮癌細胞上のPD-L1発現を誘導しCTL機能を抑制する2021
- Author(s)
  笹谷聖、廣橋良彦、久保輝文、宮﨑晃亘、鳥越俊彦
- Organizer
  第110回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K10292
[Presentation] シスプラチンはHSF1の活性化とHSP90の誘導を介して口腔扁平上皮癌細胞上のPD-L1発現を亢進させる2021
- Author(s)
  笹谷聖、廣橋良彦、久保輝文、宮﨑晃亘、鳥越俊彦
- Organizer
  第15回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-19K10292
[Presentation] シスプラチンおよび放射線は口腔扁平上皮癌細胞上のPD-L1発現を誘導する2021
- Author(s)
  笹谷聖、土橋恵、岡本準也、加藤大貴、中井裕美、宮﨑晃亘
- Organizer
  第39回日本口腔腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19K10292
[Presentation] シスプラチンおよび放射線は口腔扁平上皮癌細胞上のPD-L1発現を誘導しCTL機能を抑制する2021
- Author(s)
  笹谷聖、廣橋良彦、久保輝文、宮﨑晃亘、鳥越俊彦
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K10292
[Presentation] 口腔扁平上皮癌におけるHLA class Ⅰおよび腫瘍浸潤リンパ球発現の予後因子としての有用性の検討2021
- Author(s)
  小池和茂、出張裕也、荻和弘、西山廣陽、佐々木敬則、笹谷聖、土橋恵、塚原智英、鳥越俊彦、宮﨑晃亘
- Organizer
  第42回癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-19K10292
[Presentation] 口腔扁平上皮癌における病理組織学的新規予後規定因子の検討2021
- Author(s)
  土橋恵、岡本準也、笹谷聖、加藤大貴、中井裕美、宮﨑晃亘
- Organizer
  第39回日本口腔腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19K10292
[Presentation] Prognostic impact of HLA class I expression and its association with CD8+T-cell density in oral squamous cell carcinoma2020
- Author(s)
  小池和茂、出張裕也、西山廣陽、荻和弘、笹谷聖、土橋恵、畠中柚衣、塚原智英、鳥越俊彦、宮崎晃亘
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K10292
[Presentation] 口腔扁平上皮癌患者における腫瘍浸潤リンパ球の局在と予後との関連性についての研究2020
- Author(s)
  小池和茂、出張裕也、荻和弘、西山廣陽、佐々木敬則、土橋恵、笹谷聖、中井裕美、岡本準也、宮﨑晃亘
- Organizer
  第65回（公社）日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19K10292

1. Miyazaki Akihiro (10305237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. 宮本昇 (80749565)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 荻和弘 (40433114)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 岩本空大 (90894048)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 中井裕美 (80792126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 小林淳一 (80404739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 土橋恵 (50815264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
8. 岡本準也 (10749592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 西山廣陽 (60749563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 加藤大貴 (40894051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 佐々木敬則 (50548732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HIROHASHI Yoshihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 喜名振一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 喜名美香

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sasaya Takashi 笹谷 聖

Research Projects

Research Products

Co-Researchers

口腔癌における免疫チェックポイント阻害薬の治療効果因子としてのNotch1変異の意義

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanisms relating to immunoregulation in oral tumor microenvironment and development of novel treatments

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ストレス応答を介した化学療法による口腔癌細胞上のPD-L1誘導機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遺伝子変異とがん免疫環境は口腔癌の免疫チェックポイント阻害薬の奏効率の指標となる

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Personalized combination immunotherapy targeting cancer stem cells in oral cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Notch signaling genes and <scp>CD8</scp><sup>+</sup> T‐cell dynamics: Their contribution to immune‐checkpoint inhibitor therapy in oral squamous cell carcinoma: A retrospective study2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cisplatin-induced HSF1-HSP90 axis enhances the expression of functional PD-L1 in oral squamous cell carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three-dimensional spheroid configurations and cellular metabolic properties of oral squamous carcinomas are possible pharmacological and pathological indicators.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic value of CD45Ro+ T-cell expression in patients with oral squamous cell carcinoma.2021

Author(s)

Journal Title

Data Source

[Journal Article] Prognostic value of HLA class Ⅰ expression in patients with oral squamous cell carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Borderline Microenvironment Fibrosis Is a Novel Poor Prognostic Marker of Oral Squamous Cell Carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] PVT1を標的とした人工抗体の開発2024

Author(s)

Organizer

Data Source

[Presentation] 新規口腔がん幹細胞特異的抗原とペプチドワクチンへの応用2023

Author(s)

Organizer

Sasaya Takashi 笹谷聖

[Presentation] シスプラチンは HSF1 および HSP90 を介して口腔扁平上皮癌細胞上の PD-L1 発現を誘導する2022