Hara Yasumasa 原康雅

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Yasumasa Hara 原康雅

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Researcher Number	10824625
Other IDs	https://orcid.org/0000-0003-0451-8731
Affiliation (Current)	2022: 千葉大学, 大学院薬学研究院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2022: 千葉大学, 大学院薬学研究院, 助教 2018: 千葉大学, 大学院薬学研究院, 特任助教
Review Section/Research Field	Principal Investigator 0801:Pharmaceutical sciences and related fields / Basic Section 47050:Environmental and natural pharmaceutical resources-related Except Principal Investigator Natural medicines / Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator 共培養 / 微生物資源 / 放線菌 / 培養抽出物ライブラリー / 培養抽出物ライブラリー構築 / 海洋由来真菌 / ミコール酸含有細菌 / 培養抽出ライブラリー構築 / 土壌由来放線菌 / 放線菌Nocardia属 / 共培養抽出物ライブラリー構築 … More Except Principal Investigator … More 生理活性 / シグナル伝達 / 生体分子 / 有機化学 / 薬学 Less

Search for bioactive natural products with overcoming effects on cancer-heterogeneity
- Principal Investigator
  
  石橋正己
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Chiba University
微生物の生育環境を模倣した共培養法による新規医薬シーズ探索とその産生機構解明Principal Investigator
- Principal Investigator
  
  原康雅
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Chiba University
Advancement of resources for drug discovery seeds utilizing microbial interactions and elucidation of activation mechanism of microbial dormant gene clustersPrincipal Investigator
- Principal Investigator
  
  Yasumasa Hara
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Chiba University
Search and function elucidation of highly active natural products targeting cancer microenvironmental signals
- Principal Investigator
  
  Ishibashi Masami
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Natural medicines
- Research Institution
  Chiba University

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Acacienone, a terpenoid-like natural product having an unprecedented C20 framework isolated from Acacia mangium leaves2021
- Author(s)
  Yasumasa Hara, Yuichi Totsugi, Hiroshi Ichikawa, Shinji Harada, Kazuki Fujii, Firoj Ahmed, Samir K. Sadhu, Midori A. Arai, Masami Ishibashi
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 75 Pages: 99-104
- DOI
  10.1007/s11418-020-01457-y
- NAID
  40022463001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04640, KAKENHI-PROJECT-18H02582, KAKENHI-PROJECT-20H03394
[Journal Article] Dehydropropylpantothenamide isolated by a co-culture of Nocardia tenerifensis IFM 10554T in the presence of animal cells2020
- Author(s)
  Tomoyuki Sato, Midori A. Arai, Yixizhuoma, Yasumasa Hara, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 74 Pages: 280-289
- DOI
  10.1007/s11418-019-01380-x
- NAID
  40022183696
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03992, KAKENHI-PUBLICLY-19H04640, KAKENHI-PROJECT-20H03394
[Journal Article] Nonactic acid derivatives isolated from Streptomyces werraensis IFM12104 in a screening program for BMI1 promoter inhibitory activity2019
- Author(s)
  Yusuke Yokoyama, Midori A. Arai, Yasumasa Hara, Masami Ishibashi
- Journal Title
  
  Natural Products Communications
  
  Volume: 14 Pages: 1-5
- DOI
  10.1177/1934578x19866583
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04640, KAKENHI-PROJECT-17H03992
[Journal Article] Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-119582019
- Author(s)
  Yusuke Yokoyama, Midori A. Arai, Yasumasa Hara, Masami Ishibashi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Pages: 2998-3003
- DOI
  10.1016/j.bmc.2019.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H04640, KAKENHI-PROJECT-17H03992, KAKENHI-PROJECT-18H02582
[Journal Article] Coculture of a pathogenic actinomycete and animal cells to produce nocarjamide, a cyclic nonapeptide with Wnt signal-activating effect2018
- Author(s)
  Yasumasa Hara, Midori A. Arai, Kazufumi Toume, Hyuma Masu, Tomoyuki Sato, Katsuko Komatsu, Takashi Yaguchi, Masami Ishibashi
- Journal Title
  
  Organic Letters
  
  Volume: 20 Pages: 5831-5834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03992
[Journal Article] Isolation of Nabscessin C from <i>Nocardia abscessus</i> IFM 10029<sup>T</sup> and a Study on Biosynthetic Pathway for Nabscessins2018
- Author(s)
  Shoko Hara, Yasumasa Hara, Midori A. Arai, Yoko Kusuya, Hiroki Takahashi, Takashi Yaguchi, Masami Ishibashi
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 66 Issue: 10 Pages: 976-982
- DOI
  10.1248/cpb.c18-00430
- NAID
  130007492854
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03992
[Journal Article] Nabscessins A and B, aminocyclitol derivatives from Nocardia abscessus IFM 10029T2017
- Author(s)
  Shoko Hara, Naoki Ishikawa, Yasumasa Hara, Tatsuo Nehira, Kanae Sakai, Tohru Gonoi, Masami Ishibashi
- Journal Title
  
  Journal of Natural Products
  
  Volume: 80 Pages: 565-568
- DOI
  10.1021/acs.jnatprod.6b00935
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05696, KAKENHI-PROJECT-16K14910, KAKENHI-PROJECT-17H03992
[Presentation] 動物細胞との共培養法による病原性放線菌Nocardia属由来新規生物活性天然物の探索 (2)2021
- Author(s)
  原康雅，矢口貴志，石橋正己
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K16024
[Presentation] Andrographis paniculataからの BMI1 プロモーター阻害作用を示す天然物の探索2020
- Author(s)
  藤井一樹，荒井緑，原康雅，S. K. Sadhu，F. Ahmed，石橋正己
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20H03394
[Presentation] 微生物の生育環境を模倣した共培養法による新規天然物の探索2020
- Author(s)
  千葉まれの, 原康雅, 石橋正己
- Organizer
  日本薬学会140年会
- Data Source
  KAKENHI-PROJECT-19K21222
[Presentation] Search for new natural products from pathogenic actinomycetes of the genus Nocardia by co-culture with animal cells2020
- Author(s)
  Yasumasa Hara, Midori A. Arai, Takashi Yaguchi, Masami Ishibashi
- Organizer
  2nd German-Japanese Joint Symposium on the Biosynthesis of Natural Products
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16024
[Presentation] 関節リウマチ由来滑膜細胞に選択的にアポトーシス経路を誘導する天然物の探索2020
- Author(s)
  山崎秀太，原康雅，小谷野喬，T. Kowithayakorn，石橋正己
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20H03394
[Presentation] Search for new natural products from pathogenic actinomycetes of the genus Nocardia by co-culture with animal cells2020
- Author(s)
  Yasumasa Hara, Midori A. Arai, Takashi Yaguchi, Masami Ishibashi
- Organizer
  2nd German-Japanese Symposium on Natural Product Biosynthesis
- Data Source
  KAKENHI-PROJECT-20H03394
[Presentation] Santalum album からのWnt シグナル阻害作用をもつ天然物の探索2019
- Author(s)
  佐藤知幸，荒井緑，原康雅，益西卓瑪，小谷野喬，Thaworn Kowithayakorn，石橋正己
- Organizer
  日本生薬学会第66回年会
- Data Source
  KAKENHI-PROJECT-17H03992
[Presentation] 放線菌からのBMI1 プロモーター阻害作用をもつ天然物の探索2019
- Author(s)
  横山夕将, 荒井緑, 原康雅, 石橋正己
- Organizer
  第8回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-17H03992
[Presentation] 微生物共培養法を利用した活性天然物の探索2018
- Author(s)
  城森啓宏, 笹岡美歩，原康雅，Andi Setiawan，荒井雅吉
- Organizer
  日本生薬学会第65回年会
- Data Source
  KAKENHI-PROJECT-19K21222
[Presentation] 微生物共培養法を利用した活性天然物の探索2018
- Author(s)
  城森啓宏, 原康雅, 笹岡美歩, Andi Setiawan, 荒井雅吉
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-19K21222

1. Ishibashi Masami (90212927)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. 荒井緑 (40373261)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. 石川直樹 (20748826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 高屋明子 (80334217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 根平達夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Yasumasa 原 康雅

Yasumasa Hara 原 康雅

Research Projects

Research Products

Co-Researchers

Search for bioactive natural products with overcoming effects on cancer-heterogeneity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

微生物の生育環境を模倣した共培養法による新規医薬シーズ探索とその産生機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Advancement of resources for drug discovery seeds utilizing microbial interactions and elucidation of activation mechanism of microbial dormant gene clustersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search and function elucidation of highly active natural products targeting cancer microenvironmental signals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Acacienone, a terpenoid-like natural product having an unprecedented C20 framework isolated from Acacia mangium leaves2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Dehydropropylpantothenamide isolated by a co-culture of Nocardia tenerifensis IFM 10554T in the presence of animal cells2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Nonactic acid derivatives isolated from Streptomyces werraensis IFM12104 in a screening program for BMI1 promoter inhibitory activity2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-119582019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Coculture of a pathogenic actinomycete and animal cells to produce nocarjamide, a cyclic nonapeptide with Wnt signal-activating effect2018

Author(s)

Journal Title

Data Source

[Journal Article] Isolation of Nabscessin C from <i>Nocardia abscessus</i> IFM 10029<sup>T</sup> and a Study on Biosynthetic Pathway for Nabscessins2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Nabscessins A and B, aminocyclitol derivatives from Nocardia abscessus IFM 10029T2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 動物細胞との共培養法による病原性放線菌Nocardia属由来新規生物活性天然物の探索 (2)2021

Author(s)

Organizer

Data Source

[Presentation] Andrographis paniculataからの BMI1 プロモーター阻害作用を示す天然物の探索2020

Author(s)

Organizer

Data Source

[Presentation] 微生物の生育環境を模倣した共培養法による新規天然物の探索2020

Author(s)

Organizer

Data Source

Hara Yasumasa 原康雅

Yasumasa Hara 原康雅